The Cleveland Clinic

688 total trials 99 currently recruiting 437 completed

The Cleveland Clinic sponsors 688 registered US clinical trials on ClinicalTrials.gov, 99 of them currently recruiting, and 437 completed. 81 of these trials are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atrial Fibrillation, with 9 trials.

Trial Pipeline

688 total, page 1 of 14

RECRUITING NA

Ultrasound-Guided Versus Standard Margin Selection in Ileocecal Resection of Terminal Ileal CD

NCT07680283

RECRUITING NA

Health-Related Quality of Life and Metabolic Outcomes in PCOS

NCT07571915

RECRUITING

Wearable Technology in Heart Failure Patients

NCT07650669

RECRUITING

Dietary Tracking in Heart Failure

NCT07649148

RECRUITING

Centered Surgery - Preoperative Counseling and Patient Satisfaction

NCT07471464

RECRUITING NA

Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study

NCT07363343

RECRUITING NA

Feasibility and Ergonomic Impact of A Virtual Reality Headset in Endoscopic Procedures

NCT07493863

RECRUITING NA

Virtual Patient Groups for Sarcoidosis Associated Fatigue

NCT07073963

RECRUITING NA

Antiseptic-Coated Sutures and Pancreatic Fistula Risk After Pancreatoduodenectomy

NCT07318493

RECRUITING

Laser Ablation a Salvage Treatment for Obstructive Benign Prostatic Hyperplasia

NCT07016620

RECRUITING

Viability Assessment Using FMN Measured in Perfusate and Bile During Normothermic Machine Perfusion

NCT07315204

RECRUITING Phase 4

Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease

NCT07058155

RECRUITING NA

Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training

NCT07681973

RECRUITING NA

Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease

NCT07110376

RECRUITING Phase 4

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

NCT07222072

RECRUITING Phase 4

Preoperative BOTOX® Injection for Large Ventral Hernia Repair

NCT07220382

RECRUITING

At-Home Bowel Stimulation

NCT07574437

RECRUITING NA

Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD

NCT07059637

RECRUITING NA

Central Vein Sign in Multiple Sclerosis Extension Study

NCT07424027

RECRUITING NA

Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

NCT07087587

RECRUITING NA

Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery

NCT06946368

RECRUITING

Zimmer ActivBraid Rotator Cuff Repair (RCR) Study

NCT06971497

RECRUITING Phase 4

The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality

NCT07127354

RECRUITING Phase 4

BOOST-PD A Naturalistic Study on IPX-203 for Parkinson's Disease

NCT07138560

RECRUITING Phase 3

Non-Narcotic Pain Control After ACL Reconstruction

NCT06973785

RECRUITING NA

Gluten Free Diet in Hashimoto's Hypothyroidism

NCT07060118

RECRUITING

Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

NCT07122947

RECRUITING Phase 2

Topical Ruxolitinib Cream for Refractory Cutaneous Dermatomyositis

NCT06857240

RECRUITING

Assessment of Coronary Microvascular Dysfunction After STEMI Using Continuous Saline Thermodilution

NCT06795035

RECRUITING Phase 1

Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor

NCT07049003

RECRUITING NA

Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.

NCT06937671

RECRUITING Phase 4

Early Versus Late Adjunctive Vasopressin in Septic Shock

NCT06709573

RECRUITING Phase 2

TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

NCT06802081

RECRUITING NA

CLOSM Trial: Groin Closure Using Layered Option for Suture Material

NCT06990425

RECRUITING

Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF

NCT06849752

RECRUITING

Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease

NCT06694558

RECRUITING NA

Impact of Medjool Date Consumption on Labor and Delivery Outcomes

NCT07058792

RECRUITING NA

Physician Modified Endovascular Grafts for the Treatment of Juxtarenal Aortic Aneurysms

NCT06657794

RECRUITING

Remote Monitoring in Pregnant Women With Congenital Heart Disease Using Wrist Wearables

NCT06818760

RECRUITING

Imaging Assessments of ARPKD Kidney Disease Progression

NCT07201025

RECRUITING

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

NCT06780241

RECRUITING Phase 2

Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy

NCT06721520

RECRUITING

Detecting Mild Autonomous Cortisol Secretion in Patients With Adrenal Incidentaloma

NCT06344143

RECRUITING NA

Quantra Point-of-Care Hemostasis Monitoring

NCT06328647

RECRUITING NA

I-Score: Intensive Stroke Cycling for Optimal Recovery and Economic Value

NCT06585943

RECRUITING

Cardiovascular and Metabolic Sciences Biorepository

NCT06560424

RECRUITING Phase 4

NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow

NCT06373978

RECRUITING NA

EOIFP Block Versus OSTAP Block for Upper Abdominal Surgery

NCT06409156

RECRUITING Phase 3

Sugammadex Vs Neostigmine in Reversing Neuromuscular Blocks in Outpatient ERCP. A Randomized, Double-Blinded Trial

NCT06136585

RECRUITING NA

Laparoscopic Versus Robotic Lateral Transabdominal Adrenalectomy

NCT06407024

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 38
Phase 3 22
Phase 4 59

What the Pipeline for The Cleveland Clinic Shows

According to the ClinicalTrials.gov registry, The Cleveland Clinic is linked to 688 US clinical trials across every stage of research activity. Of those, 99 studies are currently recruiting, about 14% of the sponsor's indexed portfolio, and 437 are already marked complete, representing roughly 64% of the total.

The phase mix for The Cleveland Clinic reports 81 late-stage studies (Phase 3 and Phase 4 combined) and 76 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for The Cleveland Clinic is Atrial Fibrillation with 9 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.