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ClinicalTrials.gov 126 recruiting now official registry

Aging clinical trials

126 of 263 indexed Aging trials are currently recruiting.

263 US clinical trials · 126 currently recruiting

Aging is the subject of 263 registered US clinical trials on ClinicalTrials.gov, 126 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 48 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 14 of these trials.

The research picture

Aging has 263 registered US clinical trials, 126 of them open to new participants right now, about 48% of the total.

126
recruiting participants now
48%
of trials open to enrollment
14
in Phase 3–4 (later-stage)
14
top sponsor: University of Florida
Phase 129Phase 219Phase 36Phase 48

Active & Recent Trials

263 total, page 2 of 6

RECRUITING Phase 4 100 participants

Cardiometabolic Consequences of the Loss of Ovarian Function

University of Colorado, Denver

NCT06264882

RECRUITING NA 100 participants

Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older

Wake Forest University Health Sciences

NCT05858034

RECRUITING 100 participants

Metabolic and Functional Consequences of Aging in Health and Disease

Texas A&M University

NCT05240885

RECRUITING NA 100 participants

Mindfulness for Cognition in Early-stage Alzheimer's Disease

VA Boston Healthcare System

NCT06792877

RECRUITING NA 100 participants

Multimodal Musical Stimulation for Healthy Neurocognitive Aging

Northeastern University

NCT06229093

RECRUITING NA 100 participants

Heat Waves and the Elderly - Cooling Modalities

University of Texas Southwestern Medical Center

NCT05484739

RECRUITING NA 100 participants

Speech Perception and High Cognitive Demand

University of Maryland, College Park

NCT04997577

RECRUITING NA 90 participants

Studying the Effects of Digital Interventions on Cognition, Wellbeing, Stress, and Sleep in Older Adults

University of California, San Francisco

NCT06633978

RECRUITING NA 90 participants

Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise

University of Colorado, Boulder

NCT05000515

RECRUITING NA 85 participants

Neurobiological Mechanisms of Aging and Stress on Prospective Navigation

Georgia Institute of Technology

NCT03896529

RECRUITING Phase 2 80 participants

Empagliflozin Reversal of Arterial StiffnEss in Aging

University of Missouri-Columbia

NCT06506422

RECRUITING NA 80 participants

Emotional Well-being and Measures of Healthy Aging

Northwestern University

NCT07334106

RECRUITING NA 80 participants

Effect of Walnuts on Cognitive Function and Gut Microbiome in Older Adults

Oregon State University

NCT06942351

RECRUITING 80 participants

Molecular Optimization Via Exercise (MOVE)

Buck Institute for Research on Aging

NCT06540287

RECRUITING NA 80 participants

IH, Brain Health, and T2D

Darren P Casey

NCT07173543

RECRUITING NA 80 participants

The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

Wright State University

NCT06428721

RECRUITING Phase 4 75 participants

A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults

The Jackson Laboratory

NCT05518500

RECRUITING Early Phase 1 75 participants

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

University of Missouri-Columbia

NCT06417177

RECRUITING NA 75 participants

Cognitive Remediation

Cutter Lindbergh

NCT07171450

RECRUITING 72 participants

Postural Control During Concurrent Cognitive Tasks During Optic Flow Stimulation

Chia-Cheng Lin, PhD, PT, MSPT

NCT05117463

RECRUITING NA 72 participants

Effects of Obesity in the Aged

University of Texas Southwestern Medical Center

NCT05028309

RECRUITING NA 72 participants

Feasibility of Home-based tES for Older Adults at Risk of Falling

Hebrew SeniorLife

NCT04732533

RECRUITING Phase 1 72 participants

Rapalog Pharmacology (RAP PAC) Study

University of Wisconsin, Madison

NCT05949658

RECRUITING NA 72 participants

Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia

Wright State University

NCT03906253

RECRUITING NA 72 participants

Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse

Joel Trinity

NCT04351113

RECRUITING NA 70 participants

Using Reinforcement Learning to Personalize Electronic Health Record Tools to Facilitate Deprescribing

Brigham and Women's Hospital

NCT06660979

RECRUITING NA 68 participants

Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging

University of Florida

NCT05457725

RECRUITING NA 68 participants

Optimizing Strength Training in Older Adults

Queens College, The City University of New York

NCT06812143

RECRUITING Phase 2 66 participants

Acetate and Age-associated Arterial Dysfunction

University of Colorado, Denver

NCT05424263

RECRUITING Early Phase 1 64 participants

Early Neurovascular Adaptations in Aging Women

University of Missouri-Columbia

NCT06520982

RECRUITING Phase 4 60 participants

The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

State University of New York at Buffalo

NCT06128915

RECRUITING NA 60 participants

Effect of Snacks on Aging

University of California, Los Angeles

NCT06879626

RECRUITING Phase 1 60 participants

MTOR Inhibitors in Older Adults

University of Texas Southwestern Medical Center

NCT06727305

RECRUITING NA 60 participants

Fatty Acid Modulation of Brain Function in Older Adults

University of Vermont

NCT06192407

RECRUITING Phase 2 60 participants

The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults

UConn Health

NCT06027554

RECRUITING Phase 2 60 participants

Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals

Medical College of Wisconsin

NCT05808686

RECRUITING NA 55 participants

Reducing Blood Pressure in Mid-life Adult Binge Drinkers

The University of Texas at Arlington

NCT05522075

RECRUITING NA 54 participants

Breaking Sitting with High-intensity Interval Training for Brain Health

University of Illinois at Urbana-Champaign

NCT06243016

RECRUITING NA 50 participants

The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults

AdventHealth Translational Research Institute

NCT03761446

RECRUITING NA 48 participants

Using Nicotine to Reverse Age-related Auditory Processing Deficits

University of California, Irvine

NCT04971954

RECRUITING Early Phase 1 48 participants

Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex

University of California, Berkeley

NCT05018117

RECRUITING Early Phase 1 45 participants

Transient Receptor Potential Channels

Penn State University

NCT06444594

RECRUITING NA 45 participants

Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities

Brigham and Women's Hospital

NCT06989619

RECRUITING NA 40 participants

Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults

Scott Silveira

NCT07144527

RECRUITING Phase 1 40 participants

Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults

University of California, Berkeley

NCT06367738

RECRUITING NA 36 participants

Preliminary Testing of Cafe Move for Primary Prevention of Physical Frailty

University of Montana

NCT05720507

RECRUITING NA 36 participants

Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans

University of Alabama at Birmingham

NCT06217575

RECRUITING Phase 1 35 participants

Effect of a Daily Supplement on Plasma PAI-1 Levels

University of California, Los Angeles

NCT07469475

RECRUITING Phase 2 34 participants

Fisetin to Reduce Senescence and Mobility Impairment in PAD

Northwestern University

NCT06399809

RECRUITING NA 34 participants

Pain and Split-belt Motor Learning in Older Adults

University of Delaware

NCT07054840

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Phase Distribution

PhaseTrial count
Phase 1 29
Phase 2 19
Phase 3 6
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Aging Trial Landscape

263 indexed Aging studies · 126 recruiting (48%).

Phase mix: 14 late (III/IV) vs 48 early (I/II).

Top sponsor: University of Florida (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Aging?

PlainTrial tracks 263 US clinical trials for Aging, of which 126 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Aging?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.