Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 15 recruiting now official registry

Postoperative Pain clinical trials

15 of 64 indexed Postoperative Pain trials are currently recruiting.

64 US clinical trials · 15 currently recruiting

Postoperative Pain is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 28 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Heron Therapeutics, running 3 of these trials.

The research picture

Postoperative Pain has 64 registered US clinical trials, 15 of them open to new participants right now, about 23% of the total.

15
recruiting participants now
23%
of trials open to enrollment
28
in Phase 3–4 (later-stage)
3
top sponsor: Heron Therapeutics
Phase 14Phase 211Phase 311Phase 417

Active & Recent Trials

64 total, page 1 of 2

RECRUITING Phase 3 300 participants

A Study of TLC590 for Postsurgical Pain Following Bunionectomy

TLC Biopharmaceuticals

NCT07222748

RECRUITING Phase 3 278 participants

A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain

University of California, San Francisco

NCT05010148

RECRUITING 210 participants

Sex Hormones, Postoperative Pain and Opioid Use

Washington University School of Medicine

NCT06023225

RECRUITING Phase 2 152 participants

Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy

Brigham and Women's Hospital

NCT06483659

RECRUITING Phase 3 134 participants

RADA16 for Adult Tonsillectomy

Rutgers, The State University of New Jersey

NCT07060495

RECRUITING 100 participants

Characterization of Acute Pain

Children's National Research Institute

NCT07336264

RECRUITING Phase 4 90 participants

Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

Texas Tech University Health Sciences Center

NCT06903819

RECRUITING NA 80 participants

Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery

Massachusetts General Hospital

NCT04912531

RECRUITING Phase 4 80 participants

QL Block in Laparoscopic Myomectomy

Joseph Findley MD

NCT05979493

RECRUITING Phase 2 80 participants

Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty

Matthew Grosso, MD

NCT06479161

RECRUITING NA 75 participants

Rectus Sheath Block in Cardiac Surgery

Icahn School of Medicine at Mount Sinai

NCT05833048

RECRUITING Phase 4 56 participants

Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse

University of North Carolina, Chapel Hill

NCT07213635

RECRUITING Phase 1 48 participants

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery

Pacira Pharmaceuticals

NCT06271265

RECRUITING Phase 2 30 participants

Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI

Sam Tyagi

NCT04600089

RECRUITING NA 12 participants

Opioid Prescribing Practices in Laparoscopic Gynecologic Surgery

University of Tennessee

NCT06532708

ACTIVE NOT RECRUITING 1,200 participants

Personalizing Perioperative Analgesia in Children

Senthil Sadhasivam

NCT01140724

ACTIVE NOT RECRUITING Phase 4 904 participants

No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair

Clayton Petro

NCT05929937

ACTIVE NOT RECRUITING Phase 3 420 participants

Perioperative Lidocaine and Ketamine in Abdominal Surgery

The Cleveland Clinic

NCT04084548

ACTIVE NOT RECRUITING NA 401 participants

The Perioperative Pain Self-Management Program Trial

VA Office of Research and Development

NCT04979429

ACTIVE NOT RECRUITING NA 106 participants

Postoperative VR for Recovery After Bariatric Surgery

Beth Israel Deaconess Medical Center

NCT04754165

ACTIVE NOT RECRUITING Phase 1 100 participants

Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks

University of Arizona

NCT07099222

COMPLETED 2,000 participants

Development of a Predictive Model for Post-Discharge Nausea and Vomiting (PDNV)

University of California, San Francisco

NCT00514878

COMPLETED NA 1,821 participants

Multicenter Continuous Peripheral Nerve Block Surveillance Study

Halyard Health

NCT00653133

COMPLETED Phase 2 463 participants

Pilot Herniorrhaphy Study for Postoperative Analgesia

Heron Therapeutics

NCT02504580

COMPLETED Phase 3 375 participants

Comparison of the Safety of Q8003 Versus Morphine Equivalent Doses of Its Components (Oxycodone and Morphine) in Bunionectomy Patients

QRxPharma

NCT01280331

COMPLETED NA 350 participants

No Opioids PrescrIptions On Discharge After Surgery

Albany Medical College

NCT04469868

COMPLETED Phase 3 331 participants

Efficacy and Safety of Intravenous Acetaminophen Over 48 Hrs for the Treatment of Post-op Pain After Gynecologic Surgery

Mallinckrodt

NCT00399568

COMPLETED Phase 3 331 participants

Bupivacaine Effectiveness and Safety in SABER® Trial

Durect

NCT01052012

COMPLETED Phase 3 321 participants

Safety and Efficacy of Multiple Doses of Intranasal Ketorolac in Postoperative Pain Following Major Abdominal Surgery

Egalet

NCT00266786

COMPLETED Phase 4 304 participants

Comparing Opioid Prescription Patterns in Total Joint Arthroplasty Patients

Rush University Medical Center

NCT03236155

COMPLETED Phase 2 285 participants

Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia

Heron Therapeutics

NCT03015532

COMPLETED Phase 3 245 participants

A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty

Pacira Pharmaceuticals

NCT00745290

COMPLETED Phase 3 240 participants

Patient-Controlled Epidural Analgesia (PCEA) for Patients Who Have Had Major Open Gynecologic Surgery

Memorial Sloan Kettering Cancer Center

NCT00136682

COMPLETED 223 participants

A Prospective Assessment of Opioid Utilization Post-operatively in Sports Orthopaedic Surgeries

St. Louis University

NCT03422211

COMPLETED Phase 2 138 participants

Dose-Ranging Study for Prolonged Postoperative Analgesia in Subject Undergoing Total Knee Arthroplasty

Pacira Pharmaceuticals

NCT00485693

COMPLETED NA 132 participants

Effect of Paracervical Block on Post Operative Pain in Laparoscopic Gynecologic Surgery

Icahn School of Medicine at Mount Sinai

NCT01534416

COMPLETED NA 130 participants

A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery

59th Medical Wing

NCT01097577

COMPLETED 129 participants

PG and PK of Oxycodone to Personalize Post-op Pain Management Following Surgery in Children

Senthil Sadhasivam

NCT03495388

COMPLETED Phase 4 125 participants

Chronic Pain After Amputation

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00006427

COMPLETED Phase 4 123 participants

Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients

Washington University School of Medicine

NCT02926573

COMPLETED Phase 2 120 participants

Local Anesthetics on Postsurgical Analgesia Following Posterior Colporrhaphy

Walter Reed National Military Medical Center

NCT04032327

COMPLETED Phase 2 114 participants

Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain

Mylan

NCT04571515

COMPLETED NA 106 participants

QL vs PENG for Analgesia After Hip Arthroplasty

Medical University of South Carolina

NCT05710107

COMPLETED Phase 4 100 participants

Intravenous Acetaminophen in Craniotomy

The University of Texas Health Science Center, Houston

NCT01598701

COMPLETED NA 94 participants

Study of a Multimodality Pain Management Protocol on Postoperative Neurosurgical Pain

University of Florida

NCT01693588

COMPLETED Phase 3 93 participants

Lidocaine Patches After Cesarean Section

Yale University

NCT04443569

COMPLETED Phase 2 78 participants

Phase 2 Bunionectomy HTX-011 Administration Study

Heron Therapeutics

NCT03718039

COMPLETED NA 75 participants

Transversus Abdominis Plane (TAP) Block Laparoscopic Hysterectomy

Northwestern University

NCT01074229

COMPLETED Phase 4 72 participants

Intrathecal Morphine for Cesarean Delivery

Beth Israel Deaconess Medical Center

NCT05069012

COMPLETED Phase 4 72 participants

Extended Release Local Anesthetic for Postsurgical Pain After Posterior Colporrhaphy and Perineorrhaphy

Wake Forest University Health Sciences

NCT03875664

Page 1 of 2 Next →

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 11
Phase 3 11
Phase 4 17

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Postoperative Pain Trial Landscape

64 indexed Postoperative Pain studies · 15 recruiting (23%).

Phase mix: 28 late (III/IV) vs 15 early (I/II).

Top sponsor: Heron Therapeutics (3 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Postoperative Pain?

PlainTrial tracks 64 US clinical trials for Postoperative Pain, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Postoperative Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.