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NCT03574207 · ClinicalTrials.gov registry record · NA

Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities

A NA study of Mild Cognitive Impairment and Memory Loss, sponsored by University of Nebraska.

Recruiting
Registry status
NA
Development phase
80
Enrollment target
1
Study location

NCT03574207: Recruiting NA study of Mild Cognitive Impairment and Memory Loss, sponsored by University of Nebraska.

NCT03574207 is a NA study of Mild Cognitive Impairment and Memory Loss that is actively recruiting participants, run by University of Nebraska. The registered enrollment target is 80 participants, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT03574207, a NA study of Mild Cognitive Impairment and Memory Loss, is actively recruiting participants, sponsored by University of Nebraska.

RECRUITING
Registry status
NA
Development phase
80 participants
Enrollment target
1
Study location

Study Summary

This is a pilot study of non-invasive transcranial magnetic stimulation (TMS) to improve memory in healthy adults. It will also examine treating memory deficits in older adults with amnestic mild cognitive impairment (aMCI), a condition that frequently precedes Alzheimer's disease (AD). The study will test whether a form of non-invasive brain stimulation repetitive transcranial magnetic stimulation (rTMS) can improve memory abilities in healthy young adults, healthy older adults, and older adults with aMCI by retuning memory-related brain networks. This study is a key first step which will support the long-term goal of treating memory deficits in neurological patients. It is expected that rTMS will improve memory abilities in all participants, and that the improvements in memory will be attributable to changes in the connectivity of memory-related brain networks.

Primary Outcome

The investigators will measure memory performance before and after treatment to determine whether performance differs as a result of treatment. The main task will be a face-word association task in which participants will study a list of faces paired with single words. After a short delay, one studied face will be presented at a time, and participants will be prompted to recall the word associated with the face. The number of correct face-word associations recalled is the dependent measure.

Conditions Studied

Mild Cognitive Impairment Memory Loss

Interventions

  • DEVICE Transcranial magnetic stimulation

Study Locations (1)

Nebraska

  • University of Nebraska Medical Center - Omaha

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2019-01-01
Est. Completion 2026-12
Phase NA
University of Nebraska

407 total trials

What NCT03574207 shows while recruiting

NCT03574207 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (94% lower).

The record links to 2 conditions, with Mild Cognitive Impairment appearing as the primary indexed condition, and to 1 intervention - of which Transcranial magnetic stimulation is the first listed.

NCT03574207 reports a single indexed study location in Nebraska.

Frequently Asked Questions

What is clinical trial NCT03574207 about?

NCT03574207 is a clinical study titled "Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities". This is a pilot study of non-invasive transcranial magnetic stimulation (TMS) to improve memory in healthy adults. It will also examine treating memory deficits in older adults with amnestic mild cognitive impairment (aMCI), a condition that frequently precedes Alzheimer's disease (AD). The study wi...

What is the current status of trial NCT03574207?

This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2019-01-01. Estimated completion is 2026-12.

What conditions does trial NCT03574207 study?

This clinical trial studies the following conditions: Mild Cognitive Impairment, Memory Loss.

What interventions are being tested in trial NCT03574207?

The interventions under investigation include: Transcranial magnetic stimulation (DEVICE).

Who is sponsoring clinical trial NCT03574207?

This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT03574207 being conducted?

This trial has 1 study location across Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Mild Cognitive Impairment

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT03574207's enrollment target sits among peer trials

80 104th of 205 higher than 97 of 205 other Mild Cognitive Impairment trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Mild Cognitive Impairment trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT03574207

Source: ClinicalTrials.gov NCT03574207, the US trial registry maintained by the National Library of Medicine. NCT03574207 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.