Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Surgery clinical trials
Every US clinical trial registered for Surgery — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
121 US clinical trials · 44 currently recruiting
The research picture
Surgery has 121 registered US clinical trials, 44 of them open to new participants right now — about 36% of the total.
- 44
- recruiting participants now
- 36%
- of trials open to enrollment
- 21
- in Phase 3–4 (later-stage)
- 6
- top sponsor: University of Wisconsin, Madison
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
The Pediatric Anesthesia Quality Improvement Project
The Society for Pediatric Anesthesia
NCT00674388
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
Massachusetts General Hospital
NCT07022951
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Washington University School of Medicine
NCT05991453
Collecting Outcomes and Managing Pain After Surgery
Duke University
NCT03834818
The ImPreSS Trial: Pharmacogenomic Decision Making at Time of Surgery
University of Chicago
NCT03729180
RCT: Early Feeding After PEG Placement
Carilion Clinic
NCT04110613
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
University of Colorado, Denver
NCT06349577
Terumo Aortic Global Endovascular Registry
Vascutek
NCT04246463
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
University of Michigan
NCT05722002
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
University of Michigan
NCT06671002
Post-Discharge Risk-Based Management in Patients Undergoing High-Risk Elective Major Cancer Operations (PRS II)
Fox Chase Cancer Center
NCT05454280
Sentinel Node Biopsy in Endometrial Cancer
Queensland Centre for Gynaecological Cancer
NCT04073706
Lovenox 30 mg Twice Daily (BID) Versus 40 mg Once Daily (QD)
Oregon Health and Science University
NCT02342444
Maestro 1.1 Post-Market Registry
Moon Surgical
NCT06103136
Evaluation of Resection Techniques for Pancreatic Tumors
Methodist Health System
NCT05128890
Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes
The Cleveland Clinic
NCT06298721
A Study of Opportunistic Salpingectomy to Prevent Ovarian Cancer
Memorial Sloan Kettering Cancer Center
NCT06312124
Prevent Cardiac Surgery Associated AKI Trial
George Washington University
NCT06620523
Music Interventions During Wide-Awake Hand Surgery
University of Wisconsin, Madison
NCT05472909
Optimizing Pain Self-Management in Total Knee Arthroplasty
University of Virginia
NCT06038240
Factor VIII Inhibitor Bypass Activity (FEIBA) Versus Fresh Frozen Plasma As First Line Therapy For Bleeding After Cardiac Surgery
Northwell Health
NCT07032792
Effect of Fasting on Patient Outcomes After Wide-Awake, Local Anesthesia-only, No Tourniquet (WALANT) Procedures
University of California, Irvine
NCT05819801
Brain Function Monitoring During Surgery
University of Chicago
NCT06619730
Methods for Effective Disposal of Surplus Analgesics to Facilitate Elimination
University of Michigan
NCT05991687
Building Resilience for Surgical Recovery
The University of Texas Health Science Center, Houston
NCT06174701
Ethyl Chloride Spray to Reduce Pain From Local Anesthesia During Mohs Micrographic Surgery
University of California, Davis
NCT06920381
Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in Gynecologic Oncology Surgery
University of Wisconsin, Madison
NCT06213454
Ultrasound Evaluation for Improving Patient Selection in vNOTES
The University of Texas Health Science Center, Houston
NCT05623514
Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population
University of California, San Francis
NCT05157113
A Study of Bevonescein in Patients Undergoing Abdominopelvic Surgery
Alume Biosciences
NCT06662097
Green Light for Post-Operative Wellness
Rebecca E Kotcher, MD
NCT07218289
Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis
Vanderbilt University Medical Center
NCT05774717
INCLUDE Program: A Perioperative Wellness Program Tailored for Black Surgical Patients
Washington University School of Medicine
NCT07283783
Gastric US in ICU Patient
Dartmouth-Hitchcock Medical Center
NCT05526105
AI-driven Clinical Decision Support for Perioperative Blood Orders
Washington University School of Medicine
NCT07223853
The Neuralert Stroke Monitor Pilot Trial
Neuralert Technologies
NCT06368193
Implementation Pilot of Preoperative CGA Before Major Surgery
University of Wisconsin, Madison
NCT06184724
NO During CPB in Neonates to Reduce Risk of AKI
Children's Hospital Medical Center, Cincinnati
NCT04216927
Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty
University of California, San Diego
NCT06784882
Intervention to Improve Utilization of Extended Venous Thromboembolism Prophylaxis After Cancer Surgery
Medical University of South Carolina
NCT06451003
Physical Therapy After Endometriosis Excision
Oregon Health and Science University
NCT07127783
Geriatric Thoracic Surgery Ambulation Challenge
Dana-Farber Cancer Institute
NCT04630496
A Study of the Use of 3D Technology to Guide Head and Neck Surgery
Memorial Sloan Kettering Cancer Center
NCT06676592
LaserEn: SOLTIVE™ Thulium Laser Fiber En Bloc Resection of Bladder Tumors
University of Kansas Medical Center
NCT04979156
Operating Room Air Filtration/Sterilization
The Cleveland Clinic
NCT04610294
Perioperative Risk Study
Fox Chase Cancer Center
NCT02456389
The HeLiX (Hemorrhage During Liver Resection: traneXamic Acid) Trial
Sunnybrook Health Sciences Centre
NCT02261415
Nudges for Opioid Reduction After Major Surgery Trial
University of Washington
NCT04927351
Insignia™ Hip Stem Outcomes Study
Stryker Orthopaedics
NCT05144191
The PASTDUe Nutrition Ecosystem Project (PASTDUe)
Duke University
NCT05127109
Non-pharmacological Treatment for Pain After Spine Surgery
Dan Rhon
NCT04770480
COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study
Vanderbilt University Medical Center
NCT04889417
Effects of Weight Loss Surgery on Bone Health in Adolescents
Massachusetts General Hospital
NCT02557438
Evaluating Outcomes in Cardiac Surgery Patients Who Receive Sugammadex vs. Placebo
Endeavor Health
NCT05801679
Multicenter Phase II Study of Transanal TME (taTME)
Icahn School of Medicine at Mount Sinai
NCT03144765
Metabolomic Profiling of Racial Disparity
Nationwide Children's Hospital
NCT06266429
Permissive Hypotension After Cardiac Surgery
Massachusetts General Hospital
NCT06476613
Regional Anesthesia EMG Study
Nationwide Children's Hospital
NCT06287151
Multimodal Analgesia Effect on Post Surgical Patient
University of California, Davis
NCT04240626
TOF Monitoring Using the TetraGraph in Patients Less Than 1 Year of Age
Joseph D. Tobias
NCT06458023
TetraGraph in Rocuronium Infusions
Joseph D. Tobias
NCT06472284
Preparing Older Adults for Major Surgery With Preoperative Comprehensive Geriatric Assessments
University of Wisconsin, Madison
NCT06184919
Buccal Graft + Collagen Matrix Versus Free Gingival Graft for Keratinized Mucosa Augmentation at Implant Sites
Harvard Medical School (HMS and HSDM)
NCT05844475
RESTORE Declined Livers Study
Washington University School of Medicine
NCT04483102
Circadian Rhythm Disruption in the Hospital Intensive Care Environment
University of Pennsylvania
NCT05828680
Increasing Implementation of Post-Operative Opioid Prescribing Guidelines
University of Pennsylvania
NCT05358522
Multicenter Infection Surveillance Study Following Open Heart Surgery
Halyard Health
NCT00673712
Accuracy of Pulse CO-Oximetry Technology in Characterizing Noninvasive SpHb
University of California, Davis
NCT01997502
Outcomes of Intrathecal Analgesia in Colorectal Surgery
Mayo Clinic
NCT03411109
Redesigning Cardiac Surgery to Reduce Neurologic Injury
Dartmouth-Hitchcock Medical Center
NCT00432536
Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery
Bausch & Lomb Incorporated
NCT01591161
ICD-ON Registry: Periop Management of Cardiac Devices
Edward Hospital
NCT02052453
No Opioids PrescrIptions On Discharge After Surgery
Albany Medical College
NCT04469868
Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects
Medline Industries
NCT02222896
Study Exploring the Effect of Music on Pain After Ventral Hernia Surgery
The Cleveland Clinic
NCT05374096
Preoperative Survey to Evaluate Patient Allergy
Nationwide Children's Hospital
NCT05670756
Predictors of Recovery Expectancy
Indiana University
NCT04274491
Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus
University of California, San Francis
NCT01958320
Study of Recovery of Strength After Surgery Comparing Two Different Medications for Reversal of Muscle Relaxant
Memorial Sloan Kettering Cancer Center
NCT03116997
Opioid Prescribing After Cesarean Delivery
Vanderbilt University Medical Center
NCT03168425
Study Investigating Role of Unalike Patient Positioning on PROMIS Scores
University of Louisville
NCT03446950
Comparison of Ambu Auragain and I-Gel Supraglottic Airways in Adult Patients at an Ambulatory Surgery Center
University of Minnesota
NCT04286581
Management of Antiplatelet Regimen During Surgical Procedures
Baylor Research Institute
NCT03981835
Physical Therapy Following Total Hip Arthroplasty
Orthopedic One
NCT04199390
Foot and Ankle Post-operative Oedema Management Using Geko™
Firstkind
NCT04927234
Ambulatory Gynecologic Surgery: Finding the Optimal Opioid Prescription
Montefiore Medical Center
NCT03588910
Solution Temperature and Fluid Deficit During Hysteroscopy
The University of Texas Health Science Center, Houston
NCT05622097
Prospective Observational Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Patients Undergoing Elective Surgical Procedures
AltheaDx
NCT02605343
Thoracic Epidural Analgesia vs Surgical Site Infiltration With Liposomal Bupivacaine Following Open Gynecologic Surgery
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT04117074
Gastric Ultrasound
Alok Moharir
NCT04127331
Feasibility of Obtaining Pulse Oximetry Readings from the Oropharynx
Joseph D. Tobias
NCT05690633
Virtual Phone Visits Compared to In-Person Physical Visits for Post-Operative Follow-Up at a Sports Medicine Clinic
Jonathan Wu
NCT05998148
Single Shot vs Continuous Interscalene Block for Rotator Cuff Repair
University of Chicago
NCT01122745
What is the Impact of the Presence of a Support Person on Informed Consent
Hartford Hospital
NCT03966469
OPTiMASK: Comparison of Pre-oxygenation With Standard Face Mask Combined With High Flow Nasal Oxygen With Pre-oxygenation With Standard Face Mask Alone
Beth Israel Deaconess Medical Center
NCT05495841
Oxygen Reserve Index: Utility as Early Warning for Desaturation in Morbidly Obese Patients
Masimo Corporation
NCT03021551
TAP Versus Thoracic Epidural in Major Abdominal Resections
Corewell Health West
NCT02197988
Pudendal Nerve Block in Vaginal Surgery
MetroHealth Medical Center
NCT04198714
Comparison of Epidural and TAP Block in Abdominal Surgery
University of Nebraska
NCT01848951
NSS-2 BRIDGE Device in Post-Operative Pain Management
Jacques E. Chelly
NCT03555266
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 5 |
| Phase 3 | 9 |
| Phase 4 | 12 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Surgery Trial Landscape
ClinicalTrials.gov lists 121 US studies indexed under Surgery, and 44 of those are currently open to recruitment — roughly 36% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Surgery shows 21 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Surgery is led by University of Wisconsin, Madison with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Surgery?
PlainTrial tracks 121 US clinical trials for Surgery, of which 44 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Surgery?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.