The Cleveland Clinic

607 total trials 466 currently recruiting 100 completed

Trial Pipeline

RECRUITING

Centered Surgery - Preoperative Counseling and Patient Satisfaction

NCT07471464

RECRUITING NA

Virtual Patient Groups for Sarcoidosis Associated Fatigue

NCT07073963

RECRUITING NA

Antiseptic-Coated Sutures and Pancreatic Fistula Risk After Pancreatoduodenectomy

NCT07318493

RECRUITING

Laser Ablation a Salvage Treatment for Obstructive Benign Prostatic Hyperplasia

NCT07016620

RECRUITING

Viability Assessment Using FMN Measured in Perfusate and Bile During Normothermic Machine Perfusion

NCT07315204

RECRUITING Phase 4

Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease

NCT07058155

RECRUITING NA

Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease

NCT07110376

RECRUITING Phase 4

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

NCT07222072

RECRUITING Phase 4

Preoperative BOTOX® Injection for Large Ventral Hernia Repair

NCT07220382

RECRUITING NA

Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD

NCT07059637

RECRUITING NA

Central Vein Sign in Multiple Sclerosis Extension Study

NCT07424027

RECRUITING NA

Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

NCT07087587

RECRUITING NA

Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery

NCT06946368

RECRUITING

Zimmer ActivBraid Rotator Cuff Repair (RCR) Study

NCT06971497

RECRUITING Phase 4

The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality

NCT07127354

RECRUITING Phase 4

BOOST-PD A Naturalistic Study on IPX-203 for Parkinson's Disease

NCT07138560

RECRUITING Phase 3

Non-Narcotic Pain Control After ACL Reconstruction

NCT06973785

RECRUITING NA

Gluten Free Diet in Hashimoto's Hypothyroidism

NCT07060118

RECRUITING

Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

NCT07122947

RECRUITING Phase 2

Topical Ruxolitinib Cream for Refractory Cutaneous Dermatomyositis

NCT06857240

RECRUITING

Assessment of Coronary Microvascular Dysfunction After STEMI Using Continuous Saline Thermodilution

NCT06795035

RECRUITING Phase 1

Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor

NCT07049003

RECRUITING NA

Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.

NCT06937671

RECRUITING Phase 4

Early Versus Late Adjunctive Vasopressin in Septic Shock

NCT06709573

RECRUITING Phase 2

TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

NCT06802081

RECRUITING NA

CLOSM Trial: Groin Closure Using Layered Option for Suture Material

NCT06990425

RECRUITING

Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF

NCT06849752

RECRUITING

Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease

NCT06694558

RECRUITING NA

Impact of Medjool Date Consumption on Labor and Delivery Outcomes

NCT07058792

RECRUITING NA

Physician Modified Endovascular Grafts for the Treatment of Juxtarenal Aortic Aneurysms

NCT06657794

RECRUITING

Remote Monitoring in Pregnant Women With Congenital Heart Disease Using Wrist Wearables

NCT06818760

RECRUITING

Imaging Assessments of ARPKD Kidney Disease Progression

NCT07201025

RECRUITING

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

NCT06780241

RECRUITING Phase 2

Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy

NCT06721520

RECRUITING

Detecting Mild Autonomous Cortisol Secretion in Patients With Adrenal Incidentaloma

NCT06344143

RECRUITING NA

Quantra Point-of-Care Hemostasis Monitoring

NCT06328647

RECRUITING NA

I-Score: Intensive Stroke Cycling for Optimal Recovery and Economic Value

NCT06585943

RECRUITING

Cardiovascular and Metabolic Sciences Biorepository

NCT06560424

RECRUITING Phase 4

NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow

NCT06373978

RECRUITING NA

EOIFP Block Versus OSTAP Block for Upper Abdominal Surgery

NCT06409156

RECRUITING Phase 3

Sugammadex Vs Neostigmine in Reversing Neuromuscular Blocks in Outpatient ERCP. A Randomized, Double-Blinded Trial

NCT06136585

RECRUITING NA

Laparoscopic Versus Robotic Lateral Transabdominal Adrenalectomy

NCT06407024

RECRUITING

Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System

NCT06379321

RECRUITING NA

Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes

NCT06382636

RECRUITING

Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor

NCT06293638

RECRUITING NA

Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes

NCT06298721

RECRUITING NA

Efficacy of A Novel RinSe Device to Reduce Oral Bacteria in Intubated IntEnsive CaRe Patients: a Pilot Study

NCT06193512

RECRUITING Early Phase 1

Rebuilding Inter-limb Transfer in Cervical SCI

NCT06440538

RECRUITING

Precise and Objective Identification of Bertolotti Syndrome Using Novel Kinematic Biomarkers

NCT06225583

RECRUITING NA

Preoperative Pelvic Floor Physical Therapy to Minimize Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate

NCT06179654

RECRUITING NA

Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue

NCT06789809

RECRUITING NA

Efficacy of Low-intensity Shockwave vs Radial Wave for Treatment of Erectile Dysfunction and Pelvic Pain

NCT05868668

RECRUITING

Phenotypic Classification of FMR With CMR

NCT05965258

RECRUITING NA

Randomized Controlled Trial of Miniaturized Percutaneous Nephrolithotomy With Vacuum-Assisted Access Sheaths Versus Conventional Sheaths for Treatment of Nephrolithiasis

NCT05993546

RECRUITING NA

Home Versus Office Removal of Percutaneous Nerve Evaluation (PNE) Lead

NCT05799313

RECRUITING NA

Molecular Mechanism of Exercise in Cirrhosis

NCT05982769

RECRUITING NA

Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients

NCT05725928

RECRUITING NA

Intraoperative Electrical Stimulation to Improve Nerve Grafting Outcome

NCT06335719

RECRUITING NA

Intracardiac Echocardiography Guided Watchman Device Implant

NCT06007872

RECRUITING

CV Imaging of Metabolic Interventions

NCT05650307

RECRUITING

Development of CIRC Technologies

NCT05654272

RECRUITING Early Phase 1

HA35 Moderate Alcoholic Hepatitis (AH) Study

NCT05018481

RECRUITING

Global Cardio Oncology Registry

NCT05598879

RECRUITING Early Phase 1

HA35 Acute Alcohol Study

NCT05025865

RECRUITING NA

HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

NCT05166499

RECRUITING

Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)

NCT04869813

RECRUITING NA

Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19

NCT04858412

RECRUITING NA

Structural Modification In Supraglottic Airway Device

NCT04498598

RECRUITING NA

MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)

NCT04578392

RECRUITING Phase 4

Dextenza in the Post-op Management of Vitreoretinal Surgeries

NCT04371445

RECRUITING

Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)

NCT05628974

RECRUITING

Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy

NCT04310241

RECRUITING

Vascular Lab Resource (VLR) Biorepository

NCT05628948

RECRUITING Phase 4

Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study

NCT04191681

RECRUITING

Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis

NCT04088370

RECRUITING NA

Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy

NCT04096014

RECRUITING

A Cardiac Disease Quality of Life Study

NCT04080492

RECRUITING

Comparative Imaging Assessment of Valvular Heart Disease

NCT04126018

RECRUITING NA

rTMS Plus CCFES-mediated Functional Task Practice for Severe Stroke

NCT03870672

RECRUITING

Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis

NCT03225677

RECRUITING

Comparison of ALD, NASH, and Healthy Control Patients

NCT03224949

RECRUITING NA

Can Prophylactic Foraminotomy Prevent C5 Palsy

NCT03023696

RECRUITING

Corneal Elastography and Patient Specific Modeling

NCT03030755

RECRUITING

Ethanol Induces Skeletal Muscle Autophagy

NCT03209791

RECRUITING NA

Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)

NCT02016430

RECRUITING

DISCOVER Study: Microscope-integrated Intraoperative OCT Study

NCT02423213

RECRUITING NA

Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis

NCT03208868

RECRUITING

Analysis of Anterior Chamber Inflammation by Optical Coherence Tomography

NCT01746537

RECRUITING

Genetics of Uveitis

NCT02357238

RECRUITING

Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic

NCT00921986

RECRUITING

Mechanisms of Malnutrition in Cirrhosis With Portosystemic Shunting

NCT03121404

ACTIVE NOT RECRUITING

Continuous Glucose Monitoring in Polycystic Ovarian Syndrome

NCT07392476

ACTIVE NOT RECRUITING Phase 4

Sequential or CombinaTion Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)

NCT06854614

ACTIVE NOT RECRUITING

Shifting Options Study

NCT07225595

ACTIVE NOT RECRUITING NA

Physiological Effects Ketone Ester in Heart

NCT05924802

ACTIVE NOT RECRUITING

Microbial Metabolites and Outcomes of Pregnancy Study

NCT06362356

ACTIVE NOT RECRUITING NA

3D Holographic Guidance, Navigation, and Control for Endovascular Aortic Repair

NCT06008613

ACTIVE NOT RECRUITING

Abdominal Wall Tension in Patients Undergoing Ventral Hernia Repair Without Component Separation

NCT06051578

ACTIVE NOT RECRUITING NA

VIRtual Versus UsuAL In-office Care for Multiple Sclerosis (VIRTUAL-MS)

NCT05660187

ACTIVE NOT RECRUITING

Glycemic Control, Type II Diabetes, Parathyroidectomy

NCT05761743

Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 37
Phase 3 33
Phase 4 50

What the Pipeline for The Cleveland Clinic Shows

According to the ClinicalTrials.gov registry, The Cleveland Clinic is linked to 607 US clinical trials across every stage of research activity. Of those, 466 studies are currently recruiting — about 77% of the sponsor's indexed portfolio — and 100 are already marked complete, representing roughly 16% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for The Cleveland Clinic reports 83 late-stage studies (Phase 3 and Phase 4 combined) and 50 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for The Cleveland Clinic is Atrial Fibrillation with 9 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial