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NCT06842784 · ClinicalTrials.gov registry record
Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults
A clinical trial of Aging and Hyperthermia, sponsored by University of Texas Southwestern Medical Center.
- Recruiting
- Registry status
- 24
- Enrollment target
- 1
- Study location
NCT06842784: Recruiting study of Aging and Hyperthermia, sponsored by University of Texas Southwestern Medical Center.
NCT06842784 is a study of Aging and Hyperthermia that is actively recruiting participants, run by University of Texas Southwestern Medical Center. The registered enrollment target is 24 participants, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06842784, a study of Aging and Hyperthermia, is actively recruiting participants, sponsored by University of Texas Southwestern Medical Center.
- RECRUITING
- Registry status
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalizations and deaths are primarily due to cardiovascular events such as myocardial infarction. Previous data indicate that older adults have attenuated skin blood flow and sweating responses when exposed to heat, resulting greater increase in core body temperature. Despite these observations, relatively little is known about the risk for myocardial ischemia potentially contributing to the aforementioned higher morbidity and mortality in older adults during heat waves. The broad objective of this work is to determine the impact of ambient heat exposure on myocardial blood flow and flow reserve in young and older adults. Aim 1 will test the hypothesis that older adults exhibit attenuated myocardial flow reserve compared to young adults during heat stress. Aim 2 will determine if the percent of maximal myocardial flow reserve (assess via vasodilator stress) during heat exposure is higher in older adults compared to young adults. The expected outcome from this body of work will improve our understanding of the consequences of aging on cardiovascular responses to ambient heat stress.
Primary Outcome
Measured via myocardial contrast echocardiography.
Conditions Studied
Interventions
- OTHER Ambient heat stress
Study Locations (1)
Texas
- Texas Health Presbyterian Hospital Dallas - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2025-02-03 |
| Est. Completion | 2027-02-01 |
What NCT06842784 shows while recruiting
NCT06842784 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (99% lower).
The record links to 4 conditions, with Aging appearing as the primary indexed condition, and to 1 intervention - of which Ambient heat stress is the first listed.
NCT06842784 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06842784 about?
NCT06842784 is a clinical study titled "Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults". Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalizations and deaths are primarily due to cardiovascular events such as myocardial infarction. Previous data indicate that older adults have attenuat...
What is the current status of trial NCT06842784?
This trial is currently recruiting. The enrollment target is 24 participants. The study started on 2025-02-03. Estimated completion is 2027-02-01.
What conditions does trial NCT06842784 study?
This clinical trial studies the following conditions: Aging, Hyperthermia, Heat Stress, Heat Strain.
What interventions are being tested in trial NCT06842784?
The interventions under investigation include: Ambient heat stress (OTHER).
Who is sponsoring clinical trial NCT06842784?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06842784 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aging
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06842784's enrollment target sits among peer trials
24 214th of 262 higher than 40 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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