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2026 data Public-data reference. official source

Invasive Breast Carcinoma

Open-data reference.

46 US clinical trials · 16 currently recruiting

Active & Recent Trials

RECRUITING 2,020 participants

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

Guardant Health

NCT05059444

RECRUITING 1,300 participants

Breast Cancer Survivorship Biorepository

University of Southern California

NCT05786664

RECRUITING 1,200 participants

Biospecimen and Medical Data Collection and Tumor Biopsy in Creating Research Tissue Registry in Patients With Inflammatory or Invasive Breast Cancer

M.D. Anderson Cancer Center

NCT00477100

RECRUITING 600 participants

Impact of COVID-19 Pandemic on Out-of-Pocket Costs, Lost Wages, and Unemployment in Patients With Breast Cancer Undergoing Breast Surgery

M.D. Anderson Cancer Center

NCT04169542

RECRUITING Phase 3 200 participants

Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

City of Hope Medical Center

NCT06763328

RECRUITING Phase 2 150 participants

Avelumab With Binimetinib, Sacituzumab Govitecan, or Liposomal Doxorubicin in Treating Stage IV or Unresectable, Recurrent Triple Negative Breast Cancer

Laura Huppert, MD, BA

NCT03971409

RECRUITING NA 120 participants

Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy

M.D. Anderson Cancer Center

NCT02945579

RECRUITING NA 80 participants

Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer

Thomas Jefferson University

NCT04959474

RECRUITING Phase 2 70 participants

Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

National Cancer Institute (NCI)

NCT03606967

RECRUITING NA 55 participants

Neoadjuvant Breast Cancer Time Restricted Eating

Thomas Jefferson University

NCT05327608

RECRUITING Phase 1 54 participants

A Vaccine (MV-s-NAP) for the Treatment of Patients With Invasive Metastatic Breast Cancer

Mayo Clinic

NCT04521764

RECRUITING Early Phase 1 40 participants

Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer

Emory University

NCT05464810

RECRUITING Phase 1 36 participants

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

National Cancer Institute (NCI)

NCT07137416

RECRUITING Phase 1 18 participants

Ribociclib, Tucatinib, and Trastuzumab for the Treatment of HER2 Positive Breast Cancer

Jonsson Comprehensive Cancer Center

NCT05319873

RECRUITING NA 15 participants

NearWave Optical Molecular Monitoring

Indiana University

NCT06744465

RECRUITING 12 participants

Temporal Immunologic Changes With Hypofractionated Radiation-Induced DNA Damage in Breast Cancer

M.D. Anderson Cancer Center

NCT05406232

ACTIVE NOT RECRUITING Phase 3 5,018 participants

Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer

National Cancer Institute (NCI)

NCT01272037

ACTIVE NOT RECRUITING Phase 2 2,175 participants

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

ECOG-ACRIN Cancer Research Group

NCT04266249

ACTIVE NOT RECRUITING Phase 3 1,167 participants

Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy

Alliance for Clinical Trials in Oncology

NCT04379570

ACTIVE NOT RECRUITING Phase 3 1,155 participants

Testing MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer

National Cancer Institute (NCI)

NCT02954874

ACTIVE NOT RECRUITING Phase 3 1,056 participants

T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

Alliance for Clinical Trials in Oncology

NCT04457596

ACTIVE NOT RECRUITING Phase 3 898 participants

Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer

Alliance for Clinical Trials in Oncology

NCT03414970

ACTIVE NOT RECRUITING Phase 2 805 participants

Hypofractionated vs. Conventional Regional Nodal Radiation Therapy for Patients With Invasive Breast Cancer

M.D. Anderson Cancer Center

NCT02912312

ACTIVE NOT RECRUITING NA 798 participants

Molecular Testing and Imaging in Improving Response in Patients With Stage I-III Triple-Negative Breast Cancer Receiving Chemotherapy MDACC Breast Moonshot Initiative

M.D. Anderson Cancer Center

NCT02276443

ACTIVE NOT RECRUITING Phase 3 415 participants

Platinum in Treating Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy

ECOG-ACRIN Cancer Research Group

NCT02445391

ACTIVE NOT RECRUITING Phase 2 301 participants

Hypofractionated Radiation Therapy or Standard Radiation Therapy in Treating Patients With Ductal Breast Carcinoma In Situ or Early Invasive Breast Cancer

M.D. Anderson Cancer Center

NCT01266642

ACTIVE NOT RECRUITING Phase 2 235 participants

Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast Cancer, The DIRECT Trial

ECOG-ACRIN Cancer Research Group

NCT05710328

ACTIVE NOT RECRUITING Phase 1 208 participants

Comparing Supplemental Topical Agents for the Treatment of Acute Radiation Dermatitis in Patients With Breast Cancer

City of Hope Medical Center

NCT05340673

ACTIVE NOT RECRUITING Phase 2 200 participants

Radiation Therapy in Treating Patients With Stage 0-II Breast Cancer

M.D. Anderson Cancer Center

NCT01245712

ACTIVE NOT RECRUITING Phase 2 156 participants

Topical Afimoxifene in Treating Patients With Breast Cancer Who Have Undergone Radiation Therapy on One Breast

Northwestern University

NCT04009044

ACTIVE NOT RECRUITING NA 137 participants

Hypofractionated Regional Nodal Irradiation Clinical Trial for Women With Breast Cancer

Virginia Commonwealth University

NCT02515110

ACTIVE NOT RECRUITING Phase 2 120 participants

Metformin and Nightly Fasting in Women With Early Breast Cancer

M.D. Anderson Cancer Center

NCT05023967

ACTIVE NOT RECRUITING Phase 2 116 participants

Ixabepilone in Treating Participants With Significant Residual Disease of HER2/Neu Negative Invasive Breast Cancer After Systemic Therapy

M.D. Anderson Cancer Center

NCT00877500

ACTIVE NOT RECRUITING Phase 2 113 participants

Volumetric Specimen Imager Device for the Intraoperative Imaging of Patients With Breast Carcinoma and Breast Ductal Carcinoma In Situ, The VIVID Study

Northwestern University

NCT05545150

ACTIVE NOT RECRUITING NA 103 participants

Radiation Therapy Boost Before Surgery for the Treatment of Non-metastatic Breast Cancer

Rutgers, The State University of New Jersey

NCT04871516

ACTIVE NOT RECRUITING Phase 2 92 participants

Paclitaxel & Cyclophosphamide With or Without Trastuzumab Before Surgery in Treating Previously Untreated Breast Cancer

University of Nebraska

NCT01750073

ACTIVE NOT RECRUITING Phase 2 67 participants

Carboplatin and Paclitaxel With or Without Atezolizumab Before Surgery in Treating Patients With Newly Diagnosed, Stage II-III Triple-Negative Breast Cancer

National Cancer Institute (NCI)

NCT02883062

ACTIVE NOT RECRUITING Phase 1 57 participants

Entinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast Cancer

National Cancer Institute (NCI)

NCT02453620

ACTIVE NOT RECRUITING Phase 2 46 participants

Neoadjuvant Pembrolizumab + Decitabine Followed by Std Neoadj Chemo for Locally Advanced HER2- Breast Ca

Virginia Commonwealth University

NCT02957968

ACTIVE NOT RECRUITING Phase 2 44 participants

Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases

SWOG Cancer Research Network

NCT04647916

ACTIVE NOT RECRUITING Phase 2 42 participants

Carboplatin and Paclitaxel With or Without Panitumumab in Treating Patients With Invasive Triple Negative Breast Cancer

M.D. Anderson Cancer Center

NCT02876107

ACTIVE NOT RECRUITING 38 participants

Impact of Neoadjuvant Chemotherapy on the Peripheral Blood Immune Phenotype in Operable Breast Cancer

Mayo Clinic

NCT04897009

ACTIVE NOT RECRUITING Phase 2 25 participants

Radiation Therapy Before Surgery in Treating Patients With Hormone Receptor Positive, HER2 Negative Breast Cancer

M.D. Anderson Cancer Center

NCT03359954

COMPLETED Phase 2 200 participants

Accelerated Partial Breast Radiation Therapy Using High-Dose Rate Brachytherapy in Treating Patients With Early Stage Breast Cancer After Surgery

Rutgers, The State University of New Jersey

NCT02526498

COMPLETED Phase 2 37 participants

Nab-Paclitaxel and Atezolizumab Before Surgery in Treating Patients With Triple Negative Breast Cancer

M.D. Anderson Cancer Center

NCT02530489

COMPLETED Phase 2 36 participants

Talazoparib Before Standard Therapy in Treating Patients With Invasive, BRCA-Mutated Breast Cancer

M.D. Anderson Cancer Center

NCT02282345

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 20
Phase 3 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Invasive Breast Carcinoma Trial Landscape

ClinicalTrials.gov lists 46 US studies indexed under Invasive Breast Carcinoma, and 16 of those are currently open to recruitment — roughly 35% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Invasive Breast Carcinoma shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 26 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Invasive Breast Carcinoma is led by M.D. Anderson Cancer Center with 14 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 46 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Invasive Breast Carcinoma?

PlainTrial tracks 46 US clinical trials for Invasive Breast Carcinoma, of which 16 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Invasive Breast Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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