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Head and Neck Cancer: early-phase trial registry
89 of 260 indexed Head and Neck Cancer trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #39 of 28,707 conditions by registered trial count.
260 US clinical trials · 89 currently recruiting · #39 of 28,707 conditions by registered trial count
Head and Neck Cancer: 260 US clinical trials tracked, 89 recruiting.
Head and Neck Cancer is the subject of 260 registered US clinical trials on ClinicalTrials.gov, 89 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 137 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 19 of these trials.
Enrollment posture brief
Registry condition head-and-neck-cancer
OPEN 89 | RECR 34% | LATE 13 | EARLY 137 | RANK #39 | SPON 19
Volume-matched condition peers
Nearest open-share peer: Recurrent Malignant Solid Neoplasm (34% recruiting · 38 trials)
Head and Neck Cancer lists 89 open slots (34% of 260 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Head and Neck Cancer on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Head and Neck Cancer is recruiting below its size-band peers.
89 of 260 indexed trials (34.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Head and Neck Cancer trials is spread across many organizations.
M.D. Anderson Cancer Center accounts for 19 of 260 trials (7.3%). 124 distinct sponsors appear on at least one study for this condition label.
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Most Head and Neck Cancer trials plan to enrol fewer than 100 people.
Median target enrolment is 53 among the 251 trials that report a genuine target (sentinel values excluded). 165 of those (65.7%) plan for fewer than 100 participants.
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Head and Neck Cancer research is mostly interventional.
213 interventional and 47 observational studies make up this index (81.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
260 total, page 1 of 6
Sample Collection for Ongoing Research and Product Evaluation Study
Natera
NCT07318051
Tissue Sample Collection From Patients With Head and Neck Cancer and From Healthy Participants
Vanderbilt University Medical Center
NCT00898638
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Adela
NCT05366881
Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies
Elephas
NCT07327489
Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors
The New York Proton Center
NCT05313191
Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Diagnosing Osteoradionecrosis in Patients With Head and Neck Cancer That Is Primary, Has Come Back, or Has Spread to Other Places in the Body
M.D. Anderson Cancer Center
NCT03145077
Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT05995821
The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care
University of Chicago
NCT04541381
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Daiichi Sankyo
NCT06172478
Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
University of Colorado, Denver
NCT00900419
Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy
Medical University of South Carolina
NCT05793151
Identification and Characterization of Novel Proteins and Genes in Head and Neck Cancer
Stanford University
NCT00230308
A Study Evaluating the Integrative Medicine at Home (IM@HOME) Program in People With Cancer
Memorial Sloan Kettering Cancer Center
NCT05053230
The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads
Medical University of South Carolina
NCT05811936
Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT05658731
Improving Care for Rural Patients With Solid Tumors
University of Colorado, Denver
NCT04916990
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Pfizer
NCT07090499
Comparing Two Ways to Manage Head and Neck Lymphedema
Abramson Cancer Center at Penn Medicine
NCT05182229
Perioperative Nutritional Optimization in Head and Neck Cancer Patients
University of Illinois at Chicago
NCT04449445
Implementing the NYU Electronic Patient Visit Assessment (ePVA) for Head and Neck Cancer In Rural and Urban Populations
The University of Texas Health Science Center, Houston
NCT06030011
Locally AblatiVe TherApy in OLigO-pRogressive SOlid TUmorS (VALOROUS)
University of California, Davis
NCT06103669
Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer
National Institute on Deafness and Other Communication Disorders (NIDCD)
NCT04915183
New MRI Biomarkers in Head and Neck Cancers
Memorial Sloan Kettering Cancer Center
NCT03483337
Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers
Stanford University
NCT00568490
Building a Renewed ImaGe After Head & Neck Cancer Treatment (BRIGHT) Multi-Site RCT
Medical University of South Carolina
NCT05442957
A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
ALX Oncology
NCT07085091
ATATcH Alternating Treatment Plans for Advanced Cancer
Rutgers, The State University of New Jersey
NCT05358548
NLit and Outcomes in HNC Survivor-Caregiver Dyads
University of Kansas Medical Center
NCT07021885
A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors
Aktis Oncology
NCT07020117
Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema
Abramson Cancer Center at Penn Medicine
NCT06837480
A Motion Exergaming Approach for Symptom Management: HNC
University of Alabama at Birmingham
NCT04632654
Reflectance Confocal Microscopy of Oral Cancers in Vivo: a Preliminary Trial Comparing Intra-oral Imaging With Pathology
Memorial Sloan Kettering Cancer Center
NCT02507141
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT
University of California, San Francisco
NCT06633224
A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)
University of Texas Southwestern Medical Center
NCT05576974
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
ModeX Therapeutics, An OPKO Health Company
NCT06239194
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Perspective Therapeutics
NCT06710756
Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma
Dana-Farber Cancer Institute
NCT03875716
COPD Care Pathway Among Patients With Cancer
Wake Forest University Health Sciences
NCT05984680
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Washington University School of Medicine
NCT04354064
Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy
Covenant Health Cancer Center
NCT06183268
DESTINY-PANTUMOUR04
AstraZeneca
NCT07124000
TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers
University of Chicago
NCT05108870
Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia
UNC Lineberger Comprehensive Cancer Center
NCT07278557
Axoguard HA Plus Nerve Protector to Reduce Post-operative Neck and Shoulder Dysfunction in Patients Undergoing Neck Dissection
Matthew Spector
NCT07283861
Preservation of Swallowing in Respected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects (PRESERVE): A Randomized Trial
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
NCT03997643
Early Feeding After Oral Cavity Reconstruction
Icahn School of Medicine at Mount Sinai
NCT04787939
Training Swallowing Initiation During Expiration
Northwestern University
NCT05278039
Jump: MR Simulation For Radiation Therapy Master Protocol
Brigham and Women's Hospital
NCT04545957
Invert-Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy
University of Texas Southwestern Medical Center
NCT06477692
Apixaban or Enoxaparin After Head and Neck Cancer Surgery
Kiranya Arnold
NCT07189897
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 63 |
| Phase 2 | 74 |
| Phase 3 | 11 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Head and Neck Cancer records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Head and Neck Cancer trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Head and Neck Cancer page
260 registered trials, 89 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 89 Head and Neck Cancer trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- M.D. Anderson Cancer Center sponsors the most Head and Neck Cancer trials on record, review their full trial history before evaluating a specific study. See M.D. Anderson Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Head and Neck Cancer condition card totals 260 registered trials; most-linked intervention cisplatin; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.