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NCT01140724 · ClinicalTrials.gov registry record
Personalizing Perioperative Analgesia in Children
A clinical trial of Postoperative Pain, sponsored by Senthil Sadhasivam.
- Active
- Registry status
- 1,200
- Enrollment target
- 1
- Study location
NCT01140724 is a study of Postoperative Pain that is active but no longer recruiting, run by Senthil Sadhasivam. The registered enrollment target is 1,200 participants, above the 212-participant average among 63 other Postoperative Pain trials with a reported enrollment target (466% higher). The trial reports 1 study location across 1 state.
The verdict
NCT01140724, a study of Postoperative Pain, is active but no longer recruiting, sponsored by Senthil Sadhasivam.
- ACTIVE NOT RECRUITING
- Registry status
- 1,200 participants
- Enrollment target
- 1
- Study location
Study Summary
In the United States alone, each year approximately 5 million children undergo painful surgery, many of them experience serious side-effects with opioids and inadequate pain relief. Safe and effective analgesia is an important unmet critical medical need in children and its continued existence is an important perioperative safety and economic problem. Inadequate pain relief and serious side effects from perioperative opioids occur frequently in up to 50% of children. Morphine, the most commonly used perioperative opioid, has a narrow therapeutic index and large inter-patient variations in analgesic response and serious side effects. Frequent inter-individual variations in responses to morphine have significant clinical and economic impact with inadequate pain relief at one end of the spectrum of responses and serious adverse effects such as respiratory depression at the other end. Much of the inter-individual variability in response to a dose of morphine following surgical procedures can be explained by single nucleotide polymorphisms (SNPs) in a subset of the genes that encode proteins involved in pain mechanisms and opioid pathway.
Conditions Studied
Study Locations (1)
Pennsylvania
- UPMC Children's Hospital - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,200 participants |
| Start Date | 2022-02-07 |
| Est. Completion | 2026-12-25 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01140724
The ClinicalTrials.gov registry entry for NCT01140724 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 1,200 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 212-participant average among 63 other Postoperative Pain trials with a reported enrollment target (466% higher). The listed sponsor is Senthil Sadhasivam, which has 7 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Postoperative Pain appearing as the primary indexed condition, and to 0 interventions.
NCT01140724 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT01140724 about?
NCT01140724 is a clinical study titled "Personalizing Perioperative Analgesia in Children". In the United States alone, each year approximately 5 million children undergo painful surgery, many of them experience serious side-effects with opioids and inadequate pain relief. Safe and effective analgesia is an important unmet critical medical need in children and its continued existence is an...
What is the current status of trial NCT01140724?
This trial is currently active not recruiting. The enrollment target is 1,200 participants. The study started on 2022-02-07. Estimated completion is 2026-12-25.
What conditions does trial NCT01140724 study?
This clinical trial studies the following conditions: Postoperative Pain.
Who is sponsoring clinical trial NCT01140724?
This trial is sponsored by Senthil Sadhasivam, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01140724 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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