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ClinicalTrials.gov 126 recruiting now early-phase tilt #38 of 28,707 conditions

Aging: early-phase trial registry

126 of 263 indexed Aging trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #38 of 28,707 conditions by registered trial count.

263 US clinical trials · 126 currently recruiting · #38 of 28,707 conditions by registered trial count

Aging: 263 US clinical trials tracked, 126 recruiting.

Aging is the subject of 263 registered US clinical trials on ClinicalTrials.gov, 126 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 48 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 14 of these trials.

Enrollment posture brief

Registry condition aging

OPEN 126 | RECR 48% | LATE 14 | EARLY 48 | RANK #38 | SPON 14

Nearest open-share peer: Lung Non-Small Cell Carcinoma (48% recruiting · 48 trials)

Opioid Use Disorder60.5%Aging (this)48%Post Traumatic Stress Disord41.5%Head and Neck Cancer34.2%Melanoma33.1%
Open-enrollment share among volume-matched conditions near Aging

Aging lists 126 open slots (48% of 263 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Aging on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Aging is recruiting above its size-band peers.

    126 of 263 indexed trials (47.9%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Aging trials is spread across many organizations.

    University of Florida accounts for 14 of 263 trials (5.3%). 132 distinct sponsors appear on at least one study for this condition label.

  3. Most Aging trials plan to enrol fewer than 100 people.

    Median target enrolment is 66 among the 263 trials that report a genuine target (sentinel values excluded). 166 of those (63.1%) plan for fewer than 100 participants.

  4. Aging research is mostly interventional.

    228 interventional and 35 observational studies make up this index (86.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 129Phase 219Phase 36Phase 48

Open and recent trials

263 total, page 3 of 6

RECRUITING NA 32 participants

Far Red Light to Improve Functioning in PAD

Northwestern University

NCT06165016

RECRUITING NA 32 participants

ENhancing Exercise with LIGHT to Improve Functioning in PAD

Northwestern University

NCT06399900

RECRUITING Phase 4 32 participants

Skin Barrier Function and Inflammation in Aging: The BIA Study

University of California, San Francisco

NCT06750653

RECRUITING NA 30 participants

Ketone Ester And Salt (KEAS) in Older Adults

Indiana University

NCT06868719

RECRUITING 30 participants

Glucose Variability and Cognition in Prediabetes

University of Maryland, Baltimore

NCT04201600

RECRUITING Early Phase 1 30 participants

Examining the Effects of Theta Burst TMS on Brain Connectivity and Balance Ability in Older Adults With Balance Problems

Weinberg Medical Physics

NCT06779188

RECRUITING NA 30 participants

Spinal Networks of Balance Learning and Retention in Older Adults

University of Florida

NCT06517043

RECRUITING Phase 2 30 participants

Fiber and Calcium Absorption in Older Men

VA Office of Research and Development

NCT06519877

RECRUITING NA 30 participants

Walking Sensation Study

University of Florida

NCT06975423

RECRUITING Early Phase 1 26 participants

Angiotensin-(1-7) Cardiovascular Effects in Aging

Milton S. Hershey Medical Center

NCT05301192

RECRUITING NA 24 participants

Pilot Intervention With Near Infrared Stimulation

University of Florida

NCT03551392

RECRUITING Early Phase 1 24 participants

Gene Expression Changes In Young and Geriatric Skin

Wright State University

NCT03932162

RECRUITING NA 24 participants

Adipose Tissue Blood Flow in Aging Humans

Mayo Clinic

NCT06096532

RECRUITING Phase 4 24 participants

Role of Menopause in Thermoregulation

Penn State University

NCT06798571

RECRUITING NA 24 participants

C-Protein in Fatigue and Aging

University of Oregon

NCT05926219

RECRUITING 24 participants

Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults

University of Texas Southwestern Medical Center

NCT06842784

RECRUITING Phase 4 22 participants

Aging, Beta Blockers, and Thermoregulatory Responses

University of Texas Southwestern Medical Center

NCT06582680

RECRUITING NA 20 participants

The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers

University of Miami

NCT07415707

RECRUITING Early Phase 1 20 participants

Heat, Microvascular Function and Aging

William Hughes

NCT06633198

RECRUITING NA 20 participants

Western Diet on Cardiometabolic and Immune Function

University of Delaware

NCT06528977

RECRUITING NA 20 participants

Ultrasound for Healthy Aging

The University of Texas Health Science Center at San Antonio

NCT07168525

RECRUITING Phase 2 20 participants

Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study

Washington University School of Medicine

NCT07000734

RECRUITING NA 16 participants

Cognitive Vitality Pilot Study

Arizona State University

NCT07208279

RECRUITING NA 15 participants

Dehydration, Rehydration, and Impact on Physiology

Texas Tech University

NCT07084675

RECRUITING NA 12 participants

Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults

University of Missouri-Columbia

NCT06689618

RECRUITING Phase 2 10 participants

The Role of Sirolimus in Preventing Functional Decline in Older Adults

Irina Timofte

NCT05237687

ACTIVE NOT RECRUITING 1,000 participants

DIAMOND-Lewy Guidelines for Antipsychotic Use in Older Patients

Ohio State University

NCT06357195

ACTIVE NOT RECRUITING NA 650 participants

Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Function and Related Health Outcomes

Amazentis

NCT07060898

ACTIVE NOT RECRUITING Phase 3 629 participants

ACHIEVE Brain Health Follow-Up Study

Johns Hopkins University

NCT05532657

ACTIVE NOT RECRUITING NA 600 participants

Prepare for Your Diabetes Care

Kaiser Permanente

NCT05263310

ACTIVE NOT RECRUITING NA 479 participants

Improving Communication for Cancer Treatment: Addressing Concerns of Older Cancer Patients and Caregivers

M.D. Anderson Cancer Center

NCT05436327

ACTIVE NOT RECRUITING NA 400 participants

Underutilization of Hospice Care in Older Black Adults

University of Colorado, Denver

NCT06408090

ACTIVE NOT RECRUITING 340 participants

Couples Health Aging, Rhythms and Sleep Study

University of Utah

NCT05952284

ACTIVE NOT RECRUITING NA 300 participants

A Social Media Game to Increase Physical Activity Among Older Adult Women

The University of Texas Medical Branch, Galveston

NCT04095923

ACTIVE NOT RECRUITING NA 238 participants

Music Improvisation Training on Cognitive Function in Older Adults

University of California, San Francisco

NCT06721390

ACTIVE NOT RECRUITING 194 participants

Aging and Disease Course: Contributions to Lifespan Neurobiology of Schizophrenia

University of Texas Southwestern Medical Center

NCT04951700

ACTIVE NOT RECRUITING NA 184 participants

Feasibility of the Comfort Measures Only Time Out (CMOT)

Beth Israel Deaconess Medical Center

NCT05861323

ACTIVE NOT RECRUITING 130 participants

Passive Limb Movement: A Tool to Assess Vascular Health and Guide Rehabilitation

VA Office of Research and Development

NCT03625349

ACTIVE NOT RECRUITING NA 126 participants

The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance

Massachusetts General Hospital

NCT04908358

ACTIVE NOT RECRUITING Phase 2 112 participants

Mitochondrial-targeted Antioxidant Supplementation for Improving Age-related Vascular Dysfunction in Humans

University of Colorado, Boulder

NCT04851288

ACTIVE NOT RECRUITING Phase 2 106 participants

Everolimus Aging Study

University of Wisconsin, Madison

NCT05835999

ACTIVE NOT RECRUITING NA 90 participants

Accelerating Cognitive Gains From Digital Inverventions With Noninvasive Brain Stimulation

University of California, San Francisco

NCT06633952

ACTIVE NOT RECRUITING NA 90 participants

DiAL Health Research Study

Pennington Biomedical Research Center

NCT05549362

ACTIVE NOT RECRUITING Phase 1 70 participants

Fisetin to Improve Vascular Function in Older Adults

University of Colorado, Boulder

NCT06133634

ACTIVE NOT RECRUITING Phase 1 58 participants

Wild Blueberries and Cardiovascular Health in Middle-aged/Older Men and Postmenopausal Women

Colorado State University

NCT04530916

ACTIVE NOT RECRUITING Phase 4 55 participants

Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study)

University of Colorado, Denver

NCT05057546

ACTIVE NOT RECRUITING Early Phase 1 52 participants

A Pilot Study on Reverse Aging (The REVERSE Study)

The Christ Hospital

NCT07354620

ACTIVE NOT RECRUITING 50 participants

Preparing Older Adults for Major Surgery With Preoperative Comprehensive Geriatric Assessments

University of Wisconsin, Madison

NCT06184919

ACTIVE NOT RECRUITING Phase 3 40 participants

The Effects Of Therapeutic Plasma Exchange (TPE) On Age Related Biomarkers And Epigenetics

Dobri Kiprov

NCT06534450

ACTIVE NOT RECRUITING NA 40 participants

Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors

University of Washington

NCT05467410

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Phase Distribution

PhaseTrial count
Phase 1 29
Phase 2 19
Phase 3 6
Phase 4 8

Named interventions

Most-linked intervention names on Aging records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Other
8 trials
Placebo Dietary supplement
7 trials
Placebo Drug
6 trials
Rapamycin Drug
3 trials
MediTrain Device
3 trials
Control Other
3 trials
Metformin Drug
3 trials
Exercise Behavioral
3 trials

US sites by state

Facility locations filed on Aging trials. A trial with sites in several states counts in each.

California 33 trials
Florida 27 trials
Texas 26 trials
Massachusetts 26 trials
Colorado 20 trials
North Carolina 13 trials
Maryland 13 trials
Illinois 12 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Aging page

263 registered trials, 126 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Aging condition card totals 263 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.