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Opioid Use Disorder: early-phase trial registry
156 of 258 indexed Opioid Use Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #40 of 28,707 conditions by registered trial count.
258 US clinical trials · 156 currently recruiting · #40 of 28,707 conditions by registered trial count
Opioid Use Disorder: 258 US clinical trials tracked, 156 recruiting.
Opioid Use Disorder is the subject of 258 registered US clinical trials on ClinicalTrials.gov, 156 of them currently open to new participants. 23 are in Phase 3-4 (later-stage) and 59 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 19 of these trials.
Enrollment posture brief
Registry condition opioid-use-disorder
OPEN 156 | RECR 60% | LATE 23 | EARLY 59 | RANK #40 | SPON 19
Volume-matched condition peers
Nearest open-share peer: HIV Prevention (61% recruiting · 33 trials)
Opioid Use Disorder lists 156 open slots (60% of 258 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Opioid Use Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Opioid Use Disorder is recruiting above its size-band peers.
156 of 258 indexed trials (60.5%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Opioid Use Disorder trials is spread across many organizations.
Yale University accounts for 19 of 258 trials (7.4%). 127 distinct sponsors appear on at least one study for this condition label.
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Typical Opioid Use Disorder enrolment sits around 103 participants.
Median target enrolment is 103 among the 258 trials that report a genuine target (sentinel values excluded). 121 of those (46.9%) plan for fewer than 100 participants.
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Opioid Use Disorder research is mostly interventional.
233 interventional and 25 observational studies make up this index (90.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
258 total, page 1 of 6
Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data
University of Washington
NCT06768814
Adolescent Outcomes of Post-operative Opioid EXposure
Sharon Levy
NCT06350409
Systems Analysis and Improvement to Optimize Opioid Use Disorder Care Quality and Continuity for Patients Exiting Jail
University of Washington
NCT06593353
AvertD Post-Approval Study
Prescient Medicine Holdings
NCT07135323
Adaptive Decision Support for Addiction Treatment Master
Yale University
NCT06799117
Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement
University of Pennsylvania
NCT05897788
Following Outcomes Remotely Within Addiction Recovery Domains
Mclean Hospital
NCT06001437
Reducing Opioid Mortality in Illinois
University of Chicago
NCT04925427
Machine-Learning Prediction and Reducing Overdoses With EHR Nudges
University of Pittsburgh
NCT06806163
Pain and Opioid Management in Older Adults
University of Oklahoma
NCT05037682
Supporting Treatment Access and Recovery in COD
University of Massachusetts, Worcester
NCT05138614
A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder
VA Office of Research and Development
NCT04375033
Expanding Medication-Assisted Therapies in Central Asia
Yale University
NCT05579470
Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis
University of Michigan
NCT05665179
NavSTAR Implementation Effectiveness Trial Across a Health System
Friends Research Institute
NCT07262190
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
Yale University
NCT06323824
Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes
Senthil Sadhasivam
NCT03923374
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Wake Forest University Health Sciences
NCT04927143
Telehealth vs In-Person Evaluation of Addiction Treatment After Visiting the Emergency Department
University of California, Davis
NCT06961058
Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With PrEP Adherence and Support Services
Yale University
NCT04738825
Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder
RAND
NCT06827288
Disclosure Intervention for People in Treatment for Opioid Use Disorder
University of Delaware
NCT06458985
Psilocybin for Opioid Use Disorder (OUD)
NYU Langone Health
NCT06796062
A Study of Brenipatide in Participants With Opioid Use Disorder
Eli Lilly and Company
NCT07420283
Opioid Treatment and Peer Recovery Support
Brown University
NCT04978168
Project I Test: Implementing HIV Testing in Opioid Treatment Programs
Columbia University
NCT03135886
A Multi-site Intervention to Expand Hospital Based OUD Treatment Provision
University of Colorado, Denver
NCT06291090
Emergency Medicine Peer Outreach Worker Engagement for Recovery
University of California, Los Angeles
NCT06320015
Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention
University of Pennsylvania
NCT06843213
Standard Versus High Dose ED-Initiated Buprenorphine Induction
Yale University
NCT06494904
Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder
T. John Winhusen, PhD
NCT06651177
Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use
Elana Rosenthal
NCT06513156
E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
NYU Langone Health
NCT05722561
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
Evon Medics
NCT06434818
Community-based Education, Navigation, and Support Intervention for Military Veterans
New York University
NCT05343169
Leveraging Artificial Intelligence and Multi-Omics Data to Predict Opioid Addiction
University of California, San Diego
NCT06540105
Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department
University of California, San Francisco
NCT06872190
Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness
Ohio State University
NCT06311838
Intervening on Opioid Use and Loneliness
University of Rochester
NCT06458335
Using AI and Peer Coaching to Address Racial Disparities Among People Who Use Opioids
Friends Research Institute
NCT06569667
PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study
Boston Medical Center
NCT05769218
Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP
University of Connecticut
NCT05669534
Right Tools, Right Time, Right Place: Telehealth for Opioid Use Disorder in Vulnerable Settings
Boulder Care
NCT07169409
Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women
Yale University
NCT05547048
Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose
Rhode Island Hospital
NCT06316830
Young Houston Emergency Opioid Engagement System
The University of Texas Health Science Center, Houston
NCT04811014
Buprenorphine for Individuals in Jail
Friends Research Institute
NCT06306443
Treating Polysubstance Use Using a Novel Digital Technology
Friends Research Institute
NCT05766631
Minds and Mentors Program- R33
University of Alabama, Tuscaloo
NCT05363371
Social Functioning in Opioid Use Disorder
Medical University of South Carolina
NCT07044466
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 27 |
| Phase 2 | 32 |
| Phase 3 | 12 |
| Phase 4 | 11 |
Top Sponsors
Named interventions
Most-linked intervention names on Opioid Use Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Opioid Use Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Opioid Use Disorder page
258 registered trials, 156 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 156 Opioid Use Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Yale University sponsors the most Opioid Use Disorder trials on record, review their full trial history before evaluating a specific study. See Yale University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Opioid Use Disorder condition card totals 258 registered trials; most-linked intervention Placebo; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.