Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Tobacco Use: early-phase trial registry
33 of 77 indexed Tobacco Use trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #175 of 28,707 conditions by registered trial count.
77 US clinical trials · 33 currently recruiting · #175 of 28,707 conditions by registered trial count
Tobacco Use: 77 US clinical trials tracked, 33 recruiting.
Tobacco Use is the subject of 77 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is RAI Services Company, running 8 of these trials.
Enrollment posture brief
Registry condition tobacco-use
OPEN 33 | RECR 43% | LATE 4 | EARLY 10 | RANK #175 | SPON 8
Volume-matched condition peers
Nearest open-share peer: Acute Myelogenous Leukemia (AML) (43% recruiting · 7 trials)
Tobacco Use lists 33 open slots (43% of 77 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Tobacco Use on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Tobacco Use is recruiting above its size-band peers.
33 of 77 indexed trials (42.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Tobacco Use trials is spread across many organizations.
RAI Services Company accounts for 8 of 77 trials (10.4%). 46 distinct sponsors appear on at least one study for this condition label.
-
Typical Tobacco Use enrolment sits around 100 participants.
Median target enrolment is 100 among the 77 trials that report a genuine target (sentinel values excluded). 36 of those (46.8%) plan for fewer than 100 participants.
-
Tobacco Use research is mostly interventional.
72 interventional and 5 observational studies make up this index (93.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
77 total, page 1 of 2
The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study
Memorial Sloan Kettering Cancer Center
NCT06535867
CONNECT Cancer Survivors With Tobacco Treatment
Washington University School of Medicine
NCT07020273
Reach Through Equitable Implementation in Utah
University of Utah
NCT06881069
Overcoming Nicotine Dependence to Enable Quitting
Rush University Medical Center
NCT05513872
Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
Abramson Cancer Center at Penn Medicine
NCT07199517
Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement
Rutgers, The State University of New Jersey
NCT06033599
Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux
Louis Stokes VA Medical Center
NCT06746623
Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes
Montefiore Medical Center
NCT05642715
Cigar Legislation and Regulation in Tobacco for the Young (Project CLARITY)
University of Oklahoma
NCT07162935
Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
Philip Morris Products S.A.
NCT07108166
Journey of Transformation Curriculum for Native American Youth
University of Washington
NCT05731713
STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking
Medical University of South Carolina
NCT06922617
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
Abramson Cancer Center at Penn Medicine
NCT06264154
Developing a Scalable Tobacco Cessation Program for Cancer Survivors and Caregivers
University of Florida
NCT06851936
Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
Abramson Cancer Center at Penn Medicine
NCT06372899
Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness
University of California, San Francisco
NCT07148232
Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior
Penn State University
NCT05572671
Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain
Duke University
NCT06983678
Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse
Yale University
NCT06609369
Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation
Loma Linda University
NCT06438549
Effect of Cannabis on Cigarette Use Behavior
Johns Hopkins University
NCT06609083
Effect of Cannabis on E-Cigarette Use Behavior
Johns Hopkins University
NCT06609109
RTMS Targets Neural Circuits for Smoking Cessation
Medical University of South Carolina
NCT04903028
Opioids, Low Nicotine Cigarettes, and Chronic Pain
Duke University
NCT06747871
Developing a Positive Approach to Substance Use Prevention in North American Indian Adolescents
University of Rhode Island
NCT05380765
Oral Cannabidiol for Tobacco Cessation
Johns Hopkins University
NCT05445804
Cardiovascular Effects of Very Low Nicotine Content Cigarettes
Wake Forest University Health Sciences
NCT05707871
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
University of California, San Francisco
NCT05999383
Impact of Semaglutide on Tobacco Use and Related Health Behaviors
University of Oklahoma
NCT06986993
Abuse Liability for Five Modern Oral Nicotine Products
RAI Services Company
NCT07132814
Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia
Stony Brook University
NCT05724810
Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Masonic Cancer Center, University of Minnesota
NCT06295757
A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
Memorial Sloan Kettering Cancer Center
NCT06693700
Comparing an Opt-out to an opt-in Approach for Smoking Cessation in VA Primary Care Clinics
VA Office of Research and Development
NCT03477435
A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities
University of Minnesota
NCT05671380
Development of UP2UTobacco for High School Youth
University of Virginia
NCT05396911
Post Acute Cardiac Event Smoking (PACES) Study
Hennepin Healthcare Research Institute
NCT03413423
Teachable Moment to Opt-out of Tobacco: Interactive Voice Response Quit Line for Veteran Active Smokers With Lung Nodules
VA Office of Research and Development
NCT04574518
The Effect of Tobacco Products on Wound Healing
University of Minnesota
NCT04870970
E-cigarette Switching Older Adults
University of Maryland, Baltimore
NCT06534905
Helping Poor Smokers Quit
Washington University School of Medicine
NCT03194958
Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage
William Middleton
NCT07213947
Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products
Altria Client Services
NCT06179290
Improving Tobacco Treatment Rates for Cancer Patients Who Smoke
Abramson Cancer Center at Penn Medicine
NCT04738643
Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT)
Medical University of South Carolina
NCT03453385
Asian Youth and Tobacco Control Survey
M.D. Anderson Cancer Center
NCT00642317
A Mobile App Based Cognitive Dissonance Intervention for Smoking Cessation
Oregon Research Behavioral Intervention Strategies
NCT05797155
Responses to Regulated E-Cigarette Advertisements
University of Massachusetts, Worcester
NCT05207033
CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting
RAI Services Company
NCT05307822
A Facebook Intervention for Young Sexual and Gender Minority Smokers
University of California, San Francisco
NCT03259360
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 2 |
| Phase 3 | 1 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Tobacco Use records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Tobacco Use trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Tobacco Use page
77 registered trials, 33 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 33 Tobacco Use trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- RAI Services Company sponsors the most Tobacco Use trials on record, review their full trial history before evaluating a specific study. See RAI Services Company's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Tobacco Use condition card totals 77 registered trials; most-linked intervention Product D; top US site state Minnesota. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.