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Diabetes Mellitus clinical trials
Every US clinical trial registered for Diabetes Mellitus — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
210 US clinical trials · 49 currently recruiting
The research picture
Diabetes Mellitus has 210 registered US clinical trials, 49 of them open to new participants right now — about 23% of the total.
- 49
- recruiting participants now
- 23%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 8
- top sponsor: Takeda
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Family Investigation of Nephropathy and Diabetes (F.I.N.D.)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00342927
The T1D Exchange Registry
T1D Exchange, United States
NCT04629586
Examining Digital Health Care Delivery Models Through Medicaid Collaborative
OSF Healthcare System
NCT05555095
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study
Washington University School of Medicine
NCT02841553
Genetics Of Autoimmunity In Type I Diabetes
Medical College of Wisconsin
NCT03648918
Rare and Atypical Diabetes Network
University of South Florida
NCT05544266
Early Tracking of Childhood Health Determinants (ETCHED) Study
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT03481829
Genetic Studies of Insulin and Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00001987
Comparing Healthcare Visit Recording and Open Notes to Improve Chronic iLlness Care Experience in Older Adults
Dartmouth-Hitchcock Medical Center
NCT05955339
Lifestyle Interventions to Prevent Diabetes in U.S. Home Visiting Programs
California Polytechnic State University-San Luis Obispo
NCT06988306
Prolongation of GLP-1 Adherence When Using Continuous Glucose Monitoring
Abbott Diabetes Care
NCT06668935
Care Transitions App for Patients With Multiple Chronic Conditions
Brigham and Women's Hospital
NCT06051058
American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)
University of New Mexi
NCT04185844
Inflammation, Diabetes, Ethnicity and Obesity Cohort
University of California, San Francis
NCT03022682
Increasing CGM Use Among Patients With T2D
San Diego State University
NCT06638099
Cardiovascular Kidney and Metabolic Health Assessment and Patient Empowerment
Aventyn
NCT07403669
FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)
University of North Carolina, Chapel Hill
NCT06724406
Smart Walk: A Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women
Arizona State University
NCT06337708
Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery
University of Colorado, Denver
NCT07011147
A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer
Energenesis Biomedical Co.
NCT05930210
NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals
University of Alabama at Birmingham
NCT04055428
ED Diabetes Screening and Outpatient Care
NYU Langone Health
NCT05899023
Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART
University of North Carolina, Chapel Hill
NCT06405373
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
Nationwide Children's Hospital
NCT03622359
Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUs
C5 Biomedical
NCT06674980
SPYRAL GEMINI Pilot Study
Medtronic Vascular
NCT06907147
Effects of Ondansetron on Gastrointestinal Sensorimotor Dysfunctions in Diabetes Mellitus and Dyspepsia
Mayo Clinic
NCT03865290
Impact GLP-1 Agonists Following Bariatric
University of Missouri-Columbia
NCT06132477
Inpatient Use of Personal Continuous Glucose Monitor (CGM) to Improve Diabetes Mellitus Control
Mayo Clinic
NCT07006480
The Diabetes Staging System in Patient Aligned Care Teams
Durham VA Medical Center
NCT06142006
A Fruit and Vegetable Prescription Program
Milton S. Hershey Medical Center
NCT06107816
Therapeutic Plantar Electrical Stimulation Intervention During Hemodialysis to Improve Balance and Mobility
Hamad Medical Corporation
NCT05407207
Texts for Diabetes Control Among Homeless Persons
George Washington University
NCT05616026
Total Contact Soft Cast in Diabetic Foot Ulcers
University of Minnesota
NCT04210089
Repeat BCG Vaccinations for the Treatment of New Onset Type 1 Diabetes in Children Age 8-<18 Years
Massachusetts General Hospital
NCT05866536
Continuous Glucose Monitor for Mayo Clinic Advanced Care at Home Patients
Mayo Clinic
NCT05880810
A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors
University of Connecticut
NCT07238556
Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation
VA Office of Research and Development
NCT03995238
Improving Glycemic Control With Telemedicine and Smart Insulin Pens
University of Maryland, Baltimore
NCT06918977
Full Plate Living Nutrition Education Program
University of Wisconsin, Madison
NCT07271940
Sleep, Diabetic Retinopathy and Melatonin
University of Illinois at Chicago
NCT04547439
Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis Associated Diabetes Mellitus
Mayo Clinic
NCT06729996
Impact of Per Oral Pyloromyotomy (POP) on Glycemic Control in Diabetes
Matthew Allemang
NCT04696159
This Study is to Evaluate Whether Receiving Education and Glucose Monitoring With the CGM Device Will Improve Patient-reported Outcomes by Improving Patient's Satisfaction and Quality of Life (QOL) With Glucose Monitoring Device
Cedars-Sinai Medical Center
NCT06965803
Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)
University of Oklahoma
NCT05174052
Innovative Multi-Variable Biofeedback for Improving Gait Performance in Individuals With Diabetic Peripheral Neuropathy
Florida Institute for Human and Machine Cognition
NCT06591780
Diabetic Neuropathy in Spinal Cord Stimulator Patients
University of Chicago
NCT04687215
Screening and Nutrition for Patients With Diabetes: A Pilot Study
Villanova University
NCT05674110
A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer
Memorial Sloan Kettering Cancer Center
NCT06623396
Early Detection Initiative for Pancreatic Cancer
Pancreatic Cancer Action Network
NCT04662879
Cardiovascular Health Study (CHS)
National Heart, Lung, and Blood Institute (NHLBI)
NCT00005133
Eat Well Produce Benefit for Diabetes and Food Insecurity
Duke University
NCT05896644
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
Medtronic Vascular
NCT05198674
Dissemination of the Cardiovascular Risk Service
Korey Kennelty
NCT03660631
Biological Sample Repository for Gastrointestinal Disorders
Pichamol Jirapinyo, MD, MPH
NCT05874726
Eat, Move, Live Program for the Reduction of Cancer and Chronic Disease Risk in Underserved Communities
City of Hope Medical Center
NCT05414396
Oral Anti Diabetic Agents in the Hospital
Emory University
NCT04416269
Texting for Diabetes
St. Louis University
NCT03025984
The REST Study for CGM Use in Older Adults With Insulin-treated Diabetes
Joslin Diabetes Center
NCT05337826
People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT03520660
Black Girls Move Physical Activity and Improving Dietary Intake Among Black Adolescent Daughters
Rush University Medical Center
NCT05433415
Glucose Metabolism in Sickle Cell Disease
University of Illinois at Chicago
NCT02922296
A Sugar-Sweetened Beverage Reduction Intervention for Native American Men
Roswell Park Cancer Institute
NCT06029517
Continuous Glucose Monitoring of Hospitalized Patients With Diabetes
Baylor Research Institute
NCT04230694
Glycemic Emergency Management (GEM); An App for Rapid Response to Hypoglycemic and Hyperglycemic Situations
Marshall University
NCT02336217
Food is Medicine vs Lifestyle Medicine For Cardiovascular Kidney Metabolic (CKM) Syndrome
Rutgers, The State University of New Jersey
NCT06461273
Study of a Primary Care Hypoglycemia Prevention Program
Johns Hopkins University
NCT06353217
Community Health Workers in Pediatric Patients With Newly Diagnosed Type 1 Diabetes
Children's Hospital of Philadelphia
NCT04238949
Plant-based Diet for Kidney Transplant Recipients
George Washington University
NCT06186843
Enhancing Mental and Physical Health of Women Veterans
VA Office of Research and Development
NCT05050266
Islet Transplantation Alone (ITA) in Patients With Difficult to Control Type I Diabetes Mellitus Using a Glucocorticoid-free Immunosuppressive Regimen
City of Hope Medical Center
NCT00706420
Evaluation of VLER-Indiana Health Information Exchange Demonstration Project
VA Office of Research and Development
NCT01446705
Evaluating the Navajo Community Outreach and Patient Empowerment (COPE) Program
Brigham and Women's Hospital
NCT03326206
Evaluation of a Dashboard for Diabetes Care Integrated With the Electronic Health Record
University of Utah
NCT03826290
Action to Control Cardiovascular Risk in Diabetes (ACCORD)
National Heart, Lung, and Blood Institute (NHLBI)
NCT00000620
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications
University of Colorado, Denver
NCT03973931
Blood Glucose Monitoring in Electronic Health Records
Inova Health Care Services
NCT03542487
Improving Diabetes in Primary Care (IMPACT)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00108927
Clinical Decision Support for Medication Management and Adherence
Duke University
NCT00979225
Glucose to Goal: A Model to Support Diabetes Management in Primary Care
University of Pittsburgh
NCT02715934
Improving Quality With Outpatient Decision Support
Agency for Healthcare Research and Quality (AHRQ)
NCT00225628
Study to Evaluate the Effectiveness of a Program Developed to Improve Eye Care for Veterans With Diabetes
US Department of Veterans Affairs
NCT00119535
Randomized Trial of Telemedicine for Diabetes Care
Columbia University
NCT00271739
Diabetes-Depression Care-management Adoption Trial
University of Southern California
NCT01781013
A Clinical Trial Assessing the Impact of the Availability of Inhaled Insulin on Glucose Control
Pfizer
NCT00134147
Efficacy of Alogliptin and Pioglitazone in Subjects With Type 2 Diabetes Mellitus
Takeda
NCT00432276
Integrating Community Health Workers to Improve Diabetes Prevention
NYU Langone Health
NCT03006666
CV Disease in Adolescents With Type 2 Diabetes
Children's Hospital Medical Center, Cincinnati
NCT00114998
Study to Compare Pioglitazone and Rosiglitazone in Subjects With Type 2 Diabetes Mellitus and Dyslipidemia
Takeda
NCT00331487
Cebranopadol Efficacy and Safety in Diabetic Patients Suffering From Chronic Pain Caused by Damage to the Nerves
Tris Pharma
NCT01939366
Phase 3 28-Week Study With 24-Week and 52-week Extension Phases to Evaluate Efficacy and Safety of Exenatide Once Weekly and Dapagliflozin Versus Exenatide and Dapagliflozin Matching Placebo
AstraZeneca
NCT02229396
Meals MATTER: A Trial of Medically Tailored Meals 2 Weeks vs. 4 Weeks Post Hospital Discharge
Kaiser Permanente
NCT04351880
Evaluation of the Analytical Performance of ALLEGRO™ Instrument
Nova Biomedical
NCT04096313
Screening for Patients Needing Kidney, Kidney-Pancreas, or Islet-Cell Transplant
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00001859
Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus.
Takeda
NCT00727857
Effect of Care Management on Diabetes Outcomes
Minneapolis Veterans Affairs Medical Center
NCT00569556
Multidisciplinary Inpatient Palliative Care Intervention
Kaiser Permanente
NCT00325611
Efficacy Study of Pioglitazone Compared to Glimepiride on Coronary Atherosclerotic Disease Progression in Subjects With Type 2 Diabetes Mellitus
Takeda
NCT00225277
User Evaluation of the Invasive Component of the CNOGA TensorTip COMBO GLUCOMETER (CoG)
Sciema UG
NCT03870971
Efficacy and Safety of Alogliptin Combined With Metformin in Participants With Type 2 Diabetes Mellitus
Takeda
NCT00286442
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 13 |
| Phase 2 | 19 |
| Phase 3 | 18 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus Trial Landscape
ClinicalTrials.gov lists 210 US studies indexed under Diabetes Mellitus, and 49 of those are currently open to recruitment — roughly 23% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Diabetes Mellitus shows 26 late-stage studies (Phase 3 and Phase 4 combined) alongside 32 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Diabetes Mellitus is led by Takeda with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus?
PlainTrial tracks 210 US clinical trials for Diabetes Mellitus, of which 49 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.