Heron Therapeutics

Closed portfolio snapshot

According to ClinicalTrials.gov-derived indexes, Heron Therapeutics sits in the top decile of US sponsors by registered trial count (#668 of 15,742 sponsors by registered trial count).

23 total trials none currently recruiting 22 completed top decile by trial count

Heron Therapeutics: 23 sponsored US clinical trials, none currently recruiting.

Heron Therapeutics sponsors 23 registered US clinical trials on ClinicalTrials.gov, none currently recruiting, and 22 completed. 10 of these trials are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Postoperative Pain, with 3 trials.

Top-decile sponsor footprint

Heron Therapeutics ranks in the top decile of sponsors by registered trial count (#668 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 79/100

22 of 23 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (95.7%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Indexed trials (enrollment closed)

23 total, page 1 of 1

COMPLETED Phase 2

HTX-011 in Spinal Surgery

NCT04911062

COMPLETED Phase 4

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE.

NCT06109415

COMPLETED Phase 4

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE

NCT06109428

TERMINATED Phase 2

Aprepitant Injectable Emulsion in Patients With COVID-19 (GUARDS-1)

NCT04470622

COMPLETED Phase 1

Dose-Escalation Study of HTX-034 Following Bunionectomy

NCT04398329

COMPLETED Phase 2

HTX-011 Administration Study in Planned Caesarean Section Procedure

NCT03955211

COMPLETED Phase 3

Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen

NCT03974932

COMPLETED Phase 3

Study of Post-Herniorrhaphy Non-opioid MMA Regimens

NCT03907176

COMPLETED Phase 2

Phase 2 Bunionectomy HTX-011 Administration Study

NCT03718039

COMPLETED Phase 2

Phase 2 Herniorrhaphy Study for Opioid Elimination

NCT03695367

COMPLETED Phase 4

Bupivacaine HCl PK and Safety in Augmentation Mammoplasty

NCT03705065

COMPLETED Phase 4

Extended Delivery of Bupivacaine Study in Herniorrhaphy

NCT04102267

COMPLETED Phase 3

Bunionectomy Study for Postoperative Analgesia (EPOCH 1)

NCT03295721

COMPLETED Phase 3

Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)

NCT03237481

COMPLETED Phase 2

Phase 2B Upper Extremity Nerve Block Study

NCT03011333

COMPLETED Phase 2

Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia

NCT03015532

COMPLETED Phase 2

Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy

NCT02762929

COMPLETED Phase 2

Evaluation of the Efficacy and Safety of HTX-011 for Postoperative Analgesia Following Abdominoplasty Surgery

NCT02689258

COMPLETED Phase 2

Pilot Herniorrhaphy Study for Postoperative Analgesia

NCT02504580

COMPLETED Phase 2

A Phase 2, Two-Part Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy

NCT02471898

COMPLETED Phase 3

A Prospective, Multicenter, Study of APF530 (Granisetron) SC for Prevention of CINV in Patients Receiving HEC

NCT02106494

COMPLETED

A Phase I Study of the Effects of APF530 Exposure, Granisetron and Moxifloxacin

NCT01416259

COMPLETED Phase 3

APF530 or Aloxi (Palonosetron Hydrochloride) Combined With Dexamethasone in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy for Cancer

NCT00343460

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 11
Phase 3 6
Phase 4 4

How the Heron Therapeutics archive is shaped

23 indexed studies, none listed as recruiting (0% open); 22 completed (96%).

Phase mix: 10 late (III/IV) vs 12 early (I/II) (balanced across stages).

Top condition: Postoperative Pain (3 trials), 2 others listed.

How to read a closed sponsor archive

When recruiting_count is zero, the indexed set is completed or otherwise not open. Phase tilt still describes where archived studies sat on the investigational pathway. Re-check ClinicalTrials.gov before acting.

Heron Therapeutics: archived-pipeline peers nationwide

Peers matched on 23 indexed studies with no current recruiting: volume and archive shape, not condition overlap.

Heron Therapeutics sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0510152025 0%5%10%15%20%25% Total trials Recruiting share Heron TherapeuticsAMAG PharmaceuticalsAtriCureCara TherapeuticsCraig L Slingluff, Jr10xBio22nd Century Group23andMe3-C Institute for Social Development
Heron Therapeutics sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Heron Therapeutics sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 23 archived trials

Sponsors with similar archive density (± trial count)

What to do with this Heron Therapeutics page

23 registered trials is a research-attention snapshot, not an endorsement of Heron Therapeutics or any single study.

  • None of Heron Therapeutics's trials are currently recruiting in this registry; that can change as new trials post, or check the broader research index. Browse research indexes
  • Postoperative Pain is the condition Heron Therapeutics studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Postoperative Pain trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Heron Therapeutics pipeline card: 23 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.