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NCT03932162 · ClinicalTrials.gov registry record · Early Phase 1
Gene Expression Changes In Young and Geriatric Skin
A Early Phase 1 study of Aging and UVB Phototherapy Burn, sponsored by Wright State University.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT03932162: Recruiting Early Phase 1 study of Aging and UVB Phototherapy Burn, sponsored by Wright State University.
NCT03932162 is a Early Phase 1 study of Aging and UVB Phototherapy Burn that is actively recruiting participants, run by Wright State University. The registered enrollment target is 24 participants, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03932162, a Early Phase 1 study of Aging and UVB Phototherapy Burn, is actively recruiting participants, sponsored by Wright State University.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.
Primary Outcome
Expression genes involved in protecting skin cells from UVB damage, including p21, xeroderma pigmentosum (XPC), and polymerase eta, will be higher following UVB exposure in younger skin and geriatric skin injected with IGF-1 than in geriatric skin injected with saline as a control.
Conditions Studied
Interventions
- DRUG Insulin-Like Growth Factor 1
- OTHER No Insulin-Lie Growth Factor 1
Study Locations (1)
Ohio
- Wright State Physicians - Fairborn
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2019-09-06 |
| Est. Completion | 2025-12 |
| Phase | Early Phase 1 |
What NCT03932162 shows while recruiting
NCT03932162 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (99% lower).
The record links to 3 conditions, with Aging appearing as the primary indexed condition, and to 2 interventions - of which Insulin-Like Growth Factor 1 is the first listed.
NCT03932162 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT03932162 about?
NCT03932162 is a clinical study titled "Gene Expression Changes In Young and Geriatric Skin". This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to u...
What is the current status of trial NCT03932162?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 24 participants. The study started on 2019-09-06. Estimated completion is 2025-12.
What conditions does trial NCT03932162 study?
This clinical trial studies the following conditions: Aging, UVB Phototherapy Burn, Insulin-like Growth Factor 1.
What interventions are being tested in trial NCT03932162?
The interventions under investigation include: Insulin-Like Growth Factor 1 (DRUG), No Insulin-Lie Growth Factor 1 (OTHER).
Who is sponsoring clinical trial NCT03932162?
This trial is sponsored by Wright State University, which has 32 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03932162 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT03932162's enrollment target sits among peer trials
24 214th of 262 higher than 40 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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