Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Tobacco Use: early-phase trial registry
33 of 77 indexed Tobacco Use trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #175 of 28,707 conditions by registered trial count.
77 US clinical trials · 33 currently recruiting · #175 of 28,707 conditions by registered trial count
Tobacco Use: 77 US clinical trials tracked, 33 recruiting.
Tobacco Use is the subject of 77 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is RAI Services Company, running 8 of these trials.
Enrollment posture brief
Registry condition tobacco-use
OPEN 33 | RECR 43% | LATE 4 | EARLY 10 | RANK #175 | SPON 8
Volume-matched condition peers
Nearest open-share peer: Acute Myelogenous Leukemia (AML) (43% recruiting · 7 trials)
Tobacco Use lists 33 open slots (43% of 77 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Tobacco Use on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Tobacco Use is recruiting above its size-band peers.
33 of 77 indexed trials (42.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Tobacco Use trials is spread across many organizations.
RAI Services Company accounts for 8 of 77 trials (10.4%). 46 distinct sponsors appear on at least one study for this condition label.
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Typical Tobacco Use enrolment sits around 100 participants.
Median target enrolment is 100 among the 77 trials that report a genuine target (sentinel values excluded). 36 of those (46.8%) plan for fewer than 100 participants.
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Tobacco Use research is mostly interventional.
72 interventional and 5 observational studies make up this index (93.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
77 total, page 2 of 2
Media Literacy for High School Tobacco Prevention
University of Pittsburgh
NCT05120466
A Guided Imagery Tobacco Cessation Intervention Delivered by a Quit Line and Website
University of Arizona
NCT02968381
An Intervention to Address Parental Smoking During the Postpartum Hospitalization.
Massachusetts General Hospital
NCT00844818
A Mobile Intervention to Promote Cessation in HIV-infected Smokers
Montefiore Medical Center
NCT02432482
Emergency Department Initiated Tobacco Treatment (EDITT)
National Institute on Drug Abuse (NIDA)
NCT00252902
CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants
RAI Services Company
NCT05114863
Development of a Mindfulness-Based Treatment for the Reduction of Alcohol Use and Smoking Cessation
H. Lee Moffitt Cancer Center and Research Institute
NCT03734666
Jail-Based Use of Smoking Cessation Treatment Study
Hennepin Healthcare Research Institute
NCT03799315
Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes
22nd Century Group
NCT03559751
Feasibility Study - Filter Ventilation
Masonic Cancer Center, University of Minnesota
NCT04514471
Connecting Alaska Native People to Quit Smoking
Mayo Clinic
NCT03645941
CSD170202: A Study to Evaluate the Exposure to Tobacco Constituents From Two Moist Snuff Products
RAI Services Company
NCT03158428
Preventing Cigarette Use Among Urban Youth Via an M-Health Primary Care Preventive Intervention
University of Michigan
NCT03855410
CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches
RAI Services Company
NCT05294497
Modern Nicotine Oral Product Abuse Liability
RAI Services Company
NCT06777784
Biomarker Feedback to Motivate Tobacco Cessation in Pregnant ALaska Native Women: Phase 2
Mayo Clinic
NCT02018640
CSD201202: A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System P12
RAI Services Company
NCT05239884
A Study to Assess the Pharmacokinetics of Oral Nicotine Pouches and Lozenges in Healthy Adults
British American Tobacco (Investments) Limited
NCT04755348
Minocycline and Tobacco Craving in Smokers With Schizophrenia
University of Maryland, Baltimore
NCT02968602
Families With Substance Use and Psychosis: A Pilot Study
Mclean Hospital
NCT04284813
Salt-Based E-cigarette
Medical University of South Carolina
NCT04238832
Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free
H. Lee Moffitt Cancer Center and Research Institute
NCT05362318
BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability
RAI Services Company
NCT06105424
Baby Albert: Electronic Cigarette Pharmacokinetics (PK) and Abuse Liability
University of Oklahoma
NCT03637452
Patient Navigation-based Tobacco Harm Reduction Program Among Cancer Patients
Milton S. Hershey Medical Center
NCT04972916
Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder
Medical University of South Carolina
NCT05796791
Provider Training in Increasing Patient Tobacco Cessation Counseling and Referrals for Patients With Cancer Undergoing Radiation Therapy
OHSU Knight Cancer Institute
NCT03135782
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 2 |
| Phase 3 | 1 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Tobacco Use records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Tobacco Use trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Tobacco Use page
77 registered trials, 33 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 33 Tobacco Use trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- RAI Services Company sponsors the most Tobacco Use trials on record, review their full trial history before evaluating a specific study. See RAI Services Company's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Tobacco Use condition card totals 77 registered trials; most-linked intervention Product D; top US site state Minnesota. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.