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Insulin Resistance
Open-data reference.
122 US clinical trials · 32 currently recruiting
Active & Recent Trials
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
National Institute of Environmental Health Sciences (NIEHS)
NCT01143480
Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Lilli Health
NCT05950282
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Colorado State University
NCT05543083
Reversal of Lipid-Induced Insulin Resistance
Yale University
NCT02193295
Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma
University of Oklahoma
NCT05208671
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
University of Michigan
NCT06007404
Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance
SF Research Institute
NCT07220694
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Pichamol Jirapinyo, MD, MPH
NCT06138821
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Washington University School of Medicine
NCT05277558
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Stanford University
NCT05165706
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
University of California, Davis
NCT04984226
A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults
Mayo Clinic
NCT06820658
Neuromuscular Electrical Stimulation: A Novel Treatment for Improving Metabolism
University of Texas, El Paso
NCT06722391
Small Extracellular Vesicles and Insulin Action
Washington University School of Medicine
NCT05933707
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
University of Colorado, Denver
NCT06129110
Metabolic Adaptations to Weight Loss With and Without Exercise
University of Michigan
NCT05806801
A Sensory Strategy to Cut Sugary Beverages in African/American and Latine Adolescents
Nana Gletsu Miller
NCT07223151
Mitigating the Pro-inflammatory Phenotype of Obesity
University of Kansas Medical Center
NCT04934228
Improving Glycemic Control With Electrical Stimulation
University of Texas, El Paso
NCT03947697
Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids
Mayo Clinic
NCT03818178
New Mechanisms of Obesity
Yale University
NCT06768827
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
Stanford University
NCT05833217
Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
NCT04812314
The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults
University of New Hampshire
NCT05912348
ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence
Massachusetts General Hospital
NCT07102797
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Columbia University
NCT06354088
Metabolic Effects of Angiotensin-(1-7)
Vanderbilt University
NCT02646475
Role of Aging and Individual Variation in Exercise Training Responsiveness
Duke University
NCT06471569
The Acute T-Rex (Timing of Resistance Exercise) Study
University of Utah
NCT06366399
Graded Insulin Suppression Test P&F
Columbia University
NCT06592261
Fastomics: Metabolic and Therapeutic Effects of Prolonged Fasting
University of Minnesota
NCT07216989
Diazoxide Suppression Test P&F Study
Columbia University
NCT06606327
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
Signos
NCT05874635
Precision Nutrition and Metabolic Function
Washington University School of Medicine
NCT04131166
Insulin Resistance in HCV Infection
University of California, San Francis
NCT01858012
Muscle Insulin Resistance in Aging (Mirage)
AdventHealth Translational Research Institute
NCT02230839
Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health
Washington University School of Medicine
NCT02706262
Caveolin-1 and Vascular Dysfunction
Brigham and Women's Hospital
NCT01426529
Everolimus Aging Study
University of Wisconsin, Madison
NCT05835999
Precision Diets for Diabetes Prevention
Stanford University
NCT03919877
Understanding Dose Related Effects of Strawberry
Clinical Nutrition Research Center, Illinois Institute of Technology
NCT06173765
Role of Metformin on Muscle Health of Older Adults
University of Utah
NCT03107884
Study to Evaluate the Efficacy of an Avocado Dietary Supplement
SP Nutraceuticals
NCT07354308
Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome
University of California, San Francis
NCT06050265
PCOS & Insulin Resistance Exercise Study
University of California, San Francis
NCT02303470
Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes
Brigham and Women's Hospital
NCT05560971
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity
Vanderbilt University Medical Center
NCT03318094
Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)
The Cleveland Clinic
NCT03288025
The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes
Loma Linda University
NCT06159543
Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia
University of Missouri-Columbia
NCT06998238
Probiotics and Insulin Resistance in Obese Asthmatics
University of Alabama at Birmingham
NCT05949255
A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes)
National Center for Research Resources (NCRR)
NCT00015626
Effects of Resistance and Aerobic Exercise on Cardiovascular Health
Duke University
NCT00275145
Regional Fat Depots and Insulin Resistance
Stanford University
NCT01336777
Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT05017571
Identifying Risk for Diabetes and Heart Disease in Women
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT01809288
Financial Incentives to Exercise for Adolescents
University of Oklahoma
NCT01848353
Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00212290
Effects of Atypical Antipsychotic and Valproate Combination Therapy on Glucose and Lipid Metabolism in Schizophrenia
Washington University School of Medicine
NCT00552500
Aerobic Plus Resistance Training and Insulin Sensitivity in African American Men
Pennington Biomedical Research Center
NCT01787617
The Health Influences of Puberty (HIP) Study
University of Colorado, Denver
NCT01775813
Effects of Omega-3 Fatty Acids on Markers of Inflammation
Stanford University
NCT01129050
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults
Yale University
NCT02335021
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of BFKB8488A in Otherwise Healthy Overweight and Obese Participants With Likely Insulin Resistance
Genentech
NCT02593331
Ziprasidone for Improving Insulin Sensitivity in People With Schizophrenia Who Are at Risk for Diabetes
Veterans Medical Research Foundation
NCT00338949
Chromium and Insulin Resistance
University of California, San Francis
NCT00846248
A Trial of Tadalafil and Glycemic Traits
Thomas J. Wang, MD
NCT01444651
The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis (DAIRY Study)
Fred Hutchinson Cancer Center
NCT02663544
Safety, Pharmacokinetics and Potential Activity of HE3286 in Obese Adult Subjects
Harbor Therapeutics
NCT00555451
Assessment of Insulin Resistance, NAFLD, Predictors of CV Morbidity, and Subcutaneous Adipose and Visceral Adipose Gene Expression in Patients Undergoing Gastric Bypass Surgery
University of Massachusetts, Worcester
NCT01007955
A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin
Daiichi Sankyo
NCT00185094
Macronutrient Effects on Alzheimer's Disease (MEAL-2)
Wake Forest University Health Sciences
NCT02463084
Progressive Weight Loss and Metabolic Health
Washington University School of Medicine
NCT01299519
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People
Mayo Clinic
NCT04158375
Insulin Resistance in Patients With Major Depression
Stanford University
NCT01106313
Biologic Effects of Dehydroepiandrosterone (DHEA) in Humans
National Institute on Aging (NIA)
NCT00099697
Grains Reduce Adiposity and Improve Nutrition Study
Penn State University
NCT00924521
Timing Estrogen After MenoPaUSe
University of Colorado, Denver
NCT01605071
Effects of Exercise Training Intensity on Fitness and Insulin Sensitivity in African Americans
East Carolina University
NCT02892331
Fasting for Brain and Heart Health (FBHH)
TrueNorth Health Foundation
NCT04507516
Novel Therapy for Glucose Intolerance in HIV Disease
Stony Brook University
NCT02006914
Oral Contraceptives in the Metabolic Syndrome
Virginia Commonwealth University
NCT00205504
Metabolic Parameters 3 Months, 9 Months, and 2 Years After Bariatric Surgery
The University of Texas Health Science Center, Houston
NCT00178633
Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.
Yale University
NCT02196051
Developing an Adaptive Lifestyle Intervention Program in Family Medicine Clinics
University of Alabama at Birmingham
NCT04392284
Continuous Glucose Monitors (CGM) for Type 2 Diabetes (T2D) Risk Evaluation
Mary Ellen Vajravelu, MD
NCT05404711
Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults
University Hospitals Cleveland Medical Center
NCT01046682
Yoga Improves Aerobic Fitness, Glycemia and Mood State and Reduces Abdominal Obesity
Skidmore College
NCT02190136
Predictors of Response to Fenofibrate
University of Alabama at Birmingham
NCT01023750
Effects of Hepatic Ultrasound on Metabolic Homeostasis
Yale University
NCT04622683
Pioglitazone in Patients With Mood Disorders
Stanford University
NCT01559857
12 Weeks of Resistance Band Exercise Impacts on Metabolic Syndrome Progression in Postmenopausal Women
Pusan National University
NCT04014686
Effects of Fish Oils on Inflammation and Insulin Resistance
Philip Kern
NCT00579436
Effects of Hi-maize Resistant Starch on Insulin Sensitivity
Ingredion Incorporated
NCT01058135
Effects of Consuming Sugar-Sweetened Beverages With Meals for 10 Weeks
University of California, Davis
NCT01165853
Mitochondrial Remodeling After Exercise
Oregon State University
NCT04103424
Study of Niacin and Rosiglitazone in Dysmetabolic Dyslipidemia
Foundation Research, Florida
NCT00304993
Blood Flow Responses to an Oral Glucose Tolerance Test in Type 2 Diabetes
University of Kansas Medical Center
NCT00972452
The Incidence and Treatment of Insulin Resistance Among Men With Erectile Dysfunction
Milton S. Hershey Medical Center
NCT00284960
Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid Arthritis
Brigham and Women's Hospital
NCT01132118
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 15 |
| Phase 2 | 7 |
| Phase 3 | 2 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Insulin Resistance Trial Landscape
ClinicalTrials.gov lists 122 US studies indexed under Insulin Resistance, and 32 of those are currently open to recruitment — roughly 26% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Insulin Resistance shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 22 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Insulin Resistance is led by Washington University School of Medicine with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Insulin Resistance?
PlainTrial tracks 122 US clinical trials for Insulin Resistance, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Insulin Resistance?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.