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ClinicalTrials.gov 32 recruiting now official registry

Insulin Resistance clinical trials

32 of 122 indexed Insulin Resistance trials are currently recruiting.

122 US clinical trials · 32 currently recruiting

Insulin Resistance is the subject of 122 registered US clinical trials on ClinicalTrials.gov, 32 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 7 of these trials.

The research picture

Insulin Resistance has 122 registered US clinical trials, 32 of them open to new participants right now, about 26% of the total.

32
recruiting participants now
26%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
7
top sponsor: Washington University School of Medicine
Phase 115Phase 27Phase 32Phase 48

Active & Recent Trials

122 total, page 1 of 3

RECRUITING 725 participants

Study of the Effect of Innate on the Inflammatory Response to Endotoxin

National Institute of Environmental Health Sciences (NIEHS)

NCT01143480

RECRUITING 500 participants

Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

Lilli Health

NCT05950282

RECRUITING NA 300 participants

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

Colorado State University

NCT05543083

RECRUITING NA 250 participants

Reversal of Lipid-Induced Insulin Resistance

Yale University

NCT02193295

RECRUITING NA 234 participants

Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma

University of Oklahoma

NCT05208671

RECRUITING 175 participants

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

University of Michigan

NCT06007404

RECRUITING NA 140 participants

Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance

SF Research Institute

NCT07220694

RECRUITING NA 132 participants

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

Pichamol Jirapinyo, MD, MPH

NCT06138821

RECRUITING 117 participants

Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)

Washington University School of Medicine

NCT05277558

RECRUITING NA 110 participants

Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance

Stanford University

NCT05165706

RECRUITING Phase 2 80 participants

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

University of California, Davis

NCT04984226

RECRUITING 80 participants

A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults

Mayo Clinic

NCT06820658

RECRUITING NA 80 participants

Neuromuscular Electrical Stimulation: A Novel Treatment for Improving Metabolism

University of Texas, El Paso

NCT06722391

RECRUITING NA 72 participants

Small Extracellular Vesicles and Insulin Action

Washington University School of Medicine

NCT05933707

RECRUITING NA 70 participants

Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

University of Colorado, Denver

NCT06129110

RECRUITING NA 68 participants

Metabolic Adaptations to Weight Loss With and Without Exercise

University of Michigan

NCT05806801

RECRUITING NA 63 participants

A Sensory Strategy to Cut Sugary Beverages in African/American and Latine Adolescents

Nana Gletsu Miller

NCT07223151

RECRUITING Phase 1 60 participants

Mitigating the Pro-inflammatory Phenotype of Obesity

University of Kansas Medical Center

NCT04934228

RECRUITING NA 60 participants

Improving Glycemic Control With Electrical Stimulation

University of Texas, El Paso

NCT03947697

RECRUITING NA 60 participants

Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids

Mayo Clinic

NCT03818178

RECRUITING NA 55 participants

New Mechanisms of Obesity

Yale University

NCT06768827

RECRUITING NA 55 participants

Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2

Stanford University

NCT05833217

RECRUITING NA 46 participants

Exercise Effects on Adipose Tissue Structure and Function

University of Michigan

NCT04812314

RECRUITING NA 45 participants

The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults

University of New Hampshire

NCT05912348

RECRUITING NA 40 participants

ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence

Massachusetts General Hospital

NCT07102797

RECRUITING Phase 1 32 participants

Human Models of Selective Insulin Resistance: Alpelisib, Part I

Columbia University

NCT06354088

RECRUITING Phase 1 26 participants

Metabolic Effects of Angiotensin-(1-7)

Vanderbilt University

NCT02646475

RECRUITING NA 26 participants

Role of Aging and Individual Variation in Exercise Training Responsiveness

Duke University

NCT06471569

RECRUITING NA 20 participants

The Acute T-Rex (Timing of Resistance Exercise) Study

University of Utah

NCT06366399

RECRUITING Phase 1 15 participants

Graded Insulin Suppression Test P&F

Columbia University

NCT06592261

RECRUITING 15 participants

Fastomics: Metabolic and Therapeutic Effects of Prolonged Fasting

University of Minnesota

NCT07216989

RECRUITING Phase 1 10 participants

Diazoxide Suppression Test P&F Study

Columbia University

NCT06606327

ACTIVE NOT RECRUITING NA 20,000 participants

Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)

Signos

NCT05874635

ACTIVE NOT RECRUITING NA 300 participants

Precision Nutrition and Metabolic Function

Washington University School of Medicine

NCT04131166

ACTIVE NOT RECRUITING 250 participants

Insulin Resistance in HCV Infection

University of California, San Francisco

NCT01858012

ACTIVE NOT RECRUITING NA 200 participants

Muscle Insulin Resistance in Aging (Mirage)

AdventHealth Translational Research Institute

NCT02230839

ACTIVE NOT RECRUITING NA 180 participants

Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health

Washington University School of Medicine

NCT02706262

ACTIVE NOT RECRUITING Phase 1 120 participants

Caveolin-1 and Vascular Dysfunction

Brigham and Women's Hospital

NCT01426529

ACTIVE NOT RECRUITING Phase 2 106 participants

Everolimus Aging Study

University of Wisconsin, Madison

NCT05835999

ACTIVE NOT RECRUITING NA 100 participants

Precision Diets for Diabetes Prevention

Stanford University

NCT03919877

ACTIVE NOT RECRUITING NA 66 participants

Understanding Dose Related Effects of Strawberry

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT06173765

ACTIVE NOT RECRUITING Early Phase 1 64 participants

Role of Metformin on Muscle Health of Older Adults

University of Utah

NCT03107884

ACTIVE NOT RECRUITING NA 60 participants

Study to Evaluate the Efficacy of an Avocado Dietary Supplement

SP Nutraceuticals

NCT07354308

ACTIVE NOT RECRUITING NA 56 participants

Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome

University of California, San Francisco

NCT06050265

ACTIVE NOT RECRUITING NA 47 participants

PCOS & Insulin Resistance Exercise Study

University of California, San Francisco

NCT02303470

ACTIVE NOT RECRUITING NA 40 participants

Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes

Brigham and Women's Hospital

NCT05560971

ACTIVE NOT RECRUITING Phase 1 36 participants

Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity

Vanderbilt University Medical Center

NCT03318094

ACTIVE NOT RECRUITING NA 34 participants

Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)

The Cleveland Clinic

NCT03288025

ACTIVE NOT RECRUITING NA 31 participants

The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes

Loma Linda University

NCT06159543

ACTIVE NOT RECRUITING NA 8 participants

Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia

University of Missouri-Columbia

NCT06998238

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Phase Distribution

PhaseTrial count
Phase 1 15
Phase 2 7
Phase 3 2
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Insulin Resistance Trial Landscape

122 indexed Insulin Resistance studies · 32 recruiting (26%).

Phase mix: 10 late (III/IV) vs 22 early (I/II).

Top sponsor: Washington University School of Medicine (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Insulin Resistance?

PlainTrial tracks 122 US clinical trials for Insulin Resistance, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Insulin Resistance?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.