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Atrial Fibrillation
Open-data reference.
204 US clinical trials · 60 currently recruiting
Active & Recent Trials
Get With the Guidelines Atrial Fibrillation Registry
American Heart Association
NCT06245187
Tracking Results of Ablations to Combat AF Registry Generation 2
AtriCure
NCT05111015
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
Johns Hopkins University
NCT05836987
The Fourth Left Atrial Appendage Occlusion Study
Hamilton Health Sciences Corporation
NCT05963698
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
Brigham and Women's Hospital
NCT01258231
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
Icahn School of Medicine at Mount Sinai
NCT04045665
The Vanderbilt Atrial Fibrillation Ablation Registry
Vanderbilt University
NCT02404415
Left Atrial Appendage Occlusion Registry (LAAO Registry)
American College of Cardiology
NCT02699957
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
Population Health Research Institute
NCT03968393
The CONFORM Pivotal Trial
Conformal Medical
NCT05147792
Pericardiotomy in Cardiac Surgery
Population Health Research Institute
NCT06486636
Volunteers to Investigate Best Results for Ablation and Novel Therapies for Atrial Fibrillation
University of California, San Francis
NCT05504356
MANAGE-AF Registry -MANAGEment of Atrial Fibrillation Outcomes Registry (MANAGE-AF)
CorVita Science Foundation
NCT05978466
COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation
Stanford University
NCT02997254
Development of CIRC Technologies
The Cleveland Clinic
NCT05654272
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Yale University
NCT03907046
Safety and Efficacy of Workflows of High Volume Single Operators in a LAAO Device Implant Procedural Day
Heart Rhythm Clinical and Research Solutions
NCT06436924
PULSED AF Post-Approval Study
Medtronic Cardiac Ablation Solutions
NCT06578104
A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)
Biosense Webster
NCT06455098
Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation
Volta Medical
NCT06056271
Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure
Electrophysiology Research Foundation
NCT04160000
Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.
Tulane University School of Medicine
NCT04703166
A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System
Biosense Webster
NCT07227532
CardioFocus HeartLight Post-Approval Study
CardioFocus
NCT03168659
Mobile Health Technology-Enabled AFib Management
Johns Hopkins University
NCT06500988
Prospective Phenotyping for Genetic Subtypes of Early-onset Atrial Fibrillation
Vanderbilt University Medical Center
NCT05190679
A Study of Stellate Ganglion Block for Prevention of Atrial Fibrillation
Mayo Clinic
NCT05357690
The Dynamics of Human Atrial Fibrillation
Stanford University
NCT05366361
Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation
Vanderbilt University Medical Center
NCT06647459
The Z Stitch Early Bed Rest Assessment Study
Oregon Health and Science University
NCT06087497
Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation
University of Chicago
NCT06499857
Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies
Vanderbilt University Medical Center
NCT06575881
Positron Emission Tomography (PET) Imaging of Thrombosis
Massachusetts General Hospital
NCT03830320
A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation
Novartis Pharmaceuticals
NCT07217067
Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation
University of Illinois at Chicago
NCT02347111
Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR
Wake Forest University Health Sciences
NCT06376916
Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Brigham and Women's Hospital
NCT04880265
Warfarin Patient Self-management Implementation in the US Healthcare System
University of Utah
NCT04766216
CellFX® Nanosecond Pulsed Field Ablation (nsPFA)™ Cardiac Surgery Clamp System to Treat Atrial Fibrillation
Pulse Biosciences
NCT06959121
Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation
Icahn School of Medicine at Mount Sinai
NCT06938412
Machine Learning in Atrial Fibrillation
Stanford University
NCT05371405
Vascular Closure With a Device Compared to Manual Compression After Atrial Fibrillation Ablation: The LockeT II Study
Kansas City Heart Rhythm Research Foundation
NCT06078735
TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation
The Cleveland Clinic
NCT06802081
320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.
Johns Hopkins University
NCT06308094
Long-Term Outcomes of LAA Contrast Flow in CT Scans After Endocardial LAA Closure: The CF-CT Registry
Kansas City Heart Rhythm Research Foundation
NCT06075628
Intracardiac Echocardiography Guided Watchman Device Implant
The Cleveland Clinic
NCT06007872
Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer
OHSU Knight Cancer Institute
NCT06067438
Synaptic Plasticity in the Epicardial Ganglionated Plexi
University of Oklahoma
NCT05034419
Ondansetron for the Management of Atrial Fibrillation
Indiana University
NCT05844501
Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF
The Cleveland Clinic
NCT07122947
Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone
University of Chicago
NCT06063538
Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study
Tulane University
NCT04814420
Use of 4D-ICE in Conjunction With TEE for Left Atrial Appendage Closure
Kansas City Heart Rhythm Research Foundation
NCT06061757
Renal Denervation + PVI vs PVI Alone for Persistent AF
University of Rochester
NCT05116384
Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors
Northwell Health
NCT05643235
Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Tulane University
NCT05014802
Safety and Efficacy of the Sentinel Cerebral Protection Device in Atrial Fibrillation Ablation
Malini Madhavan
NCT04685317
Chloroquine for Patients With Symptomatic Persistent Atrial Fibrillation: A Prospective Pilot Study
University of South Florida
NCT02932007
Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)
University of Oklahoma
NCT05174052
The CoAGulation Biomarkers and Atrial Fibrillation (COAG-AF) Pilot Study
Tulane University
NCT04947657
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
Janssen Research & Development
NCT05757869
Genomic Investigation of Cardiovascular Diseases
Scripps Translational Science Institute
NCT00722748
CHAMPION-AF Clinical Trial
Boston Scientific Corporation
NCT04394546
Amplatzer Amulet LAAO vs. NOAC
Abbott Medical Devices
NCT04226547
Realtime Diagnosis From Electrocardiogram Artificial Intelligence-Guided Screening for Atrial Fibrillation With Long Follow-Up (REGAL)
Mayo Clinic
NCT05923359
SIMPLAAFY Clinical Trial
Boston Scientific Corporation
NCT06521463
Confirm Rx Insertable Cardiac Monitor SMART Registry
Abbott Medical Devices
NCT03505801
PaTH Clinical Data Research Network (CDRN) Atrial Fibrillation (AF) Clinician-Patient Partnership Cohort
University of Pittsburgh
NCT02485288
Identification of Genetic, Biochemical and Hormonal Factors Contributing to Atrial Fibrillation
The Cleveland Clinic
NCT00599118
Electrocardiogram-based Artificial Intelligence-assisted Detection of Heart Disease
Tempus AI
NCT05442203
EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)
Population Health Research Institute
NCT03950076
STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation
McGill University Health Centre/Research Institute of the McGill University Health Centre
NCT04428944
Amulet™ ADVANCE LAA
Abbott Medical Devices
NCT05997446
Acute Cognitive Changes During Atrial Fibrillation Episodes (AFCOG)
David Brunk, PA-C, MMS
NCT04033510
Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients
University of Rochester
NCT04818645
RESOLVE-AF: Clinical Evaluation of the Ablacath™ Mapping Catheter and Ablamap® System Utilizing Electrographic Flow (EGF) Mapping to Resolve Extra-PV Sources of Atrial Fibrillation and Guide Ablation Therapy.
Cortex
NCT05883631
Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF
Massachusetts General Hospital
NCT06099730
REView of ProcEdural FactoRs and Outcomes After Atrial Fibrillation Ablation With Active Esophageal COOLing: A Sub-Study of the REAL AF Registry
Heart Rhythm Clinical and Research Solutions
NCT06354777
Implementing Prescriber-Pharmacist Collaborative Care for Evidence-based Anticoagulant Use
University of Michigan
NCT05351749
AF at Home: A Virtual Education Program for Patients With Atrial Fibrillation (AF)
University of North Carolina, Chapel Hill
NCT05810896
Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF)
Mina Chung, MD
NCT03603912
A Study of IV HBI-3000 for the Conversion Recent Onset Atrial Fibrillation (AF)
HUYABIO International
NCT04680026
Therapeutic Initial Heparin Dosing for Patients With Clots or Certain Heart Conditions Admitted to the Hospital
Inova Health Care Services
NCT07250763
ECG Validation Study
Analog Device
NCT05445726
Atrial Fibrillation (AF) and Electrocardiogram (EKG) Interpretation Project ECHO
University of North Carolina, Chapel Hill
NCT05890274
Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation
University of Rochester
NCT04922281
Ablation Versus Medical Management of Atrial Fibrillation in HFpEF
Inova Health Care Services
NCT04282850
Liraglutide Effect in Atrial Fibrillation
University of Miami
NCT03856632
Non-Invasive Median Nerve Stimulation to Attenuate Atrial Tachyarrhythmias After Catheter Ablation for Atrial Fibrillation
Icahn School of Medicine at Mount Sinai
NCT06748157
Replication of the ARISTOTLE Anticoagulant Trial in Healthcare Claims Data
Brigham and Women's Hospital
NCT04593030
Effectiveness of Oral Anticoagulants in Elderly Patients With Non-Valvular Atrial Fibrillation and Heart Failure
Bristol-Myers Squibb
NCT03508271
Real-world Comparative Effectiveness of Rivaroxaban Versus VKA
Bayer
NCT02690155
GLORIA-AF Registry Program - Second and Third Phases
Boehringer Ingelheim
NCT01468701
Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation
Bristol-Myers Squibb
NCT00412984
Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate
Boehringer Ingelheim
NCT00262600
Clinical Outcomes Among Non-valvular Atrial Fibrillation Patients With Renal Dysfunction
Bayer
NCT03359876
Real-world Dosing Patterns of Rivaroxaban in the United States
Bayer
NCT03242278
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications
University of Colorado, Denver
NCT03973931
Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE I)
Sanofi
NCT00249795
Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE A)
Sanofi
NCT00249873
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 7 |
| Phase 2 | 12 |
| Phase 3 | 26 |
| Phase 4 | 19 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Atrial Fibrillation Trial Landscape
ClinicalTrials.gov lists 204 US studies indexed under Atrial Fibrillation, and 60 of those are currently open to recruitment — roughly 29% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Atrial Fibrillation shows 45 late-stage studies (Phase 3 and Phase 4 combined) alongside 19 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Atrial Fibrillation is led by The Cleveland Clinic with 9 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Atrial Fibrillation?
PlainTrial tracks 204 US clinical trials for Atrial Fibrillation, of which 60 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Atrial Fibrillation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.