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Mild Cognitive Impairment: early-phase trial registry
100 of 206 indexed Mild Cognitive Impairment trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #45 of 28,707 conditions by registered trial count.
206 US clinical trials · 100 currently recruiting · #45 of 28,707 conditions by registered trial count
Mild Cognitive Impairment: 206 US clinical trials tracked, 100 recruiting.
Mild Cognitive Impairment is the subject of 206 registered US clinical trials on ClinicalTrials.gov, 100 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 52 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 9 of these trials.
Enrollment posture brief
Registry condition mild-cognitive-impairment
OPEN 100 | RECR 49% | LATE 8 | EARLY 52 | RANK #45 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Chronic Graft Versus Host Disease (48% recruiting · 31 trials)
Mild Cognitive Impairment lists 100 open slots (49% of 206 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Mild Cognitive Impairment on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Mild Cognitive Impairment is recruiting above its size-band peers.
100 of 206 indexed trials (48.5%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Mild Cognitive Impairment trials is spread across many organizations.
Massachusetts General Hospital accounts for 9 of 206 trials (4.4%). 114 distinct sponsors appear on at least one study for this condition label.
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Typical Mild Cognitive Impairment enrolment sits around 81 participants.
Median target enrolment is 81 among the 206 trials that report a genuine target (sentinel values excluded). 114 of those (55.3%) plan for fewer than 100 participants.
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Mild Cognitive Impairment research is mostly interventional.
168 interventional and 38 observational studies make up this index (81.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
206 total, page 1 of 5
TabCAT Brain Health Assessment in Primary Care
University of California, San Francisco
NCT06090578
Longitudinal Cognitive Assessment by BoCA
Alzheimer's Light
NCT04114994
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
Massachusetts General Hospital
NCT04916210
Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
University of Michigan
NCT05929703
Retinal Imaging in Neurodegenerative Disease
Duke University
NCT03233646
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Alzheimer's Light
NCT03657745
Study to Understand Novel Biomarkers in Researching Dementia
Washington University School of Medicine
NCT06547099
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
University of Alabama at Birmingham
NCT04171323
Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia
GAP Innovations, PBC
NCT06584357
DC Longitudinal Study on Aging and Specimen Bank
Georgetown University
NCT03702907
Tennessee Alzheimer's Project
Vanderbilt University Medical Center
NCT05372172
Longitudinal Early-onset Alzheimer's Disease Study Protocol
Indiana University
NCT03507257
Wake Forest Alzheimer's Disease Clinical Core
Wake Forest University Health Sciences
NCT03140865
Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
VA Office of Research and Development
NCT04124029
ADRC Clinical Cohort (Alzheimer's Disease)
Duke University
NCT06703541
Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline
Massachusetts General Hospital
NCT06246929
Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's
Florida State University
NCT05748613
Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI)
Société des Produits Nestlé (SPN)
NCT06347315
A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment
Oregon Research Institute
NCT05725668
The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study
University of Michigan
NCT05574400
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
Massachusetts General Hospital
NCT05881239
Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease
Johns Hopkins University
NCT05795634
CBD for Individuals at Risk for Alzheimer's Disease
University of Colorado, Denver
NCT05822362
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
Natalie Denburg
NCT03954899
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Arizona State University
NCT05877196
Wayfinding Intervention and Long-Term Memory
University of California, San Francisco
NCT05625425
Effect of LEQEMBI on Cerebral and Retinal Amyloid in Mild Cognitive Impairment Due to Alzheimer's Disease
NeuroVision Imaging
NCT06400368
Sense4Safety Intervention
University of Pennsylvania
NCT07220668
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Mayo Clinic
NCT06897670
Paper-Based and Smartphone-Based Memory Supports
Baylor University
NCT06444841
Natives Engaged in Alzheimers Research - 'Ike Kupuna
University of Hawaii
NCT05534607
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
National Institute of Mental Health (NIMH)
NCT04396873
Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline
University of Texas at Austin
NCT05907343
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
United States Naval Medical Center, San Diego
NCT06413173
Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia
Stanford University
NCT04100057
Brain Health Virtual Reality Study
University of California, San Diego
NCT06124339
BID LTM Digital Intervention in Aging
University of California, San Francisco
NCT06916221
Neuromodulation of Memory in Aging
Duke University
NCT05460468
Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
University of Virginia
NCT05565833
Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
Columbia University
NCT05655325
Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
University of California, Los Angeles
NCT05417555
Dual Task Perturbation Training for OAwMCI
University of Illinois at Chicago
NCT04938349
Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance
SF Research Institute
NCT07220694
GAMES Intervention in MCI (Mild Cognitive Impairment)
Emory University
NCT07296133
LEADing Dementia End-of-Life Planning Conversations
University of Utah
NCT05909189
Brain Energy for Amyloid Transformation in Alzheimer's Disease Study
Wake Forest University Health Sciences
NCT03472664
Phase 2 - Rhythmic Light Therapy for Alzheimer's Disease Patients
Icahn School of Medicine at Mount Sinai
NCT05016219
Autoimmune Features of Neurodegenerative Disorders
Columbia University
NCT04239079
Improve New Learning and Memory in Individuals With Mild Cognitive Impairment
Kessler Foundation
NCT05396248
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
University of Pittsburgh
NCT05138848
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 24 |
| Phase 2 | 28 |
| Phase 3 | 3 |
| Phase 4 | 5 |
Top Sponsors
Named interventions
Most-linked intervention names on Mild Cognitive Impairment records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Mild Cognitive Impairment trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Mild Cognitive Impairment page
206 registered trials, 100 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 100 Mild Cognitive Impairment trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Mild Cognitive Impairment trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Mild Cognitive Impairment condition card totals 206 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.