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NCT04908358 · ClinicalTrials.gov registry record · NA
The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance
A NA study of Aging, sponsored by Massachusetts General Hospital.
- Active
- Registry status
- NA
- Development phase
- 126
- Enrollment target
- 1
- Study location
NCT04908358: Active NA study of Aging, sponsored by Massachusetts General Hospital.
NCT04908358 is a NA study of Aging that is active but no longer recruiting, run by Massachusetts General Hospital. The registered enrollment target is 126 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04908358, a NA study of Aging, is active but no longer recruiting, sponsored by Massachusetts General Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 126 participants
- Enrollment target
- 1
- Study location
Study Summary
In this research study the investigators want to find out if a non-invasive electrical brain stimulation method called RAVANS (also called tVNS) can have a beneficial effect on cognition in older individuals. The investigators also want to understand whether certain individual factors contribute to the effect of RAVANS on cognition. RAVANS is only used in research studies.
Primary Outcome
Change from baseline at each visit where FNAME is completed: Scores are z-scores with a mean of zero. Higher scores are better (there is no minimum/maximum).
Conditions Studied
Interventions
- OTHER Active transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions
- OTHER Sham transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Charlestown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 126 participants |
| Start Date | 2021-11-24 |
| Est. Completion | 2026-08-31 |
| Phase | NA |
What the registry record for NCT04908358 still lists
NCT04908358 is an interventional study that assigns participants to a tested intervention. The registered 126 participants enrollment target is mid-sized for trials with a published cap, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Aging appearing as the primary indexed condition, and to 2 interventions - of which Active transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions is the first listed.
NCT04908358 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04908358 about?
NCT04908358 is a clinical study titled "The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance". In this research study the investigators want to find out if a non-invasive electrical brain stimulation method called RAVANS (also called tVNS) can have a beneficial effect on cognition in older individuals. The investigators also want to understand whether certain individual factors contribute to ...
What is the current status of trial NCT04908358?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 126 participants. The study started on 2021-11-24. Estimated completion is 2026-08-31.
What conditions does trial NCT04908358 study?
This clinical trial studies the following conditions: Aging.
What interventions are being tested in trial NCT04908358?
The interventions under investigation include: Active transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions (OTHER), Sham transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions (OTHER).
Who is sponsoring clinical trial NCT04908358?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04908358 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aging
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04908358's enrollment target sits among peer trials
126 68th of 262 higher than 195 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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