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ClinicalTrials.gov 100 recruiting now official registry

Mild Cognitive Impairment clinical trials

100 of 206 indexed Mild Cognitive Impairment trials are currently recruiting.

206 US clinical trials · 100 currently recruiting

Mild Cognitive Impairment is the subject of 206 registered US clinical trials on ClinicalTrials.gov, 100 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 52 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 9 of these trials.

The research picture

Mild Cognitive Impairment has 206 registered US clinical trials, 100 of them open to new participants right now, about 49% of the total.

100
recruiting participants now
49%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
9
top sponsor: Massachusetts General Hospital
Phase 124Phase 228Phase 33Phase 45

Active & Recent Trials

206 total, page 3 of 5

ACTIVE NOT RECRUITING 1,400 participants

A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)

Eli Lilly and Company

NCT02951598

ACTIVE NOT RECRUITING Phase 3 629 participants

ACHIEVE Brain Health Follow-Up Study

Johns Hopkins University

NCT05532657

ACTIVE NOT RECRUITING 400 participants

Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey

C2N Diagnostics

NCT06025877

ACTIVE NOT RECRUITING NA 327 participants

MCI: CPAP Treatment of OSA (Memories2)

University of Pennsylvania

NCT03113461

ACTIVE NOT RECRUITING Phase 2 326 participants

Metformin in Alzheimer's Dementia Prevention

Columbia University

NCT04098666

ACTIVE NOT RECRUITING NA 318 participants

Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment

Oregon Research Institute

NCT04070703

ACTIVE NOT RECRUITING NA 293 participants

Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults

Northwestern University

NCT03960476

ACTIVE NOT RECRUITING NA 260 participants

Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain

Massachusetts General Hospital

NCT05373745

ACTIVE NOT RECRUITING NA 238 participants

Music Improvisation Training on Cognitive Function in Older Adults

University of California, San Francisco

NCT06721390

ACTIVE NOT RECRUITING NA 236 participants

A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos

University of Pennsylvania

NCT05030948

ACTIVE NOT RECRUITING NA 200 participants

Supportive Care for Cognitively Impaired Patients and Families

Stanford University

NCT03881579

ACTIVE NOT RECRUITING Phase 2 196 participants

Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)

NYU Langone Health

NCT04784416

ACTIVE NOT RECRUITING Phase 2 180 participants

The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's

Weill Medical College of Cornell University

NCT03649724

ACTIVE NOT RECRUITING Phase 2 180 participants

A Novel Computer-Based Functional Skills Assessment and Training Program

i-Function

NCT04679441

ACTIVE NOT RECRUITING NA 172 participants

Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure

Indiana University

NCT05601817

ACTIVE NOT RECRUITING 150 participants

Linking Tau PET to Medial Temporal Lobe Subregions With High Resolution MRI

University of Pennsylvania

NCT04251130

ACTIVE NOT RECRUITING Phase 4 121 participants

Water-based Activity to Enhance Recall in Veterans

VA Office of Research and Development

NCT04296565

ACTIVE NOT RECRUITING NA 120 participants

Everyday Memory Impairment in PD-related Cognitive Decline

Washington University School of Medicine

NCT04474379

ACTIVE NOT RECRUITING NA 112 participants

Neurofeedback to Improve Working Memory in Mild Cognitive Impairment

University of California, San Diego

NCT04566900

ACTIVE NOT RECRUITING NA 100 participants

Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure

University of Michigan

NCT05584241

ACTIVE NOT RECRUITING Phase 2 99 participants

NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)

Aptinyx

NCT04148391

ACTIVE NOT RECRUITING NA 95 participants

The Brain Health Champion Study

Brigham and Women's Hospital

NCT03772977

ACTIVE NOT RECRUITING NA 84 participants

Remote Game-based Exercise Program for Cognitive and Motor Function Improvement

University of California, Los Angeles

NCT05235113

ACTIVE NOT RECRUITING Phase 2 64 participants

Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging

Gregory Jicha, MD, PhD

NCT04120766

ACTIVE NOT RECRUITING NA 61 participants

A Scalable Nutrition Adherence Intervention

Florida State University

NCT06121986

ACTIVE NOT RECRUITING Early Phase 1 60 participants

Glutathione in Mild Cognitive Impairment

Baylor College of Medicine

NCT03493178

ACTIVE NOT RECRUITING NA 60 participants

Multi-Center Study of Sensory Stimulation to Improve Brain Function

Cognito Therapeutics

NCT03556280

ACTIVE NOT RECRUITING Early Phase 1 57 participants

Multi-Center Development of a Novel Diagnostic Test for Alzheimer's Disease

Boston University

NCT03560960

ACTIVE NOT RECRUITING Phase 2 48 participants

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study

Washington University School of Medicine

NCT04685590

ACTIVE NOT RECRUITING NA 45 participants

PRogram to Improve Stress-levels and Enhance Memory

Emory University

NCT05845918

ACTIVE NOT RECRUITING Phase 1 35 participants

rTMS in Older Adults With MCI and AUD

Medical University of South Carolina

NCT05896332

ACTIVE NOT RECRUITING Phase 1 20 participants

ALSENLITE: Senolytics for Alzheimer's Disease

Mayo Clinic

NCT04785300

ACTIVE NOT RECRUITING Early Phase 1 15 participants

Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Disease Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy

Ali Rezai

NCT05469009

ACTIVE NOT RECRUITING Phase 2 15 participants

Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment

Icahn School of Medicine at Mount Sinai

NCT06069843

ACTIVE NOT RECRUITING Phase 1 14 participants

Care Partner-Assisted Diabetes Self-Management Through Linking Continuous Glucose Monitoring With Mobile Health: Improving Outcomes for Older Adults With Mild Cognitive Impairment

NYU Langone Health

NCT05601583

COMPLETED 18,488 participants

Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Study

American College of Radiology

NCT02420756

COMPLETED 4,884 participants

Genetic Studies in Familial Dementia

University of Miami

NCT04680013

COMPLETED 1,083 participants

An Observational Study for Analysis of Mortality in Participants Who Participated in Previous 3 Studies of Galantamine

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

NCT00297414

COMPLETED NA 524 participants

Cognitive Assessment of Elderly Primary Care Patients

University of Pittsburgh

NCT01492335

COMPLETED 366 participants

Quality Improvement PrecivityAD Clinician Survey (QUIP I)

C2N Diagnostics

NCT05477056

COMPLETED Phase 3 365 participants

Assess the Prognostic Usefulness of Flutemetamol (18F) Injection for Identifying Subjects With Amnestic Mild Cognitive Impairment Who Will Convert to Clinically Probable Alzheimer's Disease

GE Healthcare

NCT01028053

COMPLETED 342 participants

Alzheimer's Disease Neuroimaging Initiative Grand Opportunity

Alzheimer's Disease Cooperative Study (ADCS)

NCT01078636

COMPLETED NA 216 participants

In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment

University of California, Berkeley

NCT04206670

COMPLETED 204 participants

NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support)

Pamlab

NCT01370954

COMPLETED NA 201 participants

Cognitive and Aerobic Resilience for the Brain

Indiana University

NCT02390453

COMPLETED NA 186 participants

Internet-based Conversational Engagement Clinical Trial

Massachusetts General Hospital

NCT02871921

COMPLETED 165 participants

Enriching Clinical Trials Requiring Amyloid Positivity With Practice Effects

University of Utah

NCT03466736

COMPLETED Phase 2 164 participants

Study of AGB101 in Mild Cognitive Impairment Due to Alzheimer's Disease

AgeneBio

NCT03486938

COMPLETED 153 participants

A Study of a Self-Administered Memory Screening Test With Automated Reporting (SAMSTAR) in Participants With Mild Cognitive Impairment

Janssen Research & Development

NCT02419183

COMPLETED Phase 2 145 participants

Health Beliefs, Glycemic Control, and Preventing Cognitive Decline in African Americans with Diabetes and Mild Cognitive Impairment: a Randomized Clinical Trial

Thomas Jefferson University

NCT04259047

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Phase Distribution

PhaseTrial count
Phase 1 24
Phase 2 28
Phase 3 3
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Mild Cognitive Impairment Trial Landscape

206 indexed Mild Cognitive Impairment studies · 100 recruiting (49%).

Phase mix: 8 late (III/IV) vs 52 early (I/II).

Top sponsor: Massachusetts General Hospital (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Mild Cognitive Impairment?

PlainTrial tracks 206 US clinical trials for Mild Cognitive Impairment, of which 100 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Mild Cognitive Impairment?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.