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2026 data Public-data reference. official source

Chronic Graft Versus Host Disease

Open-data reference.

19 US clinical trials · 11 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 700 participants

A Long-term Extension Study of PCI-32765 (Ibrutinib)

Janssen Research & Development

NCT01804686

RECRUITING 300 participants

Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study

Fred Hutchinson Cancer Center

NCT04431479

RECRUITING Phase 2 82 participants

Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease

Fred Hutchinson Cancer Center

NCT05996627

RECRUITING Phase 2 50 participants

Axatilimab for Sclerotic Chronic Graft-versus-Host Disease

Fred Hutchinson Cancer Center

NCT07011810

RECRUITING Phase 2 49 participants

Axatilimab in Combination With Extracorporeal Photopheresis (ECP) in Chronic Graft-versus-Host Disease

University of Miami

NCT06663722

RECRUITING Phase 2 45 participants

BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)

Dana-Farber Cancer Institute

NCT05922761

RECRUITING Phase 2 40 participants

Ibrutinib for the Prevention of Chronic Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant

Mayo Clinic

NCT06271616

RECRUITING Phase 2 37 participants

A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK)

Sanofi

NCT07116031

RECRUITING Phase 1 30 participants

Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD

Stefanie Sarantopoulos, MD, PhD.

NCT06233110

RECRUITING Phase 2 25 participants

Belumosudil and Rituximab for Primary Treatment of Chronic Graft-Versus-Host-Disease

Northside Hospital

NCT06046248

RECRUITING 8 participants

Evaluation of Belumosudil Whole Tablets vs. Crushed Tablets Pharmacokinetics in Patients Suffering From Chronic GvHD

M.D. Anderson Cancer Center

NCT07127926

ACTIVE NOT RECRUITING 601 participants

Improving Outcomes Assessment in Chronic GVHD

Fred Hutchinson Cancer Center

NCT00637689

ACTIVE NOT RECRUITING Phase 3 260 participants

A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.

Sanofi

NCT06143891

ACTIVE NOT RECRUITING Phase 1 25 participants

Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease

Dana-Farber Cancer Institute

NCT01937468

ACTIVE NOT RECRUITING Phase 2 18 participants

A Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Itacitinib

Incyte Corporation

NCT04640025

ACTIVE NOT RECRUITING Phase 1 18 participants

Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease

City of Hope Medical Center

NCT04212416

COMPLETED Phase 3 193 participants

Ibrutinib in Combination With Corticosteroids vs Placebo in Combination With Corticosteroids in Participants With New Onset Chronic Graft Versus Host Disease (cGVHD)

Pharmacyclics

NCT02959944

COMPLETED Phase 1 44 participants

Ofatumumab as Primary Therapy of Chronic Graft Versus Host Disease

H. Lee Moffitt Cancer Center and Research Institute

NCT01680965

COMPLETED Phase 2 20 participants

Carfilzomib in Treating Patients With Chronic Graft-Versus-Host Disease

Fred Hutchinson Cancer Center

NCT02491359

Phase Distribution

PhaseTrial count
Early Phase 1 4
Phase 2 9
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Graft Versus Host Disease Trial Landscape

ClinicalTrials.gov lists 19 US studies indexed under Chronic Graft Versus Host Disease, and 11 of those are currently open to recruitment — roughly 58% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Chronic Graft Versus Host Disease shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Chronic Graft Versus Host Disease is led by Fred Hutchinson Cancer Center with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 19 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Graft Versus Host Disease?

PlainTrial tracks 19 US clinical trials for Chronic Graft Versus Host Disease, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Graft Versus Host Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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