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ClinicalTrials.gov 20 recruiting now official registry

Age-related Macular Degeneration clinical trials

20 of 75 indexed Age-related Macular Degeneration trials are currently recruiting.

75 US clinical trials · 20 currently recruiting

Age-related Macular Degeneration is the subject of 75 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is National Eye Institute (NEI), running 8 of these trials.

The research picture

Age-related Macular Degeneration has 75 registered US clinical trials, 20 of them open to new participants right now, about 27% of the total.

20
recruiting participants now
27%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
8
top sponsor: National Eye Institute (NEI)
Phase 118Phase 28Phase 36Phase 42

Active & Recent Trials

75 total, page 1 of 2

RECRUITING NA 60,200 participants

Village-Integrated Eye Worker Trial II

University of California, San Francisco

NCT03752840

RECRUITING 20,000 participants

Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

Sanguine Biosciences

NCT05635266

RECRUITING 1,000 participants

Age-Related Macular Degeneration Benchmark Imaging Dataset (ABID)

University of Wisconsin, Madison

NCT06924021

RECRUITING 650 participants

National Eye Institute Biorepository for Retinal Diseases

National Eye Institute (NEI)

NCT01496625

RECRUITING 600 participants

High Resolution Retinal Imaging

University of Pennsylvania

NCT01866371

RECRUITING NA 500 participants

Stem Cell Ophthalmology Treatment Study II

MD Stem Cells

NCT03011541

RECRUITING Phase 1 132 participants

A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Hoffmann-La Roche

NCT06961370

RECRUITING NA 125 participants

Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD

VisionCare

NCT05438732

RECRUITING 125 participants

Progression of Early Atrophic Lesions

University of Utah

NCT05959005

RECRUITING NA 108 participants

Visual Remapping to Aid Reading With Field Loss

University of Minnesota

NCT03848663

RECRUITING 100 participants

Adaptive Optics Imaging of Outer Retinal Diseases

Food and Drug Administration (FDA)

NCT05355415

RECRUITING NA 100 participants

AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance

Duke University

NCT06619405

RECRUITING NA 80 participants

Lutein, Zeaxathin, and Fish Oil Supplementation

Texas A&M University

NCT06489873

RECRUITING Phase 1 66 participants

Study to Assess the Adverse Events and How Intravitreal ABBV-6628 Moves Through the Body of Adult Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

AbbVie

NCT07160179

RECRUITING NA 60 participants

Effects of Goji vs. Fiber on Macular Degeneration

University of California, Davis

NCT06237127

RECRUITING Phase 1 60 participants

Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration

Perceive Biotherapeutics

NCT06087458

RECRUITING Early Phase 1 50 participants

The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma

MCPHS University

NCT06593405

RECRUITING Phase 1 42 participants

A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration

Astellas Institute for Regenerative Medicine

NCT03178149

RECRUITING Phase 2 21 participants

Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD

Massachusetts Eye and Ear Infirmary

NCT04735263

RECRUITING Phase 1 15 participants

The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

University of Rochester

NCT06319872

ACTIVE NOT RECRUITING 20,000 participants

ForeseeHome NRich Registry

Notal Vision

NCT05690880

ACTIVE NOT RECRUITING 603 participants

GARM II: A Study on the Genetics of Age-related Maculopathy

University of California, Los Angeles

NCT01115387

ACTIVE NOT RECRUITING 400 participants

An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration

Genentech

NCT05300724

ACTIVE NOT RECRUITING 217 participants

Study of Dark Adaptation in Age-Related Macular Degeneration

National Eye Institute (NEI)

NCT01352975

ACTIVE NOT RECRUITING Phase 2 170 participants

A Masked, Placebo-controlled Study to Assess Iptacopan in Age-related Macular Degeneration

Novartis Pharmaceuticals

NCT05230537

ACTIVE NOT RECRUITING NA 130 participants

Efficacy of OmegaBoost to Increase Omega-3 Levels in Healthy Individuals

Western University of Health Sciences

NCT05763940

ACTIVE NOT RECRUITING Phase 3 120 participants

A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders

Outlook Therapeutics

NCT05112861

ACTIVE NOT RECRUITING 110 participants

Age-Related Eye Disease Study (AREDS) Follow-Up

National Eye Institute (NEI)

NCT00594672

ACTIVE NOT RECRUITING 73 participants

Impact of Non-Exudative Type 1 MNV on AMD Progression

University of Utah

NCT06125977

ACTIVE NOT RECRUITING 57 participants

Dark Adaptation in Participants With Age-Related Macular Degeneration

National Eye Institute (NEI)

NCT03225131

ACTIVE NOT RECRUITING 50 participants

A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)

Icahn School of Medicine at Mount Sinai

NCT03963817

ACTIVE NOT RECRUITING Phase 1 45 participants

Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration

Perceive Biotherapeutics

NCT05380492

ACTIVE NOT RECRUITING Phase 1 30 participants

Evaluation of Kamuvudine-8 in Subjects With Geographic Atrophy

Michelle Abou-Jaoude

NCT06164587

ACTIVE NOT RECRUITING Phase 1 25 participants

Safety and Tolerability of KH631 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration

Chengdu Origen Biotechnology Co.

NCT05657301

ACTIVE NOT RECRUITING Phase 1 24 participants

Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular Degeneration

Hoffmann-La Roche

NCT02286089

ACTIVE NOT RECRUITING Phase 1 20 participants

NG101 AAV Gene Therapy in Subjects With Wet Age-Related Macular Degeneration

Elisigen

NCT05984927

ACTIVE NOT RECRUITING Phase 1 18 participants

A Follow-up Study to Evaluate the Safety of RetinoStat® in Patients With Age-Related Macular Degeneration

Oxford BioMedica

NCT01678872

ACTIVE NOT RECRUITING Phase 1 9 participants

A Phase I, Open-label, Multicenter, Dose-Escalating Study to Evaluate the Safety and Tolerability of KH658 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration

Chengdu Origen Biotechnology Co.

NCT06825858

COMPLETED Phase 3 1,208 participants

Comparison of Age-related Macular Degeneration Treatments Trials: Lucentis-Avastin Trial

University of Pennsylvania

NCT00593450

COMPLETED Phase 3 734 participants

Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON)

Novartis Pharmaceuticals

NCT04005352

COMPLETED 556 participants

Functionally Validated Structural Endpoints for Early AMD

Cynthia Owsley

NCT04112667

COMPLETED 470 participants

AREDS 2 Ancillary Spectral Domain Optical Coherence Tomography Study

Duke University

NCT00734487

COMPLETED Phase 3 228 participants

A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD)

Outlook Therapeutics

NCT03834753

COMPLETED Phase 2 200 participants

Phase 2/3 Study of ALK-001 in Geographic Atrophy

Alkeus Pharmaceuticals

NCT03845582

COMPLETED Phase 3 195 participants

A 3-month Study to Assess the Safety of ONS-5010 in Subjects With Visual Impairment Due to Retinal Disorders

Outlook Therapeutics

NCT04516278

COMPLETED Phase 2 176 participants

ReCLAIM-2 Study to Evaluate Safety,Efficacy & Pharmacokinetics of Elamipretide in Subjects With AMD With Non-central GA

Stealth BioTherapeutics

NCT03891875

COMPLETED 152 participants

Genetic Analysis of Chronic Central Serous Chorioretinopathy Masquerading as Neovascular AMD

Sequenom

NCT01880788

COMPLETED 150 participants

Genetic Study of Age-Related Macular Degeneration

National Eye Institute (NEI)

NCT00357578

COMPLETED Phase 2 131 participants

Retinal and Retinal Pigment Epithelium (RPE) Autoimmunity in Age-related Macular Degeneration (AMD)

Lawrence S. Morse, MD

NCT00931489

COMPLETED 128 participants

Study on Visual Function Impairments in Dry Age-related Macular Degeneration

Duke University

NCT01822873

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Phase Distribution

PhaseTrial count
Phase 1 18
Phase 2 8
Phase 3 6
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Age-related Macular Degeneration Trial Landscape

75 indexed Age-related Macular Degeneration studies · 20 recruiting (27%).

Phase mix: 8 late (III/IV) vs 26 early (I/II).

Top sponsor: National Eye Institute (NEI) (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Age-related Macular Degeneration?

PlainTrial tracks 75 US clinical trials for Age-related Macular Degeneration, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Age-related Macular Degeneration?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.