The Cleveland Clinic
Trial Pipeline
Centered Surgery - Preoperative Counseling and Patient Satisfaction
NCT07471464
Virtual Patient Groups for Sarcoidosis Associated Fatigue
NCT07073963
Antiseptic-Coated Sutures and Pancreatic Fistula Risk After Pancreatoduodenectomy
NCT07318493
Laser Ablation a Salvage Treatment for Obstructive Benign Prostatic Hyperplasia
NCT07016620
Viability Assessment Using FMN Measured in Perfusate and Bile During Normothermic Machine Perfusion
NCT07315204
Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease
NCT07058155
Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease
NCT07110376
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
NCT07222072
Preoperative BOTOX® Injection for Large Ventral Hernia Repair
NCT07220382
Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD
NCT07059637
Central Vein Sign in Multiple Sclerosis Extension Study
NCT07424027
Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):
NCT07087587
Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery
NCT06946368
Zimmer ActivBraid Rotator Cuff Repair (RCR) Study
NCT06971497
The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality
NCT07127354
BOOST-PD A Naturalistic Study on IPX-203 for Parkinson's Disease
NCT07138560
Non-Narcotic Pain Control After ACL Reconstruction
NCT06973785
Gluten Free Diet in Hashimoto's Hypothyroidism
NCT07060118
Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF
NCT07122947
Topical Ruxolitinib Cream for Refractory Cutaneous Dermatomyositis
NCT06857240
Assessment of Coronary Microvascular Dysfunction After STEMI Using Continuous Saline Thermodilution
NCT06795035
Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor
NCT07049003
Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.
NCT06937671
Early Versus Late Adjunctive Vasopressin in Septic Shock
NCT06709573
TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation
NCT06802081
CLOSM Trial: Groin Closure Using Layered Option for Suture Material
NCT06990425
Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF
NCT06849752
Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease
NCT06694558
Impact of Medjool Date Consumption on Labor and Delivery Outcomes
NCT07058792
Physician Modified Endovascular Grafts for the Treatment of Juxtarenal Aortic Aneurysms
NCT06657794
Remote Monitoring in Pregnant Women With Congenital Heart Disease Using Wrist Wearables
NCT06818760
Imaging Assessments of ARPKD Kidney Disease Progression
NCT07201025
Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease
NCT06780241
Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy
NCT06721520
Detecting Mild Autonomous Cortisol Secretion in Patients With Adrenal Incidentaloma
NCT06344143
Quantra Point-of-Care Hemostasis Monitoring
NCT06328647
I-Score: Intensive Stroke Cycling for Optimal Recovery and Economic Value
NCT06585943
Cardiovascular and Metabolic Sciences Biorepository
NCT06560424
NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow
NCT06373978
EOIFP Block Versus OSTAP Block for Upper Abdominal Surgery
NCT06409156
Sugammadex Vs Neostigmine in Reversing Neuromuscular Blocks in Outpatient ERCP. A Randomized, Double-Blinded Trial
NCT06136585
Laparoscopic Versus Robotic Lateral Transabdominal Adrenalectomy
NCT06407024
Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System
NCT06379321
Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes
NCT06382636
Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
NCT06293638
Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes
NCT06298721
Efficacy of A Novel RinSe Device to Reduce Oral Bacteria in Intubated IntEnsive CaRe Patients: a Pilot Study
NCT06193512
Rebuilding Inter-limb Transfer in Cervical SCI
NCT06440538
Precise and Objective Identification of Bertolotti Syndrome Using Novel Kinematic Biomarkers
NCT06225583
Preoperative Pelvic Floor Physical Therapy to Minimize Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate
NCT06179654
Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue
NCT06789809
Efficacy of Low-intensity Shockwave vs Radial Wave for Treatment of Erectile Dysfunction and Pelvic Pain
NCT05868668
Phenotypic Classification of FMR With CMR
NCT05965258
Randomized Controlled Trial of Miniaturized Percutaneous Nephrolithotomy With Vacuum-Assisted Access Sheaths Versus Conventional Sheaths for Treatment of Nephrolithiasis
NCT05993546
Home Versus Office Removal of Percutaneous Nerve Evaluation (PNE) Lead
NCT05799313
Molecular Mechanism of Exercise in Cirrhosis
NCT05982769
Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients
NCT05725928
Intraoperative Electrical Stimulation to Improve Nerve Grafting Outcome
NCT06335719
Intracardiac Echocardiography Guided Watchman Device Implant
NCT06007872
CV Imaging of Metabolic Interventions
NCT05650307
Development of CIRC Technologies
NCT05654272
HA35 Moderate Alcoholic Hepatitis (AH) Study
NCT05018481
Global Cardio Oncology Registry
NCT05598879
HA35 Acute Alcohol Study
NCT05025865
HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis
NCT05166499
Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)
NCT04869813
Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19
NCT04858412
Structural Modification In Supraglottic Airway Device
NCT04498598
MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)
NCT04578392
Dextenza in the Post-op Management of Vitreoretinal Surgeries
NCT04371445
Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)
NCT05628974
Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy
NCT04310241
Vascular Lab Resource (VLR) Biorepository
NCT05628948
Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study
NCT04191681
Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis
NCT04088370
Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy
NCT04096014
A Cardiac Disease Quality of Life Study
NCT04080492
Comparative Imaging Assessment of Valvular Heart Disease
NCT04126018
rTMS Plus CCFES-mediated Functional Task Practice for Severe Stroke
NCT03870672
Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis
NCT03225677
Comparison of ALD, NASH, and Healthy Control Patients
NCT03224949
Can Prophylactic Foraminotomy Prevent C5 Palsy
NCT03023696
Corneal Elastography and Patient Specific Modeling
NCT03030755
Ethanol Induces Skeletal Muscle Autophagy
NCT03209791
Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)
NCT02016430
DISCOVER Study: Microscope-integrated Intraoperative OCT Study
NCT02423213
Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis
NCT03208868
Analysis of Anterior Chamber Inflammation by Optical Coherence Tomography
NCT01746537
Genetics of Uveitis
NCT02357238
Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
NCT00921986
Mechanisms of Malnutrition in Cirrhosis With Portosystemic Shunting
NCT03121404
Continuous Glucose Monitoring in Polycystic Ovarian Syndrome
NCT07392476
Sequential or CombinaTion Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)
NCT06854614
Shifting Options Study
NCT07225595
Physiological Effects Ketone Ester in Heart
NCT05924802
Microbial Metabolites and Outcomes of Pregnancy Study
NCT06362356
3D Holographic Guidance, Navigation, and Control for Endovascular Aortic Repair
NCT06008613
Abdominal Wall Tension in Patients Undergoing Ventral Hernia Repair Without Component Separation
NCT06051578
VIRtual Versus UsuAL In-office Care for Multiple Sclerosis (VIRTUAL-MS)
NCT05660187
Glycemic Control, Type II Diabetes, Parathyroidectomy
NCT05761743
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 13 |
| Phase 2 | 37 |
| Phase 3 | 33 |
| Phase 4 | 50 |
Therapeutic Areas
What the Pipeline for The Cleveland Clinic Shows
According to the ClinicalTrials.gov registry, The Cleveland Clinic is linked to 607 US clinical trials across every stage of research activity. Of those, 466 studies are currently recruiting — about 77% of the sponsor's indexed portfolio — and 100 are already marked complete, representing roughly 16% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for The Cleveland Clinic reports 83 late-stage studies (Phase 3 and Phase 4 combined) and 50 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for The Cleveland Clinic is Atrial Fibrillation with 9 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.