Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Fibromyalgia

Open-data reference.

77 US clinical trials · 26 currently recruiting

Active & Recent Trials

RECRUITING 800 participants

Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

Brown University

NCT05754190

RECRUITING Phase 3 620 participants

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Axsome Therapeutics

NCT07398417

RECRUITING NA 400 participants

Autoimmune Intervention Mastery Course Study

Terry L. Wahls

NCT05057676

RECRUITING NA 390 participants

Fibromyalgia Sleep A to ZZZ Study

University of Michigan

NCT06567886

RECRUITING NA 350 participants

Supraspinal Processing of Sensory Aspects of Pain

Children's Hospital Medical Center, Cincinnati

NCT05814497

RECRUITING NA 240 participants

Auricular Neuromodulation in Veterans With Fibromyalgia

VA Office of Research and Development

NCT06415591

RECRUITING NA 180 participants

Ultrasonic Neuromodulation of Cingulate Cortex for Fibromyalgia

SPIRE Therapeutics

NCT07226648

RECRUITING NA 150 participants

Explosive Synchronization of Brain Network Activity in Chronic Pain

University of Michigan

NCT04606095

RECRUITING 150 participants

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

University of Florida

NCT05277025

RECRUITING NA 125 participants

Brief Pain Exposure Therapy (BPET) For Nociplastic Pain

University of Michigan

NCT06208514

RECRUITING Phase 1 120 participants

Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

University of Alabama at Birmingham

NCT03759522

RECRUITING 100 participants

Duloxetine Metabolism and Fibromyalgia

University of Utah

NCT06866444

RECRUITING NA 100 participants

Cognitive Training to Enhance Brain Concordance During Acupuncture

Spaulding Rehabilitation Hospital

NCT06157866

RECRUITING 90 participants

Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions

Children's National Research Institute

NCT04833465

RECRUITING NA 60 participants

Neural Mechanisms of Light Driven Analgesia

University of North Carolina, Chapel Hill

NCT07245303

RECRUITING NA 60 participants

Relationships of Affect and Neuroinflammation With Clinical Pain in Veterans With Fibromyalgia

VA Office of Research and Development

NCT06574165

RECRUITING NA 60 participants

Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients

Massachusetts General Hospital

NCT06009159

RECRUITING Phase 2 50 participants

Nitrous Oxide as Treatment for Fibromyalgia

University of Chicago

NCT05357066

RECRUITING NA 45 participants

Analgesic Response to Opioids in Patients With Fibromyalgia After Conventional Acupuncture Versus Sham Acupuncture

University of California, Irvine

NCT06571110

RECRUITING NA 40 participants

Effects of Breathing and Attention Training (BAT) on Pain Modulation

University of Florida

NCT05773482

RECRUITING NA 36 participants

Self-regulation of Real-time fMRI Brain Activity in Chronic Pain

Brigham and Women's Hospital

NCT07023523

RECRUITING 25 participants

The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature

Faith A. Richardson

NCT05067998

RECRUITING NA 25 participants

The Effects of Energy Healing in Fibromyalgia

University of California, Irvine

NCT06552728

RECRUITING NA 25 participants

The Effects of Core Shamanism in Fibromyalgia

University of California, Irvine

NCT06579261

RECRUITING Early Phase 1 20 participants

MDMA-assisted Therapy for Fibromyalgia

Spaulding Rehabilitation Hospital

NCT06066853

RECRUITING NA 15 participants

Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain

Shirley Ryan AbilityLab

NCT07132775

ACTIVE NOT RECRUITING 2,500 participants

Virtual Specialty Clinic for Fibromyalgia Care

Swing Therapeutics

NCT05978297

ACTIVE NOT RECRUITING NA 360 participants

PEACE: Comparing Chronic Pain Treatment Options

Memorial Sloan Kettering Cancer Center

NCT02979574

ACTIVE NOT RECRUITING NA 300 participants

The Clinical Impact of Integrated Behavioral Health Techniques in Patients With Fibromyalgia

Mayo Clinic

NCT06988761

ACTIVE NOT RECRUITING Early Phase 1 60 participants

Two Point Discrimination

Children's Hospital Medical Center, Cincinnati

NCT03686748

ACTIVE NOT RECRUITING NA 50 participants

Microcurrent for Fibromyalgia

Paul Crawford

NCT04949100

ACTIVE NOT RECRUITING NA 40 participants

A Study Of Virtual Reality Vs Sham VR On Fibromyalgia

Mayo Clinic

NCT07202572

COMPLETED Phase 3 1,025 participants

Study of Milnacipran for the Treatment of Fibromyalgia

Forest Laboratories

NCT00314249

COMPLETED 560 participants

Quantitative EEG During PSG in Patients With and Without Fibromyalgia

SouthCoast Medical Group

NCT01674179

COMPLETED Phase 3 459 participants

Fibromyalgia TENS in Physical Therapy Study (TIPS): an Embedded Pragmatic Clinical Trial

Kathleen Sluka

NCT04683042

COMPLETED NA 389 participants

Fibromyalgia Integrative Training for Adolescents With Juvenile Fibromyalgia

Children's Hospital Medical Center, Cincinnati

NCT03268421

COMPLETED NA 301 participants

Fibromyalgia Activity Study With Transcutaneous Electrical Nerve Stimulation (FAST)

Kathleen Sluka

NCT01888640

COMPLETED NA 300 participants

Resilience Skills Self-Management for Chronic Pain.

University of Michigan

NCT03304613

COMPLETED Phase 2 300 participants

Nondrug Treatment Programs for Adults With Fibromyalgia

University of Utah

NCT00088777

COMPLETED NA 296 participants

Comprehensive vs. Assisted Management of Mood and Pain Symptoms

VA Office of Research and Development

NCT01757301

COMPLETED Phase 2 266 participants

Subgroups of Fibromyalgia Syndrome (FMS): Symptoms, Beliefs, and Tailored Treatment

University of Washington

NCT00762125

COMPLETED 197 participants

Central Mechanisms of Chronic Pain and Fatigue Subtitle: Functional Imaging of Brain and Spinal Cord

University of Florida

NCT03075254

COMPLETED Phase 2 150 participants

Gabapentin in Fibromyalgia Trial (GIFT)

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT00057278

COMPLETED NA 124 participants

Basket Study (CT-100-002) to Evaluate the Effects of a DiNaMo™ Component Training

Click Therapeutics

NCT05573685

COMPLETED Phase 3 119 participants

Effects Of Pregabalin (Lyrica) On Sleep Maintenance In Subjects With Fibromyalgia

Pfizer's Upjohn has merged with Mylan to form Viatris

NCT00883740

COMPLETED Phase 2 111 participants

Cognitive Behavioral Insomnia Therapy for Individuals With Fibromyalgia

Duke University

NCT00321451

COMPLETED Phase 2 110 participants

D-Ribose for Fatigue in Subjects With Fibromyalgia

RiboCor

NCT01315210

COMPLETED NA 105 participants

Developing Biomarkers for Fibromyalgia

University of Michigan

NCT00932061

COMPLETED NA 100 participants

Treatment of Fibromyalgia With Recovery Factors

Practitioners Alliance Network

NCT04381780

COMPLETED Phase 1 97 participants

Pain Management Techniques for Fibromyalgia

University of Michigan

NCT00086060

COMPLETED Phase 2 89 participants

A Study To Assess Esreboxetine's Effect On Concentration, Memory, Decision Making And Problem Solving In Patients With Fibromyalgia.

Pfizer

NCT00752505

COMPLETED NA 80 participants

Mechanisms of Affective Touch in Chronic Pain

Laura Case

NCT04206397

COMPLETED NA 66 participants

Healing Through Affective Self-Awareness in Fibromyalgia: a Randomized Controlled Trial

Mike Hsu

NCT00437411

COMPLETED NA 66 participants

Tai Chi Mind-Body Therapy for Fibromyalgia

Tufts Medical Center

NCT00515008

COMPLETED Phase 2 61 participants

Heart Rate Variability in Response to Metformin Challenge

Woodinville Psychiatric Associates

NCT02500628

COMPLETED NA 60 participants

Prospective Study to Evaluate a Digital Regimen for Fibromyalgia Management: An Extension Study

Swing Therapeutics

NCT05433337

COMPLETED NA 57 participants

Cranial Electrical Stimulation Effects on Symptoms in Persons With Fibromyalgia

University of Virginia

NCT00928720

COMPLETED NA 55 participants

Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)

VA Office of Research and Development

NCT02697435

COMPLETED Phase 3 51 participants

Novel Use of (Oral) Ketotifen for the Treatment of Fibromyalgia: A Pilot Study

Indiana University

NCT01553318

COMPLETED Phase 2 45 participants

The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

Brigham and Women's Hospital

NCT03674541

COMPLETED Phase 4 42 participants

Quetiapine Compared With Placebo in the Management of Fibromyalgia

East Tennessee State University

NCT01458964

COMPLETED Phase 1 40 participants

Intravenous Micronutrient Therapy (IVMT) for Fibromyalgia

National Center for Complementary and Integrative Health (NCCIH)

NCT00067405

COMPLETED Phase 2 37 participants

The Effect of Milnacipran in Patients With Fibromyalgia

Beth Israel Medical Center

NCT01108731

COMPLETED NA 34 participants

Pain Rehabilitation Virtual Reality (PRVR): Innovations to Enhance Mobility in the Presence of Pain

Stanford University

NCT04636177

COMPLETED Phase 4 30 participants

A Pilot Study on the Use of Nociceptive Flexion Reflex for Fibromyalgia

Indiana University

NCT00965601

COMPLETED NA 30 participants

Generalized Hypersensitivity in Patients With Fibromyalgia Syndrome

University of Florida

NCT04415866

COMPLETED Phase 2 27 participants

Dextromethorphan in Fibromyalgia

University of Alabama at Birmingham

NCT03538054

COMPLETED NA 24 participants

Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain

Summa Health System

NCT00554320

COMPLETED 24 participants

Effect of Temperature on Pain and Brown Adipose Activity in Fibromyalgia

University of Minnesota

NCT01322425

COMPLETED NA 23 participants

Prospective Evaluation of Reduced Impedance Noninvasive Cortical Electrostimulation (RINCE) to Reduce Fibromyalgia Effects - Extension Study

Cerephex Corporation

NCT01958853

COMPLETED Phase 4 19 participants

The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia

Mansoor Ahmed M.D.

NCT01234675

COMPLETED Phase 2 19 participants

Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain

University of Washington

NCT00524420

COMPLETED NA 12 participants

Veteran Ear Acupuncture Pilot Project

Chillicothe VA Medical Center

NCT04208659

COMPLETED NA 11 participants

Remote Gamified Sensory Perceptual Training for Patients With Fibromyalgia: a Feasibility Trial

Icahn School of Medicine at Mount Sinai

NCT04919525

COMPLETED Phase 4 8 participants

Effect of Milnacipran on Pain in Fibromyalgia

University of California, San Diego

NCT01288807

COMPLETED Phase 1 6 participants

TD-9855 Mass Balance Study

Theravance Biopharma

NCT01924143

COMPLETED Phase 3 6 participants

Safety and Efficacy of Fluoxetine in Juvenile Fibromyalgia

University of Cincinnati

NCT00115804

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 12
Phase 3 6
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Fibromyalgia Trial Landscape

ClinicalTrials.gov lists 77 US studies indexed under Fibromyalgia, and 26 of those are currently open to recruitment — roughly 34% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Fibromyalgia shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 18 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Fibromyalgia is led by University of Michigan with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 77 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Fibromyalgia?

PlainTrial tracks 77 US clinical trials for Fibromyalgia, of which 26 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Fibromyalgia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →