Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 100 recruiting now official registry

Mild Cognitive Impairment clinical trials

100 of 206 indexed Mild Cognitive Impairment trials are currently recruiting.

206 US clinical trials · 100 currently recruiting

Mild Cognitive Impairment is the subject of 206 registered US clinical trials on ClinicalTrials.gov, 100 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 52 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 9 of these trials.

The research picture

Mild Cognitive Impairment has 206 registered US clinical trials, 100 of them open to new participants right now, about 49% of the total.

100
recruiting participants now
49%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
9
top sponsor: Massachusetts General Hospital
Phase 124Phase 228Phase 33Phase 45

Active & Recent Trials

206 total, page 2 of 5

RECRUITING Phase 2 114 participants

Breathing, Relaxation, Attention Training, & Health in Older Adults (BREATHE)

University of Rochester

NCT04522791

RECRUITING 105 participants

Tau PET in Imaging and Cognition: Healthy Adults From 55-90

Yaakov Stern

NCT03372317

RECRUITING NA 100 participants

bpMedManage: Digital Technology to Support Adherence to Hypertension Medications

University of Arizona

NCT06307574

RECRUITING NA 90 participants

Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment

University of Maryland, Baltimore

NCT05948930

RECRUITING Phase 1 90 participants

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

National Institute of Mental Health (NIMH)

NCT07169630

RECRUITING Phase 2 85 participants

Treating Hyperexcitability in AD With Levetiracetam

Beth Israel Deaconess Medical Center

NCT03875638

RECRUITING NA 80 participants

Multimodal Investigation of Neural Plasticity

University of Michigan

NCT06453980

RECRUITING NA 80 participants

Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities

University of Nebraska

NCT03574207

RECRUITING Phase 2 80 participants

tDCS for Post-Stroke Cognitive Impairment

University of Oklahoma

NCT06516588

RECRUITING Phase 2 75 participants

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

University of Texas Southwestern Medical Center

NCT05446584

RECRUITING 70 participants

MCI Speech in Noise

Dartmouth-Hitchcock Medical Center

NCT06102486

RECRUITING NA 70 participants

Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

Massachusetts General Hospital

NCT05904132

RECRUITING NA 65 participants

Promoting Independence With Compensatory Cognitive Rehabilitation

University of Delaware

NCT04820335

RECRUITING NA 60 participants

Online Interplay Between Deciding and Acting With Mild Cognitive Impairment

University of Delaware

NCT06493422

RECRUITING NA 60 participants

Improving Physical Activity With Cognitive Impairment

Creighton University

NCT05370118

RECRUITING NA 60 participants

Home Sleep Therapy for Older Adults With MCI

Brain Electrophysiology Laboratory Company

NCT05771844

RECRUITING NA 60 participants

Transcranial Magnetic Stimulation for MCI

Medical University of South Carolina

NCT05992831

RECRUITING Phase 2 60 participants

The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults

UConn Health

NCT06027554

RECRUITING Phase 1 60 participants

TREAD: Time Restricted Eating Intervention for Alzheimer's Disease

University of California, San Diego

NCT06548191

RECRUITING NA 60 participants

Music Therapy for Patients With Alzheimer's Disease

Johns Hopkins University

NCT05151562

RECRUITING Phase 1 56 participants

rTMS to Improve Cognition in Parkinson's

VA Office of Research and Development

NCT03836950

RECRUITING Phase 2 55 participants

Senicapoc in Alzheimer's Disease

University of California, Davis

NCT04804241

RECRUITING Phase 2 52 participants

Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)

Johns Hopkins University

NCT04601038

RECRUITING Early Phase 1 50 participants

Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia

Mclean Hospital

NCT04430517

RECRUITING Phase 1 50 participants

CogT pSOPT Intervention Study

Stanford University

NCT06005038

RECRUITING NA 50 participants

OTC Hearing Aid and MCI

Northwestern University

NCT06112860

RECRUITING NA 50 participants

A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI

Central Arkansas Veterans Healthcare System

NCT06024473

RECRUITING Phase 1 48 participants

Safety and Target Engagement of Centella Asiatica in Cognitive Impairment

Oregon Health and Science University

NCT05591027

RECRUITING NA 40 participants

A Feasiblity Study of Green Activity Program for People Living With Memory Challenges

Indiana University

NCT06403345

RECRUITING Phase 2 40 participants

Rapamycin - Effects on Alzheimer's and Cognitive Health

The University of Texas Health Science Center at San Antonio

NCT04629495

RECRUITING 40 participants

Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside

Mclean Hospital

NCT05245903

RECRUITING Phase 1 35 participants

Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD

Butler Hospital

NCT04500847

RECRUITING NA 30 participants

Impact of Intensive Computerized Cognitive Training

Brigham and Women's Hospital

NCT06130735

RECRUITING NA 30 participants

Olfactory Training in Mild Cognitive Impairment

Jeffrey Motter

NCT06825403

RECRUITING Early Phase 1 30 participants

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

Massachusetts General Hospital

NCT06538311

RECRUITING 25 participants

Assessing Cognitive Decline at Home

Stanford University

NCT06704971

RECRUITING Early Phase 1 20 participants

Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

Johns Hopkins University

NCT04123314

RECRUITING NA 20 participants

Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment

The University of Texas Medical Branch, Galveston

NCT07416799

RECRUITING NA 20 participants

The Use of Rhythmic Light Therapy in Mild Cognitive Impairment

Icahn School of Medicine at Mount Sinai

NCT07318038

RECRUITING Phase 2 20 participants

Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)

Johns Hopkins University

NCT04765137

RECRUITING NA 20 participants

Voice Technology-Based Self-Management Intervention

Emory University

NCT06982261

RECRUITING NA 20 participants

Effects of Transcranial Ultrasound Stimulation (TUS) on Neurological and Cognitive Outcomes in Neurodegenerative Diseases

Sanmai Technologies PBC dba Sanmai

NCT07207122

RECRUITING 20 participants

OCT Angiography and NRAI in Dementia

Oregon Health and Science University

NCT03761381

RECRUITING NA 20 participants

Engage for Late-Life Depression and Comorbid Executive Dysfunction

University of Nevada, Las Vegas

NCT05356611

RECRUITING Phase 1 18 participants

Innate Immunity Stimulation Via TLR9 in Early AD

NYU Langone Health

NCT05606341

RECRUITING NA 15 participants

Feasibility of Implementing Time-restricted Eating in Women With Mild Cognitive Impairment

Julie Pendergast

NCT05858008

RECRUITING Phase 1 12 participants

A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment

Mark Tuszynski

NCT05040217

RECRUITING NA 10 participants

Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease

Helen M. Bronte-Stewart

NCT05968703

RECRUITING NA 10 participants

Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease

Emory University

NCT06484244

RECRUITING NA 9 participants

Race-Based Stress and Cognitive Training for MCI

Rosalind Franklin University of Medicine and Science

NCT06330844

← Previous Page 2 of 5 Next →

Phase Distribution

PhaseTrial count
Phase 1 24
Phase 2 28
Phase 3 3
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Mild Cognitive Impairment Trial Landscape

206 indexed Mild Cognitive Impairment studies · 100 recruiting (49%).

Phase mix: 8 late (III/IV) vs 52 early (I/II).

Top sponsor: Massachusetts General Hospital (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Mild Cognitive Impairment?

PlainTrial tracks 206 US clinical trials for Mild Cognitive Impairment, of which 100 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Mild Cognitive Impairment?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.