Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Lung Non-Small Cell Carcinoma

Open-data reference.

48 US clinical trials · 23 currently recruiting

Active & Recent Trials

RECRUITING 2,000 participants

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

Wake Forest University Health Sciences

NCT06418204

RECRUITING Phase 3 1,210 participants

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

National Cancer Institute (NCI)

NCT04267848

RECRUITING NA 400 participants

Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non-small Cell Lung or Esophageal Cancer Undergoing Radiotherapy and Their Caregivers

M.D. Anderson Cancer Center

NCT03948100

RECRUITING Phase 3 306 participants

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

National Cancer Institute (NCI)

NCT06498635

RECRUITING NA 180 participants

Evaluation of Geriatric Assessment and Management for Older Adults With Non-small Cell Lung Cancer Receiving Chemotherapy Radiation Therapy

City of Hope Medical Center

NCT06139627

RECRUITING 150 participants

Predictive Biomarkers for Pneumonitis After Chemoradiotherapy and Immunotherapy in Patients With Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT04913311

RECRUITING NA 150 participants

Quality of Life Intervention to Inform Patient Decision-Making in Early-Stage Lung Cancer

Roswell Park Cancer Institute

NCT05292521

RECRUITING NA 100 participants

The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer

Thomas Jefferson University

NCT05502523

RECRUITING NA 100 participants

A Tool for Improving the Shared Decision-making Process in Patients With Non-small Cell Lung Cancer

Mayo Clinic

NCT06122064

RECRUITING NA 100 participants

Exercise Training for the Improvement of Immune Activity and Treatment Outcomes During Immunotherapy for Non-small Cell Lung Cancer, BOOST Trial

Fred Hutchinson Cancer Center

NCT06983899

RECRUITING Phase 2 88 participants

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

SWOG Cancer Research Network

NCT06116682

RECRUITING NA 70 participants

Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study

Northwestern University

NCT05802186

RECRUITING Phase 2 60 participants

Cemiplimab and Fianlimab Before Surgery for the Treatment of Stage IB-IIIB Non-Small Cell Lung Cancer

Mayo Clinic

NCT06918132

RECRUITING 45 participants

Qualitative Study on Detection & Tx of NSCLC in Pts w/ a History of Alcohol or SUD

University of Southern California

NCT07186699

RECRUITING 40 participants

Experiences w/ & Attitudes Towards Immune Chckpt Inhibitors in NSCLC Patients Single Center Survey Based Study

University of Southern California

NCT07339254

RECRUITING Phase 2 32 participants

Biologically Guided Radiation Therapy (BgRT) and Stereotactic Body Radiation Therapy (SBRT) to Tyrosine Kinase Inhibitor in Oligoprogressive Oncogenic Positive Non-Small Cell Lung Carcinoma

City of Hope Medical Center

NCT06014827

RECRUITING Phase 2 32 participants

Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

City of Hope Medical Center

NCT05830058

RECRUITING Phase 1 30 participants

Gilteritinib for the Treatment of ALK NSCLC

University of Michigan Rogel Cancer Center

NCT06225427

RECRUITING Phase 2 30 participants

Phase II Trial of Lung Chemoemobolization

City of Hope Medical Center

NCT05672108

RECRUITING Phase 1 25 participants

Split Course Adaptive Radiation Therapy With Pembrolizumab With/Without Chemotherapy for Treating Stage IV Lung Cancer

Vanderbilt-Ingram Cancer Center

NCT05501665

RECRUITING Phase 2 20 participants

Grid Radiation Therapy for the Treatment of Stage IV Non-Small Cell Lung Cancer

Mayo Clinic

NCT06660407

RECRUITING Early Phase 1 15 participants

Low-Dose Interleukin-2 and Pembrolizumab for the Treatment of Stage IV Non-Small Cell Lung Cancer

Emory University

NCT05493566

RECRUITING Phase 2 10 participants

Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer

Alan Davis

NCT07216404

ACTIVE NOT RECRUITING Phase 3 480 participants

Testing the Addition of the Drug Atezolizumab to the Usual Radiation Treatment for Patients With Early Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT04214262

ACTIVE NOT RECRUITING Phase 3 403 participants

Self-Management Survivorship Care in Stage I-III Non-small Cell Lung Cancer or Colorectal Cancer

City of Hope Medical Center

NCT04428905

ACTIVE NOT RECRUITING Phase 3 339 participants

Nivolumab and Ipilimumab With or Without Local Consolidation Therapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT03391869

ACTIVE NOT RECRUITING 182 participants

Risk of Chemotherapy Toxicity in Older Patients With Blood Cancer or Non-small Cell Lung Cancer

Ohio State University Comprehensive Cancer Center

NCT05106374

ACTIVE NOT RECRUITING Phase 2 173 participants

Osimertinib, Surgery, and Radiation Therapy in Treating Patients With Stage IIIB or IV Non-small Cell Lung Cancer With EGFR Mutations, NORTHSTAR Study

M.D. Anderson Cancer Center

NCT03410043

ACTIVE NOT RECRUITING Phase 2 116 participants

Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

SWOG Cancer Research Network

NCT04625647

ACTIVE NOT RECRUITING NA 98 participants

Decision Aid for the Improvement of Decision-Making in Patients With Non-small Cell Lung Cancer

OHSU Knight Cancer Institute

NCT04946279

ACTIVE NOT RECRUITING 74 participants

Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME Study

M.D. Anderson Cancer Center

NCT04430725

ACTIVE NOT RECRUITING Phase 1 51 participants

CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer

Roswell Park Cancer Institute

NCT02955290

ACTIVE NOT RECRUITING Phase 1 50 participants

Single Fraction Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Non-small Cell Lung Cancer

Roswell Park Cancer Institute

NCT04073745

ACTIVE NOT RECRUITING Phase 2 47 participants

Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients

National Cancer Institute (NCI)

NCT04310020

ACTIVE NOT RECRUITING Phase 1 47 participants

Infliximab or Vedolizumab in Treating Immune Checkpoint Inhibitor-Related Colitis in Patients With Genitourinary Cancer or Melanoma

M.D. Anderson Cancer Center

NCT04407247

ACTIVE NOT RECRUITING Phase 2 45 participants

Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pulmonary Nodules, the IMPRINT-Lung Study

M.D. Anderson Cancer Center

NCT03634241

ACTIVE NOT RECRUITING Phase 2 39 participants

Danvatirsen and Durvalumab in Treating Patients With Advanced and Refractory Pancreatic, Non-Small Cell Lung Cancer, and Mismatch Repair Deficient Colorectal Cancer

M.D. Anderson Cancer Center

NCT02983578

ACTIVE NOT RECRUITING Phase 1 35 participants

Local Consolidative Therapy and Brigatinib in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT03707938

ACTIVE NOT RECRUITING 28 participants

Imaging and Blood-Based Biomarkers for the Evaluation of Early Signs of Myocardial Injury After Thoracic Radiation Therapy

Ohio State University Comprehensive Cancer Center

NCT05717998

ACTIVE NOT RECRUITING Phase 2 25 participants

Anamorelin Hydrochloride in Reducing Anorexia in Patients With Advanced Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT03637816

ACTIVE NOT RECRUITING Phase 1 24 participants

CCL21-Gene Modified Dendritic Cell Vaccine and Pembrolizumab in Treating Patients With Stage IV Non-small Cell Lung Cancer

Jonsson Comprehensive Cancer Center

NCT03546361

ACTIVE NOT RECRUITING Phase 1 21 participants

Ipilimumab and Nivolumab in Combination With Radiation Therapy in Treating Patients With Stage 2-3 Non-small Lung Cancer

M.D. Anderson Cancer Center

NCT04013542

ACTIVE NOT RECRUITING Phase 1 19 participants

Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung Metastases

Ohio State University Comprehensive Cancer Center

NCT03824327

ACTIVE NOT RECRUITING Phase 2 9 participants

Pembrolizumab Every 12 Weeks Versus Every 3 Weeks in Treating Patients With Non-small Cell Lung Cancer

Roswell Park Cancer Institute

NCT04032418

ACTIVE NOT RECRUITING Phase 2 5 participants

A Multiple Antigen Vaccine (STEMVAC) for the Treatment of Patients With Stage IV Non-Small Cell Lung Cancer

University of Washington

NCT05242965

ACTIVE NOT RECRUITING Phase 2 5 participants

Subcutaneous Atezolizumab for the Treatment of Non-small Cell Lung Cancer

University of Southern California

NCT05340309

COMPLETED NA 14 participants

Genetics and Shared Decision Making in Improving Care for Patients With Stage IVA-C Non-small Cell Lung Cancer

Thomas Jefferson University

NCT03944265

COMPLETED 13 participants

Pharmacokinetic Profiling of Pembrolizumab and Nivolumab in Patients With Melanoma and/or Non-Small Cell Lung Cancer

Mayo Clinic

NCT05740501

Phase Distribution

PhaseTrial count
Early Phase 1 10
Phase 2 16
Phase 3 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Lung Non-Small Cell Carcinoma Trial Landscape

ClinicalTrials.gov lists 48 US studies indexed under Lung Non-Small Cell Carcinoma, and 23 of those are currently open to recruitment — roughly 48% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Lung Non-Small Cell Carcinoma shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 26 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Lung Non-Small Cell Carcinoma is led by M.D. Anderson Cancer Center with 11 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 48 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Lung Non-Small Cell Carcinoma?

PlainTrial tracks 48 US clinical trials for Lung Non-Small Cell Carcinoma, of which 23 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Lung Non-Small Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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