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NCT06903819 · ClinicalTrials.gov registry record · Phase 4
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
A Phase 4 study of Depression and Postoperative Pain, sponsored by Texas Tech University Health Sciences Center.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 90
- Enrollment target
- 2
- Study locations
NCT06903819: Recruiting Phase 4 study of Depression and Postoperative Pain, sponsored by Texas Tech University Health Sciences Center.
NCT06903819 is a Phase 4 study of Depression and Postoperative Pain that is actively recruiting participants, run by Texas Tech University Health Sciences Center. The registered enrollment target is 90 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (89% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06903819, a Phase 4 study of Depression and Postoperative Pain, is actively recruiting participants, sponsored by Texas Tech University Health Sciences Center.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 90 participants
- Enrollment target
- 2
- Study locations
Study Summary
The goal of this clinical trial is to learn if ketamine, given during surgery, can help improve recovery for adults with serious orthopedic trauma. The study will test whether ketamine reduces pain, lowers the need for opioids, and improves mental health outcomes like depression and post-traumatic stress disorder (PTSD). The main questions it aims to answer are: Does ketamine reduce pain after surgery compared to standard anesthesia? Does ketamine reduce the amount of opioids patients need for pain control? Does ketamine improve symptoms of depression and PTSD after orthopedic trauma? Researchers will compare patients who receive ketamine during surgery with those who receive standard anesthesia without ketamine to see if ketamine helps improve both physical and psychological recovery. Participants will: Be randomly assigned to receive either a single dose of ketamine or standard anesthesia during surgery. Report their pain using a simple pain scale (Visual Analog Scale, VAS). Complete short surveys about mood and mental health (PHQ-9 for depression and PCL-5 for PTSD) at several time points after surgery. Allow the research team to review their electronic medical records to measure opioid prescriptions during recovery. Attend follow-up visits in clinic or by secure telehealth (e.g., Zoom) at 1-7 days, 2-3 weeks, 6 weeks, 3 months, and 6 months after surgery
Primary Outcome
Pain intensity will be assessed using the Visual Analog Scale (VAS), a validated 0-100 continuous scale (or 0-10 categorical equivalent). Higher scores indicate greater pain. This outcome evaluates whether intraoperative ketamine reduces postoperative pain compared to standard anesthesia.
Conditions Studied
Interventions
- DRUG Ketamine
- DRUG standard general anesthesia
Study Locations (2)
Texas
- Texas Tech University Health Sciences Center Lubbock - Lubbock
- University Medical Center - Lubbock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2025-11-06 |
| Est. Completion | 2028-05 |
| Phase | Phase 4 |
What NCT06903819 shows while recruiting
NCT06903819 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 90 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (89% lower).
The record links to 5 conditions, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Ketamine is the first listed.
NCT06903819 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06903819 about?
NCT06903819 is a clinical study titled "Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients". The goal of this clinical trial is to learn if ketamine, given during surgery, can help improve recovery for adults with serious orthopedic trauma. The study will test whether ketamine reduces pain, lowers the need for opioids, and improves mental health outcomes like depression and post-traumatic s...
What is the current status of trial NCT06903819?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 90 participants. The study started on 2025-11-06. Estimated completion is 2028-05.
What conditions does trial NCT06903819 study?
This clinical trial studies the following conditions: Depression, Postoperative Pain, Opioid Use, Posttraumatic Stress Disorder (PTSD), Orthopedic Trauma Surgery Patients.
What interventions are being tested in trial NCT06903819?
The interventions under investigation include: Ketamine (DRUG), standard general anesthesia (DRUG).
Who is sponsoring clinical trial NCT06903819?
This trial is sponsored by Texas Tech University Health Sciences Center, which has 76 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06903819 being conducted?
This trial has 2 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06903819's enrollment target sits among peer trials
90 357th of 679 higher than 320 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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