Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Post Traumatic Stress Disorder clinical trials
71 of 146 indexed Post Traumatic Stress Disorder trials are currently recruiting.
146 US clinical trials · 71 currently recruiting
Post Traumatic Stress Disorder is the subject of 146 registered US clinical trials on ClinicalTrials.gov, 71 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 19 of these trials.
The research picture
Post Traumatic Stress Disorder has 146 registered US clinical trials, 71 of them open to new participants right now, about 49% of the total.
- 71
- recruiting participants now
- 49%
- of trials open to enrollment
- 13
- in Phase 3–4 (later-stage)
- 19
- top sponsor: VA Office of Research and Development
Active & Recent Trials
146 total, page 1 of 3
Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress
Stanford University
NCT05701111
RIVER At Home Ketamine Protocols
RIVER Foundation
NCT06070766
Department of Defense PTSD Adaptive Platform Trial - Master Protocol
Global Coalition for Adaptive Research
NCT05422612
Evaluation of the Parenting in the Moment Online Program for Forcibly Displaced Families
Arizona State University
NCT06548126
Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study
Johns Hopkins University
NCT07227337
CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos
Drexel University
NCT06139159
CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
University of Texas at Austin
NCT05467683
Stepped Care for Posttraumatic Stress Disorder Study
Boston Medical Center
NCT06947538
A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD
United States Department of Defense
NCT06990191
Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers
University of Michigan
NCT05751473
Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors
Duke University
NCT06538246
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Vanderbilt University Medical Center
NCT04801589
Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD
The University of Texas at Dallas
NCT03932773
Fear and Avoidance in PTSD Patients
The University of Texas Health Science Center, Houston
NCT04770584
An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)
Transcend Therapeutics
NCT07456696
Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course
United States Department of Defense
NCT06957067
Facilitation of Extinction Retention and Reconsolidation Blockade in PTSD
Boston University
NCT04468360
Non-invasive Nerve Stimulation for PTSD and Sleep
University of Florida
NCT03170440
Department of Defense PTSD Adaptive Platform Trial - Intervention A - Fluoxetine
Global Coalition for Adaptive Research
NCT05948553
Department of Defense PTSD Adaptive Platform Trial - Intervention C - Daridorexant
Global Coalition for Adaptive Research
NCT05948540
Neuromodulation and Neurorehabilitation for mTBI
Northwestern University
NCT03819608
Morning Bright Light to Improve Sleep Quality in Veterans
Portland VA Medical Center
NCT03578003
Approach-Avoidance and Alcohol Challenge Study in PTSD
University of Texas at Austin
NCT06002633
Creative Arts Program to Reduce Burnout in Healthcare Professionals
University of Colorado, Denver
NCT04276922
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
VA Office of Research and Development
NCT05156112
Sleep and Emotion Processing in Adolescent Post-traumatic Stress Disorder
University of Wisconsin, Madison
NCT06341413
Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD
NYU Langone Health
NCT03667846
Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat
Yale University
NCT06371404
Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms
Virginia Commonwealth University
NCT07071350
Multifaceted Intervention to Restore Resilience and Overcome Risk
Icahn School of Medicine at Mount Sinai
NCT06988787
Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation
Florida State University
NCT06544408
Imaging SV2A in Mood Disorders
Yale University
NCT02734602
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
University of California, San Diego
NCT06273527
Psychotherapy Effects on Reward Processing in PTSD
University of Texas at Austin
NCT06096740
Cognitive Control Training for Extinction in PTSD
VA Office of Research and Development
NCT06629064
Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in Veterans
Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
NCT04360681
Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI
NYU Langone Health
NCT04550377
General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to COVID-19
Weill Medical College of Cornell University
NCT04626050
Sympathetic Overactivity in Post-traumatic Stress Disorder
Emory University
NCT01627301
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
Yale University
NCT01730781
rTMS-augmented Written Exposure Therapy for PTSD
VA Office of Research and Development
NCT05149534
Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.
Massachusetts General Hospital
NCT07079761
Improving Sleep in Veterans With the Polytrauma Clinical Triad
VA Office of Research and Development
NCT06477796
Amygdala Memory Enhancement
Washington University School of Medicine
NCT05065450
The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans
Children's Hospital Los Angeles
NCT06218381
Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder
NYU Langone Health
NCT05391971
Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners
University of Michigan
NCT06324383
Brain Health & Wellness Classes for Veterans With Traumatic Brain Injury
East Bay Institute for Research and Education
NCT06150196
Randomized Trial of Tele Vs. Clinic TF-CBT in Puerto Rico
Medical University of South Carolina
NCT06332209
Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma
Paul Crawford
NCT05516862
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 22 |
| Phase 3 | 8 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Post Traumatic Stress Disorder Trial Landscape
146 indexed Post Traumatic Stress Disorder studies · 71 recruiting (49%).
Phase mix: 13 late (III/IV) vs 30 early (I/II).
Top sponsor: VA Office of Research and Development (19 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Post Traumatic Stress Disorder?
PlainTrial tracks 146 US clinical trials for Post Traumatic Stress Disorder, of which 71 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Post Traumatic Stress Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.