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Massachusetts: below-average open trial sites
2,710 of 7,667 in-state trials are recruiting (35%); below the 37% national average by 2 percentage points.
According to ClinicalTrials.gov-derived indexes, Massachusetts sits in the top decile of US states by in-state trial count (#5 of 52 states by registered in-state trial count).
Massachusetts: 7,667 US clinical trials with in-state sites, 2,710 recruiting.
Massachusetts has 7,667 registered US clinical trials with a study site in-state, 2,710 of them currently recruiting (below the 37% national average by 2 percentage points). 1,108 of these trials are in Phase 3 (late-stage) and 1,636 in Phase 2. The most frequently studied condition in Massachusetts is Breast Cancer, with 184 linked trials.
Peer research-density states
Massachusetts is in the top decile by in-state trial count. Nearest hubs by indexed volume (not open-share twins):
- Pennsylvania (6,946)
- Illinois (6,854)
- Maryland (6,441)
- North Carolina (5,625)
- Arizona (5,607)
Ranked from 51 other states with active in-state trials by how close each state's indexed trial count sits to Massachusetts's.
Below-average open enrollment
Massachusetts still shows 2,710 recruiting of 7,667 in-state trials (35% open), but below the 37% national average by 2 percentage points, so archived statuses weigh heavier than the national baseline.
- 35%
- open (below national share)
- 2,710
- still recruiting despite cool share
- 1,636
- Phase 2 rows in this footprint
- 184
- top: Breast Cancer
Recruiting share is below the 37% national average by 2 percentage points. Counts include every study with at least one recorded site in the state. Registry reference only, not medical advice.
Massachusetts vs all states by indexed in-state trial count
Where this state's ClinicalTrials.gov site count sits among every state with at least one listed trial (coverage density, not care quality)
7,667 Top 10% more indexed trials than 90% of 52 states
States, banded by indexed in-state trial count
Each bar is a band; taller bars hold more states. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov · 2026-08-08
Key findings
What ClinicalTrials.gov does not surface for Massachusetts on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Massachusetts open-enrollment share matches the national baseline.
2,710 of 7,667 in-state trials (35.3%) are recruiting, against 37% nationally (-1.7 percentage points). Counts include every study with at least one recorded site in the state.
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Boston dominates Massachusetts's trial geography.
Boston lists 6,313 of 7,667 in-state trials (82.3%) across 1,385 named facilities. Cities need five or more listed trials to appear here; locations are as filed by sponsors.
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Breast Cancer is the most-studied condition in Massachusetts.
184 of 7,667 in-state trials (2.4%) list Breast Cancer. That is a local concentration figure, not a national disease ranking.
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Massachusetts sponsorship is fragmented across many organizations.
Massachusetts General Hospital appears on 730 of 7,667 in-state trials (9.5%). Sponsor identity is as filed on ClinicalTrials.gov.
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3,189 Massachusetts trials carry a completed status.
3,189 of 7,667 (41.6%) are completed. The open share above is the remainder that still lists recruiting.
By Status
| Status | Trial count |
|---|---|
| Completed | 3,189 |
| Recruiting | 2,710 |
| Active | 1,768 |
By Phase
| Phase | Trial count |
|---|---|
| NA | 2,082 |
| Phase 2 | 1,636 |
| Phase 1 | 1,272 |
| Phase 3 | 1,108 |
| Phase 4 | 294 |
| Early Phase 1 | 72 |
Top Conditions
Top Sponsors
Where trials run in Massachusetts
Boston carries 6,313 of Massachusetts's 7,667 indexed trials (82%) across 1,385 named sites, ahead of Worcester at 432. 8 cities clear five listed trials, together naming 1,795 distinct sites.
| City | Trials | Listed sites |
|---|---|---|
| Boston | 6,313 | 1,385 |
| Worcester | 432 | 162 |
| Springfield | 149 | 54 |
| Burlington | 140 | 39 |
| Cambridge | 123 | 59 |
| Charlestown | 101 | 38 |
| Belmont | 75 | 19 |
| Waltham | 63 | 39 |
Distinct trials and named sites per city, as filed with ClinicalTrials.gov; cities under five trials omitted. Vintage 2026-08-08.
Volume high
Massachusetts indexes 7,667 in-state trials (p92 by registry volume among 52 states with sites).
Massachusetts: in-state trial volume sits in the high tercile
Geography is concentrated: Boston alone accounts for 82% of Massachusetts's indexed trials (6,313 of 7,667), with Worcester a distant second at 432.
Phase mix: 1,108 Phase 3 vs 1,636 Phase 2 (balanced across stages).
Top condition: Breast Cancer (184 trials); top sponsor Massachusetts General Hospital (730).
high-volume · high-open figures (7,667 trials · 35% open) describe registry geography under the volume high read, not clinic capacity or protocol fit. Confirm status on ClinicalTrials.gov before acting.
States near Massachusetts on in-state trial volume
Cross-state peers under the volume high read (high-volume · high-open), not the same-state browse list.
Similar high-volume hubs (± open share)
- Pennsylvania · 6,946 trials · 34% recruiting
- Illinois · 6,854 trials · 33% recruiting
- Maryland · 6,441 trials · 34% recruiting
- North Carolina · 5,625 trials · 33% recruiting
- Arizona · 5,607 trials · 30% recruiting
Similar high-open peers (± trial volume)
- Wyoming · 35% recruiting · 17 trials
- Ohio · 35% recruiting · 6,514 trials
- New York · 35% recruiting · 10,554 trials
- South Carolina · 35% recruiting · 1,706 trials
- Minnesota · 36% recruiting · 4,506 trials