Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Renal Cell Carcinoma

Open-data reference.

122 US clinical trials · 50 currently recruiting

Active & Recent Trials

RECRUITING 5,000 participants

Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders

National Cancer Institute (NCI)

NCT00001238

RECRUITING 1,650 participants

A Multicenter Cancer Biospecimen Collection Study

Cofactor Genomics

NCT04510129

RECRUITING NA 1,000 participants

Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)

University of California, San Francis

NCT05056077

RECRUITING 800 participants

The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors

VastBiome

NCT05037825

RECRUITING NA 600 participants

An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy

University of Texas Southwestern Medical Center

NCT04623502

RECRUITING 500 participants

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

Mohamed Abdel-Rahman

NCT04792463

RECRUITING Phase 2 480 participants

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

Diwakar Davar

NCT07223424

RECRUITING Phase 3 413 participants

A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)

Xynomic Pharmaceuticals

NCT03592472

RECRUITING Phase 1 316 participants

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

Simcha IL-18

NCT04787042

RECRUITING NA 244 participants

Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy

Wake Forest University Health Sciences

NCT05703269

RECRUITING Phase 2 210 participants

Contrast-Enhanced Ultrasound Imaging for Diagnosing Recurrent Renal Cell Carcinoma (RCC) Post Ablation

john eisenbrey

NCT05641935

RECRUITING Phase 1 174 participants

A Phase I Clinical Study to Evaluate the PK Profile, Efficacy, Safety and Immunogenicity of HLX17 vs. Keytruda® in Multiple Resected Solid Tumors

Shanghai Henlius Biotech

NCT07160335

RECRUITING NA 150 participants

Locally Ablative TherapY in Oligo-ProgressiVe GEnitourinary TumoRs (LAYOVER)

University of California, Davis

NCT06101290

RECRUITING Phase 1 140 participants

Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)

Merck Sharp & Dohme

NCT07049926

RECRUITING Phase 1 130 participants

Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

Janux Therapeutics

NCT05783622

RECRUITING Phase 1 126 participants

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

7 Hills Pharma

NCT06362369

RECRUITING Phase 1 125 participants

A First-in-Human Study of BMS-986506 in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC)

Bristol-Myers Squibb

NCT07195682

RECRUITING Phase 1 110 participants

A Study to Evaluate Safety, Efficacy, and Pharmacokinetics in Participants With Advanced Solid Tumors

Eutilex

NCT04903873

RECRUITING Phase 2 100 participants

Molecular Residual Disease (MRD) Guided Adjuvant ThErapy in Renal Cell Carcinoma (RCC)

University of Alabama at Birmingham

NCT06005818

RECRUITING Phase 1 100 participants

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

Nammi Therapeutics

NCT06582017

RECRUITING 97 participants

PET/MR for Characterization of Renal Masses (RMs)

University of Texas Southwestern Medical Center

NCT06076538

RECRUITING Phase 1 80 participants

A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

HiberCell

NCT06234605

RECRUITING Phase 1 78 participants

IDOV-Immune for Advanced Solid Tumors

ViroMissile

NCT06910657

RECRUITING Phase 1 70 participants

A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

AstraZeneca

NCT06147037

RECRUITING Phase 2 65 participants

Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer

National Cancer Institute (NCI)

NCT04981509

RECRUITING Phase 1 60 participants

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

AstraZeneca

NCT07115043

RECRUITING Phase 1 60 participants

Study of DCC-2812 in Participants With Advanced Genitourinary Cancers

Deciphera Pharmaceuticals

NCT06966024

RECRUITING Phase 1 60 participants

A Study of VET3-TGI in Patients With Solid Tumors

KaliVir Immunotherapeutics

NCT06444815

RECRUITING Phase 2 55 participants

89Zr-DFO-Atezolizumab ImmunoPET/CT in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma

James Brugarolas

NCT04006522

RECRUITING Phase 2 48 participants

Phase 2 Study of Combination Tivozanib and Nivolumab in Advanced Non-Clear Cell Renal Cell Carcinoma

M.D. Anderson Cancer Center

NCT06053658

RECRUITING Phase 2 48 participants

CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition

Mark Stein

NCT04322955

RECRUITING NA 46 participants

A Phase II Study of Cyberknife Radiosurgery for Renal Cell Carcinoma

Beth Israel Deaconess Medical Center

NCT01890590

RECRUITING Phase 1 40 participants

Retifanlimab and Ruxolitinib In Solid Malignancies

University of California, San Diego

NCT07219576

RECRUITING Phase 1 35 participants

[18F]PT2385 PET/CT in Patients With Renal Cell Carcinoma

Orhan Kemal Oz

NCT04989959

RECRUITING Phase 2 32 participants

Pre-NEOSHIFT-RCC: Neoadjuvant HIF-Inhibitor Immunotherapy in RCC

Dana-Farber Cancer Institute

NCT07397611

RECRUITING Phase 2 32 participants

Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

City of Hope Medical Center

NCT05830058

RECRUITING Phase 1 30 participants

Open-Label Phase 1/2 Study of NEO-811 in Subjects With Locally Advanced or Metastatic Non-Resectable Clear Cell Renal Cell Carcinoma

Neomorph

NCT07300241

RECRUITING Phase 2 30 participants

Neoadjuvant Lenvatinib and Pembrolizumab for IVC Tumor Thrombus

University of Texas Southwestern Medical Center

NCT05319015

RECRUITING Early Phase 1 30 participants

Neoadjuvant Pembrolizumab and Lenvatinib for Renal Cell Carcinoma

Abramson Cancer Center at Penn Medicine

NCT05733715

RECRUITING Phase 2 30 participants

Trial Of Stereotactic Body Radiation Therapy (SBRT) for Oligoprogression on Immune Checkpoint Inhibitors (ICI) in Metastatic Renal Cell Carcinoma

Yale University

NCT04974671

RECRUITING Early Phase 1 20 participants

Rapid Sequencing of Approved Therapies in Patients with Metastatic or Unresectable Clear Cell Renal Cell Carcinoma

Icahn School of Medicine at Mount Sinai

NCT05188118

RECRUITING Phase 2 20 participants

Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03786796

RECRUITING Phase 2 20 participants

A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases

M.D. Anderson Cancer Center

NCT05048212

RECRUITING Phase 2 20 participants

Stereotactic Body Proton Therapy for Treatment of Primary Renal Cell Carcinoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06376669

RECRUITING Phase 2 18 participants

Sequential Treatment of Cabozantinib for Advanced Renal Cell Carcinoma (RCC)

University of Texas Southwestern Medical Center

NCT05931393

RECRUITING Phase 2 17 participants

Neoadjuvant Pembrolizumab and Axitinib in Renal Cell Carcinoma With Inferior Vena Cava Tumor Thrombus

University of Colorado, Denver

NCT05969496

RECRUITING 16 participants

Analysis of Primary and Metastatic Tumors in Patients With Renal Cell Carcinoma and Urothelial Carcinoma

Fox Chase Cancer Center

NCT03291028

RECRUITING Early Phase 1 10 participants

Memory-like Natural Killer (NK) Cell Therapy in Patients With Renal Cell Carcinoma or Urothelial Carcinoma

Dana-Farber Cancer Institute

NCT06318871

RECRUITING Phase 2 10 participants

A Study of Cemiplimab and Fianlimab in People With Clear Cell Renal Cell Carcinoma

Memorial Sloan Kettering Cancer Center

NCT06699602

RECRUITING NA 5 participants

Transplantation of Reconstructed Renal Allografts Following Ex-Vivo Partial Nephrectomy

Case Comprehensive Cancer Center

NCT05725421

ACTIVE NOT RECRUITING Phase 3 1,069 participants

Lenvatinib/Everolimus or Lenvatinib/Pembrolizumab Versus Sunitinib Alone as Treatment of Advanced Renal Cell Carcinoma

Eisai

NCT02811861

ACTIVE NOT RECRUITING Phase 1 914 participants

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

Exelixis

NCT03170960

ACTIVE NOT RECRUITING Phase 3 855 participants

Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma

Exelixis

NCT03937219

ACTIVE NOT RECRUITING Phase 3 701 participants

A Study of Nivolumab Combined With Cabozantinib Compared to Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma

Bristol-Myers Squibb

NCT03141177

ACTIVE NOT RECRUITING Phase 1 552 participants

A Study Evaluating AB248 Alone or in Combination With Pembrolizumab in Adult Patients With Solid Tumors

Asher Biotherapeutics

NCT05653882

ACTIVE NOT RECRUITING Phase 3 437 participants

A Study of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Participants With Advanced Kidney Cancer

Bristol-Myers Squibb

NCT03873402

ACTIVE NOT RECRUITING Phase 3 343 participants

Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma

AVEO Pharmaceuticals

NCT04987203

ACTIVE NOT RECRUITING Phase 1 325 participants

A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors

Exelixis

NCT03845166

ACTIVE NOT RECRUITING Phase 1 296 participants

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

Inhibrx Biosciences

NCT04198766

ACTIVE NOT RECRUITING Phase 2 272 participants

A Study of Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Renal Cell Carcinoma (V940-004).

Merck Sharp & Dohme

NCT06307431

ACTIVE NOT RECRUITING Phase 2 199 participants

A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advanced Unresectable or Metastatic Renal Cell Carcinoma

Hoffmann-La Roche

NCT05805501

ACTIVE NOT RECRUITING Phase 1 180 participants

P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid Tumors

Poseida Therapeutics

NCT05239143

ACTIVE NOT RECRUITING Phase 1 179 participants

Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

NGM Biopharmaceuticals

NCT04913337

ACTIVE NOT RECRUITING Phase 1 179 participants

A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors

Daiichi Sankyo

NCT04707248

ACTIVE NOT RECRUITING Phase 2 147 participants

A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)

Merck Sharp & Dohme

NCT06099782

ACTIVE NOT RECRUITING Phase 1 138 participants

A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

Toray Industries

NCT03872947

ACTIVE NOT RECRUITING Phase 3 120 participants

Dynamic Contrast Enhancement Computed Tomography for Evaluating Tumor Perfusion in Patients With Metastatic Renal Cell Carcinoma Receiving Targeted Therapies: Renal Cell Carcinoma (RCC) Scramble

M.D. Anderson Cancer Center

NCT01224288

ACTIVE NOT RECRUITING Phase 2 118 participants

A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)

Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT03634540

ACTIVE NOT RECRUITING NA 114 participants

Evaluation of a Simple-Prep Controlled Embolic

Fluidx Medical Technology

NCT06453642

ACTIVE NOT RECRUITING Phase 1 110 participants

A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001)

Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT02293980

ACTIVE NOT RECRUITING Phase 1 98 participants

Study of Nivolumab and Axitinib in Patients With Advanced Renal Cell Carcinoma

Fox Chase Cancer Center

NCT03172754

ACTIVE NOT RECRUITING Phase 1 89 participants

A Study of Recombinant Vaccinia Virus in Combination With Cemiplimab for Renal Cell Carcinoma

SillaJen

NCT03294083

ACTIVE NOT RECRUITING Phase 2 86 participants

Follow-up After Metastasectomy in Patients With Kidney Cancer

M.D. Anderson Cancer Center

NCT00918775

ACTIVE NOT RECRUITING Phase 2 84 participants

Study of High Dose Interleukin-2 (IL-2) and Stereotactic Body Radiation (SBRT) in Patients With Metastatic Renal Cancer

Providence Health & Services

NCT02306954

ACTIVE NOT RECRUITING Phase 1 83 participants

A Study of HFB200603 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors

HiFiBiO Therapeutics

NCT05789069

ACTIVE NOT RECRUITING 72 participants

Analyzing Clinical Outcomes and Genomic Data of American Indian Patient Population

University of Oklahoma

NCT05863052

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors

HiFiBiO Therapeutics

NCT05238883

ACTIVE NOT RECRUITING Phase 1 70 participants

Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab

Dan Zandberg

NCT04074967

ACTIVE NOT RECRUITING Phase 2 70 participants

Study of Zirconium Zr 89 Crefmirlimab Berdoxam PET/CT in Subjects With Advanced or Metastatic Malignancies

ImaginAb

NCT05013099

ACTIVE NOT RECRUITING Phase 1 60 participants

A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6482-024/LITESPARK-024)

Merck Sharp & Dohme

NCT05468697

ACTIVE NOT RECRUITING Phase 2 60 participants

Cabozantinib In Combo With NIVO + IPI In Advanced NCCRCC

Bradley A. McGregor, MD

NCT04413123

ACTIVE NOT RECRUITING Phase 1 51 participants

ITIL-306 in Advanced Solid Tumors

Instil Bio

NCT05397093

ACTIVE NOT RECRUITING Phase 1 50 participants

Phase 1b/2 Trial of Ipilimumab, Nivolumab, and Ciforadenant (Adenosine A2a Receptor Antagonist) in First-line Advanced Renal Cell Carcinoma.

M.D. Anderson Cancer Center

NCT05501054

ACTIVE NOT RECRUITING Phase 2 50 participants

Pre-Surgical Sutent in Renal Cell Carcinoma (RCC)

M.D. Anderson Cancer Center

NCT00715442

ACTIVE NOT RECRUITING Phase 2 46 participants

High Dose IL 2 and Entinostat in RCC

Roberto Pili

NCT03501381

ACTIVE NOT RECRUITING NA 42 participants

PRO-VISION: Patient Reported Outcomes-Based Monitoring of VEGF-Inhibitor Side Effects in ONcology

UNC Lineberger Comprehensive Cancer Center

NCT05592665

ACTIVE NOT RECRUITING Phase 2 40 participants

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

ImmunityBio

NCT03228667

ACTIVE NOT RECRUITING Phase 2 32 participants

Cabozantinib or Sunitinib Malate in Treating Participants With Metastatic Variant Histology Renal Cell Carcinoma

M.D. Anderson Cancer Center

NCT03541902

ACTIVE NOT RECRUITING 28 participants

TFE Renal Cell Carcinoma: A Prospective Registry and Translational Research Initiative

Children's Hospital Medical Center, Cincinnati

NCT03630536

ACTIVE NOT RECRUITING Phase 1 26 participants

A Study of APX005M in Combination With Nivolumab and Ipilimumab in Treatment Naïve Patients With Advanced Melanoma or Renal Cell Carcinoma (RCC)

Yale University

NCT04495257

ACTIVE NOT RECRUITING Phase 1 25 participants

Neo-adjuvant SABR for IVC Tumor Thrombus in Newly Diagnosed RCC

University of Texas Southwestern Medical Center

NCT02473536

ACTIVE NOT RECRUITING Phase 2 24 participants

177LuPSMA in Renal Cell Carcinoma

Dana-Farber Cancer Institute

NCT06964958

ACTIVE NOT RECRUITING Phase 2 22 participants

Neoadjuvant Cabozantinib in Treating Patients With Locally Advanced Kidney Cancer

Emory University

NCT04022343

COMPLETED 2,424 participants

Case-Control Study of Renal Cell Cancer Among Caucasions and African Americans in the United States

National Cancer Institute (NCI)

NCT00340457

COMPLETED Phase 3 658 participants

A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma

Exelixis

NCT01865747

COMPLETED Phase 3 650 participants

Survival Study Of Oncophage® vs. Observation In Patients With Kidney Cancer

Agenus

NCT00033904

COMPLETED 618 participants

Retrospective Study on Referral Patterns for High Risk Patients Post Nephrectomy

Pfizer

NCT04309617

COMPLETED Phase 3 512 participants

Temsirolimus Versus Sorafenib As Second-Line Therapy In Patients With Advanced RCC Who Have Failed First-Line Sunitinib

Pfizer

NCT00474786

COMPLETED Phase 2 471 participants

Efficacy and Safety Comparison of RAD001 Versus Sunitinib in the First-line and Second-line Treatment of Patients With Metastatic Renal Cell Carcinoma

Novartis Pharmaceuticals

NCT00903175

COMPLETED 407 participants

NANOTECH RCC Biomarkers

Washington University School of Medicine

NCT02923284

Phase Distribution

PhaseTrial count
Early Phase 1 51
Phase 2 39
Phase 3 10

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Renal Cell Carcinoma Trial Landscape

ClinicalTrials.gov lists 122 US studies indexed under Renal Cell Carcinoma, and 50 of those are currently open to recruitment — roughly 41% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Renal Cell Carcinoma shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 90 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Renal Cell Carcinoma is led by M.D. Anderson Cancer Center with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Renal Cell Carcinoma?

PlainTrial tracks 122 US clinical trials for Renal Cell Carcinoma, of which 50 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Renal Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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