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ClinicalTrials.gov 15 recruiting now official registry

Postoperative Pain clinical trials

15 of 64 indexed Postoperative Pain trials are currently recruiting.

64 US clinical trials · 15 currently recruiting

Postoperative Pain is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 28 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Heron Therapeutics, running 3 of these trials.

The research picture

Postoperative Pain has 64 registered US clinical trials, 15 of them open to new participants right now, about 23% of the total.

15
recruiting participants now
23%
of trials open to enrollment
28
in Phase 3–4 (later-stage)
3
top sponsor: Heron Therapeutics
Phase 14Phase 211Phase 311Phase 417

Active & Recent Trials

64 total, page 2 of 2

COMPLETED Early Phase 1 71 participants

Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week

St. Luke's-Roosevelt Hospital Center

NCT01881776

COMPLETED Phase 4 70 participants

Single-shot TAP Block vs Continuous TAP Block

Indiana University

NCT02475031

COMPLETED NA 70 participants

PENG Block for Arthroscopic Hip Surgery

University of Virginia

NCT04508504

COMPLETED Phase 4 70 participants

Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery

University Hospitals Cleveland Medical Center

NCT02509312

COMPLETED NA 69 participants

Efficacy of EXPAREL in Comparison to Standard of Care for the Treatment of Post Operative Dental Implant Pain

Bellaire Facial Surgery Center

NCT02533440

COMPLETED Phase 2 66 participants

Postoperative Pain Control in Children Undergoing Laparoscopic Appendectomy: Peripheral Nerve Block Versus Local Anesthetic

Ann & Robert H Lurie Children's Hospital of Chicago

NCT01662401

COMPLETED Phase 1 63 participants

A Phase 1 Study to Evaluate Pregabalin and Acetaminophen in Healthy Volunteers

Nevakar

NCT04265456

COMPLETED NA 60 participants

Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular Infiltration

University of Texas Southwestern Medical Center

NCT02658240

COMPLETED Phase 4 50 participants

Pain Control With Total Knee Replacement

Texas Tech University Health Sciences Center

NCT01680549

COMPLETED Phase 4 44 participants

Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries

John Fowler

NCT02313675

COMPLETED Phase 4 41 participants

Comparative Study of Two Different Techniques to Perform TAP-blocks

Maimonides Medical Center

NCT02571439

COMPLETED Phase 4 31 participants

Effect of Postoperative Single Dose of Ketamine on Pain After Mastectomy

NYU Langone Health

NCT04831736

COMPLETED Phase 4 20 participants

Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study

Sight Medical Doctors P

NCT04168112

COMPLETED Phase 2 10 participants

Assess the Feasibility and Efficacy of the CollaRx® Bupivacaine Implant Laparoscopic Inguinal or Umbilical Herniorrhaphy

Innocoll

NCT01224145

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Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 11
Phase 3 11
Phase 4 17

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Postoperative Pain Trial Landscape

64 indexed Postoperative Pain studies · 15 recruiting (23%).

Phase mix: 28 late (III/IV) vs 15 early (I/II).

Top sponsor: Heron Therapeutics (3 trials), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Postoperative Pain?

PlainTrial tracks 64 US clinical trials for Postoperative Pain, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Postoperative Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.