Mayo Clinic
Trial Pipeline
Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE)
NCT07169799
Thalamus Seizure Detection With a Deep Brain Stimulator System
NCT06700356
Comparing Acoustic Resonance Therapy (ART) vs. Cognitive Behavioral Therapy for Insomnia (CBT-I)
NCT07486882
Itraconazole Therapy In Bronchiectasis With Airway Mold
NCT07283497
Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting
NCT07344714
Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury
NCT07210411
Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders
NCT06333652
Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction
NCT07401771
A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness
NCT07420803
Enhancing Brain And Mental Health Through Breathing Practice
NCT07369752
RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)
NCT07266545
Ambient Sensing Room to Detect Early Signs of Adverse Events in Hospitalized Patients With Cancer
NCT07477886
Writing Relaxing Beats in Adolescents Who Have Sickle Cell Disease
NCT07222475
Uroselective Alpha-1-Antagonist to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery
NCT07174349
Remote Assessment of Digital Neurologic Testing
NCT07014982
Magnetic Resonance Elastography to Monitor Response to Manual Therapy in Myofascial Pain
NCT07278570
Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI
NCT07210437
68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease
NCT07273188
A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi
NCT07223580
Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer
NCT06997094
AI-Guided Left Bundle Branch Area Pacing
NCT07206602
CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study
NCT06220396
Ultrasound Microvessel Imaging for the Evaluation of Ovarian and Adnexal Lesions
NCT07280312
Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables
NCT07012148
Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder
NCT07213466
BLOOM: Pragmatic Feasibility Trial
NCT07287332
Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)
NCT07104812
Oral Methadone in Cardiac Surgery
NCT07221617
An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma
NCT06444412
Use of [18F] Fluoroethyl-L-tyrosine PET/MRI for Identifying Small Functional Pituitary Adenomas
NCT07456878
Satisfaction and Feasibility Evaluation of an Electronic Massager Compared to Massage Therapist-delivered Massage
NCT07042776
Autologous Dendritic Cell Vaccine For Recurrent Respiratory Papillomatosis (RRP) Patients
NCT07317154
Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis
NCT07217405
The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
NCT07285044
Ex Vivo Expansion (ACT-X)
NCT07137312
One vs. Two Stents for Gallbladder Disease
NCT07222527
BMS-986340 in Combination With Nivolumab, Gemcitabine and Nab-paclitaxel for the Treatment of Metastatic and Recurrent Pancreatic Adenocarcinoma
NCT07226856
Minimal Sedation During Knee Replacement Surgery
NCT07371390
Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension
NCT06770023
Studying Quality of Life Inclusive of Mental Health and Cognitive Behavioral Therapy for Cancer Distress for the Improvement of Quality of Life in Stage III-IV Melanoma Patients
NCT07379138
A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke
NCT07291024
A Study Of MCG In Cardiac Amyloidosis
NCT07218705
A Study of SCAD Using Stress Contrast Echocardiography
NCT07178509
Impact of Physician Behavior on Cancer Distress
NCT07325006
Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial
NCT07188532
24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients
NCT07325240
Health and Wellness Coaching to Improve Thoracic Transplant Caregiver Self-Efficacy
NCT07361159
Voices: Messages of Wisdom and Hope in the Face of Illness
NCT07381179
MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers
NCT06911008
Comparison of Iliac Crest Marrow vs. Proximal Tibia Avitus® Bone Graft
NCT07434505
Smoking Cessation Trial in Recurrent Acute Pancreatitis and Chronic Pancreatitis
NCT07171112
The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron
NCT07103720
A Mindfulness-Based Stress Reduction Program for Improving Mental Health Outcomes for Underserved Cancer Patients in Minnesota
NCT07291011
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
NCT06967558
A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure
NCT07083011
A Study Of Resilience And Mental Well-Being Through Breathing Practice For Clinical Care Professionals
NCT07218458
A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD
NCT07093528
A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography
NCT07216469
Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment
NCT07221409
The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes
NCT06976619
Inpatient Use of Personal Continuous Glucose Monitor (CGM) to Improve Diabetes Mellitus Control
NCT07006480
Molecular and ctDNA Characterization of High-Risk Endometrial Cancer
NCT07062016
Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer
NCT06525766
Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU
NCT07351799
Deciphering Preserved Autonomic Function After Multiple Sclerosis
NCT07012135
Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams
NCT07164131
A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma
NCT07074756
A Study of Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet
NCT07137286
Screening and Staging of Benign vs Malignant Pelvic Abnormalities
NCT07407959
A Study Investigating the Impact of IMT With CR On Exercise Responses In HF
NCT07086131
Educational Tools for the Improvement of Early Advance Care Planning in Adolescents and Young Adults With Advanced Solid Tumors and High-Grade Brain Tumors
NCT07174661
Effect of Vagal Nerve Stimulation on Gastric Motor Functions
NCT06038929
An Optimized Ultrasound Twinkling Marker for the Imaging of Lymph Nodes in Patients With Clinically Node-Positive Breast Cancer, The UTMOST2 Trial
NCT06999798
Integrating Molecular Pathology, Radiology, and Genetics to Improve Breast Cancer Risk
NCT07207564
Evaluating In Home Cancer Therapy Versus In Clinic Cancer Therapy in Black Men With Locally Advanced, Biochemically Recurrent and Metastatic Prostate Cancer
NCT07073794
Q702 for the Treatment of Patients With Hematologic Malignancies
NCT06712810
Androgen Deprivation Therapy (Relugolix) for the Improvement of Diagnostic Imaging (PSMA PET/CT Scan) in Patients With High Risk or Very High Risk Prostate Cancer, The EnrichPSMA Trial
NCT07025369
Impact of RFA on Esophageal Distensibility and Mucosal Impedance
NCT07126535
Prehabilitation With Aerobic and Resistance Exercise for Improving Physical Fitness and Quality of Life Outcomes in Older Patients Undergoing CAR-T Therapy for Relapsed or Refractory Multiple Myeloma
NCT07045727
Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma
NCT07076472
Feasibility and Effect of Wrapping Nerves With a Multi-Layer Perinatal Tissue Allograft During Prostatectomy
NCT06940271
Sequential Treatments or Combinations Including Dasatinib, Quercetin, Fisetin and/or Temozolomide for the Treatment of Previously Treated Glioma With Residual Disease
NCT07025226
Ketogenic Intervention for Bipolar Depression
NCT07121894
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults
NCT06940037
Minibeam Radiation Therapy With Tungsten Slit Collimator for the Treatment of Recurrent or Metastatic Skin or Soft Tissue Tumors, MBRT1 Trial
NCT07062003
AI Assisted Personalized Legacy Program (Reflections: My Story) for Patients With Serious Illness
NCT07009210
Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida
NCT06918119
Surface EMG Testing on Swallowing in EoE Patients
NCT07156357
Effect of Prolonged Fasting Time on Gastric Residual Volume in Patients Taking GLP1 Receptor Agonists
NCT07006142
Therapeutic Plasma Exchange With Enfortumab Vedotin and Pembrolizumab for Treatment of Bladder Cancers
NCT07087860
Exploring the Effect of Calaspargase Pegol on the Coagulation System in Pediatric Acute Lymphoblastic Leukemia (ALL) Patients: Pilot Study
NCT07071051
Continuous Glucose Monitoring for the Management of Hyperglycemia in Patients With Glioblastoma
NCT07091864
5-strain Probiotic Formulation in HR-positive Breast Cancer Receiving Aromatase Inhibitor to Prevent Bone Loss
NCT07044310
Augmented Reality Real-Time Guidance for MRI-Guided Interventions
NCT07120906
Post COVID-19 Syndrome Treatment With Variable Pulse Transcranial Magnetic Stimulation
NCT06865222
WATCH (Wearable Artificial inTelligence for Cardiac Function and Health Monitoring)
NCT07058064
Management of Dyssynergic Defecation
NCT07225803
Virtual Support Platform (HERCaRE Application) for the Improvement of Survivorship Among Black Breast Cancer Survivors
NCT07126522
A Study of Mobility Outcomes in Post-Pulmonary Embolic Disease
NCT06695247
Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)
NCT07100990
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 138 |
| Phase 2 | 148 |
| Phase 3 | 31 |
| Phase 4 | 57 |
Therapeutic Areas
What the Pipeline for Mayo Clinic Shows
According to the ClinicalTrials.gov registry, Mayo Clinic is linked to 1,066 US clinical trials across every stage of research activity. Of those, 512 studies are currently recruiting — about 48% of the sponsor's indexed portfolio — and 413 are already marked complete, representing roughly 39% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for Mayo Clinic reports 88 late-stage studies (Phase 3 and Phase 4 combined) and 286 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for Mayo Clinic is Healthy with 36 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.