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ClinicalTrials.gov 26 recruiting now official registry

Fibromyalgia clinical trials

26 of 77 indexed Fibromyalgia trials are currently recruiting.

77 US clinical trials · 26 currently recruiting

Fibromyalgia is the subject of 77 registered US clinical trials on ClinicalTrials.gov, 26 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most active sponsor is University of Michigan, running 6 of these trials.

The research picture

Fibromyalgia has 77 registered US clinical trials, 26 of them open to new participants right now, about 34% of the total.

26
recruiting participants now
34%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
6
top sponsor: University of Michigan
Phase 16Phase 212Phase 36Phase 44

Active & Recent Trials

77 total, page 1 of 2

RECRUITING 800 participants

Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

Brown University

NCT05754190

RECRUITING Phase 3 620 participants

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Axsome Therapeutics

NCT07398417

RECRUITING NA 400 participants

Autoimmune Intervention Mastery Course Study

Terry L. Wahls

NCT05057676

RECRUITING NA 390 participants

Fibromyalgia Sleep A to ZZZ Study

University of Michigan

NCT06567886

RECRUITING NA 350 participants

Supraspinal Processing of Sensory Aspects of Pain

Children's Hospital Medical Center, Cincinnati

NCT05814497

RECRUITING NA 240 participants

Auricular Neuromodulation in Veterans With Fibromyalgia

VA Office of Research and Development

NCT06415591

RECRUITING NA 180 participants

Ultrasonic Neuromodulation of Cingulate Cortex for Fibromyalgia

SPIRE Therapeutics

NCT07226648

RECRUITING NA 150 participants

Explosive Synchronization of Brain Network Activity in Chronic Pain

University of Michigan

NCT04606095

RECRUITING 150 participants

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

University of Florida

NCT05277025

RECRUITING NA 125 participants

Brief Pain Exposure Therapy (BPET) For Nociplastic Pain

University of Michigan

NCT06208514

RECRUITING Phase 1 120 participants

Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

University of Alabama at Birmingham

NCT03759522

RECRUITING 100 participants

Duloxetine Metabolism and Fibromyalgia

University of Utah

NCT06866444

RECRUITING NA 100 participants

Cognitive Training to Enhance Brain Concordance During Acupuncture

Spaulding Rehabilitation Hospital

NCT06157866

RECRUITING 90 participants

Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions

Children's National Research Institute

NCT04833465

RECRUITING NA 60 participants

Neural Mechanisms of Light Driven Analgesia

University of North Carolina, Chapel Hill

NCT07245303

RECRUITING NA 60 participants

Relationships of Affect and Neuroinflammation With Clinical Pain in Veterans With Fibromyalgia

VA Office of Research and Development

NCT06574165

RECRUITING NA 60 participants

Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients

Massachusetts General Hospital

NCT06009159

RECRUITING Phase 2 50 participants

Nitrous Oxide as Treatment for Fibromyalgia

University of Chicago

NCT05357066

RECRUITING NA 45 participants

Analgesic Response to Opioids in Patients With Fibromyalgia After Conventional Acupuncture Versus Sham Acupuncture

University of California, Irvine

NCT06571110

RECRUITING NA 40 participants

Effects of Breathing and Attention Training (BAT) on Pain Modulation

University of Florida

NCT05773482

RECRUITING NA 36 participants

Self-regulation of Real-time fMRI Brain Activity in Chronic Pain

Brigham and Women's Hospital

NCT07023523

RECRUITING 25 participants

The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature

Faith A. Richardson

NCT05067998

RECRUITING NA 25 participants

The Effects of Energy Healing in Fibromyalgia

University of California, Irvine

NCT06552728

RECRUITING NA 25 participants

The Effects of Core Shamanism in Fibromyalgia

University of California, Irvine

NCT06579261

RECRUITING Early Phase 1 20 participants

MDMA-assisted Therapy for Fibromyalgia

Spaulding Rehabilitation Hospital

NCT06066853

RECRUITING NA 15 participants

Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain

Shirley Ryan AbilityLab

NCT07132775

ACTIVE NOT RECRUITING 2,500 participants

Virtual Specialty Clinic for Fibromyalgia Care

Swing Therapeutics

NCT05978297

ACTIVE NOT RECRUITING NA 360 participants

PEACE: Comparing Chronic Pain Treatment Options

Memorial Sloan Kettering Cancer Center

NCT02979574

ACTIVE NOT RECRUITING NA 300 participants

The Clinical Impact of Integrated Behavioral Health Techniques in Patients With Fibromyalgia

Mayo Clinic

NCT06988761

ACTIVE NOT RECRUITING Early Phase 1 60 participants

Two Point Discrimination

Children's Hospital Medical Center, Cincinnati

NCT03686748

ACTIVE NOT RECRUITING NA 50 participants

Microcurrent for Fibromyalgia

Paul Crawford

NCT04949100

ACTIVE NOT RECRUITING NA 40 participants

A Study Of Virtual Reality Vs Sham VR On Fibromyalgia

Mayo Clinic

NCT07202572

COMPLETED Phase 3 1,025 participants

Study of Milnacipran for the Treatment of Fibromyalgia

Forest Laboratories

NCT00314249

COMPLETED 560 participants

Quantitative EEG During PSG in Patients With and Without Fibromyalgia

SouthCoast Medical Group

NCT01674179

COMPLETED Phase 3 459 participants

Fibromyalgia TENS in Physical Therapy Study (TIPS): an Embedded Pragmatic Clinical Trial

Kathleen Sluka

NCT04683042

COMPLETED NA 389 participants

Fibromyalgia Integrative Training for Adolescents With Juvenile Fibromyalgia

Children's Hospital Medical Center, Cincinnati

NCT03268421

COMPLETED NA 301 participants

Fibromyalgia Activity Study With Transcutaneous Electrical Nerve Stimulation (FAST)

Kathleen Sluka

NCT01888640

COMPLETED NA 300 participants

Resilience Skills Self-Management for Chronic Pain.

University of Michigan

NCT03304613

COMPLETED Phase 2 300 participants

Nondrug Treatment Programs for Adults With Fibromyalgia

University of Utah

NCT00088777

COMPLETED NA 296 participants

Comprehensive vs. Assisted Management of Mood and Pain Symptoms

VA Office of Research and Development

NCT01757301

COMPLETED Phase 2 266 participants

Subgroups of Fibromyalgia Syndrome (FMS): Symptoms, Beliefs, and Tailored Treatment

University of Washington

NCT00762125

COMPLETED 197 participants

Central Mechanisms of Chronic Pain and Fatigue Subtitle: Functional Imaging of Brain and Spinal Cord

University of Florida

NCT03075254

COMPLETED Phase 2 150 participants

Gabapentin in Fibromyalgia Trial (GIFT)

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT00057278

COMPLETED NA 124 participants

Basket Study (CT-100-002) to Evaluate the Effects of a DiNaMo™ Component Training

Click Therapeutics

NCT05573685

COMPLETED Phase 3 119 participants

Effects Of Pregabalin (Lyrica) On Sleep Maintenance In Subjects With Fibromyalgia

Pfizer's Upjohn has merged with Mylan to form Viatris

NCT00883740

COMPLETED Phase 2 111 participants

Cognitive Behavioral Insomnia Therapy for Individuals With Fibromyalgia

Duke University

NCT00321451

COMPLETED Phase 2 110 participants

D-Ribose for Fatigue in Subjects With Fibromyalgia

RiboCor

NCT01315210

COMPLETED NA 105 participants

Developing Biomarkers for Fibromyalgia

University of Michigan

NCT00932061

COMPLETED NA 100 participants

Treatment of Fibromyalgia With Recovery Factors

Practitioners Alliance Network

NCT04381780

COMPLETED Phase 1 97 participants

Pain Management Techniques for Fibromyalgia

University of Michigan

NCT00086060

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 12
Phase 3 6
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Fibromyalgia Trial Landscape

77 indexed Fibromyalgia studies · 26 recruiting (34%).

Phase mix: 10 late (III/IV) vs 18 early (I/II).

Top sponsor: University of Michigan (6 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Fibromyalgia?

PlainTrial tracks 77 US clinical trials for Fibromyalgia, of which 26 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Fibromyalgia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.