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ClinicalTrials.gov 49 recruiting now official registry

Diabetes Mellitus clinical trials

49 of 210 indexed Diabetes Mellitus trials are currently recruiting.

210 US clinical trials · 49 currently recruiting

Diabetes Mellitus is the subject of 210 registered US clinical trials on ClinicalTrials.gov, 49 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 32 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 8 of these trials.

The research picture

Diabetes Mellitus has 210 registered US clinical trials, 49 of them open to new participants right now, about 23% of the total.

49
recruiting participants now
23%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
8
top sponsor: Takeda
Phase 113Phase 219Phase 318Phase 48

Active & Recent Trials

210 total, page 1 of 5

RECRUITING 100,000 participants

Family Investigation of Nephropathy and Diabetes (F.I.N.D.)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00342927

RECRUITING 50,000 participants

The T1D Exchange Registry

T1D Exchange, United States

NCT04629586

RECRUITING 19,331 participants

Examining Digital Health Care Delivery Models Through Medicaid Collaborative

OSF Healthcare System

NCT05555095

RECRUITING 5,000 participants

Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study

Washington University School of Medicine

NCT02841553

RECRUITING 4,000 participants

Genetics Of Autoimmunity In Type I Diabetes

Medical College of Wisconsin

NCT03648918

RECRUITING 2,000 participants

Rare and Atypical Diabetes Network

University of South Florida

NCT05544266

RECRUITING 1,500 participants

Early Tracking of Childhood Health Determinants (ETCHED) Study

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT03481829

RECRUITING 1,200 participants

Genetic Studies of Insulin and Diabetes

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00001987

RECRUITING NA 1,200 participants

Comparing Healthcare Visit Recording and Open Notes to Improve Chronic iLlness Care Experience in Older Adults

Dartmouth-Hitchcock Medical Center

NCT05955339

RECRUITING NA 978 participants

Lifestyle Interventions to Prevent Diabetes in U.S. Home Visiting Programs

California Polytechnic State University-San Luis Obispo

NCT06988306

RECRUITING 800 participants

Prolongation of GLP-1 Adherence When Using Continuous Glucose Monitoring

Abbott Diabetes Care

NCT06668935

RECRUITING NA 798 participants

Care Transitions App for Patients With Multiple Chronic Conditions

Brigham and Women's Hospital

NCT06051058

RECRUITING 500 participants

American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)

University of New Mexi

NCT04185844

RECRUITING 350 participants

Inflammation, Diabetes, Ethnicity and Obesity Cohort

University of California, San Francisco

NCT03022682

RECRUITING NA 318 participants

Increasing CGM Use Among Patients With T2D

San Diego State University

NCT06638099

RECRUITING NA 300 participants

Cardiovascular Kidney and Metabolic Health Assessment and Patient Empowerment

Aventyn

NCT07403669

RECRUITING NA 256 participants

FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)

University of North Carolina, Chapel Hill

NCT06724406

RECRUITING Phase 2 240 participants

Smart Walk: A Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women

Arizona State University

NCT06337708

RECRUITING NA 240 participants

Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

University of Colorado, Denver

NCT07011147

RECRUITING Phase 3 230 participants

A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer

Energenesis Biomedical Co.

NCT05930210

RECRUITING Phase 2 200 participants

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

University of Alabama at Birmingham

NCT04055428

RECRUITING NA 200 participants

ED Diabetes Screening and Outpatient Care

NYU Langone Health

NCT05899023

RECRUITING NA 200 participants

Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART

University of North Carolina, Chapel Hill

NCT06405373

RECRUITING NA 192 participants

Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease

Nationwide Children's Hospital

NCT03622359

RECRUITING NA 177 participants

Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUs

C5 Biomedical

NCT06674980

RECRUITING NA 175 participants

SPYRAL GEMINI Pilot Study

Medtronic Vascular

NCT06907147

RECRUITING Phase 2 150 participants

Effects of Ondansetron on Gastrointestinal Sensorimotor Dysfunctions in Diabetes Mellitus and Dyspepsia

Mayo Clinic

NCT03865290

RECRUITING Phase 4 150 participants

Impact GLP-1 Agonists Following Bariatric

University of Missouri-Columbia

NCT06132477

RECRUITING NA 150 participants

Inpatient Use of Personal Continuous Glucose Monitor (CGM) to Improve Diabetes Mellitus Control

Mayo Clinic

NCT07006480

RECRUITING 120 participants

The Diabetes Staging System in Patient Aligned Care Teams

Durham VA Medical Center

NCT06142006

RECRUITING NA 120 participants

A Fruit and Vegetable Prescription Program

Milton S. Hershey Medical Center

NCT06107816

RECRUITING NA 100 participants

Therapeutic Plantar Electrical Stimulation Intervention During Hemodialysis to Improve Balance and Mobility

Hamad Medical Corporation

NCT05407207

RECRUITING NA 100 participants

Texts for Diabetes Control Among Homeless Persons

George Washington University

NCT05616026

RECRUITING NA 100 participants

Total Contact Soft Cast in Diabetic Foot Ulcers

University of Minnesota

NCT04210089

RECRUITING Phase 2 100 participants

Repeat BCG Vaccinations for the Treatment of New Onset Type 1 Diabetes in Children Age 8-<18 Years

Massachusetts General Hospital

NCT05866536

RECRUITING NA 100 participants

Continuous Glucose Monitor for Mayo Clinic Advanced Care at Home Patients

Mayo Clinic

NCT05880810

RECRUITING NA 72 participants

A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

University of Connecticut

NCT07238556

RECRUITING NA 54 participants

Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation

VA Office of Research and Development

NCT03995238

RECRUITING NA 50 participants

Improving Glycemic Control With Telemedicine and Smart Insulin Pens

University of Maryland, Baltimore

NCT06918977

RECRUITING NA 48 participants

Full Plate Living Nutrition Education Program

University of Wisconsin, Madison

NCT07271940

RECRUITING Phase 2 42 participants

Sleep, Diabetic Retinopathy and Melatonin

University of Illinois at Chicago

NCT04547439

RECRUITING Phase 2 40 participants

Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis Associated Diabetes Mellitus

Mayo Clinic

NCT06729996

RECRUITING NA 40 participants

Impact of Per Oral Pyloromyotomy (POP) on Glycemic Control in Diabetes

Matthew Allemang

NCT04696159

RECRUITING 37 participants

This Study is to Evaluate Whether Receiving Education and Glucose Monitoring With the CGM Device Will Improve Patient-reported Outcomes by Improving Patient's Satisfaction and Quality of Life (QOL) With Glucose Monitoring Device

Cedars-Sinai Medical Center

NCT06965803

RECRUITING Phase 3 28 participants

Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)

University of Oklahoma

NCT05174052

RECRUITING NA 25 participants

Innovative Multi-Variable Biofeedback for Improving Gait Performance in Individuals With Diabetic Peripheral Neuropathy

Florida Institute for Human and Machine Cognition

NCT06591780

RECRUITING 25 participants

Diabetic Neuropathy in Spinal Cord Stimulator Patients

University of Chicago

NCT04687215

RECRUITING NA 20 participants

Screening and Nutrition for Patients With Diabetes: A Pilot Study

Villanova University

NCT05674110

RECRUITING Phase 1 18 participants

A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer

Memorial Sloan Kettering Cancer Center

NCT06623396

ACTIVE NOT RECRUITING NA 8,869 participants

Early Detection Initiative for Pancreatic Cancer

Pancreatic Cancer Action Network

NCT04662879

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Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 19
Phase 3 18
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetes Mellitus Trial Landscape

210 indexed Diabetes Mellitus studies · 49 recruiting (23%).

Phase mix: 26 late (III/IV) vs 32 early (I/II).

Top sponsor: Takeda (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetes Mellitus?

PlainTrial tracks 210 US clinical trials for Diabetes Mellitus, of which 49 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetes Mellitus?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.