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NCT07227064 · ClinicalTrials.gov registry record · Phase 3
Methadone in THA for Post-op Pain and Opioid Reduction
A Phase 3 study of Post Operative Pain and Total Hip Arthroplasty, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 162
- Enrollment target
- 1
- Study location
NCT07227064 is a Phase 3 study of Post Operative Pain and Total Hip Arthroplasty that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 162 participants, below the 234-participant average among 56 other Post Operative Pain trials with a reported enrollment target (31% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07227064, a Phase 3 study of Post Operative Pain and Total Hip Arthroplasty, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 162 participants
- Enrollment target
- 1
- Study location
Study Summary
This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total hip arthroplasty under spinal anesthesia with mepivacaine. The primary outcome is patient-reported pain on a visual analog scale (VAS) 30-60 minutes after arrival in the post-anesthesia care unit (PACU). Secondary outcomes include opioid use, pain scores over time, incidence of nausea/vomiting, and quality of recovery. A total of 162 subjects will be enrolled at MUSC surgical sites.
Conditions Studied
Interventions
- DRUG Methadone
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 162 participants |
| Start Date | 2026-01-12 |
| Est. Completion | 2027-01-31 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07227064
The ClinicalTrials.gov registry entry for NCT07227064 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 162 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 234-participant average among 56 other Post Operative Pain trials with a reported enrollment target (31% lower). The listed sponsor is Medical University of South Carolina, which has 755 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Post Operative Pain appearing as the primary indexed condition, and to 1 intervention - of which Methadone is the first listed.
NCT07227064 reports 1 study location spanning 1 distinct geographic area - top geographies include South Carolina.
Frequently Asked Questions
What is clinical trial NCT07227064 about?
NCT07227064 is a clinical study titled "Methadone in THA for Post-op Pain and Opioid Reduction". This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total hip arthroplasty under spinal anesthesia with mepivacaine. Th...
What is the current status of trial NCT07227064?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 162 participants. The study started on 2026-01-12. Estimated completion is 2027-01-31.
What conditions does trial NCT07227064 study?
This clinical trial studies the following conditions: Post Operative Pain, Total Hip Arthroplasty.
What interventions are being tested in trial NCT07227064?
The interventions under investigation include: Methadone (DRUG).
Who is sponsoring clinical trial NCT07227064?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07227064 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.