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Insulin Resistance clinical trials
32 of 122 indexed Insulin Resistance trials are currently recruiting.
122 US clinical trials · 32 currently recruiting
Insulin Resistance is the subject of 122 registered US clinical trials on ClinicalTrials.gov, 32 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 7 of these trials.
The research picture
Insulin Resistance has 122 registered US clinical trials, 32 of them open to new participants right now, about 26% of the total.
- 32
- recruiting participants now
- 26%
- of trials open to enrollment
- 10
- in Phase 3–4 (later-stage)
- 7
- top sponsor: Washington University School of Medicine
Active & Recent Trials
122 total, page 1 of 3
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
National Institute of Environmental Health Sciences (NIEHS)
NCT01143480
Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Lilli Health
NCT05950282
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Colorado State University
NCT05543083
Reversal of Lipid-Induced Insulin Resistance
Yale University
NCT02193295
Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma
University of Oklahoma
NCT05208671
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
University of Michigan
NCT06007404
Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance
SF Research Institute
NCT07220694
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Pichamol Jirapinyo, MD, MPH
NCT06138821
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Washington University School of Medicine
NCT05277558
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Stanford University
NCT05165706
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
University of California, Davis
NCT04984226
A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults
Mayo Clinic
NCT06820658
Neuromuscular Electrical Stimulation: A Novel Treatment for Improving Metabolism
University of Texas, El Paso
NCT06722391
Small Extracellular Vesicles and Insulin Action
Washington University School of Medicine
NCT05933707
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
University of Colorado, Denver
NCT06129110
Metabolic Adaptations to Weight Loss With and Without Exercise
University of Michigan
NCT05806801
A Sensory Strategy to Cut Sugary Beverages in African/American and Latine Adolescents
Nana Gletsu Miller
NCT07223151
Mitigating the Pro-inflammatory Phenotype of Obesity
University of Kansas Medical Center
NCT04934228
Improving Glycemic Control With Electrical Stimulation
University of Texas, El Paso
NCT03947697
Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids
Mayo Clinic
NCT03818178
New Mechanisms of Obesity
Yale University
NCT06768827
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
Stanford University
NCT05833217
Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
NCT04812314
The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults
University of New Hampshire
NCT05912348
ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence
Massachusetts General Hospital
NCT07102797
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Columbia University
NCT06354088
Metabolic Effects of Angiotensin-(1-7)
Vanderbilt University
NCT02646475
Role of Aging and Individual Variation in Exercise Training Responsiveness
Duke University
NCT06471569
The Acute T-Rex (Timing of Resistance Exercise) Study
University of Utah
NCT06366399
Graded Insulin Suppression Test P&F
Columbia University
NCT06592261
Fastomics: Metabolic and Therapeutic Effects of Prolonged Fasting
University of Minnesota
NCT07216989
Diazoxide Suppression Test P&F Study
Columbia University
NCT06606327
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
Signos
NCT05874635
Precision Nutrition and Metabolic Function
Washington University School of Medicine
NCT04131166
Insulin Resistance in HCV Infection
University of California, San Francisco
NCT01858012
Muscle Insulin Resistance in Aging (Mirage)
AdventHealth Translational Research Institute
NCT02230839
Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health
Washington University School of Medicine
NCT02706262
Caveolin-1 and Vascular Dysfunction
Brigham and Women's Hospital
NCT01426529
Everolimus Aging Study
University of Wisconsin, Madison
NCT05835999
Precision Diets for Diabetes Prevention
Stanford University
NCT03919877
Understanding Dose Related Effects of Strawberry
Clinical Nutrition Research Center, Illinois Institute of Technology
NCT06173765
Role of Metformin on Muscle Health of Older Adults
University of Utah
NCT03107884
Study to Evaluate the Efficacy of an Avocado Dietary Supplement
SP Nutraceuticals
NCT07354308
Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome
University of California, San Francisco
NCT06050265
PCOS & Insulin Resistance Exercise Study
University of California, San Francisco
NCT02303470
Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes
Brigham and Women's Hospital
NCT05560971
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity
Vanderbilt University Medical Center
NCT03318094
Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)
The Cleveland Clinic
NCT03288025
The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes
Loma Linda University
NCT06159543
Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia
University of Missouri-Columbia
NCT06998238
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 7 |
| Phase 3 | 2 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Insulin Resistance Trial Landscape
122 indexed Insulin Resistance studies · 32 recruiting (26%).
Phase mix: 10 late (III/IV) vs 22 early (I/II).
Top sponsor: Washington University School of Medicine (7 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Insulin Resistance?
PlainTrial tracks 122 US clinical trials for Insulin Resistance, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Insulin Resistance?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.