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Dementia clinical trials
Every US clinical trial registered for Dementia — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
202 US clinical trials · 79 currently recruiting
The research picture
Dementia has 202 registered US clinical trials, 79 of them open to new participants right now — about 39% of the total.
- 79
- recruiting participants now
- 39%
- of trials open to enrollment
- 13
- in Phase 3–4 (later-stage)
- 8
- top sponsor: University of Washington
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Alzheimer's Prevention Registry: A Program to Accelerate Enrollment Into Studies
Banner Health
NCT02022943
Alzheimer Prevention Trials (APT) Webstudy
University of Southern California
NCT03638583
TabCAT Brain Health Assessment in Primary Care
University of California, San Francis
NCT06090578
Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial
Northwestern University
NCT05607732
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
Duke University
NCT04262206
Genetic Characterization of Movement Disorders and Dementias
National Institute on Aging (NIA)
NCT02014246
Alzheimer's Disease Genetics Study
Indiana University
NCT00064870
NYSCF Scientific Discovery Biobank
New York Stem Cell Foundation Research Institute
NCT06203106
5-Cog 2.0: A Pragmatic Clinical Trial
Albert Einstein College of Medicine
NCT05515224
Clinical Applications of Advanced Ophthalmic Imaging
University of Miami
NCT03135327
Phase I Human Analytics (HALO) Study
HALO Diagnostics
NCT05423860
The INSPIRE Study: Intervention Strategies for Preserving Intellectual Resilience and Engagement
Healthy Minds Initiative
NCT06741865
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Alzheimer's Light
NCT03657745
Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers
University of Washington
NCT05596760
Study to Understand Novel Biomarkers in Researching Dementia
Washington University School of Medicine
NCT06547099
Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce
University of North Carolina, Chapel Hill
NCT06239688
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
University of Alabama at Birmingham
NCT04171323
DC Longitudinal Study on Aging and Specimen Bank
Georgetown University
NCT03702907
Tennessee Alzheimer's Project
Vanderbilt University Medical Center
NCT05372172
Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0
Hebrew SeniorLife
NCT05950607
Paradoxical Lucidity in Severe End-Stage Dementia
NYU Langone Health
NCT05234866
ADRC Clinical Cohort (Alzheimer's Disease)
Duke University
NCT06703541
Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase
University of Alabama, Tuscaloo
NCT05820919
Trial-Ready Cohort-Down Syndrome (TRC-DS)
University of Southern California
NCT04165109
Evaluating the Efficacy of the Pain Identification and Communication Toolkit
Weill Medical College of Cornell University
NCT06168604
Dementia and Diabetes Prevention Program
University of California, Davis
NCT04141878
Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's
Florida State University
NCT05748613
Connect-Home: Alzheimer's Disease and Related Dementias
University of North Carolina, Chapel Hill
NCT06840587
Persons With Dementia and Their Extended Family Caregivers
Karen Roberto
NCT04863859
Enhancing Triadic Communication About Cognition for Older Adults With Alzheimer's Disease or Related Dementias Facing a Cancer Management Decision
University of Rochester
NCT06313853
HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
Johns Hopkins University
NCT06930560
Testing the Pain Clinical Practice Guideline
University of Maryland, Baltimore
NCT05858996
A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
Washington University School of Medicine
NCT06647498
A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
Washington University School of Medicine
NCT05552157
Caregiver as Navigator: Develop Skills Online (CAN-DO)
Emory University
NCT06177990
Coaching Dementia Caregivers to Master Care-Resistant Behavior
University of Alabama at Birmingham
NCT05098652
δ in Dementia Clinical Trials
The University of Texas Health Science Center at San Antonio
NCT05592678
Learning Skills Together Family Caregiver Complex Intervention
Case Western Reserve University
NCT05846984
Dementia Caregivers' Link to Assistance and Resources
Visiting Nurse Service of New York
NCT06860035
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
National Institute of Mental Health (NIMH)
NCT04396873
Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
Massachusetts General Hospital
NCT06052397
Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia
Hebrew SeniorLife
NCT05661084
Dementia Care Partner Hospital Assessment Tool
University of Wisconsin, Madison
NCT05592366
Door-Through-Door Companion Rideshare Technology for Individuals With Alzheimer's Disease and Related Dementias (AD/ADRD)
Onward Health
NCT06850870
Improving PCP Advance Care Planning for People With ADRD
University of Pittsburgh
NCT06565169
Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia
University of Texas at Austin
NCT06511752
The BRAIN App (Phase 2 SBIR)
Hopeful Aging
NCT06298474
Effect of Cognitive Empathy Training on Dementia Caregivers
Emory University
NCT06650527
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia
David Wilson
NCT05374278
NiteCAPP: Web-based Interventions for Insomnia in Rural Dementia Caregivers
University of South Florida
NCT04896775
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
University of Washington
NCT06411561
Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain
University of Washington
NCT04692441
Sleep Enhancement for Older Adults Living With Memory Loss And Their Care Partners
Emory University
NCT06250725
Testing & Refinement of CarePair: An Assessment and Referral Platform to Support Family Caregivers of Alzheimer's Disease and Related Dementias.
University of Southern California
NCT06418971
Early-Stage Partner in Care Living Alone Plus
Arizona State University
NCT06962111
Caregivers Preparing for Their Own Health Care Emergency
University of California, Davis
NCT06635876
Ferritin and Iron Burden in SAH sIRB
Duke University
NCT03754725
Comparing Structured Retrieval Practice and Reading-Based Education for Dementia Caregivers
Virginia Wesleyan University
NCT07413406
Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes
Indiana University
NCT05643144
Clinical Trial Evaluating the Efficacy of AGB101 for Reducing Hippocampal Overactivity in Older Adults
Johns Hopkins University
NCT06919926
Exploration of an Online Education Program to Support Caregivers' Knowledge Transfer
Texas Christian University
NCT07377331
Development of a Personalized, Psychosocial Intervention for Menopausal Individuals With Elevated Dementia Risk
University of Chicago
NCT06965686
Delirium Identification in Older Patients With Alzheimer's and Other Related Dementias In the Emergency Department
Ohio State University
NCT06326424
E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app
University of Iowa
NCT07032350
University of Central Florida Music Study
University of Central Florida
NCT07306065
Web-based Cognitive Behavioral Treatment for Insomnia in Dementia Caregivers
University of South Florida
NCT04632628
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
University of Texas at Austin
NCT05741853
Dynamic Light Scattering Ocular Measurement in the Detection of Dementia
MD Stem Cells
NCT06613971
Resilient Together for Dementia (RT-D)
Icahn School of Medicine at Mount Sinai
NCT06619327
Caregiver Bootcamp
Emory University
NCT07006116
DECIDE: Dyads and Families
Emory University
NCT05139290
Community Health Worker-Led Transition Support for Persons Living With Dementia and Caregivers
University of Texas at Austin
NCT06831318
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
Mclean Hospital
NCT05245903
Environmental and Sensory Intervention for Nursing Home Residents With Dementia Who Exhibit Persistent Vocalizations
Drexel University
NCT06568107
Combating Alzheimer's Through Sleep and Exercise
University of Miami
NCT04855630
Investigating Dynamic Interactions in Distributed Cognitive Control Networks
University of Alabama at Birmingham
NCT05927974
Assessing Cognitive Decline at Home
Stanford University
NCT06704971
OCT Angiography and NRAI in Dementia
Oregon Health and Science University
NCT03761381
Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease
Brigham and Women's Hospital
NCT06489548
ToolBox Detect: Low Cost Detection of Cognitive Decline in Primary Care Settings
Northwestern University
NCT04852601
Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)
Anne Murray
NCT07224347
Sex-specific Risk Factors and Trajectories of Blood Biomarkers for Alzheimer's Disease and Related Dementias
Anne Murray
NCT07224139
Changing Talk Online Training (CHATO) National Trial
University of Kansas Medical Center
NCT04610944
The Brain Health Study: A Pragmatic, Patient-Centered Trial
Kaiser Permanente
NCT05356702
Screening for Memory Studies
John Wesson Ashford Jr
NCT01123018
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
Massachusetts General Hospital
NCT06284213
A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)
Eli Lilly and Company
NCT05738486
The BRAIN Intensive Care Unit (ICU) Study: Bringing to Light the Risk Factors
Vanderbilt University Medical Center
NCT00392795
Minnesota Inclusive LTSS for LGBTQ Seniors
University of Minnesota
NCT05530590
Brain Attack Surveillance in Corpus Christi--Cognitive (BASIC-Cognitive)
University of Michigan
NCT03403257
ACHIEVE Brain Health Follow-Up Study
Johns Hopkins University
NCT05532657
BRINK (BRain In Kidney Disease) Memory Study 2.0
Anne Murray
NCT04975464
A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease
Janssen Research & Development
NCT04619420
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001
Washington University School of Medicine
NCT01760005
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
C2N Diagnostics
NCT06025877
A Study of Caregiver Connections Via Technology in Dementia
Mayo Clinic
NCT05779839
A Study to Evaluate the Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia (MK-1167-008)
Merck Sharp & Dohme
NCT06721156
Reducing Risk of Dementia Through Deprescribing
Indiana University
NCT04270474
The PorchLight Project
University of Minnesota
NCT05550727
PLAN: Dementia Literacy Education and Navigation for Korean Elders With Probable Dementia and Their Caregivers
Johns Hopkins University
NCT03909347
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 10 |
| Phase 2 | 19 |
| Phase 3 | 10 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Dementia Trial Landscape
ClinicalTrials.gov lists 202 US studies indexed under Dementia, and 79 of those are currently open to recruitment — roughly 39% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Dementia shows 13 late-stage studies (Phase 3 and Phase 4 combined) alongside 29 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Dementia is led by University of Washington with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Dementia?
PlainTrial tracks 202 US clinical trials for Dementia, of which 79 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Dementia?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.