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NCT01140724 · ClinicalTrials.gov registry record
Personalizing Perioperative Analgesia in Children
A clinical trial of Postoperative Pain, sponsored by Senthil Sadhasivam.
- Active
- Registry status
- 1,200
- Enrollment target
- 1
- Study location
NCT01140724: Active study of Postoperative Pain, sponsored by Senthil Sadhasivam.
NCT01140724 is a study of Postoperative Pain that is active but no longer recruiting, run by Senthil Sadhasivam. The registered enrollment target is 1,200 participants, above the 222-participant average among 120 other Postoperative Pain trials with a reported enrollment target (441% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01140724, a study of Postoperative Pain, is active but no longer recruiting, sponsored by Senthil Sadhasivam.
- ACTIVE NOT RECRUITING
- Registry status
- 1,200 participants
- Enrollment target
- 1
- Study location
Study Summary
In the United States alone, each year approximately 5 million children undergo painful surgery, many of them experience serious side-effects with opioids and inadequate pain relief. Safe and effective analgesia is an important unmet critical medical need in children and its continued existence is an important perioperative safety and economic problem. Inadequate pain relief and serious side effects from perioperative opioids occur frequently in up to 50% of children. Morphine, the most commonly used perioperative opioid, has a narrow therapeutic index and large inter-patient variations in analgesic response and serious side effects. Frequent inter-individual variations in responses to morphine have significant clinical and economic impact with inadequate pain relief at one end of the spectrum of responses and serious adverse effects such as respiratory depression at the other end. Much of the inter-individual variability in response to a dose of morphine following surgical procedures can be explained by single nucleotide polymorphisms (SNPs) in a subset of the genes that encode proteins involved in pain mechanisms and opioid pathway.
Primary Outcome
Look at polymorphisms in genes that regulate pain perception, opioid transport and opioid receptor signaling to see if there is a relationship to more pain and need for a higher morphine requirement.
Conditions Studied
Study Locations (1)
Pennsylvania
- UPMC Children's Hospital - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,200 participants |
| Start Date | 2022-02-07 |
| Est. Completion | 2026-12-25 |
What the registry record for NCT01140724 still lists
NCT01140724 is an observational study that tracks outcomes without assigning an intervention. Its 1,200 participants enrollment target places it among the larger protocols in the corpus, above the 222-participant average among 120 other Postoperative Pain trials with a reported enrollment target (441% higher).
The record links to 1 condition, with Postoperative Pain appearing as the primary indexed condition, and to 0 interventions.
NCT01140724 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT01140724 about?
NCT01140724 is a clinical study titled "Personalizing Perioperative Analgesia in Children". In the United States alone, each year approximately 5 million children undergo painful surgery, many of them experience serious side-effects with opioids and inadequate pain relief. Safe and effective analgesia is an important unmet critical medical need in children and its continued existence is an...
What is the current status of trial NCT01140724?
This trial is currently active not recruiting. The enrollment target is 1,200 participants. The study started on 2022-02-07. Estimated completion is 2026-12-25.
What conditions does trial NCT01140724 study?
This clinical trial studies the following conditions: Postoperative Pain.
Who is sponsoring clinical trial NCT01140724?
This trial is sponsored by Senthil Sadhasivam, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01140724 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Postoperative Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01140724's enrollment target sits among peer trials
1,200 4th of 120 higher than 117 of 120 other Postoperative Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Postoperative Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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