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ClinicalTrials.gov 126 recruiting now official registry

Aging clinical trials

126 of 263 indexed Aging trials are currently recruiting.

263 US clinical trials · 126 currently recruiting

Aging is the subject of 263 registered US clinical trials on ClinicalTrials.gov, 126 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 48 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 14 of these trials.

The research picture

Aging has 263 registered US clinical trials, 126 of them open to new participants right now, about 48% of the total.

126
recruiting participants now
48%
of trials open to enrollment
14
in Phase 3–4 (later-stage)
14
top sponsor: University of Florida
Phase 129Phase 219Phase 36Phase 48

Active & Recent Trials

263 total, page 4 of 6

ACTIVE NOT RECRUITING NA 37 participants

Aerobic Exercise and Cerebrovascular Function

VA Office of Research and Development

NCT03803904

ACTIVE NOT RECRUITING NA 31 participants

Effects of MetAP2 Inhibition on Bioenergetics and Aging-associated Characteristics in Adipose Tissue in Healthy Participants

AdventHealth Translational Research Institute

NCT05989035

ACTIVE NOT RECRUITING NA 30 participants

Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure

University of Pittsburgh

NCT06576297

ACTIVE NOT RECRUITING Phase 3 30 participants

Combination Gerotherapeutic Interventions for Healthspan Improvement

AgelessRx

NCT07475546

ACTIVE NOT RECRUITING Phase 1 30 participants

Towards Understanding Between ADT Treatment, Circadian Rhythm, and Physiological Responsiveness

University of Maryland, Baltimore

NCT05968144

ACTIVE NOT RECRUITING NA 25 participants

Personalized Approach to Promote Healthy Aging

Arizona State University

NCT06734468

ACTIVE NOT RECRUITING 24 participants

Brown Adipose Tissue Pilot

AdventHealth Translational Research Institute

NCT03793127

ACTIVE NOT RECRUITING NA 24 participants

Restylane Refyne for Correction of Horizontal Neck Rhytides

Siperstein Dermatology

NCT04162496

ACTIVE NOT RECRUITING Early Phase 1 22 participants

MitoQ and Exercise Effects on Vascular Health

University of Colorado, Denver

NCT05686967

ACTIVE NOT RECRUITING NA 20 participants

Digital Literacy Intervention to Address Support, Literacy and Communication in Older Adults

Johns Hopkins University

NCT06479707

ACTIVE NOT RECRUITING NA 20 participants

RHA® Redensity With New Anesthetic Agent Perioral Rhytids (PAS)

Teoxane

NCT06378086

ACTIVE NOT RECRUITING NA 20 participants

Greens-Based Crossover Trial to Improve Epigenetic Aging in Adults

Auburn University

NCT06537232

ACTIVE NOT RECRUITING NA 15 participants

The Fuel and Rhythm (FAR) Phase 2 Study

University of Florida

NCT05482711

ACTIVE NOT RECRUITING NA 11 participants

Individualized Brain Stimulation to Improve Mobility in Alzheimer's Disease

Hebrew SeniorLife

NCT04289402

ACTIVE NOT RECRUITING NA 7 participants

Non-invasive Nerve Stimulation and Cognitive Training to Improve Cognitive Performance in Healthy Older Adults

University of Florida

NCT04276805

ACTIVE NOT RECRUITING Phase 2 6 participants

Isa-Pom-Dex in Elderly/Frail Subjects With RRMM

UNC Lineberger Comprehensive Cancer Center

NCT05911321

COMPLETED NA 2,700 participants

Zinc Versus Multivitamin Micronutrient Supplementation in the Setting of COVID-19

Mayo Clinic

NCT04551339

COMPLETED NA 2,050 participants

Trial of the Impact of the Electronic Frailty Integrated With Social Needs

Wake Forest University Health Sciences

NCT05293730

COMPLETED 800 participants

MIND-ICU Study: Delirium and Dementia in Veterans Surviving ICU Care

VA Office of Research and Development

NCT00400062

COMPLETED 588 participants

Health Outcomes After Participating in Exercise (HOPE)

Wake Forest University Health Sciences

NCT03430115

COMPLETED 556 participants

Functionally Validated Structural Endpoints for Early AMD

Cynthia Owsley

NCT04112667

COMPLETED NA 487 participants

Improvement in Memory With Plasticity-Based Adaptive Cognitive Training (IMPACT)

Posit Science Corporation

NCT00283010

COMPLETED NA 414 participants

Preparing Older Veterans With Serious and Chronic Illness for Decision Making

VA Office of Research and Development

NCT01550731

COMPLETED NA 400 participants

Life 2: Improving Fitness and Function in Elders

US Department of Veterans Affairs

NCT00435188

COMPLETED NA 334 participants

ABC Trial: Awakening and Breathing Controlled

National Institute on Aging (NIA)

NCT00097630

COMPLETED NA 305 participants

MY PALS: A Community-Based Physical Activity Support Program for Older Adults

University of Washington

NCT00132288

COMPLETED Phase 3 260 participants

SeniorWISE: Improving Everyday Memory in At-Risk Elderly

National Institute on Aging (NIA)

NCT00094731

COMPLETED NA 238 participants

CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy

Duke University

NCT00427193

COMPLETED NA 216 participants

Optimizing Electronic Health Record Prompts With Behavioral Economics to Improve Prescribing for Older Adults

Brigham and Women's Hospital

NCT04284553

COMPLETED NA 186 participants

Internet-based Conversational Engagement Clinical Trial

Massachusetts General Hospital

NCT02871921

COMPLETED NA 175 participants

Activities for Cognitive Enhancement of Seniors

Stanford University

NCT01094509

COMPLETED Early Phase 1 160 participants

Immune Response to Pneumococcal Vaccination in Aging HIV Positive Adults

Medical University of South Carolina

NCT03039491

COMPLETED NA 151 participants

A Needs-focused Palliative Care Intervention for Older Adults in ICUs

Duke University

NCT04414787

COMPLETED NA 134 participants

Mindfulness Meditation in Chronic Stress

Oregon Health and Science University

NCT01386060

COMPLETED NA 118 participants

Stretching and Yoga Exercise Study

University of Illinois at Urbana-Champaign

NCT01650532

COMPLETED NA 106 participants

Oxytocin's Effect on Socioemotional Aging

University of Florida

NCT01823146

COMPLETED NA 105 participants

Frequency of Aerobic/Resistance Training in Older Women

University of Alabama at Birmingham

NCT01031394

COMPLETED NA 102 participants

Effect of Exercise Intervention on Various Physiologic Factors That Change With Increasing Age

Mayo Clinic

NCT00283673

COMPLETED NA 101 participants

Health in Motion- A Pragmatic Clinical Trial- Home

Blue Marble Rehab

NCT05016141

COMPLETED Early Phase 1 100 participants

Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women

University of Colorado, Denver

NCT02042196

COMPLETED Phase 3 100 participants

Exercise, Executive Processes and the Aging Brain

National Institute on Aging (NIA)

NCT00430976

COMPLETED 94 participants

Pilot Observational Study Examining the Effect of Endocrine Therapy on Aging

University of Michigan

NCT05700006

COMPLETED 90 participants

Taste Perception and Chronic Disease Risk

Tufts University

NCT01023906

COMPLETED 90 participants

Epigenetics in the Aging Process

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00242255

COMPLETED NA 89 participants

The UNCODE Study: Unravelling the Neural Contributors Of Dynapenia in Elders

Ohio University

NCT02505529

COMPLETED NA 86 participants

Increasing Physical Activity Among Sedentary Older Adults:What, Where, When, and With Whom

Brandeis University

NCT03124537

COMPLETED Phase 1 80 participants

Muscle Anabolic Interventions to Accelerate Recovery From Hospitalization in Geriatric Patients

The University of Texas Medical Branch, Galveston

NCT02990533

COMPLETED 71 participants

Long-term Caloric Restriction and Cellular Aging Markers

University of California, San Francisco

NCT01256840

COMPLETED NA 70 participants

Health Enhancement And Resilience Training

University of California, San Francisco

NCT01959126

COMPLETED NA 66 participants

Bioenergetics and Muscle Function Improvement With AMAZ-02 in Elderly Skeletal Muscle (ENERGIZE Trial)

Amazentis

NCT03283462

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Phase Distribution

PhaseTrial count
Phase 1 29
Phase 2 19
Phase 3 6
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Aging Trial Landscape

263 indexed Aging studies · 126 recruiting (48%).

Phase mix: 14 late (III/IV) vs 48 early (I/II).

Top sponsor: University of Florida (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Aging?

PlainTrial tracks 263 US clinical trials for Aging, of which 126 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Aging?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.