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Postoperative Pain clinical trials
15 of 64 indexed Postoperative Pain trials are currently recruiting.
64 US clinical trials · 15 currently recruiting
Postoperative Pain is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 28 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Heron Therapeutics, running 3 of these trials.
The research picture
Postoperative Pain has 64 registered US clinical trials, 15 of them open to new participants right now, about 23% of the total.
- 15
- recruiting participants now
- 23%
- of trials open to enrollment
- 28
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Heron Therapeutics
Active & Recent Trials
64 total, page 2 of 2
Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
St. Luke's-Roosevelt Hospital Center
NCT01881776
Single-shot TAP Block vs Continuous TAP Block
Indiana University
NCT02475031
PENG Block for Arthroscopic Hip Surgery
University of Virginia
NCT04508504
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
University Hospitals Cleveland Medical Center
NCT02509312
Efficacy of EXPAREL in Comparison to Standard of Care for the Treatment of Post Operative Dental Implant Pain
Bellaire Facial Surgery Center
NCT02533440
Postoperative Pain Control in Children Undergoing Laparoscopic Appendectomy: Peripheral Nerve Block Versus Local Anesthetic
Ann & Robert H Lurie Children's Hospital of Chicago
NCT01662401
A Phase 1 Study to Evaluate Pregabalin and Acetaminophen in Healthy Volunteers
Nevakar
NCT04265456
Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular Infiltration
University of Texas Southwestern Medical Center
NCT02658240
Pain Control With Total Knee Replacement
Texas Tech University Health Sciences Center
NCT01680549
Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries
John Fowler
NCT02313675
Comparative Study of Two Different Techniques to Perform TAP-blocks
Maimonides Medical Center
NCT02571439
Effect of Postoperative Single Dose of Ketamine on Pain After Mastectomy
NYU Langone Health
NCT04831736
Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study
Sight Medical Doctors P
NCT04168112
Assess the Feasibility and Efficacy of the CollaRx® Bupivacaine Implant Laparoscopic Inguinal or Umbilical Herniorrhaphy
Innocoll
NCT01224145
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 11 |
| Phase 3 | 11 |
| Phase 4 | 17 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Postoperative Pain Trial Landscape
64 indexed Postoperative Pain studies · 15 recruiting (23%).
Phase mix: 28 late (III/IV) vs 15 early (I/II).
Top sponsor: Heron Therapeutics (3 trials), 9 others listed. 14 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Postoperative Pain?
PlainTrial tracks 64 US clinical trials for Postoperative Pain, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Postoperative Pain?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.