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2026 data Public-data reference. official source

Atrial Fibrillation

Open-data reference.

204 US clinical trials · 60 currently recruiting

Active & Recent Trials

RECRUITING 17,198 participants

Get With the Guidelines Atrial Fibrillation Registry

American Heart Association

NCT06245187

RECRUITING 10,000 participants

Tracking Results of Ablations to Combat AF Registry Generation 2

AtriCure

NCT05111015

RECRUITING Phase 3 5,350 participants

The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

Johns Hopkins University

NCT05836987

RECRUITING NA 4,000 participants

The Fourth Left Atrial Appendage Occlusion Study

Hamilton Health Sciences Corporation

NCT05963698

RECRUITING 4,000 participants

Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

Brigham and Women's Hospital

NCT01258231

RECRUITING Phase 3 3,200 participants

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Icahn School of Medicine at Mount Sinai

NCT04045665

RECRUITING 3,000 participants

The Vanderbilt Atrial Fibrillation Ablation Registry

Vanderbilt University

NCT02404415

RECRUITING 3,000 participants

Left Atrial Appendage Occlusion Registry (LAAO Registry)

American College of Cardiology

NCT02699957

RECRUITING Phase 4 2,270 participants

Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress

Population Health Research Institute

NCT03968393

RECRUITING NA 1,600 participants

The CONFORM Pivotal Trial

Conformal Medical

NCT05147792

RECRUITING NA 1,400 participants

Pericardiotomy in Cardiac Surgery

Population Health Research Institute

NCT06486636

RECRUITING 1,125 participants

Volunteers to Investigate Best Results for Ablation and Novel Therapies for Atrial Fibrillation

University of California, San Francis

NCT05504356

RECRUITING 1,000 participants

MANAGE-AF Registry -MANAGEment of Atrial Fibrillation Outcomes Registry (MANAGE-AF)

CorVita Science Foundation

NCT05978466

RECRUITING 1,000 participants

COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation

Stanford University

NCT02997254

RECRUITING 1,000 participants

Development of CIRC Technologies

The Cleveland Clinic

NCT05654272

RECRUITING Phase 3 700 participants

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Yale University

NCT03907046

RECRUITING 678 participants

Safety and Efficacy of Workflows of High Volume Single Operators in a LAAO Device Implant Procedural Day

Heart Rhythm Clinical and Research Solutions

NCT06436924

RECRUITING 580 participants

PULSED AF Post-Approval Study

Medtronic Cardiac Ablation Solutions

NCT06578104

RECRUITING NA 440 participants

A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)

Biosense Webster

NCT06455098

RECRUITING 400 participants

Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation

Volta Medical

NCT06056271

RECRUITING Phase 4 360 participants

Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure

Electrophysiology Research Foundation

NCT04160000

RECRUITING 360 participants

Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.

Tulane University School of Medicine

NCT04703166

RECRUITING NA 276 participants

A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System

Biosense Webster

NCT07227532

RECRUITING NA 250 participants

CardioFocus HeartLight Post-Approval Study

CardioFocus

NCT03168659

RECRUITING NA 248 participants

Mobile Health Technology-Enabled AFib Management

Johns Hopkins University

NCT06500988

RECRUITING 225 participants

Prospective Phenotyping for Genetic Subtypes of Early-onset Atrial Fibrillation

Vanderbilt University Medical Center

NCT05190679

RECRUITING Phase 2 220 participants

A Study of Stellate Ganglion Block for Prevention of Atrial Fibrillation

Mayo Clinic

NCT05357690

RECRUITING 200 participants

The Dynamics of Human Atrial Fibrillation

Stanford University

NCT05366361

RECRUITING 200 participants

Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation

Vanderbilt University Medical Center

NCT06647459

RECRUITING NA 200 participants

The Z Stitch Early Bed Rest Assessment Study

Oregon Health and Science University

NCT06087497

RECRUITING Phase 3 200 participants

Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

University of Chicago

NCT06499857

RECRUITING 200 participants

Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies

Vanderbilt University Medical Center

NCT06575881

RECRUITING Phase 1 165 participants

Positron Emission Tomography (PET) Imaging of Thrombosis

Massachusetts General Hospital

NCT03830320

RECRUITING Phase 2 165 participants

A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation

Novartis Pharmaceuticals

NCT07217067

RECRUITING Phase 4 162 participants

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

University of Illinois at Chicago

NCT02347111

RECRUITING Phase 3 153 participants

Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR

Wake Forest University Health Sciences

NCT06376916

RECRUITING 150 participants

Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Brigham and Women's Hospital

NCT04880265

RECRUITING NA 150 participants

Warfarin Patient Self-management Implementation in the US Healthcare System

University of Utah

NCT04766216

RECRUITING NA 135 participants

CellFX® Nanosecond Pulsed Field Ablation (nsPFA)™ Cardiac Surgery Clamp System to Treat Atrial Fibrillation

Pulse Biosciences

NCT06959121

RECRUITING NA 120 participants

Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation

Icahn School of Medicine at Mount Sinai

NCT06938412

RECRUITING 120 participants

Machine Learning in Atrial Fibrillation

Stanford University

NCT05371405

RECRUITING NA 110 participants

Vascular Closure With a Device Compared to Manual Compression After Atrial Fibrillation Ablation: The LockeT II Study

Kansas City Heart Rhythm Research Foundation

NCT06078735

RECRUITING Phase 2 100 participants

TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

The Cleveland Clinic

NCT06802081

RECRUITING NA 100 participants

320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.

Johns Hopkins University

NCT06308094

RECRUITING 100 participants

Long-Term Outcomes of LAA Contrast Flow in CT Scans After Endocardial LAA Closure: The CF-CT Registry

Kansas City Heart Rhythm Research Foundation

NCT06075628

RECRUITING NA 100 participants

Intracardiac Echocardiography Guided Watchman Device Implant

The Cleveland Clinic

NCT06007872

RECRUITING Phase 2 90 participants

Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer

OHSU Knight Cancer Institute

NCT06067438

RECRUITING Phase 1 90 participants

Synaptic Plasticity in the Epicardial Ganglionated Plexi

University of Oklahoma

NCT05034419

RECRUITING Phase 4 80 participants

Ondansetron for the Management of Atrial Fibrillation

Indiana University

NCT05844501

RECRUITING 75 participants

Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

The Cleveland Clinic

NCT07122947

RECRUITING Early Phase 1 63 participants

Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone

University of Chicago

NCT06063538

RECRUITING NA 60 participants

Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study

Tulane University

NCT04814420

RECRUITING NA 52 participants

Use of 4D-ICE in Conjunction With TEE for Left Atrial Appendage Closure

Kansas City Heart Rhythm Research Foundation

NCT06061757

RECRUITING NA 50 participants

Renal Denervation + PVI vs PVI Alone for Persistent AF

University of Rochester

NCT05116384

RECRUITING NA 50 participants

Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors

Northwell Health

NCT05643235

RECRUITING 50 participants

Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Tulane University

NCT05014802

RECRUITING NA 48 participants

Safety and Efficacy of the Sentinel Cerebral Protection Device in Atrial Fibrillation Ablation

Malini Madhavan

NCT04685317

RECRUITING Phase 2 40 participants

Chloroquine for Patients With Symptomatic Persistent Atrial Fibrillation: A Prospective Pilot Study

University of South Florida

NCT02932007

RECRUITING Phase 3 28 participants

Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)

University of Oklahoma

NCT05174052

RECRUITING 20 participants

The CoAGulation Biomarkers and Atrial Fibrillation (COAG-AF) Pilot Study

Tulane University

NCT04947657

ACTIVE NOT RECRUITING Phase 3 20,284 participants

A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation

Janssen Research & Development

NCT05757869

ACTIVE NOT RECRUITING 15,000 participants

Genomic Investigation of Cardiovascular Diseases

Scripps Translational Science Institute

NCT00722748

ACTIVE NOT RECRUITING NA 3,000 participants

CHAMPION-AF Clinical Trial

Boston Scientific Corporation

NCT04394546

ACTIVE NOT RECRUITING NA 2,650 participants

Amplatzer Amulet LAAO vs. NOAC

Abbott Medical Devices

NCT04226547

ACTIVE NOT RECRUITING NA 2,000 participants

Realtime Diagnosis From Electrocardiogram Artificial Intelligence-Guided Screening for Atrial Fibrillation With Long Follow-Up (REGAL)

Mayo Clinic

NCT05923359

ACTIVE NOT RECRUITING NA 1,857 participants

SIMPLAAFY Clinical Trial

Boston Scientific Corporation

NCT06521463

ACTIVE NOT RECRUITING 1,826 participants

Confirm Rx Insertable Cardiac Monitor SMART Registry

Abbott Medical Devices

NCT03505801

ACTIVE NOT RECRUITING 1,500 participants

PaTH Clinical Data Research Network (CDRN) Atrial Fibrillation (AF) Clinician-Patient Partnership Cohort

University of Pittsburgh

NCT02485288

ACTIVE NOT RECRUITING 1,300 participants

Identification of Genetic, Biochemical and Hormonal Factors Contributing to Atrial Fibrillation

The Cleveland Clinic

NCT00599118

ACTIVE NOT RECRUITING NA 1,000 participants

Electrocardiogram-based Artificial Intelligence-assisted Detection of Heart Disease

Tempus AI

NCT05442203

ACTIVE NOT RECRUITING Phase 4 948 participants

EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)

Population Health Research Institute

NCT03950076

ACTIVE NOT RECRUITING NA 617 participants

STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation

McGill University Health Centre/Research Institute of the McGill University Health Centre

NCT04428944

ACTIVE NOT RECRUITING 610 participants

Amulet™ ADVANCE LAA

Abbott Medical Devices

NCT05997446

ACTIVE NOT RECRUITING 600 participants

Acute Cognitive Changes During Atrial Fibrillation Episodes (AFCOG)

David Brunk, PA-C, MMS

NCT04033510

ACTIVE NOT RECRUITING NA 477 participants

Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients

University of Rochester

NCT04818645

ACTIVE NOT RECRUITING NA 400 participants

RESOLVE-AF: Clinical Evaluation of the Ablacath™ Mapping Catheter and Ablamap® System Utilizing Electrographic Flow (EGF) Mapping to Resolve Extra-PV Sources of Atrial Fibrillation and Guide Ablation Therapy.

Cortex

NCT05883631

ACTIVE NOT RECRUITING NA 360 participants

Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF

Massachusetts General Hospital

NCT06099730

ACTIVE NOT RECRUITING 312 participants

REView of ProcEdural FactoRs and Outcomes After Atrial Fibrillation Ablation With Active Esophageal COOLing: A Sub-Study of the REAL AF Registry

Heart Rhythm Clinical and Research Solutions

NCT06354777

ACTIVE NOT RECRUITING NA 306 participants

Implementing Prescriber-Pharmacist Collaborative Care for Evidence-based Anticoagulant Use

University of Michigan

NCT05351749

ACTIVE NOT RECRUITING NA 300 participants

AF at Home: A Virtual Education Program for Patients With Atrial Fibrillation (AF)

University of North Carolina, Chapel Hill

NCT05810896

ACTIVE NOT RECRUITING Phase 4 175 participants

Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF)

Mina Chung, MD

NCT03603912

ACTIVE NOT RECRUITING Phase 2 150 participants

A Study of IV HBI-3000 for the Conversion Recent Onset Atrial Fibrillation (AF)

HUYABIO International

NCT04680026

ACTIVE NOT RECRUITING Phase 4 145 participants

Therapeutic Initial Heparin Dosing for Patients With Clots or Certain Heart Conditions Admitted to the Hospital

Inova Health Care Services

NCT07250763

ACTIVE NOT RECRUITING Phase 2 141 participants

ECG Validation Study

Analog Device

NCT05445726

ACTIVE NOT RECRUITING NA 120 participants

Atrial Fibrillation (AF) and Electrocardiogram (EKG) Interpretation Project ECHO

University of North Carolina, Chapel Hill

NCT05890274

ACTIVE NOT RECRUITING NA 120 participants

Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation

University of Rochester

NCT04922281

ACTIVE NOT RECRUITING NA 60 participants

Ablation Versus Medical Management of Atrial Fibrillation in HFpEF

Inova Health Care Services

NCT04282850

ACTIVE NOT RECRUITING Phase 4 60 participants

Liraglutide Effect in Atrial Fibrillation

University of Miami

NCT03856632

ACTIVE NOT RECRUITING NA 34 participants

Non-Invasive Median Nerve Stimulation to Attenuate Atrial Tachyarrhythmias After Catheter Ablation for Atrial Fibrillation

Icahn School of Medicine at Mount Sinai

NCT06748157

COMPLETED 220,518 participants

Replication of the ARISTOTLE Anticoagulant Trial in Healthcare Claims Data

Brigham and Women's Hospital

NCT04593030

COMPLETED 60,000 participants

Effectiveness of Oral Anticoagulants in Elderly Patients With Non-Valvular Atrial Fibrillation and Heart Failure

Bristol-Myers Squibb

NCT03508271

COMPLETED 38,831 participants

Real-world Comparative Effectiveness of Rivaroxaban Versus VKA

Bayer

NCT02690155

COMPLETED 37,235 participants

GLORIA-AF Registry Program - Second and Third Phases

Boehringer Ingelheim

NCT01468701

COMPLETED Phase 3 20,976 participants

Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation

Bristol-Myers Squibb

NCT00412984

COMPLETED Phase 3 18,113 participants

Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate

Boehringer Ingelheim

NCT00262600

COMPLETED 16,000 participants

Clinical Outcomes Among Non-valvular Atrial Fibrillation Patients With Renal Dysfunction

Bayer

NCT03359876

COMPLETED 12,507 participants

Real-world Dosing Patterns of Rivaroxaban in the United States

Bayer

NCT03242278

COMPLETED NA 9,501 participants

Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications

University of Colorado, Denver

NCT03973931

COMPLETED Phase 3 9,016 participants

Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE I)

Sanofi

NCT00249795

COMPLETED Phase 3 7,554 participants

Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE A)

Sanofi

NCT00249873

Phase Distribution

PhaseTrial count
Early Phase 1 7
Phase 2 12
Phase 3 26
Phase 4 19

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Atrial Fibrillation Trial Landscape

ClinicalTrials.gov lists 204 US studies indexed under Atrial Fibrillation, and 60 of those are currently open to recruitment — roughly 29% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Atrial Fibrillation shows 45 late-stage studies (Phase 3 and Phase 4 combined) alongside 19 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Atrial Fibrillation is led by The Cleveland Clinic with 9 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Atrial Fibrillation?

PlainTrial tracks 204 US clinical trials for Atrial Fibrillation, of which 60 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Atrial Fibrillation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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