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NCT07222072 · ClinicalTrials.gov registry record · Phase 4
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
A Phase 4 study of Postoperative Pain and Spinal Surgery, sponsored by The Cleveland Clinic.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT07222072: Recruiting Phase 4 study of Postoperative Pain and Spinal Surgery, sponsored by The Cleveland Clinic.
NCT07222072 is a Phase 4 study of Postoperative Pain and Spinal Surgery that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 120 participants, below the 231-participant average among 120 other Postoperative Pain trials with a reported enrollment target (48% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07222072, a Phase 4 study of Postoperative Pain and Spinal Surgery, is actively recruiting participants, sponsored by The Cleveland Clinic.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surgery and collect preliminary data to inform a larger clinical trial that will test the opioid-sparing effects of methadone at 3 months after spine surgery.
Primary Outcome
Willingness of participants to be randomized Indicates acceptability of randomization among eligible patients Outcome Measure: % of eligible patient consenting to randomization
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Methadone
Study Locations (1)
Ohio
- Cleveland Clinic - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2025-11-15 |
| Est. Completion | 2028-10 |
| Phase | Phase 4 |
What NCT07222072 shows while recruiting
NCT07222072 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 231-participant average among 120 other Postoperative Pain trials with a reported enrollment target (48% lower).
The record links to 2 conditions, with Postoperative Pain appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT07222072 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT07222072 about?
NCT07222072 is a clinical study titled "Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study". The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surger...
What is the current status of trial NCT07222072?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 120 participants. The study started on 2025-11-15. Estimated completion is 2028-10.
What conditions does trial NCT07222072 study?
This clinical trial studies the following conditions: Postoperative Pain, Spinal Surgery.
What interventions are being tested in trial NCT07222072?
The interventions under investigation include: Placebo (DRUG), Methadone (DRUG).
Who is sponsoring clinical trial NCT07222072?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07222072 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Postoperative Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07222072's enrollment target sits among peer trials
120 45th of 120 higher than 74 of 120 other Postoperative Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Postoperative Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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