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NCT05467410 · ClinicalTrials.gov registry record · NA
Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors
A NA study of Aging and Cognitive Impairment, sponsored by University of Washington.
- Active
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 2
- Study locations
NCT05467410: Active NA study of Aging and Cognitive Impairment, sponsored by University of Washington.
NCT05467410 is a NA study of Aging and Cognitive Impairment that is active but no longer recruiting, run by University of Washington. The registered enrollment target is 40 participants, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (98% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05467410, a NA study of Aging and Cognitive Impairment, is active but no longer recruiting, sponsored by University of Washington.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 2
- Study locations
Study Summary
More than 60% of intensive care unit (ICU) patients are adults ages 60 and older, who are at high risk for ICU-acquired cognitive impairment. After ICU discharge, ICU survivors often experience sleep disturbances and inactivity, and almost 80% of ICU patients experience disturbances in circadian rhythm, which may affect cognitive function. Understanding the optimal, chronotherapeutic timing of cognitive interventions is crucial to promote circadian realignment and cognitive function, and may improve intervention feasibility, acceptability, and efficacy. Specific Aim 1 will determine feasibility, acceptability, and preliminary effect sizes for: 1) a morning session of a computerized cognitive training intervention \[COG\]; and 2) a late afternoon/early evening session of the COG intervention; compared to 3) standard inpatient care/usual care \[UC\]. Specific Aim 2 will examine circadian rhythm parameters to determine the optimal timing of the daily COG intervention. Exploratory Aim 3 will explore if the effects of the COG intervention on cognitive function are mediated by daytime activity, and explore if selected biological and clinical factors moderate intervention effects on cognitive function.
Primary Outcome
A retention rate of \>70% will determine feasibility: the percentage of participants who complete at least 60 minutes of COG-AM sessions and all cognitive outcome assessments. Adherence to the COG-AM intervention will be defined as the proportion of minutes spent training by the total minutes required per protocol (total minutes trained / \[30 minutes x number of intervention days\]).
Conditions Studied
Interventions
- BEHAVIORAL COG-AM
- BEHAVIORAL COG-PM
Study Locations (2)
Washington
- Harborview Medical Center - Seattle
- University of Washington Medical Center - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2023-11-15 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What the registry record for NCT05467410 still lists
NCT05467410 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (98% lower).
The record links to 6 conditions, with Aging appearing as the primary indexed condition, and to 2 interventions - of which COG-AM is the first listed.
NCT05467410 reports a single indexed study location in Washington.
Frequently Asked Questions
What is clinical trial NCT05467410 about?
NCT05467410 is a clinical study titled "Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors". More than 60% of intensive care unit (ICU) patients are adults ages 60 and older, who are at high risk for ICU-acquired cognitive impairment. After ICU discharge, ICU survivors often experience sleep disturbances and inactivity, and almost 80% of ICU patients experience disturbances in circadian rhy...
What is the current status of trial NCT05467410?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2023-11-15. Estimated completion is 2026-12-31.
What conditions does trial NCT05467410 study?
This clinical trial studies the following conditions: Aging, Cognitive Impairment, Critical Illness, Circadian Dysrhythmia, Intensive Care Unit Delirium.
What interventions are being tested in trial NCT05467410?
The interventions under investigation include: COG-AM (BEHAVIORAL), COG-PM (BEHAVIORAL).
Who is sponsoring clinical trial NCT05467410?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05467410 being conducted?
This trial has 2 study locations across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05467410's enrollment target sits among peer trials
40 173rd of 262 higher than 84 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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