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ClinicalTrials.gov 54 recruiting now official registry

Post Traumatic Stress Disorder clinical trials

Every US clinical trial registered for Post Traumatic Stress Disorder — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

89 US clinical trials · 54 currently recruiting

The research picture

Post Traumatic Stress Disorder has 89 registered US clinical trials, 54 of them open to new participants right now — about 61% of the total.

54
recruiting participants now
61%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
8
top sponsor: VA Office of Research and Development

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 80,800 participants

Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress

Stanford University

NCT05701111

RECRUITING 50,000 participants

RIVER At Home Ketamine Protocols

RIVER Foundation

NCT06070766

RECRUITING Phase 2 800 participants

Department of Defense PTSD Adaptive Platform Trial - Master Protocol

Global Coalition for Adaptive Research

NCT05422612

RECRUITING NA 720 participants

Evaluation of the Parenting in the Moment Online Program for Forcibly Displaced Families

Arizona State University

NCT06548126

RECRUITING NA 676 participants

Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study

Johns Hopkins University

NCT07227337

RECRUITING NA 600 participants

CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos

Drexel University

NCT06139159

RECRUITING NA 600 participants

CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy

University of Texas at Austin

NCT05467683

RECRUITING NA 428 participants

Stepped Care for Posttraumatic Stress Disorder Study

Boston Medical Center

NCT06947538

RECRUITING NA 420 participants

A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD

United States Department of Defense

NCT06990191

RECRUITING NA 410 participants

Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers

University of Michigan

NCT05751473

RECRUITING Phase 3 372 participants

Goal-Directed Sedation in Mechanically Ventilated Infants and Children

Vanderbilt University Medical Center

NCT04801589

RECRUITING NA 330 participants

Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD

The University of Texas at Dallas

NCT03932773

RECRUITING NA 300 participants

Fear and Avoidance in PTSD Patients

The University of Texas Health Science Center, Houston

NCT04770584

RECRUITING Phase 3 300 participants

An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

Transcend Therapeutics

NCT07456696

RECRUITING NA 280 participants

Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

United States Department of Defense

NCT06957067

RECRUITING Phase 2 256 participants

Facilitation of Extinction Retention and Reconsolidation Blockade in PTSD

Boston University

NCT04468360

RECRUITING NA 221 participants

Non-invasive Nerve Stimulation for PTSD and Sleep

University of Florida

NCT03170440

RECRUITING Phase 2 200 participants

Department of Defense PTSD Adaptive Platform Trial - Intervention A - Fluoxetine

Global Coalition for Adaptive Research

NCT05948553

RECRUITING Phase 2 200 participants

Department of Defense PTSD Adaptive Platform Trial - Intervention C - Daridorexant

Global Coalition for Adaptive Research

NCT05948540

RECRUITING NA 200 participants

Neuromodulation and Neurorehabilitation for mTBI

Northwestern University

NCT03819608

RECRUITING NA 194 participants

OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit

VA Office of Research and Development

NCT05156112

RECRUITING NA 180 participants

Sleep and Emotion Processing in Adolescent Post-traumatic Stress Disorder

University of Wisconsin, Madison

NCT06341413

RECRUITING Phase 2 150 participants

Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD

NYU Langone Health

NCT03667846

RECRUITING 150 participants

Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat

Yale University

NCT06371404

RECRUITING Phase 2 148 participants

Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms

Virginia Commonwealth University

NCT07071350

RECRUITING NA 136 participants

Multifaceted Intervention to Restore Resilience and Overcome Risk

Icahn School of Medicine at Mount Sinai

NCT06988787

RECRUITING NA 132 participants

Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation

Florida State University

NCT06544408

RECRUITING Phase 2 128 participants

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

University of California, San Diego

NCT06273527

RECRUITING NA 120 participants

Psychotherapy Effects on Reward Processing in PTSD

University of Texas at Austin

NCT06096740

RECRUITING NA 120 participants

Cognitive Control Training for Extinction in PTSD

VA Office of Research and Development

NCT06629064

RECRUITING Phase 2 120 participants

Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in Veterans

Pharmacotherapies for Alcohol and Substance Use Disorders Alliance

NCT04360681

RECRUITING Phase 2 120 participants

Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI

NYU Langone Health

NCT04550377

RECRUITING 100 participants

Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

Yale University

NCT01730781

RECRUITING NA 98 participants

rTMS-augmented Written Exposure Therapy for PTSD

VA Office of Research and Development

NCT05149534

RECRUITING Phase 2 96 participants

Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.

Massachusetts General Hospital

NCT07079761

RECRUITING NA 90 participants

Amygdala Memory Enhancement

Washington University School of Medicine

NCT05065450

RECRUITING NA 80 participants

The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans

Children's Hospital Los Angeles

NCT06218381

RECRUITING Phase 4 80 participants

Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder

NYU Langone Health

NCT05391971

RECRUITING NA 80 participants

Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners

University of Michigan

NCT06324383

RECRUITING NA 75 participants

Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma

Paul Crawford

NCT05516862

RECRUITING NA 60 participants

TMS-fNIRS Personalized Dosing

Florida State University

NCT05916417

RECRUITING NA 50 participants

Mechanisms Underlying Efficacy of Prolonged Exposure

Massachusetts General Hospital

NCT05788302

RECRUITING Phase 1 50 participants

Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

Yale University

NCT05915013

RECRUITING NA 40 participants

Exploring Virtual Reality Adventure Training Exergaming

The University of Texas at Arlington

NCT05563805

RECRUITING Phase 2 40 participants

Determining the Potential for Efficacy of OTX-601 in Reducing PTSD Symptoms

Oui Therapeutics

NCT07316088

RECRUITING Phase 2 40 participants

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

Stephen Robert Marder

NCT05790239

RECRUITING NA 40 participants

Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

Wayne State University

NCT06740487

RECRUITING NA 30 participants

Targeting the Default Mode Network: A TMS-fMRI Study

Allyson Rosen

NCT05646732

RECRUITING NA 30 participants

Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI

The University of Texas Health Science Center at San Antonio

NCT07351305

RECRUITING Phase 2 30 participants

The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects

Yale University

NCT05786066

RECRUITING NA 20 participants

Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD

Montefiore Medical Center

NCT05929911

RECRUITING NA 20 participants

Innovative Multimodal and Attention Training to Improve Emotion Communication in Veterans With TBI and PTSD

VA Office of Research and Development

NCT05478759

RECRUITING NA 20 participants

eTMS for Veterans and First Responders With PTSD

Virginia Polytechnic Institute and State University

NCT06294106

RECRUITING Phase 2 18 participants

MDMA for AUD/PTSD Comorbidity

Carolina L Haass-Koffler

NCT05943665

ACTIVE NOT RECRUITING NA 191 participants

Efficacy of Virtual Warrior Renew Therapy for Veterans Who Experienced Military Sexual Trauma

Seattle Institute for Biomedical and Clinical Research

NCT05776719

ACTIVE NOT RECRUITING NA 80 participants

Testing the Effectiveness of a Therapist-Assisted Self-Management Program for Veterans Who Finished PTSD Therapy

VA Office of Research and Development

NCT05797441

ACTIVE NOT RECRUITING NA 70 participants

Web-administered STAIR for Patients on Behavioral Health Waitlists

Boston Medical Center

NCT06431022

ACTIVE NOT RECRUITING NA 40 participants

MOSAIC (MOthers' AdvocateS In the Community) for Pregnant Women and Mothers of Children Under 5 With Experience of Intimate Partner Violence

Michigan State University

NCT05106361

ACTIVE NOT RECRUITING Phase 1 20 participants

A Study of Psilocybin for PTSD

Johns Hopkins University

NCT06407635

ACTIVE NOT RECRUITING NA 20 participants

An Adjunctive Neurofeedback Training Program to Enhance Wellness Among Trauma-Exposed Postpartum Mothers

Wayne State University

NCT06054412

ACTIVE NOT RECRUITING NA 9 participants

Targeted Plasticity Therapy for Posttraumatic Stress Disorder

Baylor Research Institute

NCT04064762

COMPLETED 4,193 participants

National Child Traumatic Stress Network (NCTSN) Quality Improvement Initiative Database

Hugo W. Moser Research Institute at Kennedy Krieger

NCT01591694

COMPLETED NA 528 participants

Remotely Resolving Psychological Stress (Remote RePS)

University of California, San Francis

NCT03196999

COMPLETED NA 274 participants

Cognitive-Behavioral Conjoint Therapy (CBCT) Project

VA Office of Research and Development

NCT02720016

COMPLETED Phase 2 245 participants

ALTO-100 in MDD and/or PTSD

Alto Neuroscience

NCT05117632

COMPLETED NA 206 participants

The Family of Heroes: an Evaluation of an Online Educational Tool

Department of Veterans Affairs, New Jersey

NCT01554839

COMPLETED NA 200 participants

PTSD Training for PCPs in a Virtual World

San Francisco Veterans Affairs Medical Center

NCT03898271

COMPLETED NA 178 participants

Brief Peer Supported webSTAIR Compared to Enhanced Wait List

Palo Alto Veterans Institute for Research

NCT04286165

COMPLETED NA 170 participants

Quantifying the Efficacy and Role of Service Dogs for Military Veterans With PTSD

University of Arizona

NCT03245814

COMPLETED Phase 1 95 participants

Cannabidiol as a Treatment for AUD Comorbid With PTSD

NYU Langone Health

NCT03248167

COMPLETED NA 90 participants

Psychological Symptoms and Families of COVID-19 Patients

Rush University Medical Center

NCT04501445

COMPLETED NA 86 participants

Effectiveness of Cognitive, Exposure, and Skills Group Manualized Treatments in Operations Iraqi (OIF)/Operation Enduring Freedom (OEF) Female Veterans

New Mexico VA Healthcare System

NCT02069873

COMPLETED NA 80 participants

Primary-Care Based Mindfulness Intervention

Emory University

NCT03922581

COMPLETED NA 76 participants

Rehabilitation of Executive Functioning in Veterans With PTSD and Mild TBI

VA Office of Research and Development

NCT01921179

COMPLETED Phase 1 75 participants

Biological Signatures, Probiotic Among Those With mTBI and PTSD

VA Office of Research and Development

NCT02723344

COMPLETED NA 65 participants

Physiological Augmentation of Mindfulness Meditation

Emory University

NCT02754557

COMPLETED NA 45 participants

Effect of Mindfulness Meditation on Physiological Response to Unpredictable Stimuli

Georgetown University

NCT03206437

COMPLETED NA 45 participants

The Effects of the Safe and Sound Protocol on PTSD Symptoms and Anxiety

Indiana University

NCT04999852

COMPLETED NA 41 participants

Effects of a Short-term Exercise Intervention on Sleep in Women Exposed to Trauma: A Randomized Controlled Trial

University of Georgia

NCT05097352

COMPLETED 30 participants

Perceptions of MDMA-Assisted Therapy Among Veterans With PTSD

Albany Research Institute

NCT05895318

COMPLETED Phase 3 30 participants

Frontline Clinician Psilocybin Study

University of Washington

NCT05163496

COMPLETED Early Phase 1 28 participants

Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury

The University of Texas Health Science Center at San Antonio

NCT04280965

COMPLETED NA 25 participants

Transcranial Direct Current Stimulation (tDCS) in Human Subjects With PTSD Receiving an Exposure-based, Behavioral Therapy

The University of Texas Health Science Center at San Antonio

NCT05419999

COMPLETED NA 24 participants

Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain

Summa Health System

NCT00554320

COMPLETED 18 participants

The Effect of Nasal Continuous Positive Airway Pressure Treatment on PTSD Symptoms.

Northport Veterans Affairs Medical Center

NCT01512771

COMPLETED NA 16 participants

Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma

University of Massachusetts, Worcester

NCT03845985

COMPLETED NA 16 participants

Trauma Intervention for Affect Regulation, AIDS, and Substances

University of Miami

NCT02923141

COMPLETED NA 9 participants

CCTAP: Cognitive Control Training for Treatment of AUD-PTSD

Posit Science Corporation

NCT03200028

COMPLETED NA 7 participants

Pilot Study of PRX-03140 to Assess Safety for Use in Adult Subjects With Post Traumatic Stress Disorder

Alachua Government Services

NCT01492699

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 15
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Post Traumatic Stress Disorder Trial Landscape

ClinicalTrials.gov lists 89 US studies indexed under Post Traumatic Stress Disorder, and 54 of those are currently open to recruitment — roughly 61% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Post Traumatic Stress Disorder shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 20 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Post Traumatic Stress Disorder is led by VA Office of Research and Development with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 89 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Post Traumatic Stress Disorder?

PlainTrial tracks 89 US clinical trials for Post Traumatic Stress Disorder, of which 54 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Post Traumatic Stress Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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