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ClinicalTrials.gov 15 recruiting now official registry

Chronic Graft Versus Host Disease clinical trials

15 of 31 indexed Chronic Graft Versus Host Disease trials are currently recruiting.

31 US clinical trials · 15 currently recruiting

Chronic Graft Versus Host Disease is the subject of 31 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is Fred Hutchinson Cancer Center, running 5 of these trials.

The research picture

Chronic Graft Versus Host Disease has 31 registered US clinical trials, 15 of them open to new participants right now, about 48% of the total.

15
recruiting participants now
48%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
5
top sponsor: Fred Hutchinson Cancer Center
Phase 16Phase 213Phase 34

Active & Recent Trials

31 total, page 1 of 1

RECRUITING Phase 3 700 participants

A Long-term Extension Study of PCI-32765 (Ibrutinib)

Janssen Research & Development

NCT01804686

RECRUITING 300 participants

Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study

Fred Hutchinson Cancer Center

NCT04431479

RECRUITING Phase 3 240 participants

A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

Incyte Corporation

NCT06585774

RECRUITING Phase 2 120 participants

A Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease

Incyte Corporation

NCT06388564

RECRUITING Phase 2 82 participants

Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease

Fred Hutchinson Cancer Center

NCT05996627

RECRUITING Phase 2 60 participants

A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)

Incyte Corporation

NCT07124078

RECRUITING Phase 2 50 participants

Axatilimab for Sclerotic Chronic Graft-versus-Host Disease

Fred Hutchinson Cancer Center

NCT07011810

RECRUITING Phase 2 49 participants

Axatilimab in Combination With Extracorporeal Photopheresis (ECP) in Chronic Graft-versus-Host Disease

University of Miami

NCT06663722

RECRUITING Phase 2 45 participants

BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)

Dana-Farber Cancer Institute

NCT05922761

RECRUITING Phase 2 40 participants

Ibrutinib for the Prevention of Chronic Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant

Mayo Clinic

NCT06271616

RECRUITING Phase 2 37 participants

A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK)

Sanofi

NCT07116031

RECRUITING NA 36 participants

Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial

Dana-Farber Cancer Institute

NCT05236062

RECRUITING Phase 1 30 participants

Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD

Stefanie Sarantopoulos, MD, PhD.

NCT06233110

RECRUITING Phase 2 25 participants

Belumosudil and Rituximab for Primary Treatment of Chronic Graft-Versus-Host-Disease

Northside Hospital

NCT06046248

RECRUITING 8 participants

Evaluation of Belumosudil Whole Tablets vs. Crushed Tablets Pharmacokinetics in Patients Suffering From Chronic GvHD

M.D. Anderson Cancer Center

NCT07127926

ACTIVE NOT RECRUITING 601 participants

Improving Outcomes Assessment in Chronic GVHD

Fred Hutchinson Cancer Center

NCT00637689

ACTIVE NOT RECRUITING Phase 3 260 participants

A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.

Sanofi

NCT06143891

ACTIVE NOT RECRUITING Phase 2 241 participants

A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)

Syndax Pharmaceuticals

NCT04710576

ACTIVE NOT RECRUITING NA 120 participants

Psychosocial Mobile App for Chronic Graft-Versus-Host Disease

Massachusetts General Hospital

NCT05690971

ACTIVE NOT RECRUITING Phase 2 35 participants

Daily IL-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease

Dana-Farber Cancer Institute

NCT01366092

ACTIVE NOT RECRUITING Phase 1 25 participants

Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease

Dana-Farber Cancer Institute

NCT01937468

ACTIVE NOT RECRUITING 22 participants

Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease

Washington University School of Medicine

NCT02611180

ACTIVE NOT RECRUITING NA 20 participants

Digital Health Intervention to Promote Quality of Life in Adults With Chronic Graft Versus Host Disease

University of Miami

NCT06688942

ACTIVE NOT RECRUITING Phase 2 18 participants

A Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Itacitinib

Incyte Corporation

NCT04640025

ACTIVE NOT RECRUITING Phase 1 18 participants

Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease

City of Hope Medical Center

NCT04212416

ACTIVE NOT RECRUITING Phase 1 14 participants

Alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation

National Cancer Institute (NCI)

NCT02669251

ACTIVE NOT RECRUITING NA 10 participants

Tele-Palliative Care Intervention for Patients With Chronic Graft-Versus-Host Disease

Massachusetts General Hospital

NCT06458127

COMPLETED Phase 3 193 participants

Ibrutinib in Combination With Corticosteroids vs Placebo in Combination With Corticosteroids in Participants With New Onset Chronic Graft Versus Host Disease (cGVHD)

Pharmacyclics

NCT02959944

COMPLETED Phase 1 44 participants

Ofatumumab as Primary Therapy of Chronic Graft Versus Host Disease

H. Lee Moffitt Cancer Center and Research Institute

NCT01680965

COMPLETED Phase 1 24 participants

Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

National Cancer Institute (NCI)

NCT02759731

COMPLETED Phase 2 20 participants

Carfilzomib in Treating Patients With Chronic Graft-Versus-Host Disease

Fred Hutchinson Cancer Center

NCT02491359

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 13
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Graft Versus Host Disease Trial Landscape

31 indexed Chronic Graft Versus Host Disease studies · 15 recruiting (48%).

Phase mix: 4 late (III/IV) vs 19 early (I/II).

Top sponsor: Fred Hutchinson Cancer Center (5 trials), 9 others listed. 31 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Graft Versus Host Disease?

PlainTrial tracks 31 US clinical trials for Chronic Graft Versus Host Disease, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Graft Versus Host Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.