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Atrial Fibrillation clinical trials
60 of 204 indexed Atrial Fibrillation trials are currently recruiting.
204 US clinical trials · 60 currently recruiting
Atrial Fibrillation is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 60 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is The Cleveland Clinic, running 9 of these trials.
The research picture
Atrial Fibrillation has 204 registered US clinical trials, 60 of them open to new participants right now, about 29% of the total.
- 60
- recruiting participants now
- 29%
- of trials open to enrollment
- 45
- in Phase 3–4 (later-stage)
- 9
- top sponsor: The Cleveland Clinic
Active & Recent Trials
204 total, page 1 of 5
Get With the Guidelines Atrial Fibrillation Registry
American Heart Association
NCT06245187
Tracking Results of Ablations to Combat AF Registry Generation 2
AtriCure
NCT05111015
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
Johns Hopkins University
NCT05836987
The Fourth Left Atrial Appendage Occlusion Study
Hamilton Health Sciences Corporation
NCT05963698
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
Brigham and Women's Hospital
NCT01258231
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
Icahn School of Medicine at Mount Sinai
NCT04045665
The Vanderbilt Atrial Fibrillation Ablation Registry
Vanderbilt University
NCT02404415
Left Atrial Appendage Occlusion Registry (LAAO Registry)
American College of Cardiology
NCT02699957
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
Population Health Research Institute
NCT03968393
The CONFORM Pivotal Trial
Conformal Medical
NCT05147792
Pericardiotomy in Cardiac Surgery
Population Health Research Institute
NCT06486636
Volunteers to Investigate Best Results for Ablation and Novel Therapies for Atrial Fibrillation
University of California, San Francisco
NCT05504356
MANAGE-AF Registry -MANAGEment of Atrial Fibrillation Outcomes Registry (MANAGE-AF)
CorVita Science Foundation
NCT05978466
COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation
Stanford University
NCT02997254
Development of CIRC Technologies
The Cleveland Clinic
NCT05654272
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Yale University
NCT03907046
Safety and Efficacy of Workflows of High Volume Single Operators in a LAAO Device Implant Procedural Day
Heart Rhythm Clinical and Research Solutions
NCT06436924
PULSED AF Post-Approval Study
Medtronic Cardiac Ablation Solutions
NCT06578104
A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)
Biosense Webster
NCT06455098
Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation
Volta Medical
NCT06056271
Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure
Electrophysiology Research Foundation
NCT04160000
Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.
Tulane University School of Medicine
NCT04703166
A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System
Biosense Webster
NCT07227532
CardioFocus HeartLight Post-Approval Study
CardioFocus
NCT03168659
Mobile Health Technology-Enabled AFib Management
Johns Hopkins University
NCT06500988
Prospective Phenotyping for Genetic Subtypes of Early-onset Atrial Fibrillation
Vanderbilt University Medical Center
NCT05190679
A Study of Stellate Ganglion Block for Prevention of Atrial Fibrillation
Mayo Clinic
NCT05357690
The Dynamics of Human Atrial Fibrillation
Stanford University
NCT05366361
Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation
Vanderbilt University Medical Center
NCT06647459
The Z Stitch Early Bed Rest Assessment Study
Oregon Health and Science University
NCT06087497
Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation
University of Chicago
NCT06499857
Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies
Vanderbilt University Medical Center
NCT06575881
Positron Emission Tomography (PET) Imaging of Thrombosis
Massachusetts General Hospital
NCT03830320
A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation
Novartis Pharmaceuticals
NCT07217067
Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation
University of Illinois at Chicago
NCT02347111
Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR
Wake Forest University Health Sciences
NCT06376916
Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Brigham and Women's Hospital
NCT04880265
Warfarin Patient Self-management Implementation in the US Healthcare System
University of Utah
NCT04766216
CellFX® Nanosecond Pulsed Field Ablation (nsPFA)™ Cardiac Surgery Clamp System to Treat Atrial Fibrillation
Pulse Biosciences
NCT06959121
Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation
Icahn School of Medicine at Mount Sinai
NCT06938412
Machine Learning in Atrial Fibrillation
Stanford University
NCT05371405
Vascular Closure With a Device Compared to Manual Compression After Atrial Fibrillation Ablation: The LockeT II Study
Kansas City Heart Rhythm Research Foundation
NCT06078735
TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation
The Cleveland Clinic
NCT06802081
320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.
Johns Hopkins University
NCT06308094
Long-Term Outcomes of LAA Contrast Flow in CT Scans After Endocardial LAA Closure: The CF-CT Registry
Kansas City Heart Rhythm Research Foundation
NCT06075628
Intracardiac Echocardiography Guided Watchman Device Implant
The Cleveland Clinic
NCT06007872
Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer
OHSU Knight Cancer Institute
NCT06067438
Synaptic Plasticity in the Epicardial Ganglionated Plexi
University of Oklahoma
NCT05034419
Ondansetron for the Management of Atrial Fibrillation
Indiana University
NCT05844501
Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF
The Cleveland Clinic
NCT07122947
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 12 |
| Phase 3 | 26 |
| Phase 4 | 19 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Atrial Fibrillation Trial Landscape
204 indexed Atrial Fibrillation studies · 60 recruiting (29%).
Phase mix: 45 late (III/IV) vs 19 early (I/II).
Top sponsor: The Cleveland Clinic (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Atrial Fibrillation?
PlainTrial tracks 204 US clinical trials for Atrial Fibrillation, of which 60 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Atrial Fibrillation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.