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Postoperative Pain: later-stage trial registry
42 of 121 indexed Postoperative Pain trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #102 of 28,707 conditions by registered trial count.
121 US clinical trials · 42 currently recruiting · #102 of 28,707 conditions by registered trial count
Postoperative Pain: 121 US clinical trials tracked, 42 recruiting.
Postoperative Pain is the subject of 121 registered US clinical trials on ClinicalTrials.gov, 42 of them currently open to new participants. 55 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is Medical University of South Carolina, running 5 of these trials.
Enrollment posture brief
Registry condition postoperative-pain
OPEN 42 | RECR 35% | LATE 55 | EARLY 23 | RANK #102 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Invasive Breast Carcinoma (35% recruiting · 46 trials)
Postoperative Pain lists 42 open slots (35% of 121 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Postoperative Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Postoperative Pain is recruiting below its size-band peers.
42 of 121 indexed trials (34.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Postoperative Pain trials is spread across many organizations.
Medical University of South Carolina accounts for 5 of 121 trials (4.1%). 94 distinct sponsors appear on at least one study for this condition label.
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Typical Postoperative Pain enrolment sits around 100 participants.
Median target enrolment is 100 among the 121 trials that report a genuine target (sentinel values excluded). 59 of those (48.8%) plan for fewer than 100 participants.
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Postoperative Pain research is mostly interventional.
110 interventional and 11 observational studies make up this index (90.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
121 total, page 1 of 3
A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves
AtriCure
NCT05110989
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Thomas Jefferson University
NCT07102641
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
Brown University
NCT05754190
A Study of TLC590 for Postsurgical Pain Following Bunionectomy
TLC Biopharmaceuticals
NCT07222748
A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain
University of California, San Francisco
NCT05010148
Simethicone as Part of ERAS in Bariatric Surgery Patients
Madigan Army Medical Center
NCT06812832
ZYNRELEF for Pain Management in Total Knee Arthroplasty
Baptist Health South Florida
NCT05644496
Sex Hormones, Postoperative Pain and Opioid Use
Washington University School of Medicine
NCT06023225
Methadone in TKA for Post-op Pain and Opioid Reduction
Medical University of South Carolina
NCT07226076
Methadone in THA for Post-op Pain and Opioid Reduction
Medical University of South Carolina
NCT07227064
Dextromethorphan for Treatment of Postoperative Pain
Nathanael Heckmann
NCT05278494
Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy
Brigham and Women's Hospital
NCT06483659
RADA16 for Adult Tonsillectomy
Rutgers, The State University of New Jersey
NCT07060495
Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy
Texas Tech University Health Sciences Center
NCT06349772
Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine
Boston Children's Hospital
NCT06471348
Subpectoral Bupivacaine for Pain Management in Adolescent Reduction Mammaplasty
Connecticut Children's Medical Center
NCT05898087
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
The Cleveland Clinic
NCT07222072
Opioid Use After Laparoscopic Salpingectomy
Johns Hopkins University
NCT06434233
Characterization of Acute Pain
Children's National Research Institute
NCT07336264
Pain With Differing Insufflation Pressures During Laparoscopic Hysterectomy
University of Tennessee
NCT06508814
Preoperative Acetazolamide
Prisma Health-Upstate
NCT07101250
Force Sensor Study
University of California, San Francisco
NCT07434583
Post-operative Cesarean Trial of Pain Control
University of Colorado, Denver
NCT05131178
Effects of Assisted Robotic vs Laparoscopic Sleeve Gastrectomy
Ricard Corcelles
NCT06425016
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
Texas Tech University Health Sciences Center
NCT06903819
A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi
Mayo Clinic
NCT07223580
Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery
Massachusetts General Hospital
NCT04912531
QL Block in Laparoscopic Myomectomy
Joseph Findley MD
NCT05979493
Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty
Matthew Grosso, MD
NCT06479161
Liposomal Bupivacaine and Transoral Robotic Surgery
Geisinger Clinic
NCT05862792
Post Operative Infusion Pump Pain Study
Rutgers, The State University of New Jersey
NCT07349810
Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease
University of Texas Southwestern Medical Center
NCT06158620
Rectus Sheath Block in Cardiac Surgery
Icahn School of Medicine at Mount Sinai
NCT05833048
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
University of North Carolina, Chapel Hill
NCT07213635
Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties
Melinda Seering
NCT05868330
Temperature Rise Caused by Short or Long-wavelengths
University of Florida
NCT06418958
Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery
Pacira Pharmaceuticals
NCT06271265
QL vs LAI for Palatoplasty
Medical University of South Carolina
NCT06420336
Sensory Outcomes in Active Substance Users
Boston Medical Center
NCT06639438
Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI
Sam Tyagi
NCT04600089
Dextenza in the Post-op Management of Vitreoretinal Surgeries
The Cleveland Clinic
NCT04371445
Opioid Prescribing Practices in Laparoscopic Gynecologic Surgery
University of Tennessee
NCT06532708
Personalizing Perioperative Analgesia in Children
Senthil Sadhasivam
NCT01140724
No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair
Clayton Petro
NCT05929937
Quality of Recovery From Mastectomy With and Without PECS Blocks
Endeavor Health
NCT05795413
Perioperative Lidocaine and Ketamine in Abdominal Surgery
The Cleveland Clinic
NCT04084548
The Perioperative Pain Self-Management Program Trial
VA Office of Research and Development
NCT04979429
Postoperative VR for Recovery After Bariatric Surgery
Beth Israel Deaconess Medical Center
NCT04754165
Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks
University of Arizona
NCT07099222
Comparing Perioperative Outcomes in Pain Control
University of California, San Diego
NCT05690282
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 15 |
| Phase 3 | 17 |
| Phase 4 | 38 |
Top Sponsors
Named interventions
Most-linked intervention names on Postoperative Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Postoperative Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Postoperative Pain page
121 registered trials, 42 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 42 Postoperative Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Medical University of South Carolina sponsors the most Postoperative Pain trials on record, review their full trial history before evaluating a specific study. See Medical University of South Carolina's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Postoperative Pain condition card totals 121 registered trials; most-linked intervention Placebo; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.