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NCT07226076 · ClinicalTrials.gov registry record · Phase 3
Methadone in TKA for Post-op Pain and Opioid Reduction
A Phase 3 study of Post Operative Pain, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 162
- Enrollment target
- 1
- Study location
NCT07226076 is a Phase 3 study of Post Operative Pain that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 162 participants, below the 234-participant average among 56 other Post Operative Pain trials with a reported enrollment target (31% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07226076, a Phase 3 study of Post Operative Pain, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 162 participants
- Enrollment target
- 1
- Study location
Study Summary
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
Conditions Studied
Interventions
- DRUG Methadone Hydrochloride
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 162 participants |
| Start Date | 2026-01-08 |
| Est. Completion | 2027-01-15 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07226076
The ClinicalTrials.gov registry entry for NCT07226076 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 162 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 234-participant average among 56 other Post Operative Pain trials with a reported enrollment target (31% lower). The listed sponsor is Medical University of South Carolina, which has 755 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Post Operative Pain appearing as the primary indexed condition, and to 1 intervention - of which Methadone Hydrochloride is the first listed.
NCT07226076 reports 1 study location spanning 1 distinct geographic area - top geographies include South Carolina.
Frequently Asked Questions
What is clinical trial NCT07226076 about?
NCT07226076 is a clinical study titled "Methadone in TKA for Post-op Pain and Opioid Reduction". This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
What is the current status of trial NCT07226076?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 162 participants. The study started on 2026-01-08. Estimated completion is 2027-01-15.
What conditions does trial NCT07226076 study?
This clinical trial studies the following conditions: Post Operative Pain.
What interventions are being tested in trial NCT07226076?
The interventions under investigation include: Methadone Hydrochloride (DRUG).
Who is sponsoring clinical trial NCT07226076?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07226076 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.