Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Spinal Cord Injuries

Open-data reference.

203 US clinical trials · 108 currently recruiting

Active & Recent Trials

RECRUITING NA 764 participants

Human-like Robotic Controllers for Enhanced Motor Learning

Shirley Ryan AbilityLab

NCT04578665

RECRUITING NA 250 participants

Spinal Cord Injury Model Systems (SCIMS) - Education Module

University of Miami

NCT06003686

RECRUITING NA 250 participants

Virtual Walking Intervention for Neuropathic Pain in Spinal Cord Injury

Texas A&M University

NCT05005026

RECRUITING NA 228 participants

Hemodynamic Management Following Acute Traumatic Spinal Cord Injury

The University of Texas Health Science Center, Houston

NCT06451133

RECRUITING 200 participants

Effectiveness of the Collaborative Community Clinic for Persons With Spinal Cord Injury and Disease

Washington University School of Medicine

NCT04457206

RECRUITING Phase 2 196 participants

Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury

Temple University

NCT05317832

RECRUITING 160 participants

AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis

University of Alabama at Birmingham

NCT04721717

RECRUITING NA 160 participants

Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions

University of Pittsburgh

NCT02592291

RECRUITING NA 144 participants

Dosing of Overground Robotic Gait Training with Functional Outcomes and Neuroplasticity After Spinal Cord Injury

Baylor Research Institute

NCT05218447

RECRUITING 140 participants

SCIVAX: Biomarkers of Immune Dysfunction and Vaccine Responsiveness in Chronic SCI

Northwell Health

NCT05869968

RECRUITING NA 120 participants

Transcutaneous Tibial Nerve Stimulation for Spinal Cord Injury Neurogenic Bladder

The University of Texas Health Science Center, Houston

NCT04350359

RECRUITING Phase 2 120 participants

Intravesical LGG VS Saline Bladder Wash RCT

Medstar Health Research Institute

NCT05230511

RECRUITING NA 120 participants

Spinal Cord Stimulation and Training

Washington University School of Medicine

NCT05472584

RECRUITING NA 108 participants

Promoting Recovery Outcomes Through Precise Early Locomotor Interventions in Persons With Spinal Cord Injury

Milap Sandhu

NCT06176833

RECRUITING NA 100 participants

Epidural Stimulation After Neurologic Damage

University of Minnesota

NCT03026816

RECRUITING NA 100 participants

Non-invasive BCI-controlled Assistive Devices

University of Texas at Austin

NCT05183152

RECRUITING NA 96 participants

Telenutrition for Individuals With SCI

Santa Clara Valley Health & Hospital System

NCT05468437

RECRUITING NA 80 participants

Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury

Mayo Clinic

NCT07210411

RECRUITING 80 participants

Development of a Novel Evaluation Scale of Mental Body Representation (MBR) for Adults With Spinal Cord Injury

University of Minnesota

NCT07029802

RECRUITING NA 69 participants

Deciphering Preserved Autonomic Function After Spinal Cord Injury

Mayo Clinic

NCT04493372

RECRUITING NA 62 participants

BioFLO for Respiratory Recovery in SCI

University of Florida

NCT06011876

RECRUITING 60 participants

Role of Endothelial Function in SCI CVD Risk

Craig Hospital

NCT06443151

RECRUITING 60 participants

Patient and Caregiver Perspectives on Intravesical Instillations for Urinary Symptoms

Medstar Health Research Institute

NCT07390591

RECRUITING NA 60 participants

Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

The Methodist Hospital Research Institute

NCT06213012

RECRUITING NA 60 participants

Combination Therapy to Improve SCI Recovery.

Spaulding Rehabilitation Hospital

NCT05563103

RECRUITING NA 60 participants

The Impact of Expressive Emotional Writing on Facilitating Grief Resolution in Adults With Spinal Cord Injury

University of Alabama at Birmingham

NCT06147258

RECRUITING NA 60 participants

Low Oxygen Therapy to Enhance Walking Recovery After SCI.

Spaulding Rehabilitation Hospital

NCT06521723

RECRUITING NA 60 participants

Ketogenic Diet to Improve Neuro-recovery

Ohio State University

NCT03509571

RECRUITING NA 60 participants

Upper Extremity Functional Electrical Stimulation (FES) for Restoration of Upper Extremity Function After Spinal Cord Injury (SCI)

University of Miami

NCT06672458

RECRUITING NA 60 participants

ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury

ONWARD Medical

NCT07147296

RECRUITING NA 50 participants

Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI

Jill M. Wecht, Ed.D.

NCT06000592

RECRUITING Phase 4 50 participants

Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes

Marzieh Salehi

NCT06706284

RECRUITING NA 50 participants

Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching

Shirley Ryan AbilityLab

NCT05424172

RECRUITING NA 49 participants

Eccentric Muscle Training, Stimulation, and Biomarkers in SCI

Ohio State University

NCT05337982

RECRUITING 48 participants

Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury

Craig Hospital

NCT07227740

RECRUITING NA 48 participants

Virtual Walking Therapy for Neuropathic Pain Following Incomplete Spinal Cord Injury

Texas A&M University

NCT06330181

RECRUITING NA 44 participants

Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury

Spaulding Rehabilitation Hospital

NCT02323945

RECRUITING Phase 4 42 participants

Feasibility of Early Gabapentin as an Intervention for Neurorecovery

MetroHealth Medical Center

NCT05302999

RECRUITING NA 40 participants

HAPPINESS: cHAnging the Perceived Pain INtEnSity in Populations With Spinal Cord Injury and With Health Disparities: A Feasibility Study

University of Minnesota

NCT06140355

RECRUITING NA 40 participants

Physical Therapy Wound Care Modalities in Patients With Spinal Cord Injury (SCI)

Wake Forest University Health Sciences

NCT05458947

RECRUITING NA 40 participants

Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea

Wayne State University

NCT03736382

RECRUITING Phase 1 40 participants

NVG-291 in Spinal Cord Injury Subjects

NervGen Pharma

NCT05965700

RECRUITING NA 40 participants

MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury

Columbia University

NCT05553457

RECRUITING 40 participants

Endothelial Dysfunction After SCI

Craig Hospital

NCT07227727

RECRUITING NA 36 participants

Spinal Cord Stimulation for Respiratory Rehabilitation in Patients With Chronic Spinal Cord Injury

University of Louisville

NCT06019949

RECRUITING NA 36 participants

Upper Extremity Training for Chronic Cervical Spinal Cord Injury

Kessler Foundation

NCT04921592

RECRUITING NA 36 participants

Influence of Spinal Stimulation Frequency on Spasticity, Motor Control, and Pain After Spinal Cord Injury

Shepherd Center, Atlanta GA

NCT06214208

RECRUITING NA 36 participants

Task-specific Epidural Stimulation Study

University of Louisville

NCT03364660

RECRUITING NA 36 participants

Nomad P-KAFO Study

Shirley Ryan AbilityLab

NCT05644522

RECRUITING Phase 1 36 participants

Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury

EicOsis Human Health

NCT06438471

RECRUITING 35 participants

Impact of Gut Microbiome on Metabolic and Bowel Function During the First Year After Spinal Cord Injury

University of Alabama at Birmingham

NCT05670288

RECRUITING NA 30 participants

Spinal Cord Stimulation and Respiration After Injury

University of Louisville

NCT05178056

RECRUITING Phase 1 30 participants

Bacteriophage Therapy in Spinal Cord Injury Patients With Bacteriuria

Barbara Wells Trautner

NCT06559618

RECRUITING NA 30 participants

Utility of Multisensory Body-Representation in Spinal Cord Injury (SCI) With Pain

University of Miami

NCT06010251

RECRUITING NA 30 participants

Multi-speed Ergonomic Wheelchair

VA Office of Research and Development

NCT05776030

RECRUITING NA 30 participants

Multi-functional Neuroprosthetic System for Restoration of Motor Function in Spinal Cord Injury

Anne Bryden

NCT02329652

RECRUITING Phase 2 30 participants

Effects of 5HTP on the Injured Human Spinal Cord

University of Alberta

NCT04520178

RECRUITING NA 30 participants

Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury

Kessler Foundation

NCT05432999

RECRUITING NA 27 participants

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

Leigh R. Hochberg, MD, PhD.

NCT00912041

RECRUITING NA 26 participants

Spinal Cord Stimulation for Autonomic Recovery in Inpatient Rehabilitation After Acute SCI

University of Washington

NCT06540859

RECRUITING NA 25 participants

Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning

Medical University of South Carolina

NCT05094362

RECRUITING NA 24 participants

Dosing rTMS for Depression Post-SCI

VA Office of Research and Development

NCT05553353

RECRUITING Phase 2 24 participants

Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries

The University of Texas Medical Branch, Galveston

NCT04565925

RECRUITING NA 24 participants

Mild Intermittent Hypoxia: A Prophylactic for Autonomic Dysfunction in Individuals With Spinal Cord Injuries

VA Office of Research and Development

NCT05351827

RECRUITING NA 24 participants

Remote Ischemic Conditioning for PwSCI

Washington University School of Medicine

NCT07488793

RECRUITING NA 24 participants

A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI

Kessler Foundation

NCT06238492

RECRUITING Phase 2 21 participants

Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury

North Florida Foundation for Research and Education

NCT04460872

RECRUITING NA 20 participants

Transcutaneous Spinal Stimulation and Exercise for Locomotion

University of Washington

NCT03509558

RECRUITING NA 20 participants

High Intensity Training for Neurological Injury Using Overground Exoskeletons in Inpatient Rehabilitation

The University of Texas Health Science Center, Houston

NCT04973852

RECRUITING Phase 2 20 participants

Epidural Stimulation and Resistance Training After SCI

United States Department of Defense

NCT04782947

RECRUITING NA 20 participants

Yoga Breath Training to Improve Cardiorespiratory Synchrony in Spinal Cord Injury

Spaulding Rehabilitation Hospital

NCT06514950

RECRUITING NA 20 participants

Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study

Kessler Foundation

NCT06452264

RECRUITING NA 20 participants

Seated Balance Using the Indego™

James J. Peters Veterans Affairs Medical Center

NCT04047992

RECRUITING NA 20 participants

Transcutaneous Spinal Cord Stimulation in Children With Incomplete Spinal Cord Injury

Hugo W. Moser Research Institute at Kennedy Krieger

NCT06242873

RECRUITING NA 18 participants

AMPLIFY Study: Transcutaneous Spinal Direct Current Stimulation to Enhance Locomotor Rehabilitation After SCI

University of Florida

NCT05700942

RECRUITING NA 18 participants

Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

Mayo Clinic

NCT07210437

RECRUITING NA 16 participants

Locomotor and Bladder Function in Individuals With Acute Spinal Cord Injury

Claudia Angeli

NCT04879862

RECRUITING Early Phase 1 16 participants

Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury

University of Mississippi Medical Center

NCT06274021

RECRUITING NA 16 participants

Auricular Vagus Nerve Stimulation (aVNS) in Chronic Spinal Cord Injuries (SCI)

University of Miami

NCT06588608

RECRUITING Phase 1 16 participants

Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults With Neurogenic Detrusor Overactivity-related Incontinence Following Spinal Cord Injury Who Regularly Perform Clean Intermittent Catheterization

EG 427

NCT06596291

RECRUITING NA 16 participants

Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI

University of Washington

NCT06313515

RECRUITING NA 15 participants

Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI

Medical University of South Carolina

NCT05492188

RECRUITING NA 15 participants

Usability of the Adapted Rower for People With Spinal Cord Injury

University of South Carolina

NCT05959837

RECRUITING NA 15 participants

Abdominal Functional Electrical Stimulation to Improve Bowel Function in Spinal Cord Injury

Craig Hospital

NCT06345781

RECRUITING NA 15 participants

The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain

University of Minnesota

NCT05741788

RECRUITING NA 14 participants

Treatment of Depression Post-SCI

Medical University of South Carolina

NCT04263285

RECRUITING NA 13 participants

Diet and Exercise Solutions to Postprandial Hypotension

Ohio State University

NCT06882460

RECRUITING NA 13 participants

Grasp-Release Assessment of a Networked Neuroprosthesis Device

MetroHealth Medical Center

NCT05863754

RECRUITING NA 12 participants

Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury

University of California, Los Angeles

NCT04883463

RECRUITING NA 12 participants

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

University of California, San Francis

NCT04144972

RECRUITING NA 12 participants

Finding the Best Combination of Brain and Spinal Cord Stimulation With Hand Training After Spinal Cord Injury

Bronx VA Medical Center

NCT06104735

RECRUITING NA 12 participants

Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)

Kessler Foundation

NCT05731986

RECRUITING NA 12 participants

Brain-Controlled Spinal Stimulation Walking Therapy After Incomplete Spinal Cord Injury (SCI)

University of Miami

NCT06406855

RECRUITING NA 12 participants

Augmenting Rehabilitation Outcomes and Functional Neuroplasticity Using Epidural Stimulation of Cervical Spinal Cord

The Methodist Hospital Research Institute

NCT06225245

RECRUITING NA 12 participants

Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury

University of Mississippi Medical Center

NCT05457205

RECRUITING NA 10 participants

Evaluation of an Advanced Lower Extremity Neuroprostheses

Case Western Reserve University

NCT00623389

RECRUITING NA 10 participants

Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury

University of Louisville

NCT04032990

RECRUITING NA 10 participants

Neurostimulation for Respiratory Function After Spinal Cord Injury

Shirley Ryan AbilityLab

NCT05756894

RECRUITING NA 10 participants

Spinal Decompression Plus Nerve Graft Implantation Following TSCI

Francis Farhadi

NCT06243211

RECRUITING NA 9 participants

Closed-loop Spinal Stimulation for Restoration of Upper Extremity Function After Spinal Cord Injury

University of Washington

NCT05267951

Phase Distribution

PhaseTrial count
Early Phase 1 12
Phase 2 14
Phase 3 2
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Spinal Cord Injuries Trial Landscape

ClinicalTrials.gov lists 203 US studies indexed under Spinal Cord Injuries, and 108 of those are currently open to recruitment — roughly 53% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Spinal Cord Injuries shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 26 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Spinal Cord Injuries is led by University of Louisville with 9 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Spinal Cord Injuries?

PlainTrial tracks 203 US clinical trials for Spinal Cord Injuries, of which 108 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Spinal Cord Injuries?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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