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Postoperative Pain
Open-data reference.
63 US clinical trials · 15 currently recruiting
Active & Recent Trials
A Study of TLC590 for Postsurgical Pain Following Bunionectomy
TLC Biopharmaceuticals
NCT07222748
A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain
University of California, San Francis
NCT05010148
Sex Hormones, Postoperative Pain and Opioid Use
Washington University School of Medicine
NCT06023225
Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy
Brigham and Women's Hospital
NCT06483659
RADA16 for Adult Tonsillectomy
Rutgers, The State University of New Jersey
NCT07060495
Characterization of Acute Pain
Children's National Research Institute
NCT07336264
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
Texas Tech University Health Sciences Center
NCT06903819
Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery
Massachusetts General Hospital
NCT04912531
QL Block in Laparoscopic Myomectomy
Joseph Findley MD
NCT05979493
Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty
Matthew Grosso, MD
NCT06479161
Rectus Sheath Block in Cardiac Surgery
Icahn School of Medicine at Mount Sinai
NCT05833048
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
University of North Carolina, Chapel Hill
NCT07213635
Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery
Pacira Pharmaceuticals
NCT06271265
Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI
Sam Tyagi
NCT04600089
Opioid Prescribing Practices in Laparoscopic Gynecologic Surgery
University of Tennessee
NCT06532708
Personalizing Perioperative Analgesia in Children
Senthil Sadhasivam
NCT01140724
No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair
Clayton Petro
NCT05929937
Perioperative Lidocaine and Ketamine in Abdominal Surgery
The Cleveland Clinic
NCT04084548
The Perioperative Pain Self-Management Program Trial
VA Office of Research and Development
NCT04979429
Postoperative VR for Recovery After Bariatric Surgery
Beth Israel Deaconess Medical Center
NCT04754165
Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks
University of Arizona
NCT07099222
Development of a Predictive Model for Post-Discharge Nausea and Vomiting (PDNV)
University of California, San Francis
NCT00514878
Multicenter Continuous Peripheral Nerve Block Surveillance Study
Halyard Health
NCT00653133
Pilot Herniorrhaphy Study for Postoperative Analgesia
Heron Therapeutics
NCT02504580
Comparison of the Safety of Q8003 Versus Morphine Equivalent Doses of Its Components (Oxycodone and Morphine) in Bunionectomy Patients
QRxPharma
NCT01280331
No Opioids PrescrIptions On Discharge After Surgery
Albany Medical College
NCT04469868
Efficacy and Safety of Intravenous Acetaminophen Over 48 Hrs for the Treatment of Post-op Pain After Gynecologic Surgery
Mallinckrodt
NCT00399568
Bupivacaine Effectiveness and Safety in SABER® Trial
Durect
NCT01052012
Safety and Efficacy of Multiple Doses of Intranasal Ketorolac in Postoperative Pain Following Major Abdominal Surgery
Egalet
NCT00266786
Comparing Opioid Prescription Patterns in Total Joint Arthroplasty Patients
Rush University Medical Center
NCT03236155
Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia
Heron Therapeutics
NCT03015532
A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty
Pacira Pharmaceuticals
NCT00745290
Patient-Controlled Epidural Analgesia (PCEA) for Patients Who Have Had Major Open Gynecologic Surgery
Memorial Sloan Kettering Cancer Center
NCT00136682
A Prospective Assessment of Opioid Utilization Post-operatively in Sports Orthopaedic Surgeries
St. Louis University
NCT03422211
Dose-Ranging Study for Prolonged Postoperative Analgesia in Subject Undergoing Total Knee Arthroplasty
Pacira Pharmaceuticals
NCT00485693
Effect of Paracervical Block on Post Operative Pain in Laparoscopic Gynecologic Surgery
Icahn School of Medicine at Mount Sinai
NCT01534416
A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery
59th Medical Wing
NCT01097577
PG and PK of Oxycodone to Personalize Post-op Pain Management Following Surgery in Children
Senthil Sadhasivam
NCT03495388
Chronic Pain After Amputation
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00006427
Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients
Washington University School of Medicine
NCT02926573
Local Anesthetics on Postsurgical Analgesia Following Posterior Colporrhaphy
Walter Reed National Military Medical Center
NCT04032327
Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain
Mylan
NCT04571515
QL vs PENG for Analgesia After Hip Arthroplasty
Medical University of South Carolina
NCT05710107
Intravenous Acetaminophen in Craniotomy
The University of Texas Health Science Center, Houston
NCT01598701
Study of a Multimodality Pain Management Protocol on Postoperative Neurosurgical Pain
University of Florida
NCT01693588
Lidocaine Patches After Cesarean Section
Yale University
NCT04443569
Phase 2 Bunionectomy HTX-011 Administration Study
Heron Therapeutics
NCT03718039
Transversus Abdominis Plane (TAP) Block Laparoscopic Hysterectomy
Northwestern University
NCT01074229
Intrathecal Morphine for Cesarean Delivery
Beth Israel Deaconess Medical Center
NCT05069012
Extended Release Local Anesthetic for Postsurgical Pain After Posterior Colporrhaphy and Perineorrhaphy
Wake Forest University Health Sciences
NCT03875664
Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
St. Luke's-Roosevelt Hospital Center
NCT01881776
Single-shot TAP Block vs Continuous TAP Block
Indiana University
NCT02475031
PENG Block for Arthroscopic Hip Surgery
University of Virginia
NCT04508504
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
University Hospitals Cleveland Medical Center
NCT02509312
Efficacy of EXPAREL in Comparison to Standard of Care for the Treatment of Post Operative Dental Implant Pain
Bellaire Facial Surgery Center
NCT02533440
Postoperative Pain Control in Children Undergoing Laparoscopic Appendectomy: Peripheral Nerve Block Versus Local Anesthetic
Ann & Robert H Lurie Children's Hospital of Chicago
NCT01662401
A Phase 1 Study to Evaluate Pregabalin and Acetaminophen in Healthy Volunteers
Nevakar
NCT04265456
Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular Infiltration
University of Texas Southwestern Medical Center
NCT02658240
Pain Control With Total Knee Replacement
Texas Tech University Health Sciences Center
NCT01680549
Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries
John Fowler
NCT02313675
Effect of Postoperative Single Dose of Ketamine on Pain After Mastectomy
NYU Langone Health
NCT04831736
Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study
Sight Medical Doctors P
NCT04168112
Assess the Feasibility and Efficacy of the CollaRx® Bupivacaine Implant Laparoscopic Inguinal or Umbilical Herniorrhaphy
Innocoll
NCT01224145
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 4 |
| Phase 2 | 11 |
| Phase 3 | 11 |
| Phase 4 | 16 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Postoperative Pain Trial Landscape
ClinicalTrials.gov lists 63 US studies indexed under Postoperative Pain, and 15 of those are currently open to recruitment — roughly 24% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Postoperative Pain shows 27 late-stage studies (Phase 3 and Phase 4 combined) alongside 15 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Postoperative Pain is led by Heron Therapeutics with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 63 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Postoperative Pain?
PlainTrial tracks 63 US clinical trials for Postoperative Pain, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Postoperative Pain?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.