Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Spinal Cord Injuries
Open-data reference.
203 US clinical trials · 108 currently recruiting
Active & Recent Trials
Human-like Robotic Controllers for Enhanced Motor Learning
Shirley Ryan AbilityLab
NCT04578665
Spinal Cord Injury Model Systems (SCIMS) - Education Module
University of Miami
NCT06003686
Virtual Walking Intervention for Neuropathic Pain in Spinal Cord Injury
Texas A&M University
NCT05005026
Hemodynamic Management Following Acute Traumatic Spinal Cord Injury
The University of Texas Health Science Center, Houston
NCT06451133
Effectiveness of the Collaborative Community Clinic for Persons With Spinal Cord Injury and Disease
Washington University School of Medicine
NCT04457206
Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury
Temple University
NCT05317832
AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis
University of Alabama at Birmingham
NCT04721717
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
University of Pittsburgh
NCT02592291
Dosing of Overground Robotic Gait Training with Functional Outcomes and Neuroplasticity After Spinal Cord Injury
Baylor Research Institute
NCT05218447
SCIVAX: Biomarkers of Immune Dysfunction and Vaccine Responsiveness in Chronic SCI
Northwell Health
NCT05869968
Transcutaneous Tibial Nerve Stimulation for Spinal Cord Injury Neurogenic Bladder
The University of Texas Health Science Center, Houston
NCT04350359
Intravesical LGG VS Saline Bladder Wash RCT
Medstar Health Research Institute
NCT05230511
Spinal Cord Stimulation and Training
Washington University School of Medicine
NCT05472584
Promoting Recovery Outcomes Through Precise Early Locomotor Interventions in Persons With Spinal Cord Injury
Milap Sandhu
NCT06176833
Epidural Stimulation After Neurologic Damage
University of Minnesota
NCT03026816
Non-invasive BCI-controlled Assistive Devices
University of Texas at Austin
NCT05183152
Telenutrition for Individuals With SCI
Santa Clara Valley Health & Hospital System
NCT05468437
Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury
Mayo Clinic
NCT07210411
Development of a Novel Evaluation Scale of Mental Body Representation (MBR) for Adults With Spinal Cord Injury
University of Minnesota
NCT07029802
Deciphering Preserved Autonomic Function After Spinal Cord Injury
Mayo Clinic
NCT04493372
BioFLO for Respiratory Recovery in SCI
University of Florida
NCT06011876
Role of Endothelial Function in SCI CVD Risk
Craig Hospital
NCT06443151
Patient and Caregiver Perspectives on Intravesical Instillations for Urinary Symptoms
Medstar Health Research Institute
NCT07390591
Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury
The Methodist Hospital Research Institute
NCT06213012
Combination Therapy to Improve SCI Recovery.
Spaulding Rehabilitation Hospital
NCT05563103
The Impact of Expressive Emotional Writing on Facilitating Grief Resolution in Adults With Spinal Cord Injury
University of Alabama at Birmingham
NCT06147258
Low Oxygen Therapy to Enhance Walking Recovery After SCI.
Spaulding Rehabilitation Hospital
NCT06521723
Ketogenic Diet to Improve Neuro-recovery
Ohio State University
NCT03509571
Upper Extremity Functional Electrical Stimulation (FES) for Restoration of Upper Extremity Function After Spinal Cord Injury (SCI)
University of Miami
NCT06672458
ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury
ONWARD Medical
NCT07147296
Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI
Jill M. Wecht, Ed.D.
NCT06000592
Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes
Marzieh Salehi
NCT06706284
Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching
Shirley Ryan AbilityLab
NCT05424172
Eccentric Muscle Training, Stimulation, and Biomarkers in SCI
Ohio State University
NCT05337982
Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury
Craig Hospital
NCT07227740
Virtual Walking Therapy for Neuropathic Pain Following Incomplete Spinal Cord Injury
Texas A&M University
NCT06330181
Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury
Spaulding Rehabilitation Hospital
NCT02323945
Feasibility of Early Gabapentin as an Intervention for Neurorecovery
MetroHealth Medical Center
NCT05302999
HAPPINESS: cHAnging the Perceived Pain INtEnSity in Populations With Spinal Cord Injury and With Health Disparities: A Feasibility Study
University of Minnesota
NCT06140355
Physical Therapy Wound Care Modalities in Patients With Spinal Cord Injury (SCI)
Wake Forest University Health Sciences
NCT05458947
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea
Wayne State University
NCT03736382
NVG-291 in Spinal Cord Injury Subjects
NervGen Pharma
NCT05965700
MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury
Columbia University
NCT05553457
Endothelial Dysfunction After SCI
Craig Hospital
NCT07227727
Spinal Cord Stimulation for Respiratory Rehabilitation in Patients With Chronic Spinal Cord Injury
University of Louisville
NCT06019949
Upper Extremity Training for Chronic Cervical Spinal Cord Injury
Kessler Foundation
NCT04921592
Influence of Spinal Stimulation Frequency on Spasticity, Motor Control, and Pain After Spinal Cord Injury
Shepherd Center, Atlanta GA
NCT06214208
Task-specific Epidural Stimulation Study
University of Louisville
NCT03364660
Nomad P-KAFO Study
Shirley Ryan AbilityLab
NCT05644522
Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury
EicOsis Human Health
NCT06438471
Impact of Gut Microbiome on Metabolic and Bowel Function During the First Year After Spinal Cord Injury
University of Alabama at Birmingham
NCT05670288
Spinal Cord Stimulation and Respiration After Injury
University of Louisville
NCT05178056
Bacteriophage Therapy in Spinal Cord Injury Patients With Bacteriuria
Barbara Wells Trautner
NCT06559618
Utility of Multisensory Body-Representation in Spinal Cord Injury (SCI) With Pain
University of Miami
NCT06010251
Multi-speed Ergonomic Wheelchair
VA Office of Research and Development
NCT05776030
Multi-functional Neuroprosthetic System for Restoration of Motor Function in Spinal Cord Injury
Anne Bryden
NCT02329652
Effects of 5HTP on the Injured Human Spinal Cord
University of Alberta
NCT04520178
Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury
Kessler Foundation
NCT05432999
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Leigh R. Hochberg, MD, PhD.
NCT00912041
Spinal Cord Stimulation for Autonomic Recovery in Inpatient Rehabilitation After Acute SCI
University of Washington
NCT06540859
Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning
Medical University of South Carolina
NCT05094362
Dosing rTMS for Depression Post-SCI
VA Office of Research and Development
NCT05553353
Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries
The University of Texas Medical Branch, Galveston
NCT04565925
Mild Intermittent Hypoxia: A Prophylactic for Autonomic Dysfunction in Individuals With Spinal Cord Injuries
VA Office of Research and Development
NCT05351827
Remote Ischemic Conditioning for PwSCI
Washington University School of Medicine
NCT07488793
A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI
Kessler Foundation
NCT06238492
Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
North Florida Foundation for Research and Education
NCT04460872
Transcutaneous Spinal Stimulation and Exercise for Locomotion
University of Washington
NCT03509558
High Intensity Training for Neurological Injury Using Overground Exoskeletons in Inpatient Rehabilitation
The University of Texas Health Science Center, Houston
NCT04973852
Epidural Stimulation and Resistance Training After SCI
United States Department of Defense
NCT04782947
Yoga Breath Training to Improve Cardiorespiratory Synchrony in Spinal Cord Injury
Spaulding Rehabilitation Hospital
NCT06514950
Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study
Kessler Foundation
NCT06452264
Seated Balance Using the Indego™
James J. Peters Veterans Affairs Medical Center
NCT04047992
Transcutaneous Spinal Cord Stimulation in Children With Incomplete Spinal Cord Injury
Hugo W. Moser Research Institute at Kennedy Krieger
NCT06242873
AMPLIFY Study: Transcutaneous Spinal Direct Current Stimulation to Enhance Locomotor Rehabilitation After SCI
University of Florida
NCT05700942
Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI
Mayo Clinic
NCT07210437
Locomotor and Bladder Function in Individuals With Acute Spinal Cord Injury
Claudia Angeli
NCT04879862
Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury
University of Mississippi Medical Center
NCT06274021
Auricular Vagus Nerve Stimulation (aVNS) in Chronic Spinal Cord Injuries (SCI)
University of Miami
NCT06588608
Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults With Neurogenic Detrusor Overactivity-related Incontinence Following Spinal Cord Injury Who Regularly Perform Clean Intermittent Catheterization
EG 427
NCT06596291
Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI
University of Washington
NCT06313515
Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
Medical University of South Carolina
NCT05492188
Usability of the Adapted Rower for People With Spinal Cord Injury
University of South Carolina
NCT05959837
Abdominal Functional Electrical Stimulation to Improve Bowel Function in Spinal Cord Injury
Craig Hospital
NCT06345781
The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain
University of Minnesota
NCT05741788
Treatment of Depression Post-SCI
Medical University of South Carolina
NCT04263285
Diet and Exercise Solutions to Postprandial Hypotension
Ohio State University
NCT06882460
Grasp-Release Assessment of a Networked Neuroprosthesis Device
MetroHealth Medical Center
NCT05863754
Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury
University of California, Los Angeles
NCT04883463
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
University of California, San Francis
NCT04144972
Finding the Best Combination of Brain and Spinal Cord Stimulation With Hand Training After Spinal Cord Injury
Bronx VA Medical Center
NCT06104735
Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)
Kessler Foundation
NCT05731986
Brain-Controlled Spinal Stimulation Walking Therapy After Incomplete Spinal Cord Injury (SCI)
University of Miami
NCT06406855
Augmenting Rehabilitation Outcomes and Functional Neuroplasticity Using Epidural Stimulation of Cervical Spinal Cord
The Methodist Hospital Research Institute
NCT06225245
Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury
University of Mississippi Medical Center
NCT05457205
Evaluation of an Advanced Lower Extremity Neuroprostheses
Case Western Reserve University
NCT00623389
Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury
University of Louisville
NCT04032990
Neurostimulation for Respiratory Function After Spinal Cord Injury
Shirley Ryan AbilityLab
NCT05756894
Spinal Decompression Plus Nerve Graft Implantation Following TSCI
Francis Farhadi
NCT06243211
Closed-loop Spinal Stimulation for Restoration of Upper Extremity Function After Spinal Cord Injury
University of Washington
NCT05267951
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 12 |
| Phase 2 | 14 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Spinal Cord Injuries Trial Landscape
ClinicalTrials.gov lists 203 US studies indexed under Spinal Cord Injuries, and 108 of those are currently open to recruitment — roughly 53% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Spinal Cord Injuries shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 26 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Spinal Cord Injuries is led by University of Louisville with 9 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Spinal Cord Injuries?
PlainTrial tracks 203 US clinical trials for Spinal Cord Injuries, of which 108 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Spinal Cord Injuries?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.