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NCT05992831 · ClinicalTrials.gov registry record · NA
Transcranial Magnetic Stimulation for MCI
A NA study of Depression and Mild Cognitive Impairment, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT05992831: Recruiting NA study of Depression and Mild Cognitive Impairment, sponsored by Medical University of South Carolina.
NCT05992831 is a NA study of Depression and Mild Cognitive Impairment that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 60 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05992831, a NA study of Depression and Mild Cognitive Impairment, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this phase II study is to establish the dose-response curves of a safe and clinically feasible non-invasive brain stimulation technique (accelerated Transcranial Magnetic Stimulation (TMS)) to improve both depression and cognitive function in Mild Cognitive Impairment (MCI) patients with comorbid depression. It is known that TMS can effectively treat depression. Identifying the right dose of accelerated TMS in MCI patients is necessary prior to designing subsequent trials to determine efficacy. These results will inform future clinical trials of accelerated TMS for MCI, with the long-term goal of developing an efficacious treatment to prevent dementia.
Primary Outcome
The GDS is a \~3 minute self-report questionnaire of depression symptoms to which respondents answer yes/no (range=0-30, where higher scores indicate greater depression severity). Co-Participants will complete an informant-reported short form.
Conditions Studied
Interventions
- DEVICE Sham Comparator
- DEVICE Accelerated iTBS
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-06-18 |
| Est. Completion | 2028-04-30 |
| Phase | NA |
What NCT05992831 shows while recruiting
NCT05992831 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (92% lower).
The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Sham Comparator is the first listed.
NCT05992831 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT05992831 about?
NCT05992831 is a clinical study titled "Transcranial Magnetic Stimulation for MCI". The goal of this phase II study is to establish the dose-response curves of a safe and clinically feasible non-invasive brain stimulation technique (accelerated Transcranial Magnetic Stimulation (TMS)) to improve both depression and cognitive function in Mild Cognitive Impairment (MCI) patients with...
What is the current status of trial NCT05992831?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2024-06-18. Estimated completion is 2028-04-30.
What conditions does trial NCT05992831 study?
This clinical trial studies the following conditions: Depression, Mild Cognitive Impairment.
What interventions are being tested in trial NCT05992831?
The interventions under investigation include: Sham Comparator (DEVICE), Accelerated iTBS (DEVICE).
Who is sponsoring clinical trial NCT05992831?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05992831 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05992831's enrollment target sits among peer trials
60 428th of 679 higher than 234 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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