Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Mild Cognitive Impairment clinical trials
100 of 206 indexed Mild Cognitive Impairment trials are currently recruiting.
206 US clinical trials · 100 currently recruiting
Mild Cognitive Impairment is the subject of 206 registered US clinical trials on ClinicalTrials.gov, 100 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 52 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 9 of these trials.
The research picture
Mild Cognitive Impairment has 206 registered US clinical trials, 100 of them open to new participants right now, about 49% of the total.
- 100
- recruiting participants now
- 49%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 9
- top sponsor: Massachusetts General Hospital
Active & Recent Trials
206 total, page 1 of 5
TabCAT Brain Health Assessment in Primary Care
University of California, San Francisco
NCT06090578
Longitudinal Cognitive Assessment by BoCA
Alzheimer's Light
NCT04114994
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
Massachusetts General Hospital
NCT04916210
Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
University of Michigan
NCT05929703
Retinal Imaging in Neurodegenerative Disease
Duke University
NCT03233646
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Alzheimer's Light
NCT03657745
Study to Understand Novel Biomarkers in Researching Dementia
Washington University School of Medicine
NCT06547099
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
University of Alabama at Birmingham
NCT04171323
Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia
GAP Innovations, PBC
NCT06584357
DC Longitudinal Study on Aging and Specimen Bank
Georgetown University
NCT03702907
Tennessee Alzheimer's Project
Vanderbilt University Medical Center
NCT05372172
Longitudinal Early-onset Alzheimer's Disease Study Protocol
Indiana University
NCT03507257
Wake Forest Alzheimer's Disease Clinical Core
Wake Forest University Health Sciences
NCT03140865
Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
VA Office of Research and Development
NCT04124029
ADRC Clinical Cohort (Alzheimer's Disease)
Duke University
NCT06703541
Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline
Massachusetts General Hospital
NCT06246929
Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's
Florida State University
NCT05748613
Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI)
Société des Produits Nestlé (SPN)
NCT06347315
A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment
Oregon Research Institute
NCT05725668
The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study
University of Michigan
NCT05574400
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
Massachusetts General Hospital
NCT05881239
Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease
Johns Hopkins University
NCT05795634
CBD for Individuals at Risk for Alzheimer's Disease
University of Colorado, Denver
NCT05822362
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
Natalie Denburg
NCT03954899
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Arizona State University
NCT05877196
Wayfinding Intervention and Long-Term Memory
University of California, San Francisco
NCT05625425
Effect of LEQEMBI on Cerebral and Retinal Amyloid in Mild Cognitive Impairment Due to Alzheimer's Disease
NeuroVision Imaging
NCT06400368
Sense4Safety Intervention
University of Pennsylvania
NCT07220668
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Mayo Clinic
NCT06897670
Paper-Based and Smartphone-Based Memory Supports
Baylor University
NCT06444841
Natives Engaged in Alzheimers Research - 'Ike Kupuna
University of Hawaii
NCT05534607
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
National Institute of Mental Health (NIMH)
NCT04396873
Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline
University of Texas at Austin
NCT05907343
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
United States Naval Medical Center, San Diego
NCT06413173
Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia
Stanford University
NCT04100057
Brain Health Virtual Reality Study
University of California, San Diego
NCT06124339
BID LTM Digital Intervention in Aging
University of California, San Francisco
NCT06916221
Neuromodulation of Memory in Aging
Duke University
NCT05460468
Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
University of Virginia
NCT05565833
Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
Columbia University
NCT05655325
Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
University of California, Los Angeles
NCT05417555
Dual Task Perturbation Training for OAwMCI
University of Illinois at Chicago
NCT04938349
Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance
SF Research Institute
NCT07220694
GAMES Intervention in MCI (Mild Cognitive Impairment)
Emory University
NCT07296133
LEADing Dementia End-of-Life Planning Conversations
University of Utah
NCT05909189
Brain Energy for Amyloid Transformation in Alzheimer's Disease Study
Wake Forest University Health Sciences
NCT03472664
Phase 2 - Rhythmic Light Therapy for Alzheimer's Disease Patients
Icahn School of Medicine at Mount Sinai
NCT05016219
Autoimmune Features of Neurodegenerative Disorders
Columbia University
NCT04239079
Improve New Learning and Memory in Individuals With Mild Cognitive Impairment
Kessler Foundation
NCT05396248
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
University of Pittsburgh
NCT05138848
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 24 |
| Phase 2 | 28 |
| Phase 3 | 3 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Mild Cognitive Impairment Trial Landscape
206 indexed Mild Cognitive Impairment studies · 100 recruiting (49%).
Phase mix: 8 late (III/IV) vs 52 early (I/II).
Top sponsor: Massachusetts General Hospital (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Mild Cognitive Impairment?
PlainTrial tracks 206 US clinical trials for Mild Cognitive Impairment, of which 100 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Mild Cognitive Impairment?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.