Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Healthy Participants
Open-data reference.
120 US clinical trials · 42 currently recruiting
Active & Recent Trials
Comparing the Extent to Which Two Evolocumab Drug Products Are Made Available in the Body After a Single Subcutaneous Dose
Amgen
NCT07422285
Effect of Limosilactobacillus Reuteri DSM 17648 in Healthy Adults Reporting Upper Gastrointestinal Discomfort
Novozymes A/S
NCT07163637
A Study to Assess the Bioequivalence of Trastuzumab Via Different Subcutaneous Delivery Platforms in Healthy Male Participants
Genentech
NCT07214766
A Study to Learn About a Vaccine Against E Coli in Healthy Adults
Pfizer
NCT07122986
Sparking Potential, Revealing Infant Neurocognitive Traits
University of Wisconsin, Madison
NCT07390136
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of AZD3974 in Healthy Participants
AstraZeneca
NCT07290283
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4954 in Healthy Adult Participants With or Without Elevated Lipoprotein (a) (Lp[a]) Levels, and Participants With Dyslipidemia
AstraZeneca
NCT06980428
Effects of PeptiSleep on Sleep Quality in Healthy Adults
Nuritas
NCT07258433
FIH Study to Evaluate the Tolerability of PF-07832837 in Healthy Adults and Patients
Pfizer
NCT06564389
Cognitive Strategies in Early Psychosis 1
University of Minnesota
NCT07231497
A Trial to Evaluate the Effect of CD388 on the Immunogenicity of Fluzone® HD Vaccine
Cidara Therapeutics
NCT07300085
Biomarkers Study in Infants With Prior Neonatal Brain Injury
University of Wisconsin, Madison
NCT07413900
Cognition and Ultrasound
University of Minnesota
NCT07220655
Study of S-892216 Long-acting Injectable (LAI) in Healthy Adult Participants
Shionogi
NCT07093580
First-in-human Study of Orally Administered KT-579 in Healthy Adult Participants
Kymera Therapeutics
NCT07412288
A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity
AstraZeneca
NCT07013643
Single and Multiple Ascending Doses of NTX-253 in Healthy Participants and Participants With Stable Schizophrenia
Neurosterix
NCT07344948
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of INCA033989 Following Subcutaneous or Intravenous Administration in Healthy Adult Participants
Incyte Corporation
NCT07448155
A Study to Investigate the Pharmacokinetics of Different Formulations and Safety of AZD5004 in Healthy Participants Aged 18 to 55 Years
AstraZeneca
NCT07455825
A Food Effect Study to Evaluate the Relative Bioavailability of Nalbuphine Extended-Release Tablets (NAL ER) in Healthy Participants
Trevi Therapeutics
NCT07487740
Researching Economical Adjuvants to Cancer Therapy
Florida State University
NCT07305259
Pistachio Snacking and Metabolic Flexibility
University of South Carolina
NCT07340125
A Study to Evaluate the Effect of Food on the Single-Dose Pharmacokinetics and a Drug-Drug Interaction Evaluation of Itraconazole and Carbamazepine on INCB123667 When Administered Orally to Healthy Adult Participants
Incyte Corporation
NCT06909162
Comparing the Extent to Which Three Different Formulations of LY4100511 (DC-853) Are Made Available in the Body, Alone and in the Presence of a Drug That Reduces Stomach Acid
Eli Lilly and Company
NCT06916143
Fructose Intestinal Gluconeogenesis
Touro University, California
NCT07209202
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics With AZD0780 Following Repeated Dose Administration in Healthy Adults With Elevated LDL-C Levels
AstraZeneca
NCT07423598
The Increasing Mindfulness Engagement Project
Florida State University
NCT07170202
CanCan Body Composition Study
Pennington Biomedical Research Center
NCT07305753
Royal Ancient Oats™ Study
Standard Process
NCT07371598
A Study of Oral E1018 in Healthy Adult Participants
Eisai
NCT06854042
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B or Factor VII Deficiency)
Equilibra Bioscience
NCT06349473
A Phase 1 Ethnobridging TriaL of AGA2118 in Healthy Japanese, Chinese, and Caucasian ParticipantS (ATLAS)
Angitia Incorporated Limited
NCT07361354
Temporal Interference for Thalamocortical Activity and Network Modulation
University of Wisconsin, Madison
NCT07219719
A Study to Investigate the Concentrations of Zibotentan and Dapagliflozin in Blood When Given With and Without Food
AstraZeneca
NCT07404137
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
Invicro
NCT07348276
Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.
Ball State University
NCT07045051
A Study to Determine the Safety and Tolerability of AG-236 and How it is Absorbed, Broken Down, and Eliminated From the Body in Healthy Participants
Agios Pharmaceuticals
NCT07075640
Impact of Exogenous Ketones on Sleep and Breathing in Healthy Volunteers (K-SLEEP)
Johns Hopkins University
NCT07224074
Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
Ball State University
NCT07095426
A Study of Elenestinib in Healthy Adult Female Participants
Blueprint Medicines Corporation
NCT07388511
A Study to Assess Zilucoplan Concentration in Breast Milk of Healthy Lactating Women
UCB Biopharma SRL
NCT06961747
Testing a Non-Invasive Spinal Stimulation Device
Gail Forrest
NCT07217314
A Study to Evaluate the Safety, Pharmacokinetics, and Occurrence of Anti-Drug Antibodies Following Annual Doses of CD388
Cidara Therapeutics
NCT07225959
A Study of LY4060874 in Healthy Participants
Eli Lilly and Company
NCT06709820
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD6234 After Repeat Dose Administration in Participants Who Are Overweight or Obese
AstraZeneca
NCT06132841
A Phase I Study of CDX-622
Celldex Therapeutics
NCT06650761
Effect of Low Volume Sprint Interval Training on Cardiorespiratory Fitness
California State University, San Marcos
NCT07328568
A Study of STAR-0310 in Healthy Adult Participants
Astria Therapeutics
NCT06782477
Massage: Neuroimaging and Correlates of Response - 1-week Study
University of Utah
NCT07190313
A Study of LY4064809 in Healthy Adult Participants
Eli Lilly and Company
NCT07339735
Metabolism, Excretion, and Mass Balance Study of Quemliclustat in Healthy Adult Participants (ARC-24)
Arcus Biosciences
NCT07364214
An Accessorised Prefilled Syringe to an Autoinjector Pharmacokinetic Bridging Study of Tozorakimab
AstraZeneca
NCT06908577
A Study Assessing the Drug Levels, Drug Effects, and Safety of BMS-986322 in Healthy Participants
Bristol-Myers Squibb
NCT04175925
A Study to Compare the Pharmacokinetics of CSL312 Administered by Prefilled Syringe Assembled to Autoinjector to the Pharmacokinetics Administered by Prefilled Syringe Assembled to Needle Safety Device in Healthy Subjects
CSL Behring
NCT05306275
A Study to Evaluate the Effect of Povorcitinib on the QT/QTc Interval in Healthy Participants
Incyte Corporation
NCT06441318
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-994 in Healthy Participants
Takeda
NCT03933488
A Single and Multiple Ascending Dose Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD2389 in Healthy Participants
AstraZeneca
NCT06138795
A Study for Multiple Tablet Forms of The Study Medicine (PF-07220060) in Healthy Adults
Pfizer
NCT05923411
Relative Levels of BMS-986036 in Blood Plasma in Healthy, Overweight, and Obese Participants Following Subcutaneous Administration Via Auto-injector Versus Pre-filled Syringe
Bristol-Myers Squibb
NCT04493567
Study of BLU-808 in Healthy Adult Participants
Blueprint Medicines Corporation
NCT06948032
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 as Well as the Impact of AZD4144 on the Pharmacokinetics of Rosuvastatin and Furosemide in Healthy Participants
AstraZeneca
NCT06491550
A Study to Evaluate the Effects of Mavacamten in Healthy Participants
Bristol-Myers Squibb
NCT05719805
An Investigational Study of Experimental Medication BMS-986165 in Healthy Participants to Study Electrocardiogram Effects
Bristol-Myers Squibb
NCT03541564
A Single and Multiple Ascending Dose Trial of CVL-354 in Healthy Participants
Cerevel Therapeutics
NCT05138653
A Study to Assess the Effect of Phenytoin on the Drug Levels of Afimetoran and the Effect of Afimetoran on the Drug Levels of Midazolam
Bristol-Myers Squibb
NCT05901714
A Study of TAK-071 in People With Parkinson Disease
Takeda
NCT04334317
A Study Investigating Lu AG22515 in Healthy Adults
H. Lundbeck A/S
NCT05136053
A Study to Assess the Effect of Food on the Drug Levels of Admilparant
Bristol-Myers Squibb
NCT07225647
A Study to Evaluate the Safety, Tolerability, and Drug Levels of Orally Administered BMS-986368 in Healthy Participants, Healthy Elderly Participants, and Healthy Participants of Japanese Ethnicity
Celgene
NCT06411730
Pharmacokinetics Study of Oral Rivaroxaban in Healthy Participants
Janssen Scientific Affairs
NCT01464450
A Study to Assess the Time to Onset of Action of Staccato Alprazolam Versus Midazolam and Diazepam in Healthy Participants
UCB Biopharma SRL
NCT07020988
A Study of Different Forms of TAK-994 in Healthy Adults
Takeda
NCT04745767
A Study to Evaluate the Bioequivalence of Single Oral Dose of Esomeprazole Capsule and Tablet Formulation in Healthy Participants
Takeda
NCT03083639
Study to Evaluate the Safety, Tolerability, Drug Levels and Drug Effects of BMS-986331 in Healthy Participants
Bristol-Myers Squibb
NCT04444050
Assess the Drug Interactions of BBT-877 and Midazolam, Itraconazole, and Esomeprazole in Healthy Adult Subjects
Bridge Biotherapeutics
NCT04138836
A Study to Assess New Formulations of TEV-56286
Teva Branded Pharmaceutical Products R&D
NCT06911567
A Study to Compare the Drug Levels of Atazanavir and Cobicistat Between the Coadministration of Age-Appropriate Mini-Tablet Formulations and the Coadministration of the Individual Reference Products in Healthy Adults Under Fed Conditions
Bristol-Myers Squibb
NCT05236738
A Study to Assess the Safety, Tolerability and Drug Levels of BMS-986172 in Healthy and Obese Participants, Including an Assessment of the Effects of Food on BMS-986172 Absorption
Bristol-Myers Squibb
NCT04926051
A Study to Investigate the Safety and Pharmacokinetics of AZD6793 in Healthy Japanese and Chinese Participants
AstraZeneca
NCT06368440
A Study to Characterize Single and Repeat Dose Pharmacokinetics of Tebipenem-Pivoxil-Hydrobromide (TBP-PI-HBr) and Its Major Metabolite (SPR1349) in Healthy Participants
Spero Therapeutics
NCT06727136
Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD5055 in Japanese and Chinese Healthy Volunteers..
AstraZeneca
NCT05955183
A Study to Investigate the Relative Bioavailability of AZD8630 Following a Device and Formulation Transition in Healthy Participants.
AstraZeneca
NCT06531811
A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of a Single Dose of Donzakimig in Healthy Chinese and Japanese Participants
UCB Biopharma SRL
NCT06716879
A Study to Assess the Effects of Itraconazole, Food, and pH on the Drug Levels of BMS-986368 in Healthy Participants
Celgene
NCT06170723
A STUDY TO LEARN HOW THE STUDY MEDICINE CALLED PF-07293893 AFFECTS MUSCLE BIOMARKERS OF HEALTHY ADULTS
Pfizer
NCT06413693
Washington University WU 409: Immune Responses to Rabies Vaccine.
Washington University School of Medicine
NCT07399951
A Study of Single Ascending Doses of PF-07258669 in Healthy Adult Participants
Pfizer
NCT04628793
A Study to Estimate the Effect of Multiple Dose Abrocitinib on Caffeine, Efavirenz, and Omeprazole in Healthy Participants
Pfizer
NCT05067439
A Study to Characterize the Drug Levels of an Oral Contraceptive With and Without BMS-986166 in Healthy Female Participants of Childbearing Potential
Bristol-Myers Squibb
NCT04934696
A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of JZP441 in Healthy Participants
Jazz Pharmaceuticals
NCT05720494
PF-07321332/Ritonavir and Ritonavir on Dabigatran Study in Healthy Participants
Pfizer
NCT05064800
Evaluate Safety, Pharmacokinetics and Pharmacodynamics of BBT-877 in Healthy Japanese Male
Bridge Biotherapeutics
NCT04138849
A Study to Evaluate Pharmacokinetics (PK) of Etrumadenant Tablet and Capsule Formulations in Healthy Adult Participants
Arcus Biosciences
NCT05277012
SP16 SERPIN-like Peptide Administration in Healthy Individuals
Serpin Pharma
NCT03651089
A Study to Assess the Relative Bioavailability of Brensocatib Pediatric Oral Solution to Oral Tablets in Healthy Participants
Insmed Incorporated
NCT06344728
Cognitive Conditioned Pain Modulation
University of Washington
NCT07234123
A Research Trial Looking at the Comparability of 2 Different Concentrations of Semaglutide for the 0.5 Milligram (mg) Dose
Novo Nordisk A/S
NCT05689099
A Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Divarasib in Healthy Participants
Genentech
NCT06835465
A Study to Evaluate the Food-Effect of H3B-6527
Eisai
NCT03424577
Pharmacokinetic Interaction Trial of Clofutriben With Midazolam and Prednisolone
Sparrow Pharmaceuticals
NCT07226635
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 98 |
| Phase 2 | 2 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Healthy Participants Trial Landscape
ClinicalTrials.gov lists 120 US studies indexed under Healthy Participants, and 42 of those are currently open to recruitment — roughly 35% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Healthy Participants shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 100 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Healthy Participants is led by AstraZeneca with 18 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Healthy Participants?
PlainTrial tracks 120 US clinical trials for Healthy Participants, of which 42 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Healthy Participants?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.