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Chronic Graft Versus Host Disease
Open-data reference.
19 US clinical trials · 11 currently recruiting
Active & Recent Trials
A Long-term Extension Study of PCI-32765 (Ibrutinib)
Janssen Research & Development
NCT01804686
Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study
Fred Hutchinson Cancer Center
NCT04431479
Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease
Fred Hutchinson Cancer Center
NCT05996627
Axatilimab for Sclerotic Chronic Graft-versus-Host Disease
Fred Hutchinson Cancer Center
NCT07011810
Axatilimab in Combination With Extracorporeal Photopheresis (ECP) in Chronic Graft-versus-Host Disease
University of Miami
NCT06663722
BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)
Dana-Farber Cancer Institute
NCT05922761
Ibrutinib for the Prevention of Chronic Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant
Mayo Clinic
NCT06271616
A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK)
Sanofi
NCT07116031
Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD
Stefanie Sarantopoulos, MD, PhD.
NCT06233110
Belumosudil and Rituximab for Primary Treatment of Chronic Graft-Versus-Host-Disease
Northside Hospital
NCT06046248
Evaluation of Belumosudil Whole Tablets vs. Crushed Tablets Pharmacokinetics in Patients Suffering From Chronic GvHD
M.D. Anderson Cancer Center
NCT07127926
Improving Outcomes Assessment in Chronic GVHD
Fred Hutchinson Cancer Center
NCT00637689
A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
Sanofi
NCT06143891
Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease
Dana-Farber Cancer Institute
NCT01937468
A Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Itacitinib
Incyte Corporation
NCT04640025
Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease
City of Hope Medical Center
NCT04212416
Ibrutinib in Combination With Corticosteroids vs Placebo in Combination With Corticosteroids in Participants With New Onset Chronic Graft Versus Host Disease (cGVHD)
Pharmacyclics
NCT02959944
Ofatumumab as Primary Therapy of Chronic Graft Versus Host Disease
H. Lee Moffitt Cancer Center and Research Institute
NCT01680965
Carfilzomib in Treating Patients With Chronic Graft-Versus-Host Disease
Fred Hutchinson Cancer Center
NCT02491359
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 4 |
| Phase 2 | 9 |
| Phase 3 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Chronic Graft Versus Host Disease Trial Landscape
ClinicalTrials.gov lists 19 US studies indexed under Chronic Graft Versus Host Disease, and 11 of those are currently open to recruitment — roughly 58% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Chronic Graft Versus Host Disease shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Chronic Graft Versus Host Disease is led by Fred Hutchinson Cancer Center with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 19 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Chronic Graft Versus Host Disease?
PlainTrial tracks 19 US clinical trials for Chronic Graft Versus Host Disease, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Chronic Graft Versus Host Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.