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NCT05835999 · ClinicalTrials.gov registry record · Phase 2
Everolimus Aging Study
A Phase 2 study of Aging and Insulin Resistance, sponsored by University of Wisconsin, Madison.
- Active
- Registry status
- Phase 2
- Development phase
- 106
- Enrollment target
- 1
- Study location
NCT05835999 is a Phase 2 study of Aging and Insulin Resistance that is active but no longer recruiting, run by University of Wisconsin, Madison. The registered enrollment target is 106 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05835999, a Phase 2 study of Aging and Insulin Resistance, is active but no longer recruiting, sponsored by University of Wisconsin, Madison.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 106 participants
- Enrollment target
- 1
- Study location
Study Summary
The objective of this project is to determine if mTORC1 inhibition by 24 weeks of daily (0.5 mg/day) or weekly (5 mg/week) everolimus can safely improve physiological and molecular hallmarks of aging in humans. Participants who are 55-80 years old and insulin resistant or prediabetic will be randomized to treatment and can expect to be on study for up to approximately 38 weeks. Participants aged 18-35 will not receive the intervention and can expect to be on study for up to approximately 8 weeks.
Conditions Studied
Interventions
- DRUG Everolimus 0.5 MG once per day
- DRUG Everolimus 5 MG once per week
- DRUG Placebo once per day
- DRUG Placebo once per week
Study Locations (1)
Wisconsin
- University of Wisconsin-Madison - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 106 participants |
| Start Date | 2023-03-24 |
| Est. Completion | 2026-09 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05835999
The ClinicalTrials.gov registry entry for NCT05835999 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 106 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (95% lower). The listed sponsor is University of Wisconsin, Madison, which has 1,039 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Aging appearing as the primary indexed condition, and to 4 interventions - of which Everolimus 0.5 MG once per day is the first listed.
NCT05835999 reports 1 study location spanning 1 distinct geographic area - top geographies include Wisconsin.
Frequently Asked Questions
What is clinical trial NCT05835999 about?
NCT05835999 is a clinical study titled "Everolimus Aging Study". The objective of this project is to determine if mTORC1 inhibition by 24 weeks of daily (0.5 mg/day) or weekly (5 mg/week) everolimus can safely improve physiological and molecular hallmarks of aging in humans. Participants who are 55-80 years old and insulin resistant or prediabetic will be randomi...
What is the current status of trial NCT05835999?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 106 participants. The study started on 2023-03-24. Estimated completion is 2026-09.
What conditions does trial NCT05835999 study?
This clinical trial studies the following conditions: Aging, Insulin Resistance.
What interventions are being tested in trial NCT05835999?
The interventions under investigation include: Everolimus 0.5 MG once per day (DRUG), Everolimus 5 MG once per week (DRUG), Placebo once per day (DRUG), Placebo once per week (DRUG).
Who is sponsoring clinical trial NCT05835999?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05835999 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.