Pacira Pharmaceuticals

Open enrollment across a mixed-phase pipeline

According to ClinicalTrials.gov-derived indexes, Pacira Pharmaceuticals sits in the top decile of US sponsors by registered trial count (#265 of 15,742 sponsors by registered trial count).

88 total trials 5 currently recruiting 65 completed top decile by trial count

Pacira Pharmaceuticals: 88 sponsored US clinical trials, 5 recruiting.

Pacira Pharmaceuticals sponsors 88 registered US clinical trials on ClinicalTrials.gov, 5 of them currently recruiting, and 65 completed. 38 of these trials are in Phase 3-4 (later-stage) and 35 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Osteoarthritis of the Knee, with 4 trials.

Top-decile sponsor footprint

Pacira Pharmaceuticals ranks in the top decile of sponsors by registered trial count (#265 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

F 38/100

65 of 82 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (79.3%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

88 total, page 1 of 2

RECRUITING Phase 2

A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee

NCT06884865

RECRUITING NA

Study to Assess the Efficacy and Safety of Iovera®° System in Subjects With Upper Extremity Spasticity

NCT06340451

RECRUITING Phase 1

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery

NCT06271265

RECRUITING Phase 3

ZILRETTA in Subjects With Shoulder Osteoarthritis

NCT06269705

RECRUITING

Innovations in Genicular Outcomes Registry

NCT05495334

ACTIVE NOT RECRUITING Phase 1

Study to Evaluate the Safety and Tolerability of FX201 in Patients with Osteoarthritis of the Knee

NCT04119687

TERMINATED Phase 2

A Study to Evaluate an Intra-Articular Injection of ZILRETTA Versus Triamcinolone Acetonide, Immediate Release in Subjects With Osteoarthritis of the Hip

NCT06977568

COMPLETED Phase 1

Phase 1, Dose Escalation Study to Evaluate of Safety, Pharmacokinetics and Pharmacodynamics of Liposomal Bupivacaine 13.3 Administered Via a Single Intrathecal Injection to Healthy Volunteers

NCT05456490

COMPLETED Phase 3

Phase 3, Sciatic Nerve Block With EXPAREL for Subjects Undergoing Bunionectomy

NCT05157841

COMPLETED Phase 3

Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty

NCT05139030

COMPLETED Phase 1

Study to Evaluate the Safety and Tolerability of FX301 in Patients Undergoing Bunionectomy

NCT04826328

COMPLETED Phase 3

Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries

NCT04518462

TERMINATED NA

Study to Evaluate Iovera®° in Adult Patients Undergoing Total Knee Arthroplasty

NCT04191031

TERMINATED Phase 1

Evaluation of Safety, Pharmacokinetics and Pharmacodynamics of EXPAREL® Administered Via a Single Intrathecal Injection to Healthy Volunteers

NCT04173611

COMPLETED Phase 1

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL Administered as a Pectoral Plane Block in Women Undergoing Breast Augmentation

NCT04293809

TERMINATED Phase 2

Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis

NCT04160091

TERMINATED Phase 4

Phase 4 Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries

NCT03927911

COMPLETED Phase 2

Study to Evaluate a Procedure for Intra-articular Injection of FX006 in Patients With Osteoarthritis of the Hip

NCT04065074

COMPLETED Phase 1

Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety, of EXPAREL Administered as Sciatic Nerve Block (In Popliteal Fossa), for Postsurgical Analgesia in Subjects Undergoing Bunionectomy

NCT04002089

COMPLETED Phase 3

Multicenter Study for Pediatric Subjects Evaluating Pharmacokinetics and Safety of EXPAREL

NCT03682302

COMPLETED Phase 4

Efficacy and Safety of EXPAREL Versus Standard of Care (SoC) in Subjects Undergoing Elective Cesarean Section

NCT03853694

TERMINATED Phase 3

Study to Evaluate the Efficacy and Safety of FX006 in Patients With Hip Osteoarthritis

NCT03793010

TERMINATED Phase 1

Study in Adult Subjects Undergoing Posterolateral Thoracotomy

NCT03428984

COMPLETED Phase 3

Study to Evaluate the Effect of FX006 on Synovial Inflammation in Patients With OA of the Knee

NCT03529942

COMPLETED Phase 1

Study in Pediatric Subjects Evaluating Pharmacokinetics and Safety of EXPAREL

NCT03485014

COMPLETED Phase 2

Study to Compare Exposure of TA Following Administration of FX006 or TAcs in Patients With OA of the Shoulder or Hip

NCT03382262

COMPLETED Phase 2

Study to Compare Exposure of TA Following Administration of Either FX006 or TAcs in Patients With Bilateral Knee OA

NCT03378076

COMPLETED NA

Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain

NCT03327220

COMPLETED Phase 4

Evaluate the Safety and Efficacy of EXPAREL When Administered Via Infiltration Into the TAP vs. Bupivacaine Alone in Subjects Undergoing Elective C-Sections

NCT03176459

TERMINATED Phase 4

Phase 4, Controlled Study in Adult Subjects Undergoing Primary, 1-2 Level, Open Lumbar Spinal Fusion Surgery

NCT03015961

COMPLETED Phase 3

Study to Assess the Safety of Repeat Administration of FX006 Administered to Patients With Osteoarthritis of the Knee

NCT03046446

COMPLETED Phase 1

PK Study of EXPAREL in Subjects Undergoing Open Spinal Fusion or Reconstructive Surgery

NCT02985762

TERMINATED Phase 2

Study of Local Administration of DepoTXA for Reduced Postsurgical Bleeding in Subjects Undergoing TKA

NCT02922582

COMPLETED Phase 3

Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block With EXPAREL in Total Knee Arthroplasty

NCT02713178

COMPLETED Phase 3

Efficacy, Safety, and Pharmacokinetics of Brachial Plexus Block With EXPAREL in Shoulder Surgery

NCT02713230

COMPLETED Phase 4

Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty

NCT02713490

COMPLETED Phase 2

Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes

NCT02762370

COMPLETED Phase 2

Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the Knee

NCT02637323

COMPLETED Phase 3

Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction

NCT02517905

TERMINATED Phase 4

Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section

NCT02353754

TERMINATED Phase 2

Proof of Concept Study Comparing FX006 to Kenalog®-40 in Patients With Post-Traumatic Osteoarthritis of the Knee

NCT02468583

COMPLETED Phase 3

Study of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee

NCT02357459

COMPLETED Phase 4

Pharmacokinetics and Safety of Bupivacaine HCl Spinal Block and EXPAREL Local Infiltration in Total Knee Arthroplasty

NCT02284386

COMPLETED NA

A Randomized, Study to Evaluate the Iovera° Device in Treating Pain Associated With Total Knee Arthroplasty

NCT02284113

COMPLETED NA

Study to Evaluate the Iovera° Device for Temporary Relief From Knee Pain

NCT02260921

COMPLETED Phase 4

EXPAREL Infiltration in Subjects Undergoing Femoral Nerve Block With Bupivacaine HCl for Total Knee Arthroplasty

NCT02255500

COMPLETED Phase 4

Pharmacokinetic Evaluation of EXPAREL in Adults Undergoing Tonsillectomy

NCT02199574

COMPLETED Phase 1

Safety and Pharmacokinetics Study of Redosing EXPAREL in Healthy Volunteers

NCT02210247

COMPLETED Phase 2

Study of FX006 vs Normal Saline in Patients With Osteoarthritis of the Knee

NCT02116972

COMPLETED Phase 2

Study to Characterize the Local Duration of Exposure From FX006 in Patients With Osteoarthritis of the Knee

NCT02003365

Page 1 of 2 Next →

Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 22
Phase 3 17
Phase 4 21

What is open in the Pacira Pharmaceuticals pipeline

5 recruiting of 88 indexed (6% open); 65 completed (74%).

Phase mix: 38 late (III/IV) vs 35 early (I/II) (balanced across stages).

Top condition: Osteoarthritis of the Knee (4 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Pacira Pharmaceuticals: open-pipeline peers nationwide

Peers matched on 88 registered trials and 6% open enrollment, not the therapeutic-area sidebar.

Pacira Pharmaceuticals sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 0%5%10%15%20%25% Total trials Recruiting share Pacira PharmaceuticalsAbbVie (prior sponsor, Abbott)University of Medicine and Dentistry of New JerseyAbbott NutritionFlorida International UniversityPfizerBoston CollegeCytoDynDendreon
Pacira Pharmaceuticals sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Pacira Pharmaceuticals sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 88 trials (± recruiting share)

Sponsors near 6% open enrollment (± trial volume)

What to do with this Pacira Pharmaceuticals page

88 registered trials is a research-attention snapshot, not an endorsement of Pacira Pharmaceuticals or any single study.

  • 5 of Pacira Pharmaceuticals's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Osteoarthritis of the Knee is the condition Pacira Pharmaceuticals studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Osteoarthritis of the Knee trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Pacira Pharmaceuticals pipeline card: 88 registered trials from official public datasets.Report a data error.