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Mild Cognitive Impairment clinical trials
100 of 206 indexed Mild Cognitive Impairment trials are currently recruiting.
206 US clinical trials · 100 currently recruiting
Mild Cognitive Impairment is the subject of 206 registered US clinical trials on ClinicalTrials.gov, 100 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 52 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 9 of these trials.
The research picture
Mild Cognitive Impairment has 206 registered US clinical trials, 100 of them open to new participants right now, about 49% of the total.
- 100
- recruiting participants now
- 49%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 9
- top sponsor: Massachusetts General Hospital
Active & Recent Trials
206 total, page 3 of 5
A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
Eli Lilly and Company
NCT02951598
ACHIEVE Brain Health Follow-Up Study
Johns Hopkins University
NCT05532657
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
C2N Diagnostics
NCT06025877
MCI: CPAP Treatment of OSA (Memories2)
University of Pennsylvania
NCT03113461
Metformin in Alzheimer's Dementia Prevention
Columbia University
NCT04098666
Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment
Oregon Research Institute
NCT04070703
Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults
Northwestern University
NCT03960476
Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain
Massachusetts General Hospital
NCT05373745
Music Improvisation Training on Cognitive Function in Older Adults
University of California, San Francisco
NCT06721390
A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos
University of Pennsylvania
NCT05030948
Supportive Care for Cognitively Impaired Patients and Families
Stanford University
NCT03881579
Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)
NYU Langone Health
NCT04784416
The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's
Weill Medical College of Cornell University
NCT03649724
A Novel Computer-Based Functional Skills Assessment and Training Program
i-Function
NCT04679441
Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure
Indiana University
NCT05601817
Linking Tau PET to Medial Temporal Lobe Subregions With High Resolution MRI
University of Pennsylvania
NCT04251130
Water-based Activity to Enhance Recall in Veterans
VA Office of Research and Development
NCT04296565
Everyday Memory Impairment in PD-related Cognitive Decline
Washington University School of Medicine
NCT04474379
Neurofeedback to Improve Working Memory in Mild Cognitive Impairment
University of California, San Diego
NCT04566900
Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure
University of Michigan
NCT05584241
NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)
Aptinyx
NCT04148391
The Brain Health Champion Study
Brigham and Women's Hospital
NCT03772977
Remote Game-based Exercise Program for Cognitive and Motor Function Improvement
University of California, Los Angeles
NCT05235113
Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging
Gregory Jicha, MD, PhD
NCT04120766
A Scalable Nutrition Adherence Intervention
Florida State University
NCT06121986
Glutathione in Mild Cognitive Impairment
Baylor College of Medicine
NCT03493178
Multi-Center Study of Sensory Stimulation to Improve Brain Function
Cognito Therapeutics
NCT03556280
Multi-Center Development of a Novel Diagnostic Test for Alzheimer's Disease
Boston University
NCT03560960
Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study
Washington University School of Medicine
NCT04685590
PRogram to Improve Stress-levels and Enhance Memory
Emory University
NCT05845918
rTMS in Older Adults With MCI and AUD
Medical University of South Carolina
NCT05896332
ALSENLITE: Senolytics for Alzheimer's Disease
Mayo Clinic
NCT04785300
Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Disease Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy
Ali Rezai
NCT05469009
Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment
Icahn School of Medicine at Mount Sinai
NCT06069843
Care Partner-Assisted Diabetes Self-Management Through Linking Continuous Glucose Monitoring With Mobile Health: Improving Outcomes for Older Adults With Mild Cognitive Impairment
NYU Langone Health
NCT05601583
Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Study
American College of Radiology
NCT02420756
Genetic Studies in Familial Dementia
University of Miami
NCT04680013
An Observational Study for Analysis of Mortality in Participants Who Participated in Previous 3 Studies of Galantamine
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
NCT00297414
Cognitive Assessment of Elderly Primary Care Patients
University of Pittsburgh
NCT01492335
Quality Improvement PrecivityAD Clinician Survey (QUIP I)
C2N Diagnostics
NCT05477056
Assess the Prognostic Usefulness of Flutemetamol (18F) Injection for Identifying Subjects With Amnestic Mild Cognitive Impairment Who Will Convert to Clinically Probable Alzheimer's Disease
GE Healthcare
NCT01028053
Alzheimer's Disease Neuroimaging Initiative Grand Opportunity
Alzheimer's Disease Cooperative Study (ADCS)
NCT01078636
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment
University of California, Berkeley
NCT04206670
NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support)
Pamlab
NCT01370954
Cognitive and Aerobic Resilience for the Brain
Indiana University
NCT02390453
Internet-based Conversational Engagement Clinical Trial
Massachusetts General Hospital
NCT02871921
Enriching Clinical Trials Requiring Amyloid Positivity With Practice Effects
University of Utah
NCT03466736
Study of AGB101 in Mild Cognitive Impairment Due to Alzheimer's Disease
AgeneBio
NCT03486938
A Study of a Self-Administered Memory Screening Test With Automated Reporting (SAMSTAR) in Participants With Mild Cognitive Impairment
Janssen Research & Development
NCT02419183
Health Beliefs, Glycemic Control, and Preventing Cognitive Decline in African Americans with Diabetes and Mild Cognitive Impairment: a Randomized Clinical Trial
Thomas Jefferson University
NCT04259047
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 24 |
| Phase 2 | 28 |
| Phase 3 | 3 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Mild Cognitive Impairment Trial Landscape
206 indexed Mild Cognitive Impairment studies · 100 recruiting (49%).
Phase mix: 8 late (III/IV) vs 52 early (I/II).
Top sponsor: Massachusetts General Hospital (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Mild Cognitive Impairment?
PlainTrial tracks 206 US clinical trials for Mild Cognitive Impairment, of which 100 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Mild Cognitive Impairment?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.