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NCT07227064 · ClinicalTrials.gov registry record · Phase 3
Methadone in THA for Post-op Pain and Opioid Reduction
A Phase 3 study of Postoperative Pain and Total Hip Arthroplasty, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 162
- Enrollment target
- 1
- Study location
NCT07227064: Recruiting Phase 3 study of Postoperative Pain and Total Hip Arthroplasty, sponsored by Medical University of South Carolina.
NCT07227064 is a Phase 3 study of Postoperative Pain and Total Hip Arthroplasty that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 162 participants, below the 230-participant average among 120 other Postoperative Pain trials with a reported enrollment target (30% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07227064, a Phase 3 study of Postoperative Pain and Total Hip Arthroplasty, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 162 participants
- Enrollment target
- 1
- Study location
Study Summary
This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total hip arthroplasty under spinal anesthesia with mepivacaine. The primary outcome is patient-reported pain on a visual analog scale (VAS) 30-60 minutes after arrival in the post-anesthesia care unit (PACU). Secondary outcomes include opioid use, pain scores over time, incidence of nausea/vomiting, and quality of recovery. A total of 162 subjects will be enrolled at MUSC surgical sites.
Primary Outcome
Patient reported hip pain on a Visual Analog Scale (VAS) from 0-100mm at approximately 30-60 minutes after arriving to the recovery unit after surgery. A lower pain score means a better outcome.
Conditions Studied
Interventions
- DRUG Methadone
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 162 participants |
| Start Date | 2026-01-12 |
| Est. Completion | 2027-01-31 |
| Phase | Phase 3 |
What NCT07227064 shows while recruiting
NCT07227064 is an interventional study that assigns participants to a tested intervention. The registered 162 participants enrollment target is mid-sized for trials with a published cap, below the 230-participant average among 120 other Postoperative Pain trials with a reported enrollment target (30% lower).
The record links to 2 conditions, with Postoperative Pain appearing as the primary indexed condition, and to 1 intervention - of which Methadone is the first listed.
NCT07227064 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT07227064 about?
NCT07227064 is a clinical study titled "Methadone in THA for Post-op Pain and Opioid Reduction". This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total hip arthroplasty under spinal anesthesia with mepivacaine. Th...
What is the current status of trial NCT07227064?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 162 participants. The study started on 2026-01-12. Estimated completion is 2027-01-31.
What conditions does trial NCT07227064 study?
This clinical trial studies the following conditions: Postoperative Pain, Total Hip Arthroplasty.
What interventions are being tested in trial NCT07227064?
The interventions under investigation include: Methadone (DRUG).
Who is sponsoring clinical trial NCT07227064?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07227064 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Postoperative Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07227064's enrollment target sits among peer trials
162 31st of 120 higher than 89 of 120 other Postoperative Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Postoperative Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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