Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Insulin Resistance: early-phase trial registry
32 of 122 indexed Insulin Resistance trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #100 of 28,707 conditions by registered trial count.
122 US clinical trials · 32 currently recruiting · #100 of 28,707 conditions by registered trial count
Insulin Resistance: 122 US clinical trials tracked, 32 recruiting.
Insulin Resistance is the subject of 122 registered US clinical trials on ClinicalTrials.gov, 32 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 7 of these trials.
Enrollment posture brief
Registry condition insulin-resistance
OPEN 32 | RECR 26% | LATE 10 | EARLY 22 | RANK #100 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Attention Deficit Hyperactivity Disorder (ADHD) (26% recruiting · 19 trials)
Insulin Resistance lists 32 open slots (26% of 122 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Insulin Resistance on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Insulin Resistance is recruiting below its size-band peers.
32 of 122 indexed trials (26.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Insulin Resistance trials is spread across many organizations.
Washington University School of Medicine accounts for 7 of 122 trials (5.7%). 72 distinct sponsors appear on at least one study for this condition label.
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Most Insulin Resistance trials plan to enrol fewer than 100 people.
Median target enrolment is 53 among the 121 trials that report a genuine target (sentinel values excluded). 92 of those (76%) plan for fewer than 100 participants.
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Insulin Resistance research is mostly interventional.
102 interventional and 20 observational studies make up this index (83.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
122 total, page 1 of 3
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
National Institute of Environmental Health Sciences (NIEHS)
NCT01143480
Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Lilli Health
NCT05950282
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Colorado State University
NCT05543083
Reversal of Lipid-Induced Insulin Resistance
Yale University
NCT02193295
Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma
University of Oklahoma
NCT05208671
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
University of Michigan
NCT06007404
Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance
SF Research Institute
NCT07220694
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Pichamol Jirapinyo, MD, MPH
NCT06138821
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Washington University School of Medicine
NCT05277558
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Stanford University
NCT05165706
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
University of California, Davis
NCT04984226
A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults
Mayo Clinic
NCT06820658
Neuromuscular Electrical Stimulation: A Novel Treatment for Improving Metabolism
University of Texas, El Paso
NCT06722391
Small Extracellular Vesicles and Insulin Action
Washington University School of Medicine
NCT05933707
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
University of Colorado, Denver
NCT06129110
Metabolic Adaptations to Weight Loss With and Without Exercise
University of Michigan
NCT05806801
A Sensory Strategy to Cut Sugary Beverages in African/American and Latine Adolescents
Nana Gletsu Miller
NCT07223151
Mitigating the Pro-inflammatory Phenotype of Obesity
University of Kansas Medical Center
NCT04934228
Improving Glycemic Control With Electrical Stimulation
University of Texas, El Paso
NCT03947697
Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids
Mayo Clinic
NCT03818178
New Mechanisms of Obesity
Yale University
NCT06768827
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
Stanford University
NCT05833217
Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
NCT04812314
The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults
University of New Hampshire
NCT05912348
ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence
Massachusetts General Hospital
NCT07102797
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Columbia University
NCT06354088
Metabolic Effects of Angiotensin-(1-7)
Vanderbilt University
NCT02646475
Role of Aging and Individual Variation in Exercise Training Responsiveness
Duke University
NCT06471569
The Acute T-Rex (Timing of Resistance Exercise) Study
University of Utah
NCT06366399
Graded Insulin Suppression Test P&F
Columbia University
NCT06592261
Fastomics: Metabolic and Therapeutic Effects of Prolonged Fasting
University of Minnesota
NCT07216989
Diazoxide Suppression Test P&F Study
Columbia University
NCT06606327
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
Signos
NCT05874635
Precision Nutrition and Metabolic Function
Washington University School of Medicine
NCT04131166
Insulin Resistance in HCV Infection
University of California, San Francisco
NCT01858012
Muscle Insulin Resistance in Aging (Mirage)
AdventHealth Translational Research Institute
NCT02230839
Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health
Washington University School of Medicine
NCT02706262
Caveolin-1 and Vascular Dysfunction
Brigham and Women's Hospital
NCT01426529
Everolimus Aging Study
University of Wisconsin, Madison
NCT05835999
Precision Diets for Diabetes Prevention
Stanford University
NCT03919877
Understanding Dose Related Effects of Strawberry
Clinical Nutrition Research Center, Illinois Institute of Technology
NCT06173765
Role of Metformin on Muscle Health of Older Adults
University of Utah
NCT03107884
Study to Evaluate the Efficacy of an Avocado Dietary Supplement
SP Nutraceuticals
NCT07354308
Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome
University of California, San Francisco
NCT06050265
PCOS & Insulin Resistance Exercise Study
University of California, San Francisco
NCT02303470
Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes
Brigham and Women's Hospital
NCT05560971
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity
Vanderbilt University Medical Center
NCT03318094
Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)
The Cleveland Clinic
NCT03288025
The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes
Loma Linda University
NCT06159543
Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia
University of Missouri-Columbia
NCT06998238
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 7 |
| Phase 3 | 2 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Insulin Resistance records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Insulin Resistance trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Insulin Resistance page
122 registered trials, 32 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 32 Insulin Resistance trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Washington University School of Medicine sponsors the most Insulin Resistance trials on record, review their full trial history before evaluating a specific study. See Washington University School of Medicine's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Insulin Resistance condition card totals 122 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.