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NCT07226076 · ClinicalTrials.gov registry record · Phase 3
Methadone in TKA for Post-op Pain and Opioid Reduction
A Phase 3 study of Postoperative Pain, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 162
- Enrollment target
- 1
- Study location
NCT07226076: Recruiting Phase 3 study of Postoperative Pain, sponsored by Medical University of South Carolina.
NCT07226076 is a Phase 3 study of Postoperative Pain that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 162 participants, below the 230-participant average among 120 other Postoperative Pain trials with a reported enrollment target (30% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07226076, a Phase 3 study of Postoperative Pain, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 162 participants
- Enrollment target
- 1
- Study location
Study Summary
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
Primary Outcome
Patient reported pain on a Visual Analog Scale (VAS) from 0-100mm at approximately 30-60 minutes after arriving to the recovery unit after surgery. A lower pain score means a better outcome.
Conditions Studied
Interventions
- DRUG Methadone Hydrochloride
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 162 participants |
| Start Date | 2026-01-08 |
| Est. Completion | 2027-01-15 |
| Phase | Phase 3 |
What NCT07226076 shows while recruiting
NCT07226076 is an interventional study that assigns participants to a tested intervention. The registered 162 participants enrollment target is mid-sized for trials with a published cap, below the 230-participant average among 120 other Postoperative Pain trials with a reported enrollment target (30% lower).
The record links to 1 condition, with Postoperative Pain appearing as the primary indexed condition, and to 1 intervention - of which Methadone Hydrochloride is the first listed.
NCT07226076 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT07226076 about?
NCT07226076 is a clinical study titled "Methadone in TKA for Post-op Pain and Opioid Reduction". This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
What is the current status of trial NCT07226076?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 162 participants. The study started on 2026-01-08. Estimated completion is 2027-01-15.
What conditions does trial NCT07226076 study?
This clinical trial studies the following conditions: Postoperative Pain.
What interventions are being tested in trial NCT07226076?
The interventions under investigation include: Methadone Hydrochloride (DRUG).
Who is sponsoring clinical trial NCT07226076?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07226076 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Postoperative Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07226076's enrollment target sits among peer trials
162 31st of 120 higher than 89 of 120 other Postoperative Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Postoperative Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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Methadone in THA for Post-op Pain and Opioid Reduction
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Comparison of the Safety of Q8003 Versus Morphine Equivalent Doses of Its Components (Oxycodone and Morphine) in Bunionectomy Patients
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