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Post Traumatic Stress Disorder clinical trials
Every US clinical trial registered for Post Traumatic Stress Disorder — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
89 US clinical trials · 54 currently recruiting
The research picture
Post Traumatic Stress Disorder has 89 registered US clinical trials, 54 of them open to new participants right now — about 61% of the total.
- 54
- recruiting participants now
- 61%
- of trials open to enrollment
- 4
- in Phase 3–4 (later-stage)
- 8
- top sponsor: VA Office of Research and Development
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress
Stanford University
NCT05701111
RIVER At Home Ketamine Protocols
RIVER Foundation
NCT06070766
Department of Defense PTSD Adaptive Platform Trial - Master Protocol
Global Coalition for Adaptive Research
NCT05422612
Evaluation of the Parenting in the Moment Online Program for Forcibly Displaced Families
Arizona State University
NCT06548126
Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study
Johns Hopkins University
NCT07227337
CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos
Drexel University
NCT06139159
CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
University of Texas at Austin
NCT05467683
Stepped Care for Posttraumatic Stress Disorder Study
Boston Medical Center
NCT06947538
A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD
United States Department of Defense
NCT06990191
Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers
University of Michigan
NCT05751473
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Vanderbilt University Medical Center
NCT04801589
Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD
The University of Texas at Dallas
NCT03932773
Fear and Avoidance in PTSD Patients
The University of Texas Health Science Center, Houston
NCT04770584
An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)
Transcend Therapeutics
NCT07456696
Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course
United States Department of Defense
NCT06957067
Facilitation of Extinction Retention and Reconsolidation Blockade in PTSD
Boston University
NCT04468360
Non-invasive Nerve Stimulation for PTSD and Sleep
University of Florida
NCT03170440
Department of Defense PTSD Adaptive Platform Trial - Intervention A - Fluoxetine
Global Coalition for Adaptive Research
NCT05948553
Department of Defense PTSD Adaptive Platform Trial - Intervention C - Daridorexant
Global Coalition for Adaptive Research
NCT05948540
Neuromodulation and Neurorehabilitation for mTBI
Northwestern University
NCT03819608
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
VA Office of Research and Development
NCT05156112
Sleep and Emotion Processing in Adolescent Post-traumatic Stress Disorder
University of Wisconsin, Madison
NCT06341413
Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD
NYU Langone Health
NCT03667846
Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat
Yale University
NCT06371404
Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms
Virginia Commonwealth University
NCT07071350
Multifaceted Intervention to Restore Resilience and Overcome Risk
Icahn School of Medicine at Mount Sinai
NCT06988787
Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation
Florida State University
NCT06544408
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
University of California, San Diego
NCT06273527
Psychotherapy Effects on Reward Processing in PTSD
University of Texas at Austin
NCT06096740
Cognitive Control Training for Extinction in PTSD
VA Office of Research and Development
NCT06629064
Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in Veterans
Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
NCT04360681
Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI
NYU Langone Health
NCT04550377
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
Yale University
NCT01730781
rTMS-augmented Written Exposure Therapy for PTSD
VA Office of Research and Development
NCT05149534
Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.
Massachusetts General Hospital
NCT07079761
Amygdala Memory Enhancement
Washington University School of Medicine
NCT05065450
The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans
Children's Hospital Los Angeles
NCT06218381
Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder
NYU Langone Health
NCT05391971
Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners
University of Michigan
NCT06324383
Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma
Paul Crawford
NCT05516862
TMS-fNIRS Personalized Dosing
Florida State University
NCT05916417
Mechanisms Underlying Efficacy of Prolonged Exposure
Massachusetts General Hospital
NCT05788302
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
Yale University
NCT05915013
Exploring Virtual Reality Adventure Training Exergaming
The University of Texas at Arlington
NCT05563805
Determining the Potential for Efficacy of OTX-601 in Reducing PTSD Symptoms
Oui Therapeutics
NCT07316088
MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder
Stephen Robert Marder
NCT05790239
Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder
Wayne State University
NCT06740487
Targeting the Default Mode Network: A TMS-fMRI Study
Allyson Rosen
NCT05646732
Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI
The University of Texas Health Science Center at San Antonio
NCT07351305
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Yale University
NCT05786066
Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD
Montefiore Medical Center
NCT05929911
Innovative Multimodal and Attention Training to Improve Emotion Communication in Veterans With TBI and PTSD
VA Office of Research and Development
NCT05478759
eTMS for Veterans and First Responders With PTSD
Virginia Polytechnic Institute and State University
NCT06294106
MDMA for AUD/PTSD Comorbidity
Carolina L Haass-Koffler
NCT05943665
Efficacy of Virtual Warrior Renew Therapy for Veterans Who Experienced Military Sexual Trauma
Seattle Institute for Biomedical and Clinical Research
NCT05776719
Testing the Effectiveness of a Therapist-Assisted Self-Management Program for Veterans Who Finished PTSD Therapy
VA Office of Research and Development
NCT05797441
Web-administered STAIR for Patients on Behavioral Health Waitlists
Boston Medical Center
NCT06431022
MOSAIC (MOthers' AdvocateS In the Community) for Pregnant Women and Mothers of Children Under 5 With Experience of Intimate Partner Violence
Michigan State University
NCT05106361
A Study of Psilocybin for PTSD
Johns Hopkins University
NCT06407635
An Adjunctive Neurofeedback Training Program to Enhance Wellness Among Trauma-Exposed Postpartum Mothers
Wayne State University
NCT06054412
Targeted Plasticity Therapy for Posttraumatic Stress Disorder
Baylor Research Institute
NCT04064762
National Child Traumatic Stress Network (NCTSN) Quality Improvement Initiative Database
Hugo W. Moser Research Institute at Kennedy Krieger
NCT01591694
Remotely Resolving Psychological Stress (Remote RePS)
University of California, San Francis
NCT03196999
Cognitive-Behavioral Conjoint Therapy (CBCT) Project
VA Office of Research and Development
NCT02720016
ALTO-100 in MDD and/or PTSD
Alto Neuroscience
NCT05117632
The Family of Heroes: an Evaluation of an Online Educational Tool
Department of Veterans Affairs, New Jersey
NCT01554839
PTSD Training for PCPs in a Virtual World
San Francisco Veterans Affairs Medical Center
NCT03898271
Brief Peer Supported webSTAIR Compared to Enhanced Wait List
Palo Alto Veterans Institute for Research
NCT04286165
Quantifying the Efficacy and Role of Service Dogs for Military Veterans With PTSD
University of Arizona
NCT03245814
Cannabidiol as a Treatment for AUD Comorbid With PTSD
NYU Langone Health
NCT03248167
Psychological Symptoms and Families of COVID-19 Patients
Rush University Medical Center
NCT04501445
Effectiveness of Cognitive, Exposure, and Skills Group Manualized Treatments in Operations Iraqi (OIF)/Operation Enduring Freedom (OEF) Female Veterans
New Mexico VA Healthcare System
NCT02069873
Primary-Care Based Mindfulness Intervention
Emory University
NCT03922581
Rehabilitation of Executive Functioning in Veterans With PTSD and Mild TBI
VA Office of Research and Development
NCT01921179
Biological Signatures, Probiotic Among Those With mTBI and PTSD
VA Office of Research and Development
NCT02723344
Physiological Augmentation of Mindfulness Meditation
Emory University
NCT02754557
Effect of Mindfulness Meditation on Physiological Response to Unpredictable Stimuli
Georgetown University
NCT03206437
The Effects of the Safe and Sound Protocol on PTSD Symptoms and Anxiety
Indiana University
NCT04999852
Effects of a Short-term Exercise Intervention on Sleep in Women Exposed to Trauma: A Randomized Controlled Trial
University of Georgia
NCT05097352
Perceptions of MDMA-Assisted Therapy Among Veterans With PTSD
Albany Research Institute
NCT05895318
Frontline Clinician Psilocybin Study
University of Washington
NCT05163496
Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury
The University of Texas Health Science Center at San Antonio
NCT04280965
Transcranial Direct Current Stimulation (tDCS) in Human Subjects With PTSD Receiving an Exposure-based, Behavioral Therapy
The University of Texas Health Science Center at San Antonio
NCT05419999
Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain
Summa Health System
NCT00554320
The Effect of Nasal Continuous Positive Airway Pressure Treatment on PTSD Symptoms.
Northport Veterans Affairs Medical Center
NCT01512771
Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma
University of Massachusetts, Worcester
NCT03845985
Trauma Intervention for Affect Regulation, AIDS, and Substances
University of Miami
NCT02923141
CCTAP: Cognitive Control Training for Treatment of AUD-PTSD
Posit Science Corporation
NCT03200028
Pilot Study of PRX-03140 to Assess Safety for Use in Adult Subjects With Post Traumatic Stress Disorder
Alachua Government Services
NCT01492699
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 15 |
| Phase 3 | 3 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Post Traumatic Stress Disorder Trial Landscape
ClinicalTrials.gov lists 89 US studies indexed under Post Traumatic Stress Disorder, and 54 of those are currently open to recruitment — roughly 61% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Post Traumatic Stress Disorder shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 20 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Post Traumatic Stress Disorder is led by VA Office of Research and Development with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 89 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Post Traumatic Stress Disorder?
PlainTrial tracks 89 US clinical trials for Post Traumatic Stress Disorder, of which 54 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Post Traumatic Stress Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.