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Mild Cognitive Impairment clinical trials
100 of 206 indexed Mild Cognitive Impairment trials are currently recruiting.
206 US clinical trials · 100 currently recruiting
Mild Cognitive Impairment is the subject of 206 registered US clinical trials on ClinicalTrials.gov, 100 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 52 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 9 of these trials.
The research picture
Mild Cognitive Impairment has 206 registered US clinical trials, 100 of them open to new participants right now, about 49% of the total.
- 100
- recruiting participants now
- 49%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 9
- top sponsor: Massachusetts General Hospital
Active & Recent Trials
206 total, page 2 of 5
Breathing, Relaxation, Attention Training, & Health in Older Adults (BREATHE)
University of Rochester
NCT04522791
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
Yaakov Stern
NCT03372317
bpMedManage: Digital Technology to Support Adherence to Hypertension Medications
University of Arizona
NCT06307574
Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment
University of Maryland, Baltimore
NCT05948930
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
National Institute of Mental Health (NIMH)
NCT07169630
Treating Hyperexcitability in AD With Levetiracetam
Beth Israel Deaconess Medical Center
NCT03875638
Multimodal Investigation of Neural Plasticity
University of Michigan
NCT06453980
Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities
University of Nebraska
NCT03574207
tDCS for Post-Stroke Cognitive Impairment
University of Oklahoma
NCT06516588
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
University of Texas Southwestern Medical Center
NCT05446584
MCI Speech in Noise
Dartmouth-Hitchcock Medical Center
NCT06102486
Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
Massachusetts General Hospital
NCT05904132
Promoting Independence With Compensatory Cognitive Rehabilitation
University of Delaware
NCT04820335
Online Interplay Between Deciding and Acting With Mild Cognitive Impairment
University of Delaware
NCT06493422
Improving Physical Activity With Cognitive Impairment
Creighton University
NCT05370118
Home Sleep Therapy for Older Adults With MCI
Brain Electrophysiology Laboratory Company
NCT05771844
Transcranial Magnetic Stimulation for MCI
Medical University of South Carolina
NCT05992831
The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults
UConn Health
NCT06027554
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
University of California, San Diego
NCT06548191
Music Therapy for Patients With Alzheimer's Disease
Johns Hopkins University
NCT05151562
rTMS to Improve Cognition in Parkinson's
VA Office of Research and Development
NCT03836950
Senicapoc in Alzheimer's Disease
University of California, Davis
NCT04804241
Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
Johns Hopkins University
NCT04601038
Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia
Mclean Hospital
NCT04430517
CogT pSOPT Intervention Study
Stanford University
NCT06005038
OTC Hearing Aid and MCI
Northwestern University
NCT06112860
A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI
Central Arkansas Veterans Healthcare System
NCT06024473
Safety and Target Engagement of Centella Asiatica in Cognitive Impairment
Oregon Health and Science University
NCT05591027
A Feasiblity Study of Green Activity Program for People Living With Memory Challenges
Indiana University
NCT06403345
Rapamycin - Effects on Alzheimer's and Cognitive Health
The University of Texas Health Science Center at San Antonio
NCT04629495
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
Mclean Hospital
NCT05245903
Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD
Butler Hospital
NCT04500847
Impact of Intensive Computerized Cognitive Training
Brigham and Women's Hospital
NCT06130735
Olfactory Training in Mild Cognitive Impairment
Jeffrey Motter
NCT06825403
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
Massachusetts General Hospital
NCT06538311
Assessing Cognitive Decline at Home
Stanford University
NCT06704971
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
Johns Hopkins University
NCT04123314
Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment
The University of Texas Medical Branch, Galveston
NCT07416799
The Use of Rhythmic Light Therapy in Mild Cognitive Impairment
Icahn School of Medicine at Mount Sinai
NCT07318038
Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)
Johns Hopkins University
NCT04765137
Voice Technology-Based Self-Management Intervention
Emory University
NCT06982261
Effects of Transcranial Ultrasound Stimulation (TUS) on Neurological and Cognitive Outcomes in Neurodegenerative Diseases
Sanmai Technologies PBC dba Sanmai
NCT07207122
OCT Angiography and NRAI in Dementia
Oregon Health and Science University
NCT03761381
Engage for Late-Life Depression and Comorbid Executive Dysfunction
University of Nevada, Las Vegas
NCT05356611
Innate Immunity Stimulation Via TLR9 in Early AD
NYU Langone Health
NCT05606341
Feasibility of Implementing Time-restricted Eating in Women With Mild Cognitive Impairment
Julie Pendergast
NCT05858008
A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment
Mark Tuszynski
NCT05040217
Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
Helen M. Bronte-Stewart
NCT05968703
Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease
Emory University
NCT06484244
Race-Based Stress and Cognitive Training for MCI
Rosalind Franklin University of Medicine and Science
NCT06330844
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 24 |
| Phase 2 | 28 |
| Phase 3 | 3 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Mild Cognitive Impairment Trial Landscape
206 indexed Mild Cognitive Impairment studies · 100 recruiting (49%).
Phase mix: 8 late (III/IV) vs 52 early (I/II).
Top sponsor: Massachusetts General Hospital (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Mild Cognitive Impairment?
PlainTrial tracks 206 US clinical trials for Mild Cognitive Impairment, of which 100 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Mild Cognitive Impairment?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.