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NCT05301192 · ClinicalTrials.gov registry record · Early Phase 1
Angiotensin-(1-7) Cardiovascular Effects in Aging
A Early Phase 1 study of Aging, sponsored by Milton S. Hershey Medical Center.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 26
- Enrollment target
- 1
- Study location
NCT05301192: Recruiting Early Phase 1 study of Aging, sponsored by Milton S. Hershey Medical Center.
NCT05301192 is a Early Phase 1 study of Aging that is actively recruiting participants, run by Milton S. Hershey Medical Center. The registered enrollment target is 26 participants, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05301192, a Early Phase 1 study of Aging, is actively recruiting participants, sponsored by Milton S. Hershey Medical Center.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 26 participants
- Enrollment target
- 1
- Study location
Study Summary
Aging is an independent risk factor for developing hypertension and cardiovascular disease; however, the mechanisms underlying age-related cardiovascular disease remain poorly understood. One hallmark of aging is an increase in sympathetic nervous system activity, which can decrease the number and/or sensitivity of β2 adrenergic receptors to reduce dilation of blood vessels and increase blood pressure. Identifying new targets to restore vascular β2 adrenergic receptor signaling may help reduce cardiovascular risk in aging. This study will test the hypothesis that angiotensin-(1-7), a protective hormone of the renin-angiotensin system, can reduce cardiovascular sympathetic outflow and blood pressure and improve endothelial function in older healthy humans.
Primary Outcome
Muscle sympathetic nerve burst rate will be measured continuously using peroneal nerve microneurography during angiotensin-(1-7) versus saline infusion.
Conditions Studied
Interventions
- DRUG Saline
- DRUG Angiotensin-(1-7)
Study Locations (1)
Pennsylvania
- Penn State Milton S. Hershey Medical Center - Hershey
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2022-12-09 |
| Est. Completion | 2026-12 |
| Phase | Early Phase 1 |
What NCT05301192 shows while recruiting
NCT05301192 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Aging appearing as the primary indexed condition, and to 2 interventions - of which Saline is the first listed.
NCT05301192 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05301192 about?
NCT05301192 is a clinical study titled "Angiotensin-(1-7) Cardiovascular Effects in Aging". Aging is an independent risk factor for developing hypertension and cardiovascular disease; however, the mechanisms underlying age-related cardiovascular disease remain poorly understood. One hallmark of aging is an increase in sympathetic nervous system activity, which can decrease the number and/o...
What is the current status of trial NCT05301192?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 26 participants. The study started on 2022-12-09. Estimated completion is 2026-12.
What conditions does trial NCT05301192 study?
This clinical trial studies the following conditions: Aging.
What interventions are being tested in trial NCT05301192?
The interventions under investigation include: Saline (DRUG), Angiotensin-(1-7) (DRUG).
Who is sponsoring clinical trial NCT05301192?
This trial is sponsored by Milton S. Hershey Medical Center, which has 396 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05301192 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aging
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05301192's enrollment target sits among peer trials
26 210th of 262 higher than 51 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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