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NCT06750653 · ClinicalTrials.gov registry record · Phase 4
Skin Barrier Function and Inflammation in Aging: The BIA Study
A Phase 4 study of Aging and Inflammation, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 32
- Enrollment target
- 1
- Study location
NCT06750653: Recruiting Phase 4 study of Aging and Inflammation, sponsored by University of California, San Francisco.
NCT06750653 is a Phase 4 study of Aging and Inflammation that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 32 participants, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06750653, a Phase 4 study of Aging and Inflammation, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 32 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a randomized, investigator-blinded, self-controlled pilot study of the physiologic response to topical moisturizers among older adults with dry skin. The overarching hypothesis is that skin barrier decline is an important source of chronic inflammation, and that skin barrier restoration with moisturizers can reduce serum biomarkers of inflammation. The primary objective is to determine the feasibility for a larger trial, and the secondary objectives are to determine the extent to which measures of serum inflammation, skin barrier function, and the skin microbiome change in response to moisturizers. Participants will be asked to apply one of two topical moisturizers that are widely available over the counter in the US (Vaseline® 100% pure petroleum jelly or CeraVe® moisturizing cream) once daily for 4 weeks to the front of the torso, buttocks, arms, and legs. Subjects will act as their own control (i.e. they will be asked to apply the study moisturizer they are randomized to for one intervention period (4 weeks) and not to apply topical moisturizers for the other 4- week intervention period). Participants will be randomized in a 1:1:1:1 ratio to one of 4 treatment groups: i. no intervention then CeraVe; ii. CeraVe then no intervention; iii. no intervention then Vaseline; iv. Vaseline then no intervention. At each visit (baseline, week 4, and week 8), participants will undergo skin barrier testing, skin microbiome sampling, and phlebotomy to measure serum inflammatory markers.
Primary Outcome
To demonstrate the feasibility of a moisturizer-based skin barrier enhancement randomized controlled trial using these measures: Enrollment Rate: Number of participants enrolled in the study within a specified time frame Retention Rate: Percentage of participants who complete the study without dropping out, assessed at the end of the trial. Adherence to Protocol: Percentage of participants who adhere to the treatment regimen as outlined, calculated based on participant self-reports or product
Conditions Studied
Interventions
- OTHER CeraVe Moisturizing Cream
- DRUG Vaseline
Study Locations (1)
California
- UCSF - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2025-02-06 |
| Est. Completion | 2026-04-15 |
| Phase | Phase 4 |
What NCT06750653 shows while recruiting
NCT06750653 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (99% lower).
The record links to 3 conditions, with Aging appearing as the primary indexed condition, and to 2 interventions - of which CeraVe Moisturizing Cream is the first listed.
NCT06750653 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06750653 about?
NCT06750653 is a clinical study titled "Skin Barrier Function and Inflammation in Aging: The BIA Study". This is a randomized, investigator-blinded, self-controlled pilot study of the physiologic response to topical moisturizers among older adults with dry skin. The overarching hypothesis is that skin barrier decline is an important source of chronic inflammation, and that skin barrier restoration with...
What is the current status of trial NCT06750653?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 32 participants. The study started on 2025-02-06. Estimated completion is 2026-04-15.
What conditions does trial NCT06750653 study?
This clinical trial studies the following conditions: Aging, Inflammation, Skin Inflammation.
What interventions are being tested in trial NCT06750653?
The interventions under investigation include: CeraVe Moisturizing Cream (OTHER), Vaseline (DRUG).
Who is sponsoring clinical trial NCT06750653?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06750653 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06750653's enrollment target sits among peer trials
32 188th of 262 higher than 72 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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