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Postoperative Pain: later-stage trial registry
42 of 121 indexed Postoperative Pain trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #102 of 28,707 conditions by registered trial count.
121 US clinical trials · 42 currently recruiting · #102 of 28,707 conditions by registered trial count
Postoperative Pain: 121 US clinical trials tracked, 42 recruiting.
Postoperative Pain is the subject of 121 registered US clinical trials on ClinicalTrials.gov, 42 of them currently open to new participants. 55 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is Medical University of South Carolina, running 5 of these trials.
Enrollment posture brief
Registry condition postoperative-pain
OPEN 42 | RECR 35% | LATE 55 | EARLY 23 | RANK #102 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Invasive Breast Carcinoma (35% recruiting · 46 trials)
Postoperative Pain lists 42 open slots (35% of 121 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Postoperative Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Postoperative Pain is recruiting below its size-band peers.
42 of 121 indexed trials (34.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Postoperative Pain trials is spread across many organizations.
Medical University of South Carolina accounts for 5 of 121 trials (4.1%). 94 distinct sponsors appear on at least one study for this condition label.
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Typical Postoperative Pain enrolment sits around 100 participants.
Median target enrolment is 100 among the 121 trials that report a genuine target (sentinel values excluded). 59 of those (48.8%) plan for fewer than 100 participants.
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Postoperative Pain research is mostly interventional.
110 interventional and 11 observational studies make up this index (90.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
121 total, page 2 of 3
ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery
University of California, Davis
NCT05805423
Development of a Predictive Model for Post-Discharge Nausea and Vomiting (PDNV)
University of California, San Francisco
NCT00514878
Multicenter Continuous Peripheral Nerve Block Surveillance Study
Halyard Health
NCT00653133
Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Herniorrhaphy
Viatris Specialty
NCT06215859
Pilot Herniorrhaphy Study for Postoperative Analgesia
Heron Therapeutics
NCT02504580
Comparison of the Safety of Q8003 Versus Morphine Equivalent Doses of Its Components (Oxycodone and Morphine) in Bunionectomy Patients
QRxPharma
NCT01280331
A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain
Talphera
NCT01539538
No Opioids PrescrIptions On Discharge After Surgery
Albany Medical College
NCT04469868
Efficacy and Safety of Intravenous Acetaminophen Over 48 Hrs for the Treatment of Post-op Pain After Gynecologic Surgery
Mallinckrodt
NCT00399568
Bupivacaine Effectiveness and Safety in SABER® Trial
Durect
NCT01052012
Safety and Efficacy of Multiple Doses of Intranasal Ketorolac in Postoperative Pain Following Major Abdominal Surgery
Egalet
NCT00266786
Comparing Opioid Prescription Patterns in Total Joint Arthroplasty Patients
Rush University Medical Center
NCT03236155
Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia
Heron Therapeutics
NCT03015532
Maxigesic IV Phase 3 Bunionectomy Study
AFT Pharmaceuticals
NCT02689063
Ibuprofen Extended-Release Dental Pain Study
SCOLR Pharma
NCT00707057
A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty
Pacira Pharmaceuticals
NCT00745290
Patient-Controlled Epidural Analgesia (PCEA) for Patients Who Have Had Major Open Gynecologic Surgery
Memorial Sloan Kettering Cancer Center
NCT00136682
A Prospective Assessment of Opioid Utilization Post-operatively in Sports Orthopaedic Surgeries
St. Louis University
NCT03422211
Dose-Ranging Study for Prolonged Postoperative Analgesia in Subject Undergoing Total Knee Arthroplasty
Pacira Pharmaceuticals
NCT00485693
Effect of Paracervical Block on Post Operative Pain in Laparoscopic Gynecologic Surgery
Icahn School of Medicine at Mount Sinai
NCT01534416
A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery
59th Medical Wing
NCT01097577
PG and PK of Oxycodone to Personalize Post-op Pain Management Following Surgery in Children
Senthil Sadhasivam
NCT03495388
Chronic Pain After Amputation
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00006427
Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients
Washington University School of Medicine
NCT02926573
Local Anesthetics on Postsurgical Analgesia Following Posterior Colporrhaphy
Walter Reed National Military Medical Center
NCT04032327
Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain
Mylan
NCT04571515
An Open Label, Prospective Study of the Analgesic Efficacy of Oral Xartemis Compared to Generic Oxycodone/APAP( Acetaminophen) in the Treatment of Moderate to Severe Post Operative Pain.
Lotus Clinical Research
NCT02101476
Pharmacogenetic-guided Choice of Post-surgery Analgesics
University of Pennsylvania
NCT05548660
Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain.
Mylan Specialty
NCT05317312
Acupuncture for Post-Operative Pain Control for Patients Undergoing Gynecological Surgery
Icahn School of Medicine at Mount Sinai
NCT02855567
QL vs PENG for Analgesia After Hip Arthroplasty
Medical University of South Carolina
NCT05710107
Intravenous Acetaminophen in Craniotomy
The University of Texas Health Science Center, Houston
NCT01598701
Study of a Multimodality Pain Management Protocol on Postoperative Neurosurgical Pain
University of Florida
NCT01693588
A Multicenter, Randomized, Placebo-Controlled Phase 2 Study to Evaluate the Clinical Efficacy, Safety, and Tolerability of ARX-F01 Sublingual Sufentanil in Patients Undergoing Elective Unilateral Total Knee Replacement
Talphera
NCT00612534
Lidocaine Patches After Cesarean Section
Yale University
NCT04443569
Phase 2 Bunionectomy HTX-011 Administration Study
Heron Therapeutics
NCT03718039
Proximal Versus Distal Adductor Canal Blocks for Total Knee Arthroplasty
Benaroya Research Institute
NCT02701114
Transversus Abdominis Plane (TAP) Block Laparoscopic Hysterectomy
Northwestern University
NCT01074229
Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery
University of Wisconsin, Madison
NCT01444924
Oral vs Intravenous Acetominophen for Postoperative Pain in Minimally Invasive Gynecologic Surgery
Scripps Health
NCT03391284
Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions
University of Southern California
NCT05374499
Intrathecal Morphine for Cesarean Delivery
Beth Israel Deaconess Medical Center
NCT05069012
Extended Release Local Anesthetic for Postsurgical Pain After Posterior Colporrhaphy and Perineorrhaphy
Wake Forest University Health Sciences
NCT03875664
Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
St. Luke's-Roosevelt Hospital Center
NCT01881776
Single-shot TAP Block vs Continuous TAP Block
Indiana University
NCT02475031
PENG Block for Arthroscopic Hip Surgery
University of Virginia
NCT04508504
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
University Hospitals Cleveland Medical Center
NCT02509312
Efficacy of EXPAREL in Comparison to Standard of Care for the Treatment of Post Operative Dental Implant Pain
Bellaire Facial Surgery Center
NCT02533440
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Laparoscopic Colorectomy
Vivozon
NCT02992041
Efficacy of IV Acetaminophen for Pain Management
Aultman Health Foundation
NCT02028715
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 15 |
| Phase 3 | 17 |
| Phase 4 | 38 |
Top Sponsors
Named interventions
Most-linked intervention names on Postoperative Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Postoperative Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Postoperative Pain page
121 registered trials, 42 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 42 Postoperative Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Medical University of South Carolina sponsors the most Postoperative Pain trials on record, review their full trial history before evaluating a specific study. See Medical University of South Carolina's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Postoperative Pain condition card totals 121 registered trials; most-linked intervention Placebo; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.