Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 44 recruiting now official registry

Surgery clinical trials

Every US clinical trial registered for Surgery — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

121 US clinical trials · 44 currently recruiting

The research picture

Surgery has 121 registered US clinical trials, 44 of them open to new participants right now — about 36% of the total.

44
recruiting participants now
36%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
6
top sponsor: University of Wisconsin, Madison

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 5,000,000 participants

The Pediatric Anesthesia Quality Improvement Project

The Society for Pediatric Anesthesia

NCT00674388

RECRUITING 1,200,000 participants

The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes

Massachusetts General Hospital

NCT07022951

RECRUITING NA 13,000 participants

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

Washington University School of Medicine

NCT05991453

RECRUITING NA 10,000 participants

Collecting Outcomes and Managing Pain After Surgery

Duke University

NCT03834818

RECRUITING NA 1,900 participants

The ImPreSS Trial: Pharmacogenomic Decision Making at Time of Surgery

University of Chicago

NCT03729180

RECRUITING NA 1,200 participants

RCT: Early Feeding After PEG Placement

Carilion Clinic

NCT04110613

RECRUITING NA 1,100 participants

Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury

University of Colorado, Denver

NCT06349577

RECRUITING 1,000 participants

Terumo Aortic Global Endovascular Registry

Vascutek

NCT04246463

RECRUITING Phase 4 900 participants

Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

University of Michigan

NCT05722002

RECRUITING Phase 4 900 participants

Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial

University of Michigan

NCT06671002

RECRUITING Phase 3 880 participants

Post-Discharge Risk-Based Management in Patients Undergoing High-Risk Elective Major Cancer Operations (PRS II)

Fox Chase Cancer Center

NCT05454280

RECRUITING Phase 3 760 participants

Sentinel Node Biopsy in Endometrial Cancer

Queensland Centre for Gynaecological Cancer

NCT04073706

RECRUITING Phase 4 606 participants

Lovenox 30 mg Twice Daily (BID) Versus 40 mg Once Daily (QD)

Oregon Health and Science University

NCT02342444

RECRUITING 600 participants

Maestro 1.1 Post-Market Registry

Moon Surgical

NCT06103136

RECRUITING 431 participants

Evaluation of Resection Techniques for Pancreatic Tumors

Methodist Health System

NCT05128890

RECRUITING NA 300 participants

Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes

The Cleveland Clinic

NCT06298721

RECRUITING NA 266 participants

A Study of Opportunistic Salpingectomy to Prevent Ovarian Cancer

Memorial Sloan Kettering Cancer Center

NCT06312124

RECRUITING Phase 2 242 participants

Prevent Cardiac Surgery Associated AKI Trial

George Washington University

NCT06620523

RECRUITING NA 170 participants

Music Interventions During Wide-Awake Hand Surgery

University of Wisconsin, Madison

NCT05472909

RECRUITING NA 150 participants

Optimizing Pain Self-Management in Total Knee Arthroplasty

University of Virginia

NCT06038240

RECRUITING Phase 2 140 participants

Factor VIII Inhibitor Bypass Activity (FEIBA) Versus Fresh Frozen Plasma As First Line Therapy For Bleeding After Cardiac Surgery

Northwell Health

NCT07032792

RECRUITING NA 134 participants

Effect of Fasting on Patient Outcomes After Wide-Awake, Local Anesthesia-only, No Tourniquet (WALANT) Procedures

University of California, Irvine

NCT05819801

RECRUITING NA 100 participants

Brain Function Monitoring During Surgery

University of Chicago

NCT06619730

RECRUITING NA 100 participants

Methods for Effective Disposal of Surplus Analgesics to Facilitate Elimination

University of Michigan

NCT05991687

RECRUITING NA 90 participants

Building Resilience for Surgical Recovery

The University of Texas Health Science Center, Houston

NCT06174701

RECRUITING Early Phase 1 80 participants

Ethyl Chloride Spray to Reduce Pain From Local Anesthesia During Mohs Micrographic Surgery

University of California, Davis

NCT06920381

RECRUITING Phase 4 80 participants

Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in Gynecologic Oncology Surgery

University of Wisconsin, Madison

NCT06213454

RECRUITING NA 75 participants

Ultrasound Evaluation for Improving Patient Selection in vNOTES

The University of Texas Health Science Center, Houston

NCT05623514

RECRUITING Phase 4 70 participants

Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population

University of California, San Francis

NCT05157113

RECRUITING Phase 2 64 participants

A Study of Bevonescein in Patients Undergoing Abdominopelvic Surgery

Alume Biosciences

NCT06662097

RECRUITING NA 60 participants

Green Light for Post-Operative Wellness

Rebecca E Kotcher, MD

NCT07218289

RECRUITING Phase 1 60 participants

Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis

Vanderbilt University Medical Center

NCT05774717

RECRUITING NA 50 participants

INCLUDE Program: A Perioperative Wellness Program Tailored for Black Surgical Patients

Washington University School of Medicine

NCT07283783

RECRUITING NA 50 participants

Gastric US in ICU Patient

Dartmouth-Hitchcock Medical Center

NCT05526105

RECRUITING NA 50 participants

AI-driven Clinical Decision Support for Perioperative Blood Orders

Washington University School of Medicine

NCT07223853

RECRUITING NA 50 participants

The Neuralert Stroke Monitor Pilot Trial

Neuralert Technologies

NCT06368193

RECRUITING NA 42 participants

Implementation Pilot of Preoperative CGA Before Major Surgery

University of Wisconsin, Madison

NCT06184724

RECRUITING Phase 3 40 participants

NO During CPB in Neonates to Reduce Risk of AKI

Children's Hospital Medical Center, Cincinnati

NCT04216927

RECRUITING Phase 4 40 participants

Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty

University of California, San Diego

NCT06784882

RECRUITING NA 30 participants

Intervention to Improve Utilization of Extended Venous Thromboembolism Prophylaxis After Cancer Surgery

Medical University of South Carolina

NCT06451003

RECRUITING NA 30 participants

Physical Therapy After Endometriosis Excision

Oregon Health and Science University

NCT07127783

RECRUITING NA 30 participants

Geriatric Thoracic Surgery Ambulation Challenge

Dana-Farber Cancer Institute

NCT04630496

RECRUITING NA 27 participants

A Study of the Use of 3D Technology to Guide Head and Neck Surgery

Memorial Sloan Kettering Cancer Center

NCT06676592

RECRUITING 20 participants

LaserEn: SOLTIVE™ Thulium Laser Fiber En Bloc Resection of Bladder Tumors

University of Kansas Medical Center

NCT04979156

ACTIVE NOT RECRUITING NA 66,273 participants

Operating Room Air Filtration/Sterilization

The Cleveland Clinic

NCT04610294

ACTIVE NOT RECRUITING NA 1,456 participants

Perioperative Risk Study

Fox Chase Cancer Center

NCT02456389

ACTIVE NOT RECRUITING Phase 3 1,386 participants

The HeLiX (Hemorrhage During Liver Resection: traneXamic Acid) Trial

Sunnybrook Health Sciences Centre

NCT02261415

ACTIVE NOT RECRUITING NA 484 participants

Nudges for Opioid Reduction After Major Surgery Trial

University of Washington

NCT04927351

ACTIVE NOT RECRUITING NA 313 participants

Insignia™ Hip Stem Outcomes Study

Stryker Orthopaedics

NCT05144191

ACTIVE NOT RECRUITING Phase 4 300 participants

The PASTDUe Nutrition Ecosystem Project (PASTDUe)

Duke University

NCT05127109

ACTIVE NOT RECRUITING NA 267 participants

Non-pharmacological Treatment for Pain After Spine Surgery

Dan Rhon

NCT04770480

ACTIVE NOT RECRUITING NA 250 participants

COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study

Vanderbilt University Medical Center

NCT04889417

ACTIVE NOT RECRUITING 240 participants

Effects of Weight Loss Surgery on Bone Health in Adolescents

Massachusetts General Hospital

NCT02557438

ACTIVE NOT RECRUITING Phase 3 175 participants

Evaluating Outcomes in Cardiac Surgery Patients Who Receive Sugammadex vs. Placebo

Endeavor Health

NCT05801679

ACTIVE NOT RECRUITING NA 100 participants

Multicenter Phase II Study of Transanal TME (taTME)

Icahn School of Medicine at Mount Sinai

NCT03144765

ACTIVE NOT RECRUITING 84 participants

Metabolomic Profiling of Racial Disparity

Nationwide Children's Hospital

NCT06266429

ACTIVE NOT RECRUITING NA 80 participants

Permissive Hypotension After Cardiac Surgery

Massachusetts General Hospital

NCT06476613

ACTIVE NOT RECRUITING NA 80 participants

Regional Anesthesia EMG Study

Nationwide Children's Hospital

NCT06287151

ACTIVE NOT RECRUITING Phase 4 60 participants

Multimodal Analgesia Effect on Post Surgical Patient

University of California, Davis

NCT04240626

ACTIVE NOT RECRUITING NA 50 participants

TOF Monitoring Using the TetraGraph in Patients Less Than 1 Year of Age

Joseph D. Tobias

NCT06458023

ACTIVE NOT RECRUITING NA 50 participants

TetraGraph in Rocuronium Infusions

Joseph D. Tobias

NCT06472284

ACTIVE NOT RECRUITING 50 participants

Preparing Older Adults for Major Surgery With Preoperative Comprehensive Geriatric Assessments

University of Wisconsin, Madison

NCT06184919

ACTIVE NOT RECRUITING NA 32 participants

Buccal Graft + Collagen Matrix Versus Free Gingival Graft for Keratinized Mucosa Augmentation at Implant Sites

Harvard Medical School (HMS and HSDM)

NCT05844475

ACTIVE NOT RECRUITING NA 25 participants

RESTORE Declined Livers Study

Washington University School of Medicine

NCT04483102

ACTIVE NOT RECRUITING 15 participants

Circadian Rhythm Disruption in the Hospital Intensive Care Environment

University of Pennsylvania

NCT05828680

COMPLETED NA 26,562 participants

Increasing Implementation of Post-Operative Opioid Prescribing Guidelines

University of Pennsylvania

NCT05358522

COMPLETED Phase 4 647 participants

Multicenter Infection Surveillance Study Following Open Heart Surgery

Halyard Health

NCT00673712

COMPLETED 621 participants

Accuracy of Pulse CO-Oximetry Technology in Characterizing Noninvasive SpHb

University of California, Davis

NCT01997502

COMPLETED 601 participants

Outcomes of Intrathecal Analgesia in Colorectal Surgery

Mayo Clinic

NCT03411109

COMPLETED 469 participants

Redesigning Cardiac Surgery to Reduce Neurologic Injury

Dartmouth-Hitchcock Medical Center

NCT00432536

COMPLETED Phase 3 369 participants

Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery

Bausch & Lomb Incorporated

NCT01591161

COMPLETED 350 participants

ICD-ON Registry: Periop Management of Cardiac Devices

Edward Hospital

NCT02052453

COMPLETED NA 350 participants

No Opioids PrescrIptions On Discharge After Surgery

Albany Medical College

NCT04469868

COMPLETED Phase 3 347 participants

Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects

Medline Industries

NCT02222896

COMPLETED NA 321 participants

Study Exploring the Effect of Music on Pain After Ventral Hernia Surgery

The Cleveland Clinic

NCT05374096

COMPLETED 250 participants

Preoperative Survey to Evaluate Patient Allergy

Nationwide Children's Hospital

NCT05670756

COMPLETED 202 participants

Predictors of Recovery Expectancy

Indiana University

NCT04274491

COMPLETED Phase 2 202 participants

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus

University of California, San Francis

NCT01958320

COMPLETED Phase 3 201 participants

Study of Recovery of Strength After Surgery Comparing Two Different Medications for Reversal of Muscle Relaxant

Memorial Sloan Kettering Cancer Center

NCT03116997

COMPLETED NA 190 participants

Opioid Prescribing After Cesarean Delivery

Vanderbilt University Medical Center

NCT03168425

COMPLETED NA 155 participants

Study Investigating Role of Unalike Patient Positioning on PROMIS Scores

University of Louisville

NCT03446950

COMPLETED NA 148 participants

Comparison of Ambu Auragain and I-Gel Supraglottic Airways in Adult Patients at an Ambulatory Surgery Center

University of Minnesota

NCT04286581

COMPLETED 147 participants

Management of Antiplatelet Regimen During Surgical Procedures

Baylor Research Institute

NCT03981835

COMPLETED NA 130 participants

Physical Therapy Following Total Hip Arthroplasty

Orthopedic One

NCT04199390

COMPLETED NA 123 participants

Foot and Ankle Post-operative Oedema Management Using Geko™

Firstkind

NCT04927234

COMPLETED Phase 2 120 participants

Ambulatory Gynecologic Surgery: Finding the Optimal Opioid Prescription

Montefiore Medical Center

NCT03588910

COMPLETED NA 112 participants

Solution Temperature and Fluid Deficit During Hysteroscopy

The University of Texas Health Science Center, Houston

NCT05622097

COMPLETED 110 participants

Prospective Observational Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Patients Undergoing Elective Surgical Procedures

AltheaDx

NCT02605343

COMPLETED Phase 3 106 participants

Thoracic Epidural Analgesia vs Surgical Site Infiltration With Liposomal Bupivacaine Following Open Gynecologic Surgery

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT04117074

COMPLETED NA 100 participants

Gastric Ultrasound

Alok Moharir

NCT04127331

COMPLETED NA 100 participants

Feasibility of Obtaining Pulse Oximetry Readings from the Oropharynx

Joseph D. Tobias

NCT05690633

COMPLETED NA 90 participants

Virtual Phone Visits Compared to In-Person Physical Visits for Post-Operative Follow-Up at a Sports Medicine Clinic

Jonathan Wu

NCT05998148

COMPLETED 88 participants

Single Shot vs Continuous Interscalene Block for Rotator Cuff Repair

University of Chicago

NCT01122745

COMPLETED 82 participants

What is the Impact of the Presence of a Support Person on Informed Consent

Hartford Hospital

NCT03966469

COMPLETED 80 participants

OPTiMASK: Comparison of Pre-oxygenation With Standard Face Mask Combined With High Flow Nasal Oxygen With Pre-oxygenation With Standard Face Mask Alone

Beth Israel Deaconess Medical Center

NCT05495841

COMPLETED 80 participants

Oxygen Reserve Index: Utility as Early Warning for Desaturation in Morbidly Obese Patients

Masimo Corporation

NCT03021551

COMPLETED NA 75 participants

TAP Versus Thoracic Epidural in Major Abdominal Resections

Corewell Health West

NCT02197988

COMPLETED NA 72 participants

Pudendal Nerve Block in Vaginal Surgery

MetroHealth Medical Center

NCT04198714

COMPLETED 72 participants

Comparison of Epidural and TAP Block in Abdominal Surgery

University of Nebraska

NCT01848951

COMPLETED NA 65 participants

NSS-2 BRIDGE Device in Post-Operative Pain Management

Jacques E. Chelly

NCT03555266

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 5
Phase 3 9
Phase 4 12

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Surgery Trial Landscape

ClinicalTrials.gov lists 121 US studies indexed under Surgery, and 44 of those are currently open to recruitment — roughly 36% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Surgery shows 21 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Surgery is led by University of Wisconsin, Madison with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Surgery?

PlainTrial tracks 121 US clinical trials for Surgery, of which 44 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Surgery?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →