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STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking
NCT06922617 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to investigate whether non-cigarette tobacco products, namely e-cigarettes (nicotine vapes), can help people who smoke and are in treatment for substance use disorder quit smoking by switching completely to e-cigarettes as compared to FDA-approved medications, namely nicotine replacement therapy in the form of patches and lozenges. Participation will last 6 months and will include five in-person study visits and eleven virtual assessments. Participants will also complete a short daily diary on their phones each day for the first twelve weeks. To qualify, participants must be within 30 days of SUD treatment program admission. This study is being conducted at three outpatient SUD treatment programs across South Carolina. These sites include: 1) the Center for Drug and Alcohol Problems (CDAP) in Charleston, SC, 2) Behavioral Health Services of Pickens County (BHSPC) in Pickens, SC, and 3) Shoreline Behavioral Health Services in Conway, SC. the Medical University of South Carolina in Charleston, SC, Behavioral Health Services in Pickens, SC, and the Medical University of South Carolina in Florence, SC.
Conditions Studied
Interventions
- BEHAVIORAL Counseling
- BEHAVIORAL Switching to E-Cigarette
- DRUG Quitting using Medication
Study Locations (4)
South Carolina
- MUSC Charleston, Center for Drug and Alcohol Problems — Charleston
- Shoreline Behavioral Health Services — Conway
- Phoenix Center — Greenville
- Behavioral Health Services of Pickens County — Pickens
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2025-10-17 |
| Est. Completion | 2028-09-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06922617
The ClinicalTrials.gov registry entry for NCT06922617 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Medical University of South Carolina, which has 643 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Substance Use Disorders appearing as the primary indexed condition, and to 3 interventions — of which Counseling is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06922617 reports 4 study locations spanning 1 distinct geographic area — top geographies include South Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06922617 about?
NCT06922617 is a clinical study titled "STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking". The purpose of this study is to investigate whether non-cigarette tobacco products, namely e-cigarettes (nicotine vapes), can help people who smoke and are in treatment for substance use disorder quit smoking by switching completely to e-cigarettes as compared to FDA-approved medications, namely nic...
What is the current status of trial NCT06922617?
This trial is currently recruiting. It is a NA study. The enrollment target is 240 participants. The study started on 2025-10-17. Estimated completion is 2028-09-01.
What conditions does trial NCT06922617 study?
This clinical trial studies the following conditions: Substance Use Disorders, Tobacco Use. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06922617?
The interventions under investigation include: Counseling (BEHAVIORAL), Switching to E-Cigarette (BEHAVIORAL), Quitting using Medication (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06922617?
This trial is sponsored by Medical University of South Carolina, which has 643 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06922617 being conducted?
This trial has 4 study locations across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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