Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Tobacco Use
Open-data reference.
77 US clinical trials · 33 currently recruiting
Active & Recent Trials
The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study
Memorial Sloan Kettering Cancer Center
NCT06535867
CONNECT Cancer Survivors With Tobacco Treatment
Washington University School of Medicine
NCT07020273
Reach Through Equitable Implementation in Utah
University of Utah
NCT06881069
Overcoming Nicotine Dependence to Enable Quitting
Rush University Medical Center
NCT05513872
Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
Abramson Cancer Center at Penn Medicine
NCT07199517
Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement
Rutgers, The State University of New Jersey
NCT06033599
Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux
Louis Stokes VA Medical Center
NCT06746623
Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes
Montefiore Medical Center
NCT05642715
Cigar Legislation and Regulation in Tobacco for the Young (Project CLARITY)
University of Oklahoma
NCT07162935
Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
Philip Morris Products S.A.
NCT07108166
Journey of Transformation Curriculum for Native American Youth
University of Washington
NCT05731713
STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking
Medical University of South Carolina
NCT06922617
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
Abramson Cancer Center at Penn Medicine
NCT06264154
Developing a Scalable Tobacco Cessation Program for Cancer Survivors and Caregivers
University of Florida
NCT06851936
Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
Abramson Cancer Center at Penn Medicine
NCT06372899
Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness
University of California, San Francis
NCT07148232
Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior
Penn State University
NCT05572671
Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain
Duke University
NCT06983678
Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse
Yale University
NCT06609369
Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation
Loma Linda University
NCT06438549
Effect of Cannabis on Cigarette Use Behavior
Johns Hopkins University
NCT06609083
Effect of Cannabis on E-Cigarette Use Behavior
Johns Hopkins University
NCT06609109
RTMS Targets Neural Circuits for Smoking Cessation
Medical University of South Carolina
NCT04903028
Opioids, Low Nicotine Cigarettes, and Chronic Pain
Duke University
NCT06747871
Developing a Positive Approach to Substance Use Prevention in North American Indian Adolescents
University of Rhode Island
NCT05380765
Oral Cannabidiol for Tobacco Cessation
Johns Hopkins University
NCT05445804
Cardiovascular Effects of Very Low Nicotine Content Cigarettes
Wake Forest University Health Sciences
NCT05707871
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
University of California, San Francis
NCT05999383
Impact of Semaglutide on Tobacco Use and Related Health Behaviors
University of Oklahoma
NCT06986993
Abuse Liability for Five Modern Oral Nicotine Products
RAI Services Company
NCT07132814
Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia
Stony Brook University
NCT05724810
Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Masonic Cancer Center, University of Minnesota
NCT06295757
A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
Memorial Sloan Kettering Cancer Center
NCT06693700
Comparing an Opt-out to an opt-in Approach for Smoking Cessation in VA Primary Care Clinics
VA Office of Research and Development
NCT03477435
A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities
University of Minnesota
NCT05671380
Development of UP2UTobacco for High School Youth
University of Virginia
NCT05396911
Post Acute Cardiac Event Smoking (PACES) Study
Hennepin Healthcare Research Institute
NCT03413423
Teachable Moment to Opt-out of Tobacco: Interactive Voice Response Quit Line for Veteran Active Smokers With Lung Nodules
VA Office of Research and Development
NCT04574518
The Effect of Tobacco Products on Wound Healing
University of Minnesota
NCT04870970
E-cigarette Switching Older Adults
University of Maryland, Baltimore
NCT06534905
Helping Poor Smokers Quit
Washington University School of Medicine
NCT03194958
Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage
William Middleton
NCT07213947
Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products
Altria Client Services
NCT06179290
Improving Tobacco Treatment Rates for Cancer Patients Who Smoke
Abramson Cancer Center at Penn Medicine
NCT04738643
Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT)
Medical University of South Carolina
NCT03453385
Asian Youth and Tobacco Control Survey
M.D. Anderson Cancer Center
NCT00642317
A Mobile App Based Cognitive Dissonance Intervention for Smoking Cessation
Oregon Research Behavioral Intervention Strategies
NCT05797155
Responses to Regulated E-Cigarette Advertisements
University of Massachusetts, Worcester
NCT05207033
CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting
RAI Services Company
NCT05307822
A Facebook Intervention for Young Sexual and Gender Minority Smokers
University of California, San Francis
NCT03259360
Media Literacy for High School Tobacco Prevention
University of Pittsburgh
NCT05120466
A Guided Imagery Tobacco Cessation Intervention Delivered by a Quit Line and Website
University of Arizona
NCT02968381
An Intervention to Address Parental Smoking During the Postpartum Hospitalization.
Massachusetts General Hospital
NCT00844818
A Mobile Intervention to Promote Cessation in HIV-infected Smokers
Montefiore Medical Center
NCT02432482
Emergency Department Initiated Tobacco Treatment (EDITT)
National Institute on Drug Abuse (NIDA)
NCT00252902
CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants
RAI Services Company
NCT05114863
Development of a Mindfulness-Based Treatment for the Reduction of Alcohol Use and Smoking Cessation
H. Lee Moffitt Cancer Center and Research Institute
NCT03734666
Jail-Based Use of Smoking Cessation Treatment Study
Hennepin Healthcare Research Institute
NCT03799315
Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes
22nd Century Group
NCT03559751
Feasibility Study - Filter Ventilation
Masonic Cancer Center, University of Minnesota
NCT04514471
Connecting Alaska Native People to Quit Smoking
Mayo Clinic
NCT03645941
CSD170202: A Study to Evaluate the Exposure to Tobacco Constituents From Two Moist Snuff Products
RAI Services Company
NCT03158428
Preventing Cigarette Use Among Urban Youth Via an M-Health Primary Care Preventive Intervention
University of Michigan
NCT03855410
CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches
RAI Services Company
NCT05294497
Modern Nicotine Oral Product Abuse Liability
RAI Services Company
NCT06777784
Biomarker Feedback to Motivate Tobacco Cessation in Pregnant ALaska Native Women: Phase 2
Mayo Clinic
NCT02018640
CSD201202: A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System P12
RAI Services Company
NCT05239884
A Study to Assess the Pharmacokinetics of Oral Nicotine Pouches and Lozenges in Healthy Adults
British American Tobacco (Investments) Limited
NCT04755348
Minocycline and Tobacco Craving in Smokers With Schizophrenia
University of Maryland, Baltimore
NCT02968602
Families With Substance Use and Psychosis: A Pilot Study
Mclean Hospital
NCT04284813
Salt-Based E-cigarette
Medical University of South Carolina
NCT04238832
Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free
H. Lee Moffitt Cancer Center and Research Institute
NCT05362318
BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability
RAI Services Company
NCT06105424
Baby Albert: Electronic Cigarette Pharmacokinetics (PK) and Abuse Liability
University of Oklahoma
NCT03637452
Patient Navigation-based Tobacco Harm Reduction Program Among Cancer Patients
Milton S. Hershey Medical Center
NCT04972916
Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder
Medical University of South Carolina
NCT05796791
Provider Training in Increasing Patient Tobacco Cessation Counseling and Referrals for Patients With Cancer Undergoing Radiation Therapy
OHSU Knight Cancer Institute
NCT03135782
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 8 |
| Phase 2 | 2 |
| Phase 3 | 1 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Tobacco Use Trial Landscape
ClinicalTrials.gov lists 77 US studies indexed under Tobacco Use, and 33 of those are currently open to recruitment — roughly 43% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Tobacco Use shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 10 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Tobacco Use is led by RAI Services Company with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 77 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Tobacco Use?
PlainTrial tracks 77 US clinical trials for Tobacco Use, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Tobacco Use?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.