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NCT07222072 · ClinicalTrials.gov registry record · Phase 4

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

A Phase 4 study of Post Operative Pain and Spinal Surgery, sponsored by The Cleveland Clinic.

Recruiting
Registry status
Phase 4
Development phase
120
Enrollment target
1
Study location

NCT07222072 is a Phase 4 study of Post Operative Pain and Spinal Surgery that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 120 participants, below the 234-participant average among 56 other Post Operative Pain trials with a reported enrollment target (49% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT07222072, a Phase 4 study of Post Operative Pain and Spinal Surgery, is actively recruiting participants, sponsored by The Cleveland Clinic.

RECRUITING
Registry status
Phase 4
Development phase
120 participants
Enrollment target
1
Study location

Study Summary

The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surgery and collect preliminary data to inform a larger clinical trial that will test the opioid-sparing effects of methadone at 3 months after spine surgery.

Conditions Studied

Post Operative Pain Spinal Surgery

Interventions

  • DRUG Placebo
  • DRUG Methadone

Study Locations (1)

Ohio

  • Cleveland Clinic - Cleveland

Trial Details

FieldValue
Enrollment Target 120 participants
Start Date 2025-11-15
Est. Completion 2028-10
Phase Phase 4

Sponsor

The Cleveland Clinic

688 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07222072

The ClinicalTrials.gov registry entry for NCT07222072 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 234-participant average among 56 other Post Operative Pain trials with a reported enrollment target (49% lower). The listed sponsor is The Cleveland Clinic, which has 688 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Post Operative Pain appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT07222072 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.

Frequently Asked Questions

What is clinical trial NCT07222072 about?

NCT07222072 is a clinical study titled "Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study". The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surger...

What is the current status of trial NCT07222072?

This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 120 participants. The study started on 2025-11-15. Estimated completion is 2028-10.

What conditions does trial NCT07222072 study?

This clinical trial studies the following conditions: Post Operative Pain, Spinal Surgery.

What interventions are being tested in trial NCT07222072?

The interventions under investigation include: Placebo (DRUG), Methadone (DRUG).

Who is sponsoring clinical trial NCT07222072?

This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07222072 being conducted?

This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.