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NCT05446584 · ClinicalTrials.gov registry record · Phase 2
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
A Phase 2 study of Mild Cognitive Impairment and Mild Traumatic Brain Injury, sponsored by University of Texas Southwestern Medical Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 75
- Enrollment target
- 1
- Study location
NCT05446584: Recruiting Phase 2 study of Mild Cognitive Impairment and Mild Traumatic Brain Injury, sponsored by University of Texas Southwestern Medical Center.
NCT05446584 is a Phase 2 study of Mild Cognitive Impairment and Mild Traumatic Brain Injury that is actively recruiting participants, run by University of Texas Southwestern Medical Center. The registered enrollment target is 75 participants, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05446584, a Phase 2 study of Mild Cognitive Impairment and Mild Traumatic Brain Injury, is actively recruiting participants, sponsored by University of Texas Southwestern Medical Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 75 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.
Primary Outcome
The RAVLT is a verbal episodic memory test that is sensitive to mesial and lateral verbal episodic memory circuit dysfunction. The primary outcome measure for this task is the total number of items immediately recalled during the learning trials and after the 20 minute delayed recall trial. Changes in scores from baseline to testing immediately following the completion of each condition will be examined.
Conditions Studied
Interventions
- DEVICE High Definition Transcranial Direct Current Stimulation
Study Locations (1)
Texas
- University of Texas Southwestern Medical Center - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2023-04-20 |
| Est. Completion | 2027-05-31 |
| Phase | Phase 2 |
What NCT05446584 shows while recruiting
NCT05446584 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (94% lower).
The record links to 5 conditions, with Mild Cognitive Impairment appearing as the primary indexed condition, and to 1 intervention - of which High Definition Transcranial Direct Current Stimulation is the first listed.
NCT05446584 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05446584 about?
NCT05446584 is a clinical study titled "Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History". This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those ...
What is the current status of trial NCT05446584?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 75 participants. The study started on 2023-04-20. Estimated completion is 2027-05-31.
What conditions does trial NCT05446584 study?
This clinical trial studies the following conditions: Mild Cognitive Impairment, Mild Traumatic Brain Injury, Concussion, Brain, Amnestic Mild Cognitive Disorder, Amnestic Mild Cognitive Impairment.
What interventions are being tested in trial NCT05446584?
The interventions under investigation include: High Definition Transcranial Direct Current Stimulation (DEVICE).
Who is sponsoring clinical trial NCT05446584?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05446584 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05446584's enrollment target sits among peer trials
75 112th of 205 higher than 94 of 205 other Mild Cognitive Impairment trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mild Cognitive Impairment trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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