Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Atrial Fibrillation: later-stage trial registry
60 of 204 indexed Atrial Fibrillation trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #46 of 28,707 conditions by registered trial count.
204 US clinical trials · 60 currently recruiting · #46 of 28,707 conditions by registered trial count
Atrial Fibrillation: 204 US clinical trials tracked, 60 recruiting.
Atrial Fibrillation is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 60 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is The Cleveland Clinic, running 9 of these trials.
Enrollment posture brief
Registry condition atrial-fibrillation
OPEN 60 | RECR 29% | LATE 45 | EARLY 19 | RANK #46 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Addiction (29% recruiting · 17 trials)
Atrial Fibrillation lists 60 open slots (29% of 204 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Atrial Fibrillation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Atrial Fibrillation is recruiting below its size-band peers.
60 of 204 indexed trials (29.4%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Atrial Fibrillation trials is spread across many organizations.
The Cleveland Clinic accounts for 9 of 204 trials (4.4%). 109 distinct sponsors appear on at least one study for this condition label.
-
Typical Atrial Fibrillation enrolment sits around 200 participants.
Median target enrolment is 200 among the 203 trials that report a genuine target (sentinel values excluded). 59 of those (29.1%) plan for fewer than 100 participants.
-
Atrial Fibrillation splits between interventional and observational designs.
137 interventional and 67 observational studies make up this index (67.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
204 total, page 1 of 5
Get With the Guidelines Atrial Fibrillation Registry
American Heart Association
NCT06245187
Tracking Results of Ablations to Combat AF Registry Generation 2
AtriCure
NCT05111015
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
Johns Hopkins University
NCT05836987
The Fourth Left Atrial Appendage Occlusion Study
Hamilton Health Sciences Corporation
NCT05963698
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
Brigham and Women's Hospital
NCT01258231
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
Icahn School of Medicine at Mount Sinai
NCT04045665
The Vanderbilt Atrial Fibrillation Ablation Registry
Vanderbilt University
NCT02404415
Left Atrial Appendage Occlusion Registry (LAAO Registry)
American College of Cardiology
NCT02699957
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
Population Health Research Institute
NCT03968393
The CONFORM Pivotal Trial
Conformal Medical
NCT05147792
Pericardiotomy in Cardiac Surgery
Population Health Research Institute
NCT06486636
Volunteers to Investigate Best Results for Ablation and Novel Therapies for Atrial Fibrillation
University of California, San Francisco
NCT05504356
MANAGE-AF Registry -MANAGEment of Atrial Fibrillation Outcomes Registry (MANAGE-AF)
CorVita Science Foundation
NCT05978466
COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation
Stanford University
NCT02997254
Development of CIRC Technologies
The Cleveland Clinic
NCT05654272
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Yale University
NCT03907046
Safety and Efficacy of Workflows of High Volume Single Operators in a LAAO Device Implant Procedural Day
Heart Rhythm Clinical and Research Solutions
NCT06436924
PULSED AF Post-Approval Study
Medtronic Cardiac Ablation Solutions
NCT06578104
A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)
Biosense Webster
NCT06455098
Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation
Volta Medical
NCT06056271
Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure
Electrophysiology Research Foundation
NCT04160000
Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.
Tulane University School of Medicine
NCT04703166
A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System
Biosense Webster
NCT07227532
CardioFocus HeartLight Post-Approval Study
CardioFocus
NCT03168659
Mobile Health Technology-Enabled AFib Management
Johns Hopkins University
NCT06500988
Prospective Phenotyping for Genetic Subtypes of Early-onset Atrial Fibrillation
Vanderbilt University Medical Center
NCT05190679
A Study of Stellate Ganglion Block for Prevention of Atrial Fibrillation
Mayo Clinic
NCT05357690
The Dynamics of Human Atrial Fibrillation
Stanford University
NCT05366361
Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation
Vanderbilt University Medical Center
NCT06647459
The Z Stitch Early Bed Rest Assessment Study
Oregon Health and Science University
NCT06087497
Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation
University of Chicago
NCT06499857
Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies
Vanderbilt University Medical Center
NCT06575881
Positron Emission Tomography (PET) Imaging of Thrombosis
Massachusetts General Hospital
NCT03830320
A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation
Novartis Pharmaceuticals
NCT07217067
Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation
University of Illinois at Chicago
NCT02347111
Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR
Wake Forest University Health Sciences
NCT06376916
Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Brigham and Women's Hospital
NCT04880265
Warfarin Patient Self-management Implementation in the US Healthcare System
University of Utah
NCT04766216
CellFX® Nanosecond Pulsed Field Ablation (nsPFA)™ Cardiac Surgery Clamp System to Treat Atrial Fibrillation
Pulse Biosciences
NCT06959121
Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation
Icahn School of Medicine at Mount Sinai
NCT06938412
Machine Learning in Atrial Fibrillation
Stanford University
NCT05371405
Vascular Closure With a Device Compared to Manual Compression After Atrial Fibrillation Ablation: The LockeT II Study
Kansas City Heart Rhythm Research Foundation
NCT06078735
TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation
The Cleveland Clinic
NCT06802081
320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.
Johns Hopkins University
NCT06308094
Long-Term Outcomes of LAA Contrast Flow in CT Scans After Endocardial LAA Closure: The CF-CT Registry
Kansas City Heart Rhythm Research Foundation
NCT06075628
Intracardiac Echocardiography Guided Watchman Device Implant
The Cleveland Clinic
NCT06007872
Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer
OHSU Knight Cancer Institute
NCT06067438
Synaptic Plasticity in the Epicardial Ganglionated Plexi
University of Oklahoma
NCT05034419
Ondansetron for the Management of Atrial Fibrillation
Indiana University
NCT05844501
Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF
The Cleveland Clinic
NCT07122947
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 12 |
| Phase 3 | 26 |
| Phase 4 | 19 |
Top Sponsors
Named interventions
Most-linked intervention names on Atrial Fibrillation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Atrial Fibrillation trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Atrial Fibrillation page
204 registered trials, 60 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 60 Atrial Fibrillation trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- The Cleveland Clinic sponsors the most Atrial Fibrillation trials on record, review their full trial history before evaluating a specific study. See The Cleveland Clinic's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Atrial Fibrillation condition card totals 204 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.