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ClinicalTrials.gov 50 recruiting now official registry

Renal Cell Carcinoma clinical trials

50 of 122 indexed Renal Cell Carcinoma trials are currently recruiting.

122 US clinical trials · 50 currently recruiting

Renal Cell Carcinoma is the subject of 122 registered US clinical trials on ClinicalTrials.gov, 50 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 90 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 7 of these trials.

The research picture

Renal Cell Carcinoma has 122 registered US clinical trials, 50 of them open to new participants right now, about 41% of the total.

50
recruiting participants now
41%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
7
top sponsor: M.D. Anderson Cancer Center
Phase 151Phase 239Phase 310

Active & Recent Trials

122 total, page 1 of 3

RECRUITING 5,000 participants

Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders

National Cancer Institute (NCI)

NCT00001238

RECRUITING 1,650 participants

A Multicenter Cancer Biospecimen Collection Study

Cofactor Genomics

NCT04510129

RECRUITING NA 1,000 participants

Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)

University of California, San Francisco

NCT05056077

RECRUITING 800 participants

The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors

VastBiome

NCT05037825

RECRUITING NA 600 participants

An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy

University of Texas Southwestern Medical Center

NCT04623502

RECRUITING 500 participants

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

Mohamed Abdel-Rahman

NCT04792463

RECRUITING Phase 2 480 participants

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

Diwakar Davar

NCT07223424

RECRUITING Phase 3 413 participants

A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)

Xynomic Pharmaceuticals

NCT03592472

RECRUITING Phase 1 316 participants

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

Simcha IL-18

NCT04787042

RECRUITING NA 244 participants

Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy

Wake Forest University Health Sciences

NCT05703269

RECRUITING Phase 2 210 participants

Contrast-Enhanced Ultrasound Imaging for Diagnosing Recurrent Renal Cell Carcinoma (RCC) Post Ablation

john eisenbrey

NCT05641935

RECRUITING Phase 1 174 participants

A Phase I Clinical Study to Evaluate the PK Profile, Efficacy, Safety and Immunogenicity of HLX17 vs. Keytruda® in Multiple Resected Solid Tumors

Shanghai Henlius Biotech

NCT07160335

RECRUITING NA 150 participants

Locally Ablative TherapY in Oligo-ProgressiVe GEnitourinary TumoRs (LAYOVER)

University of California, Davis

NCT06101290

RECRUITING Phase 1 140 participants

Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)

Merck Sharp & Dohme

NCT07049926

RECRUITING Phase 1 130 participants

Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

Janux Therapeutics

NCT05783622

RECRUITING Phase 1 126 participants

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

7 Hills Pharma

NCT06362369

RECRUITING Phase 1 125 participants

A First-in-Human Study of BMS-986506 in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC)

Bristol-Myers Squibb

NCT07195682

RECRUITING Phase 1 110 participants

A Study to Evaluate Safety, Efficacy, and Pharmacokinetics in Participants With Advanced Solid Tumors

Eutilex

NCT04903873

RECRUITING Phase 2 100 participants

Molecular Residual Disease (MRD) Guided Adjuvant ThErapy in Renal Cell Carcinoma (RCC)

University of Alabama at Birmingham

NCT06005818

RECRUITING Phase 1 100 participants

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

Nammi Therapeutics

NCT06582017

RECRUITING 97 participants

PET/MR for Characterization of Renal Masses (RMs)

University of Texas Southwestern Medical Center

NCT06076538

RECRUITING Phase 1 80 participants

A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

HiberCell

NCT06234605

RECRUITING Phase 1 78 participants

IDOV-Immune for Advanced Solid Tumors

ViroMissile

NCT06910657

RECRUITING Phase 1 70 participants

A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

AstraZeneca

NCT06147037

RECRUITING Phase 2 65 participants

Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer

National Cancer Institute (NCI)

NCT04981509

RECRUITING Phase 1 60 participants

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

AstraZeneca

NCT07115043

RECRUITING Phase 1 60 participants

Study of DCC-2812 in Participants With Advanced Genitourinary Cancers

Deciphera Pharmaceuticals

NCT06966024

RECRUITING Phase 1 60 participants

A Study of VET3-TGI in Patients With Solid Tumors

KaliVir Immunotherapeutics

NCT06444815

RECRUITING Phase 2 55 participants

89Zr-DFO-Atezolizumab ImmunoPET/CT in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma

James Brugarolas

NCT04006522

RECRUITING Phase 2 48 participants

Phase 2 Study of Combination Tivozanib and Nivolumab in Advanced Non-Clear Cell Renal Cell Carcinoma

M.D. Anderson Cancer Center

NCT06053658

RECRUITING Phase 2 48 participants

CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition

Mark Stein

NCT04322955

RECRUITING NA 46 participants

A Phase II Study of Cyberknife Radiosurgery for Renal Cell Carcinoma

Beth Israel Deaconess Medical Center

NCT01890590

RECRUITING Phase 1 40 participants

Retifanlimab and Ruxolitinib In Solid Malignancies

University of California, San Diego

NCT07219576

RECRUITING Phase 1 35 participants

[18F]PT2385 PET/CT in Patients With Renal Cell Carcinoma

Orhan Kemal Oz

NCT04989959

RECRUITING Phase 2 32 participants

Pre-NEOSHIFT-RCC: Neoadjuvant HIF-Inhibitor Immunotherapy in RCC

Dana-Farber Cancer Institute

NCT07397611

RECRUITING Phase 2 32 participants

Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

City of Hope Medical Center

NCT05830058

RECRUITING Phase 1 30 participants

Open-Label Phase 1/2 Study of NEO-811 in Subjects With Locally Advanced or Metastatic Non-Resectable Clear Cell Renal Cell Carcinoma

Neomorph

NCT07300241

RECRUITING Phase 2 30 participants

Neoadjuvant Lenvatinib and Pembrolizumab for IVC Tumor Thrombus

University of Texas Southwestern Medical Center

NCT05319015

RECRUITING Early Phase 1 30 participants

Neoadjuvant Pembrolizumab and Lenvatinib for Renal Cell Carcinoma

Abramson Cancer Center at Penn Medicine

NCT05733715

RECRUITING Phase 2 30 participants

Trial Of Stereotactic Body Radiation Therapy (SBRT) for Oligoprogression on Immune Checkpoint Inhibitors (ICI) in Metastatic Renal Cell Carcinoma

Yale University

NCT04974671

RECRUITING Early Phase 1 20 participants

Rapid Sequencing of Approved Therapies in Patients with Metastatic or Unresectable Clear Cell Renal Cell Carcinoma

Icahn School of Medicine at Mount Sinai

NCT05188118

RECRUITING Phase 2 20 participants

Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03786796

RECRUITING Phase 2 20 participants

A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases

M.D. Anderson Cancer Center

NCT05048212

RECRUITING Phase 2 20 participants

Stereotactic Body Proton Therapy for Treatment of Primary Renal Cell Carcinoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06376669

RECRUITING Phase 2 18 participants

Sequential Treatment of Cabozantinib for Advanced Renal Cell Carcinoma (RCC)

University of Texas Southwestern Medical Center

NCT05931393

RECRUITING Phase 2 17 participants

Neoadjuvant Pembrolizumab and Axitinib in Renal Cell Carcinoma With Inferior Vena Cava Tumor Thrombus

University of Colorado, Denver

NCT05969496

RECRUITING 16 participants

Analysis of Primary and Metastatic Tumors in Patients With Renal Cell Carcinoma and Urothelial Carcinoma

Fox Chase Cancer Center

NCT03291028

RECRUITING Early Phase 1 10 participants

Memory-like Natural Killer (NK) Cell Therapy in Patients With Renal Cell Carcinoma or Urothelial Carcinoma

Dana-Farber Cancer Institute

NCT06318871

RECRUITING Phase 2 10 participants

A Study of Cemiplimab and Fianlimab in People With Clear Cell Renal Cell Carcinoma

Memorial Sloan Kettering Cancer Center

NCT06699602

RECRUITING NA 5 participants

Transplantation of Reconstructed Renal Allografts Following Ex-Vivo Partial Nephrectomy

Case Comprehensive Cancer Center

NCT05725421

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Phase Distribution

PhaseTrial count
Phase 1 51
Phase 2 39
Phase 3 10

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Renal Cell Carcinoma Trial Landscape

122 indexed Renal Cell Carcinoma studies · 50 recruiting (41%).

Phase mix: 10 late (III/IV) vs 90 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Renal Cell Carcinoma?

PlainTrial tracks 122 US clinical trials for Renal Cell Carcinoma, of which 50 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Renal Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.