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NCT06983678 · ClinicalTrials.gov registry record · NA
Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain
A NA study of Chronic Pain and Tobacco Use, sponsored by Duke University.
- Recruiting
- Registry status
- NA
- Development phase
- 132
- Enrollment target
- 1
- Study location
NCT06983678: Recruiting NA study of Chronic Pain and Tobacco Use, sponsored by Duke University.
NCT06983678 is a NA study of Chronic Pain and Tobacco Use that is actively recruiting participants, run by Duke University. The registered enrollment target is 132 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06983678, a NA study of Chronic Pain and Tobacco Use, is actively recruiting participants, sponsored by Duke University.
- RECRUITING
- Registry status
- NA
- Development phase
- 132 participants
- Enrollment target
- 1
- Study location
Study Summary
Individuals with chronic pain are more likely to smoke cigarettes and have more difficulty quitting smoking than the general population, in part because withdrawal from smoking can lead to temporary increases in pain. This research will examine how smoking withdrawal changes the way the brain processes pain, and whether these withdrawal-related changes interfere with the ability to stop smoking. The results of this research will provide important information that can be used to guide the development of interventions to help people with chronic pain who smoke cigarettes to quit smoking and improve their health.
Primary Outcome
Participants will rate their current pain intensity following each of the heat stimulus blocks during the fMRI scans. Pain intensity is measured on a 0-10 visual analogue scale, with higher scores indicating greater pain.
Conditions Studied
Interventions
- BEHAVIORAL Smoking as usual fMRI session
- BEHAVIORAL Abstinent fMRI session
Study Locations (1)
North Carolina
- Duke North Pavilion - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 132 participants |
| Start Date | 2025-11-04 |
| Est. Completion | 2030-03-31 |
| Phase | NA |
What NCT06983678 shows while recruiting
NCT06983678 is an interventional study that assigns participants to a tested intervention. The registered 132 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (83% lower).
The record links to 2 conditions, with Chronic Pain appearing as the primary indexed condition, and to 2 interventions - of which Smoking as usual fMRI session is the first listed.
NCT06983678 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT06983678 about?
NCT06983678 is a clinical study titled "Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain". Individuals with chronic pain are more likely to smoke cigarettes and have more difficulty quitting smoking than the general population, in part because withdrawal from smoking can lead to temporary increases in pain. This research will examine how smoking withdrawal changes the way the brain proces...
What is the current status of trial NCT06983678?
This trial is currently recruiting. It is a NA study. The enrollment target is 132 participants. The study started on 2025-11-04. Estimated completion is 2030-03-31.
What conditions does trial NCT06983678 study?
This clinical trial studies the following conditions: Chronic Pain, Tobacco Use.
What interventions are being tested in trial NCT06983678?
The interventions under investigation include: Smoking as usual fMRI session (BEHAVIORAL), Abstinent fMRI session (BEHAVIORAL).
Who is sponsoring clinical trial NCT06983678?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06983678 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06983678's enrollment target sits among peer trials
132 111th of 301 higher than 191 of 301 other Chronic Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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