Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 79 recruiting now official registry

Dementia clinical trials

Every US clinical trial registered for Dementia — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

202 US clinical trials · 79 currently recruiting

The research picture

Dementia has 202 registered US clinical trials, 79 of them open to new participants right now — about 39% of the total.

79
recruiting participants now
39%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
8
top sponsor: University of Washington

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 500,000 participants

Alzheimer's Prevention Registry: A Program to Accelerate Enrollment Into Studies

Banner Health

NCT02022943

RECRUITING 200,000 participants

Alzheimer Prevention Trials (APT) Webstudy

University of Southern California

NCT03638583

RECRUITING NA 180,000 participants

TabCAT Brain Health Assessment in Primary Care

University of California, San Francis

NCT06090578

RECRUITING NA 45,257 participants

Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial

Northwestern University

NCT05607732

RECRUITING Phase 4 20,000 participants

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Duke University

NCT04262206

RECRUITING 12,000 participants

Genetic Characterization of Movement Disorders and Dementias

National Institute on Aging (NIA)

NCT02014246

RECRUITING 10,000 participants

Alzheimer's Disease Genetics Study

Indiana University

NCT00064870

RECRUITING 10,000 participants

NYSCF Scientific Discovery Biobank

New York Stem Cell Foundation Research Institute

NCT06203106

RECRUITING NA 6,600 participants

5-Cog 2.0: A Pragmatic Clinical Trial

Albert Einstein College of Medicine

NCT05515224

RECRUITING NA 5,000 participants

Clinical Applications of Advanced Ophthalmic Imaging

University of Miami

NCT03135327

RECRUITING 2,000 participants

Phase I Human Analytics (HALO) Study

HALO Diagnostics

NCT05423860

RECRUITING NA 2,000 participants

The INSPIRE Study: Intervention Strategies for Preserving Intellectual Resilience and Engagement

Healthy Minds Initiative

NCT06741865

RECRUITING 2,000 participants

Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy

Alzheimer's Light

NCT03657745

RECRUITING NA 1,800 participants

Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers

University of Washington

NCT05596760

RECRUITING 1,800 participants

Study to Understand Novel Biomarkers in Researching Dementia

Washington University School of Medicine

NCT06547099

RECRUITING NA 1,764 participants

Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce

University of North Carolina, Chapel Hill

NCT06239688

RECRUITING NA 1,305 participants

The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia

University of Alabama at Birmingham

NCT04171323

RECRUITING 1,000 participants

DC Longitudinal Study on Aging and Specimen Bank

Georgetown University

NCT03702907

RECRUITING 1,000 participants

Tennessee Alzheimer's Project

Vanderbilt University Medical Center

NCT05372172

RECRUITING NA 750 participants

Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0

Hebrew SeniorLife

NCT05950607

RECRUITING 520 participants

Paradoxical Lucidity in Severe End-Stage Dementia

NYU Langone Health

NCT05234866

RECRUITING 500 participants

ADRC Clinical Cohort (Alzheimer's Disease)

Duke University

NCT06703541

RECRUITING NA 456 participants

Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase

University of Alabama, Tuscaloo

NCT05820919

RECRUITING 450 participants

Trial-Ready Cohort-Down Syndrome (TRC-DS)

University of Southern California

NCT04165109

RECRUITING NA 440 participants

Evaluating the Efficacy of the Pain Identification and Communication Toolkit

Weill Medical College of Cornell University

NCT06168604

RECRUITING NA 400 participants

Dementia and Diabetes Prevention Program

University of California, Davis

NCT04141878

RECRUITING NA 388 participants

Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's

Florida State University

NCT05748613

RECRUITING NA 360 participants

Connect-Home: Alzheimer's Disease and Related Dementias

University of North Carolina, Chapel Hill

NCT06840587

RECRUITING 360 participants

Persons With Dementia and Their Extended Family Caregivers

Karen Roberto

NCT04863859

RECRUITING NA 300 participants

Enhancing Triadic Communication About Cognition for Older Adults With Alzheimer's Disease or Related Dementias Facing a Cancer Management Decision

University of Rochester

NCT06313853

RECRUITING NA 300 participants

HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms

Johns Hopkins University

NCT06930560

RECRUITING Phase 2 300 participants

Testing the Pain Clinical Practice Guideline

University of Maryland, Baltimore

NCT05858996

RECRUITING Phase 2 280 participants

A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

Washington University School of Medicine

NCT06647498

RECRUITING Phase 2 280 participants

A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

Washington University School of Medicine

NCT05552157

RECRUITING NA 270 participants

Caregiver as Navigator: Develop Skills Online (CAN-DO)

Emory University

NCT06177990

RECRUITING NA 266 participants

Coaching Dementia Caregivers to Master Care-Resistant Behavior

University of Alabama at Birmingham

NCT05098652

RECRUITING NA 200 participants

δ in Dementia Clinical Trials

The University of Texas Health Science Center at San Antonio

NCT05592678

RECRUITING NA 200 participants

Learning Skills Together Family Caregiver Complex Intervention

Case Western Reserve University

NCT05846984

RECRUITING NA 200 participants

Dementia Caregivers' Link to Assistance and Resources

Visiting Nurse Service of New York

NCT06860035

RECRUITING Phase 1 184 participants

PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

National Institute of Mental Health (NIMH)

NCT04396873

RECRUITING 150 participants

Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

Massachusetts General Hospital

NCT06052397

RECRUITING NA 144 participants

Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia

Hebrew SeniorLife

NCT05661084

RECRUITING NA 128 participants

Dementia Care Partner Hospital Assessment Tool

University of Wisconsin, Madison

NCT05592366

RECRUITING Phase 1 120 participants

Door-Through-Door Companion Rideshare Technology for Individuals With Alzheimer's Disease and Related Dementias (AD/ADRD)

Onward Health

NCT06850870

RECRUITING NA 120 participants

Improving PCP Advance Care Planning for People With ADRD

University of Pittsburgh

NCT06565169

RECRUITING Early Phase 1 120 participants

Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia

University of Texas at Austin

NCT06511752

RECRUITING NA 120 participants

The BRAIN App (Phase 2 SBIR)

Hopeful Aging

NCT06298474

RECRUITING NA 118 participants

Effect of Cognitive Empathy Training on Dementia Caregivers

Emory University

NCT06650527

RECRUITING Phase 1 102 participants

First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia

David Wilson

NCT05374278

RECRUITING NA 100 participants

NiteCAPP: Web-based Interventions for Insomnia in Rural Dementia Caregivers

University of South Florida

NCT04896775

RECRUITING NA 100 participants

A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

University of Washington

NCT06411561

RECRUITING NA 90 participants

Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain

University of Washington

NCT04692441

RECRUITING NA 80 participants

Sleep Enhancement for Older Adults Living With Memory Loss And Their Care Partners

Emory University

NCT06250725

RECRUITING NA 80 participants

Testing & Refinement of CarePair: An Assessment and Referral Platform to Support Family Caregivers of Alzheimer's Disease and Related Dementias.

University of Southern California

NCT06418971

RECRUITING NA 70 participants

Early-Stage Partner in Care Living Alone Plus

Arizona State University

NCT06962111

RECRUITING NA 68 participants

Caregivers Preparing for Their Own Health Care Emergency

University of California, Davis

NCT06635876

RECRUITING Phase 1 66 participants

Ferritin and Iron Burden in SAH sIRB

Duke University

NCT03754725

RECRUITING NA 65 participants

Comparing Structured Retrieval Practice and Reading-Based Education for Dementia Caregivers

Virginia Wesleyan University

NCT07413406

RECRUITING NA 62 participants

Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes

Indiana University

NCT05643144

RECRUITING Phase 2 60 participants

Clinical Trial Evaluating the Efficacy of AGB101 for Reducing Hippocampal Overactivity in Older Adults

Johns Hopkins University

NCT06919926

RECRUITING Phase 1 60 participants

Exploration of an Online Education Program to Support Caregivers' Knowledge Transfer

Texas Christian University

NCT07377331

RECRUITING NA 60 participants

Development of a Personalized, Psychosocial Intervention for Menopausal Individuals With Elevated Dementia Risk

University of Chicago

NCT06965686

RECRUITING 60 participants

Delirium Identification in Older Patients With Alzheimer's and Other Related Dementias In the Emergency Department

Ohio State University

NCT06326424

RECRUITING NA 60 participants

E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app

University of Iowa

NCT07032350

RECRUITING NA 60 participants

University of Central Florida Music Study

University of Central Florida

NCT07306065

RECRUITING NA 60 participants

Web-based Cognitive Behavioral Treatment for Insomnia in Dementia Caregivers

University of South Florida

NCT04632628

RECRUITING NA 60 participants

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

University of Texas at Austin

NCT05741853

RECRUITING 50 participants

Dynamic Light Scattering Ocular Measurement in the Detection of Dementia

MD Stem Cells

NCT06613971

RECRUITING NA 50 participants

Resilient Together for Dementia (RT-D)

Icahn School of Medicine at Mount Sinai

NCT06619327

RECRUITING NA 48 participants

Caregiver Bootcamp

Emory University

NCT07006116

RECRUITING NA 40 participants

DECIDE: Dyads and Families

Emory University

NCT05139290

RECRUITING NA 40 participants

Community Health Worker-Led Transition Support for Persons Living With Dementia and Caregivers

University of Texas at Austin

NCT06831318

RECRUITING 40 participants

Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside

Mclean Hospital

NCT05245903

RECRUITING NA 32 participants

Environmental and Sensory Intervention for Nursing Home Residents With Dementia Who Exhibit Persistent Vocalizations

Drexel University

NCT06568107

RECRUITING NA 30 participants

Combating Alzheimer's Through Sleep and Exercise

University of Miami

NCT04855630

RECRUITING 30 participants

Investigating Dynamic Interactions in Distributed Cognitive Control Networks

University of Alabama at Birmingham

NCT05927974

RECRUITING 25 participants

Assessing Cognitive Decline at Home

Stanford University

NCT06704971

RECRUITING 20 participants

OCT Angiography and NRAI in Dementia

Oregon Health and Science University

NCT03761381

RECRUITING Phase 2 16 participants

Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease

Brigham and Women's Hospital

NCT06489548

ACTIVE NOT RECRUITING NA 41,500 participants

ToolBox Detect: Low Cost Detection of Cognitive Decline in Primary Care Settings

Northwestern University

NCT04852601

ACTIVE NOT RECRUITING 19,114 participants

Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)

Anne Murray

NCT07224347

ACTIVE NOT RECRUITING 13,435 participants

Sex-specific Risk Factors and Trajectories of Blood Biomarkers for Alzheimer's Disease and Related Dementias

Anne Murray

NCT07224139

ACTIVE NOT RECRUITING NA 5,043 participants

Changing Talk Online Training (CHATO) National Trial

University of Kansas Medical Center

NCT04610944

ACTIVE NOT RECRUITING NA 3,417 participants

The Brain Health Study: A Pragmatic, Patient-Centered Trial

Kaiser Permanente

NCT05356702

ACTIVE NOT RECRUITING 2,000 participants

Screening for Memory Studies

John Wesson Ashford Jr

NCT01123018

ACTIVE NOT RECRUITING 1,892 participants

Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium

Massachusetts General Hospital

NCT06284213

ACTIVE NOT RECRUITING Phase 3 1,175 participants

A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)

Eli Lilly and Company

NCT05738486

ACTIVE NOT RECRUITING 826 participants

The BRAIN Intensive Care Unit (ICU) Study: Bringing to Light the Risk Factors

Vanderbilt University Medical Center

NCT00392795

ACTIVE NOT RECRUITING NA 760 participants

Minnesota Inclusive LTSS for LGBTQ Seniors

University of Minnesota

NCT05530590

ACTIVE NOT RECRUITING 634 participants

Brain Attack Surveillance in Corpus Christi--Cognitive (BASIC-Cognitive)

University of Michigan

NCT03403257

ACTIVE NOT RECRUITING Phase 3 629 participants

ACHIEVE Brain Health Follow-Up Study

Johns Hopkins University

NCT05532657

ACTIVE NOT RECRUITING 600 participants

BRINK (BRain In Kidney Disease) Memory Study 2.0

Anne Murray

NCT04975464

ACTIVE NOT RECRUITING Phase 2 523 participants

A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease

Janssen Research & Development

NCT04619420

ACTIVE NOT RECRUITING Phase 2 490 participants

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

Washington University School of Medicine

NCT01760005

ACTIVE NOT RECRUITING 400 participants

Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey

C2N Diagnostics

NCT06025877

ACTIVE NOT RECRUITING NA 355 participants

A Study of Caregiver Connections Via Technology in Dementia

Mayo Clinic

NCT05779839

ACTIVE NOT RECRUITING Phase 2 350 participants

A Study to Evaluate the Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia (MK-1167-008)

Merck Sharp & Dohme

NCT06721156

ACTIVE NOT RECRUITING NA 344 participants

Reducing Risk of Dementia Through Deprescribing

Indiana University

NCT04270474

ACTIVE NOT RECRUITING NA 342 participants

The PorchLight Project

University of Minnesota

NCT05550727

ACTIVE NOT RECRUITING NA 288 participants

PLAN: Dementia Literacy Education and Navigation for Korean Elders With Probable Dementia and Their Caregivers

Johns Hopkins University

NCT03909347

Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 19
Phase 3 10
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Dementia Trial Landscape

ClinicalTrials.gov lists 202 US studies indexed under Dementia, and 79 of those are currently open to recruitment — roughly 39% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Dementia shows 13 late-stage studies (Phase 3 and Phase 4 combined) alongside 29 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Dementia is led by University of Washington with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Dementia?

PlainTrial tracks 202 US clinical trials for Dementia, of which 79 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Dementia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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