Mayo Clinic

1,066 total trials 512 currently recruiting 413 completed

Trial Pipeline

RECRUITING NA

Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE)

NCT07169799

RECRUITING NA

Thalamus Seizure Detection With a Deep Brain Stimulator System

NCT06700356

RECRUITING NA

Comparing Acoustic Resonance Therapy (ART) vs. Cognitive Behavioral Therapy for Insomnia (CBT-I)

NCT07486882

RECRUITING Phase 4

Itraconazole Therapy In Bronchiectasis With Airway Mold

NCT07283497

RECRUITING

Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting

NCT07344714

RECRUITING NA

Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury

NCT07210411

RECRUITING Phase 2

Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders

NCT06333652

RECRUITING

Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

NCT07401771

RECRUITING NA

A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness

NCT07420803

RECRUITING NA

Enhancing Brain And Mental Health Through Breathing Practice

NCT07369752

RECRUITING Phase 4

RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)

NCT07266545

RECRUITING

Ambient Sensing Room to Detect Early Signs of Adverse Events in Hospitalized Patients With Cancer

NCT07477886

RECRUITING NA

Writing Relaxing Beats in Adolescents Who Have Sickle Cell Disease

NCT07222475

RECRUITING Phase 4

Uroselective Alpha-1-Antagonist to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery

NCT07174349

RECRUITING NA

Remote Assessment of Digital Neurologic Testing

NCT07014982

RECRUITING NA

Magnetic Resonance Elastography to Monitor Response to Manual Therapy in Myofascial Pain

NCT07278570

RECRUITING NA

Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

NCT07210437

RECRUITING Early Phase 1

68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease

NCT07273188

RECRUITING Phase 4

A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi

NCT07223580

RECRUITING Phase 1

Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer

NCT06997094

RECRUITING NA

AI-Guided Left Bundle Branch Area Pacing

NCT07206602

RECRUITING NA

CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study

NCT06220396

RECRUITING NA

Ultrasound Microvessel Imaging for the Evaluation of Ovarian and Adnexal Lesions

NCT07280312

RECRUITING NA

Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables

NCT07012148

RECRUITING Phase 4

Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

NCT07213466

RECRUITING NA

BLOOM: Pragmatic Feasibility Trial

NCT07287332

RECRUITING Phase 2

Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)

NCT07104812

RECRUITING Phase 4

Oral Methadone in Cardiac Surgery

NCT07221617

RECRUITING Phase 2

An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma

NCT06444412

RECRUITING Phase 1

Use of [18F] Fluoroethyl-L-tyrosine PET/MRI for Identifying Small Functional Pituitary Adenomas

NCT07456878

RECRUITING NA

Satisfaction and Feasibility Evaluation of an Electronic Massager Compared to Massage Therapist-delivered Massage

NCT07042776

RECRUITING Phase 1

Autologous Dendritic Cell Vaccine For Recurrent Respiratory Papillomatosis (RRP) Patients

NCT07317154

RECRUITING Phase 4

Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis

NCT07217405

RECRUITING Phase 2

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

NCT07285044

RECRUITING

Ex Vivo Expansion (ACT-X)

NCT07137312

RECRUITING NA

One vs. Two Stents for Gallbladder Disease

NCT07222527

RECRUITING Phase 2

BMS-986340 in Combination With Nivolumab, Gemcitabine and Nab-paclitaxel for the Treatment of Metastatic and Recurrent Pancreatic Adenocarcinoma

NCT07226856

RECRUITING NA

Minimal Sedation During Knee Replacement Surgery

NCT07371390

RECRUITING Phase 1

Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension

NCT06770023

RECRUITING NA

Studying Quality of Life Inclusive of Mental Health and Cognitive Behavioral Therapy for Cancer Distress for the Improvement of Quality of Life in Stage III-IV Melanoma Patients

NCT07379138

RECRUITING NA

A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke

NCT07291024

RECRUITING

A Study Of MCG In Cardiac Amyloidosis

NCT07218705

RECRUITING

A Study of SCAD Using Stress Contrast Echocardiography

NCT07178509

RECRUITING

Impact of Physician Behavior on Cancer Distress

NCT07325006

RECRUITING NA

Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial

NCT07188532

RECRUITING Phase 4

24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients

NCT07325240

RECRUITING NA

Health and Wellness Coaching to Improve Thoracic Transplant Caregiver Self-Efficacy

NCT07361159

RECRUITING

Voices: Messages of Wisdom and Hope in the Face of Illness

NCT07381179

RECRUITING Phase 1

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

NCT06911008

RECRUITING NA

Comparison of Iliac Crest Marrow vs. Proximal Tibia Avitus® Bone Graft

NCT07434505

RECRUITING Phase 2

Smoking Cessation Trial in Recurrent Acute Pancreatitis and Chronic Pancreatitis

NCT07171112

RECRUITING Phase 4

The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron

NCT07103720

RECRUITING NA

A Mindfulness-Based Stress Reduction Program for Improving Mental Health Outcomes for Underserved Cancer Patients in Minnesota

NCT07291011

RECRUITING Phase 2

The Role of Islet GLP-1 in the Pathogenesis of Prediabetes

NCT06967558

RECRUITING Phase 2

A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure

NCT07083011

RECRUITING NA

A Study Of Resilience And Mental Well-Being Through Breathing Practice For Clinical Care Professionals

NCT07218458

RECRUITING

A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD

NCT07093528

RECRUITING

A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography

NCT07216469

RECRUITING NA

Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment

NCT07221409

RECRUITING Phase 2

The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes

NCT06976619

RECRUITING NA

Inpatient Use of Personal Continuous Glucose Monitor (CGM) to Improve Diabetes Mellitus Control

NCT07006480

RECRUITING

Molecular and ctDNA Characterization of High-Risk Endometrial Cancer

NCT07062016

RECRUITING Phase 2

Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer

NCT06525766

RECRUITING NA

Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU

NCT07351799

RECRUITING NA

Deciphering Preserved Autonomic Function After Multiple Sclerosis

NCT07012135

RECRUITING Phase 4

Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams

NCT07164131

RECRUITING NA

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma

NCT07074756

RECRUITING

A Study of Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet

NCT07137286

RECRUITING

Screening and Staging of Benign vs Malignant Pelvic Abnormalities

NCT07407959

RECRUITING NA

A Study Investigating the Impact of IMT With CR On Exercise Responses In HF

NCT07086131

RECRUITING NA

Educational Tools for the Improvement of Early Advance Care Planning in Adolescents and Young Adults With Advanced Solid Tumors and High-Grade Brain Tumors

NCT07174661

RECRUITING NA

Effect of Vagal Nerve Stimulation on Gastric Motor Functions

NCT06038929

RECRUITING Phase 1

An Optimized Ultrasound Twinkling Marker for the Imaging of Lymph Nodes in Patients With Clinically Node-Positive Breast Cancer, The UTMOST2 Trial

NCT06999798

RECRUITING

Integrating Molecular Pathology, Radiology, and Genetics to Improve Breast Cancer Risk

NCT07207564

RECRUITING Phase 2

Evaluating In Home Cancer Therapy Versus In Clinic Cancer Therapy in Black Men With Locally Advanced, Biochemically Recurrent and Metastatic Prostate Cancer

NCT07073794

RECRUITING Phase 1

Q702 for the Treatment of Patients With Hematologic Malignancies

NCT06712810

RECRUITING Phase 2

Androgen Deprivation Therapy (Relugolix) for the Improvement of Diagnostic Imaging (PSMA PET/CT Scan) in Patients With High Risk or Very High Risk Prostate Cancer, The EnrichPSMA Trial

NCT07025369

RECRUITING

Impact of RFA on Esophageal Distensibility and Mucosal Impedance

NCT07126535

RECRUITING NA

Prehabilitation With Aerobic and Resistance Exercise for Improving Physical Fitness and Quality of Life Outcomes in Older Patients Undergoing CAR-T Therapy for Relapsed or Refractory Multiple Myeloma

NCT07045727

RECRUITING Early Phase 1

Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma

NCT07076472

RECRUITING NA

Feasibility and Effect of Wrapping Nerves With a Multi-Layer Perinatal Tissue Allograft During Prostatectomy

NCT06940271

RECRUITING Early Phase 1

Sequential Treatments or Combinations Including Dasatinib, Quercetin, Fisetin and/or Temozolomide for the Treatment of Previously Treated Glioma With Residual Disease

NCT07025226

RECRUITING NA

Ketogenic Intervention for Bipolar Depression

NCT07121894

RECRUITING NA

The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults

NCT06940037

RECRUITING NA

Minibeam Radiation Therapy With Tungsten Slit Collimator for the Treatment of Recurrent or Metastatic Skin or Soft Tissue Tumors, MBRT1 Trial

NCT07062003

RECRUITING NA

AI Assisted Personalized Legacy Program (Reflections: My Story) for Patients With Serious Illness

NCT07009210

RECRUITING NA

Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida

NCT06918119

RECRUITING

Surface EMG Testing on Swallowing in EoE Patients

NCT07156357

RECRUITING NA

Effect of Prolonged Fasting Time on Gastric Residual Volume in Patients Taking GLP1 Receptor Agonists

NCT07006142

RECRUITING Phase 2

Therapeutic Plasma Exchange With Enfortumab Vedotin and Pembrolizumab for Treatment of Bladder Cancers

NCT07087860

RECRUITING

Exploring the Effect of Calaspargase Pegol on the Coagulation System in Pediatric Acute Lymphoblastic Leukemia (ALL) Patients: Pilot Study

NCT07071051

RECRUITING NA

Continuous Glucose Monitoring for the Management of Hyperglycemia in Patients With Glioblastoma

NCT07091864

RECRUITING Phase 2

5-strain Probiotic Formulation in HR-positive Breast Cancer Receiving Aromatase Inhibitor to Prevent Bone Loss

NCT07044310

RECRUITING NA

Augmented Reality Real-Time Guidance for MRI-Guided Interventions

NCT07120906

RECRUITING NA

Post COVID-19 Syndrome Treatment With Variable Pulse Transcranial Magnetic Stimulation

NCT06865222

RECRUITING NA

WATCH (Wearable Artificial inTelligence for Cardiac Function and Health Monitoring)

NCT07058064

RECRUITING NA

Management of Dyssynergic Defecation

NCT07225803

RECRUITING NA

Virtual Support Platform (HERCaRE Application) for the Improvement of Survivorship Among Black Breast Cancer Survivors

NCT07126522

RECRUITING NA

A Study of Mobility Outcomes in Post-Pulmonary Embolic Disease

NCT06695247

RECRUITING Phase 3

Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

NCT07100990

Phase Distribution

PhaseTrial count
Phase 1 138
Phase 2 148
Phase 3 31
Phase 4 57

What the Pipeline for Mayo Clinic Shows

According to the ClinicalTrials.gov registry, Mayo Clinic is linked to 1,066 US clinical trials across every stage of research activity. Of those, 512 studies are currently recruiting — about 48% of the sponsor's indexed portfolio — and 413 are already marked complete, representing roughly 39% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for Mayo Clinic reports 88 late-stage studies (Phase 3 and Phase 4 combined) and 286 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for Mayo Clinic is Healthy with 36 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial