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NCT06471348 · ClinicalTrials.gov registry record · NA
Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine
A NA study of Postoperative Pain and Spinal Fusion, sponsored by Boston Children's Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 128
- Enrollment target
- 1
- Study location
NCT06471348: Recruiting NA study of Postoperative Pain and Spinal Fusion, sponsored by Boston Children's Hospital.
NCT06471348 is a NA study of Postoperative Pain and Spinal Fusion that is actively recruiting participants, run by Boston Children's Hospital. The registered enrollment target is 128 participants, below the 231-participant average among 120 other Postoperative Pain trials with a reported enrollment target (45% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06471348, a NA study of Postoperative Pain and Spinal Fusion, is actively recruiting participants, sponsored by Boston Children's Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 128 participants
- Enrollment target
- 1
- Study location
Study Summary
A randomized controlled trial (RCT) investigating whether the local anesthetic injection of liposomal bupivacaine during posterior spinal fusion (PSF) for AIS is more effective in reducing acute postoperative opioid consumption compared to an equal volume injection of 0.25% bupivacaine with epinephrine for patients aged 10 to 17, with 128 patients randomly assigned to one of two arms: liposomal bupivacaine or 0.25% bupivacaine with epinephrine.
Primary Outcome
Total amount of morphine equivalents per kilogram during the first 72 hours postoperatively.
Conditions Studied
Interventions
- DRUG Bupivacaine liposome injectable suspension
- DRUG Bupivacaine Hydrochloride and Epinephrine Injection
Study Locations (1)
Massachusetts
- Boston Children's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 128 participants |
| Start Date | 2025-08-15 |
| Est. Completion | 2028-08-31 |
| Phase | NA |
What NCT06471348 shows while recruiting
NCT06471348 is an interventional study that assigns participants to a tested intervention. The registered 128 participants enrollment target is mid-sized for trials with a published cap, below the 231-participant average among 120 other Postoperative Pain trials with a reported enrollment target (45% lower).
The record links to 2 conditions, with Postoperative Pain appearing as the primary indexed condition, and to 2 interventions - of which Bupivacaine liposome injectable suspension is the first listed.
NCT06471348 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06471348 about?
NCT06471348 is a clinical study titled "Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine". A randomized controlled trial (RCT) investigating whether the local anesthetic injection of liposomal bupivacaine during posterior spinal fusion (PSF) for AIS is more effective in reducing acute postoperative opioid consumption compared to an equal volume injection of 0.25% bupivacaine with epinephr...
What is the current status of trial NCT06471348?
This trial is currently recruiting. It is a NA study. The enrollment target is 128 participants. The study started on 2025-08-15. Estimated completion is 2028-08-31.
What conditions does trial NCT06471348 study?
This clinical trial studies the following conditions: Postoperative Pain, Spinal Fusion.
What interventions are being tested in trial NCT06471348?
The interventions under investigation include: Bupivacaine liposome injectable suspension (DRUG), Bupivacaine Hydrochloride and Epinephrine Injection (DRUG).
Who is sponsoring clinical trial NCT06471348?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06471348 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Postoperative Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06471348's enrollment target sits among peer trials
128 41st of 120 higher than 79 of 120 other Postoperative Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Postoperative Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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